18-wheeler
Pathogen resistance
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Lazzaro BP; Sackton TB; Clark AG (2006)
Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria.
GP00000001
18w
A1ZBR2
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
18-wheeler
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
ABC transporter pvmrp1
Xenobiotic resistance (multiresistance to antimalarial drugs)
Unknown,
Unknown
Plasmodium vivax
malaria parasite P. vivax - (species)
Intraspecific
Association Mapping
Pearson RD; Amato R; Auburn S ; et al. (2016)
Genomic analysis of local variation and recent evolution in Plasmodium vivax.
GP00001486
PVX_097025
A5KCN4
Physiology
unknown
Plasmodium vivax
malaria parasite P. vivax - (species)
Plasmodium vivax
malaria parasite P. vivax - (species)
ABC transporter pvmrp1
Plasmodium vivax
malaria parasite P. vivax - (species)
Published - Accepted by Curator
ABCA2
Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)
Coding,
Indel
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Linkage Mapping
Tay WT; Mahon RJ; Heckel DG ; et al. (2015)
Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]
GP00000002
ABCA2
A0A0S0G7V0
Physiology
65bp indel in exon16 inducing a frameshift N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
ABCA2
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
ABCA2
Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)
Coding,
Deletion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Tay WT; Mahon RJ; Heckel DG ; et al. (2015)
Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]
GP00000003
ABCA2
A0A0S0G7V0
Physiology
5bp deletion inducing a frameshift N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
ABCA2
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
ABCA2
Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)
Coding,
Insertion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Tay WT; Mahon RJ; Heckel DG ; et al. (2015)
Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]
GP00000004
ABCA2
A0A0S0G7V0
Physiology
5bp (GAATA) nucleotide duplication inducing a frameshift N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
ABCA2
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
ABCA2
Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)
Coding,
Insertion
N
Trichoplusia ni
cabbage looper - (species) D
Intraspecific
Linkage Mapping
Yang X; Chen W; Song X ; et al. (2019)
Mutation of ABC transporter ABCA2 confers resistance to Bt toxin Cry2Ab in Trichoplusia ni.
GP00002054
ABCA2
A0A0S0G7V0
Physiology
insertion of a transposon Tntransib (2581 bp) in ABCA2 which changes splicing sites in the transcript and lead to an indel in the coding region: change of 1551VETLAHALGFLRHLDKR1567 into 1551AHWGK- LYGSNTQN1563 N
Trichoplusia ni
cabbage looper - (species)
Trichoplusia ni
cabbage looper - (species) D
ABCA2
Trichoplusia ni
cabbage looper - (species)
Published - Accepted by Curator
ABCA2
Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)
Coding,
Deletion
N
Helicoverpa punctigera
(species) D
Intraspecific
Candidate Gene
Tay WT; Mahon RJ; Heckel DG ; et al. (2015)
Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]
GP00002056
ABCA2
A0A0S0G7V0
Physiology
14bp deletion resulting in missense mutations. N
Helicoverpa punctigera
(species)
Helicoverpa punctigera
(species) D
ABCA2
Helicoverpa punctigera
(species)
Published - Accepted by Curator
ABCA2
Xenobiotic resistance (insecticide; Bt Cry2Ab toxin)
Coding,
Insertion
N
Pectinophora gossypiella
pink bollworm - (species) D
Intraspecific
Candidate Gene
Mathew LG; Ponnuraj J; Mallappa B ; et al. (2018)
ABC transporter mis-splicing associated with resistance to Bt toxin Cry2Ab in laboratory- and field-[...]
GP00002057
ABCA2
A0A0S0G7V0
Physiology
loss of exon 6 caused by alternative splicing N
Pectinophora gossypiella
pink bollworm - (species)
Pectinophora gossypiella
pink bollworm - (species) D
ABCA2
Pectinophora gossypiella
pink bollworm - (species)
Published - Accepted by Curator
ABCA2
Xenobiotic resistance (insecticide; Bt Cry2Ab)
Coding,
Insertion
N
Trichoplusia ni
cabbage looper - (species) D
Intraspecific
Linkage Mapping
Yang X; Chen W; Song X ; et al. (2019)
Mutation of ABC transporter ABCA2 confers resistance to Bt toxin Cry2Ab in Trichoplusia ni.
GP00002467
ABCA2
Q9BZC7
Physiology
insertion of a 2581-bp transposon Tntransib in ABCA2. This insertion disrupts splicing sites and leads to indels in the protein sequence. CRISPR ABCA2 mutants are highly resistant to Cry2Ab. N
Trichoplusia ni
cabbage looper - (species)
Trichoplusia ni
cabbage looper - (species) D
ABCA2
Trichoplusia ni
cabbage looper - (species)
Published - Accepted by Curator
ABCB1
Xenobiotic resistance (insecticide; Bt Cry3Aa toxin)
Coding,
Deletion
N
Chrysomela tremula
(species) D
Intraspecific
Candidate Gene
Pauchet Y; Bretschneider A; Augustin S ; et al. (2016)
A P-Glycoprotein Is Linked to Resistance to the Bacillus thuringiensis Cry3Aa Toxin in a Leaf Beetle[...]
GP00002466
ABCB1
P08183
Physiology
a four-base-pair deletion at position 1561 introducing a frame shift with a premature stop codon leading to loss of the TpM1 transporter motif as well as the complete second transmembrane domain N
Chrysomela tremula
(species)
Chrysomela tremula
(species) D
ABCB1
Chrysomela tremula
(species)
Published - Accepted by Curator
ABCB4
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Bariami V; Jones CM; Poupardin R ; et al. (2012)
Gene amplification, ABC transporters and cytochrome P450s: unraveling the molecular basis of pyrethr[...]
GP00002607
Abcb4
P21440
Physiology
ABCB4 gene amplified about 6–7 times
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
ABCB4
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
ABCB7
Iron metabolism
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001379
ABCB7
O75027
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
ABCB7
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
ABCC11
Apocrine secretion (ear wax type ; axillary odor)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Yoshiura K; Kinoshita A; Ishida T ; et al. (2006)
A SNP in the ABCC11 gene is the determinant of human earwax type.
1 Additional References
GP00000010
ABCC11
Q96J66
Physiology
1 a.a. polymorphism considered best candidate - c.538G>A - G180R in the ATP-binding cassette
Homo sapiens
human - (species)
Homo sapiens
human - (species)
ABCC11
Homo sapiens
human - (species)
Published - Accepted by Curator
ABCC2
Xenobiotic resistance (insecticide)
Coding,
Deletion
N
Heliothis virescens
tobacco budworm - (species) D
Intraspecific
Linkage Mapping
Gahan LJ; Pauchet Y; Vogel H ; et al. (2010)
An ABC transporter mutation is correlated with insect resistance to Bacillus thuringiensis Cry1Ac to[...]
GP00000012
ABCC2
A0A0E3ZDK3
Physiology
22bp deletion N
Heliothis virescens
tobacco budworm - (species)
Heliothis virescens
tobacco budworm - (species) D
ABCC2
Heliothis virescens
tobacco budworm - (species)
Published - Accepted by Curator
ABCC2
Xenobiotic resistance (insecticide)
Coding,
Deletion
N
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Linkage Mapping
Baxter SW; Badenes-Pérez FR; Morrison A ; et al. (2011)
Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.
GP00000013
ABCC2
A0A0E3ZDK3
Physiology
30bp deletion N
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
ABCC2
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
ABCC2
Xenobiotic resistance (insecticide; Bt Cry1Ac)
Unknown,
Unknown
Trichoplusia ni
cabbage looper - (species) D
Intraspecific
Linkage Mapping
Baxter SW; Badenes-Pérez FR; Morrison A ; et al. (2011)
Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.
GP00000014
ABCC2
A0A0E3ZDK3
Physiology
Not identified
Trichoplusia ni
cabbage looper - (species)
Trichoplusia ni
cabbage looper - (species) D
ABCC2
Trichoplusia ni
cabbage looper - (species)
Published - Accepted by Curator
ABCC2
Xenobiotic resistance (insecticide; Bt toxins)
Coding,
Deletion
N
Spodoptera exigua
beet armyworm - (species) D
Intraspecific
Linkage Mapping
Park Y; González-Martínez RM; Navarro-Cerrillo G ; et al. (2014)
ABCC transporters mediate insect resistance to multiple Bt toxins revealed by bulk segregant analysi[...]
GP00001439
Physiology
About 500 nt genomic deletion over 2 exons involving 246 nt coding 82aa N
Spodoptera exigua
beet armyworm - (species)
Spodoptera exigua
beet armyworm - (species) D
ABCC2
Spodoptera exigua
beet armyworm - (species)
Published - Accepted by Curator
ABCC2
Xenobiotic resistance (insecticide; Bt toxins)
Coding,
Complex Change
N
Spodoptera frugiperda
fall armyworm - (species) D
Intraspecific
Candidate Gene
Banerjee R; Hasler J; Meagher R ; et al. (2017)
Mechanism and DNA-based detection of field-evolved resistance to transgenic Bt corn in fall armyworm[...]
1 Additional References
GP00002461
MRP1
H8YF43
Physiology
A nine-base deletion (position 39–47) and a two-base insertion (GC at position 2218) lead to a frameshift and the occurrence of a premature stop codon. The truncated protein is 746 amino acids whereas the ABCC2 of the susceptible strain encodes a protein of 1349 amino acids. N
Spodoptera frugiperda
fall armyworm - (species)
Spodoptera frugiperda
fall armyworm - (species) D
ABCC2
Spodoptera frugiperda
fall armyworm - (species)
Published - Accepted by Curator
ABCC2
Xenobiotic resistance (insecticide; Bt toxins)
Coding,
Complex Change
N
Spodoptera frugiperda
fall armyworm - (species) D
Intraspecific
Candidate Gene
Boaventura D; Ulrich J; Lueke B ; et al. (2020)
Molecular characterization of Cry1F resistance in fall armyworm, Spodoptera frugiperda from Brazil.
GP00002462
MRP1
H8YF43
Physiology
two mutations in the extracellular loop 4 (ECL4) of ABCC2: a deletion of two amino acids (GY) at positions 788 and 789 and the change of a proline to either lysine or arginine at position 799. Expression of mutated ABCC2 in insect cells confirmed the role of these mutations in toxin binding. N
Spodoptera frugiperda
fall armyworm - (species)
Spodoptera frugiperda
fall armyworm - (species) D
ABCC2
Spodoptera frugiperda
fall armyworm - (species)
Published - Accepted by Curator
Abdominal-B
Coloration (male-specific)
Unknown,
Unknown
Drosophila malerkotliana
(species)
Intraspecific
Linkage Mapping
Signor SA; Liu Y; Rebeiz M ; et al. (2016)
Genetic Convergence in the Evolution of Male-Specific Color Patterns in Drosophila.
GP00001548
Abd-B
P09087
Morphology
unknown
Drosophila malerkotliana
(species)
Drosophila malerkotliana
(species)
Abdominal-B
Drosophila malerkotliana
(species)
Published - Accepted by Curator
Abdominal-B
Coloration (abdomen; setae)
Cis-regulatory,
Unknown
Bombus melanopygus
(species)
Intraspecific
Association Mapping
Tian L; Rahman SR; Ezray BD ; et al. (2019)
A homeotic shift late in development drives mimetic color variation in a bumble bee.
GP00002048
Abd-B
P09087
Morphology
4kb region - probably several mutations according to recombinants with intermediate phenotypes
Bombus melanopygus
(species)
Bombus melanopygus
(species)
Abdominal-B
Bombus melanopygus
(species)
Published - Accepted by Curator
ABO histo blood group glycosyltransferase
ABO antigen blood type
Coding,
SNP
Homininae
(subfamily)
Intraspecific
Candidate Gene
Yamamoto F; Hakomori S (1990)
Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...]
1 Additional References
GP00000017
ABO
P16442
Physiology
Gly268 (group A) <-> Ala (group B)
Homininae
(subfamily)
Homininae
(subfamily)
ABO histo blood group glycosyltransferase
Homininae
(subfamily)
Published - Accepted by Curator
ABO histo blood group glycosyltransferase
ABO antigen blood type
Coding,
SNP
Homininae
(subfamily)
Intraspecific
Candidate Gene
Yamamoto F; Hakomori S (1990)
Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...]
1 Additional References
GP00000018
ABO
P16442
Physiology
Leu266 (group A) <-> Met (group B)
Homininae
(subfamily)
Homininae
(subfamily)
ABO histo blood group glycosyltransferase
Homininae
(subfamily)
Published - Accepted by Curator
ABO histo blood group glycosyltransferase
ABO antigen blood type
Coding,
Deletion
N
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Yamamoto F; Hakomori S (1990)
Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid [...]
1 Additional References
GP00000019
ABO
P16442
Physiology
1bp deletion (258G) resulting in frameshift N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
ABO histo blood group glycosyltransferase
Homo sapiens
human - (species)
Published - Accepted by Curator
ABO histo blood group glycosyltransferase
ABO antigen blood type
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Yamamoto F; McNeill PD; Yamamoto M ; et al. (1993)
Molecular genetic analysis of the ABO blood group system: 4. Another type of O allele.
1 Additional References
GP00000020
ABO
P16442
Physiology
Arg176+Gly268 (group A) <-> Gly176+Arg268 (group O03 = weak AB allele rather than complete loss-of-function)
two nucleotide substitutions at nt. 526 and nt. 802. The authors have not examined whether both amino acid substitutions are necessary to disrupt the enzymatic activity or if one of them is sufficient. Nevertheless they assume that the single amino acid substitution at aa. 268 (glycine+arginine) may be crucial for their nullifying effect.
Homo sapiens
human - (species)
Homo sapiens
human - (species)
ABO histo blood group glycosyltransferase
Homo sapiens
human - (species)
Published - Accepted by Curator
ABO histo blood group glycosyltransferase
ABO antigen blood type
Coding,
Insertion
N
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Hosseini-Maaf B; Irshaid NM; Hellberg A ; et al. (2005)
New and unusual O alleles at the ABO locus are implicated in unexpected blood group phenotypes.
1 Additional References
GP00000021
ABO
P16442
Physiology
1bp insertion resulting in premature stop codon N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
ABO histo blood group glycosyltransferase
Homo sapiens
human - (species)
Published - Accepted by Curator
ABO histo blood group glycosyltransferase
ABO antigen blood type
Coding,
SNP
N
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Hosseini-Maaf B; Irshaid NM; Hellberg A ; et al. (2005)
New and unusual O alleles at the ABO locus are implicated in unexpected blood group phenotypes.
1 Additional References
GP00000022
ABO
P16442
Physiology
1bp change resulting in stop codon N
Homo sapiens
human - (species)
Homo sapiens
human - (species)
ABO histo blood group glycosyltransferase
Homo sapiens
human - (species)
Published - Accepted by Curator
ABO histo blood group glycosyltransferase
ABO antigen blood type
Coding,
Unknown
Pan troglodytes
chimpanzee - (species)
Intraspecific
Candidate Gene
Kermarrec N; Roubinet F; Apoil PA ; et al. (1999)
Comparison of allele O sequences of the human and non-human primate ABO system.
GP00000023
ABO
P16442
Physiology
Uncertain; possibly 9bp deletion resultin in 3a.a. deletion
Pan troglodytes
chimpanzee - (species)
Pan troglodytes
chimpanzee - (species)
ABO histo blood group glycosyltransferase
Pan troglodytes
chimpanzee - (species)
Published - Accepted by Curator
ABO histo blood group glycosyltransferase
ABO antigen blood type
Unknown,
Unknown
Pan troglodytes
chimpanzee - (species)
Intraspecific
Candidate Gene
Kermarrec N; Roubinet F; Apoil PA ; et al. (1999)
Comparison of allele O sequences of the human and non-human primate ABO system.
GP00000024
ABO
P16442
Physiology
unknown
Pan troglodytes
chimpanzee - (species)
Pan troglodytes
chimpanzee - (species)
ABO histo blood group glycosyltransferase
Pan troglodytes
chimpanzee - (species)
Published - Accepted by Curator
ACD6 = ACCELERATED CELL DEATH 6
Plant size
Pathogen resistance (plant microbes)
Herbivore resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Todesco M; Balasubramanian S; Hu TT ; et al. (2010)
Natural allelic variation underlying a major fitness trade-off in Arabidopsis thaliana.
1 Additional References
GP00000025
ACD6
Q8LPS2
Physiology
Physiology
Physiology
Various
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
ACD6 = ACCELERATED CELL DEATH 6
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)
Xenobiotic resistance (insecticide; cyclic ketoenol)
Coding,
SNP
Bemisia tabaci
(species) D
Intraspecific
Candidate Gene
Lueke B; Douris V; Hopkinson JE ; et al. (2020)
Identification and functional characterization of a novel acetyl-CoA carboxylase mutation associated[...]
1 Additional References
GP00002513
ACC
Q7JV23
Physiology
A2083V
Bemisia tabaci
(species)
Bemisia tabaci
(species) D
acetyl-CoA carboxylase (ACC)
Bemisia tabaci
(species)
Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)
Xenobiotic resistance (insecticide; spiromesifen)
Coding,
SNP
Trialeurodes vaporariorum
greenhouse whitefly - (species) D
Intraspecific
Candidate Gene
Karatolos N; Williamson MS; Denholm I ; et al. (2012)
Resistance to spiromesifen in Trialeurodes vaporariorum is associated with a single amino acid repla[...]
1 Additional References
GP00002556
ACC
Q7JV23
Physiology
E645K
Trialeurodes vaporariorum
greenhouse whitefly - (species)
Trialeurodes vaporariorum
greenhouse whitefly - (species) D
acetyl-CoA carboxylase (ACC)
Trialeurodes vaporariorum
greenhouse whitefly - (species)
Published - Accepted by Curator
acetyl-CoA carboxylase (ACC)
Xenobiotic resistance (insecticide; spirotetramat)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Singh KS; Cordeiro EMG; Troczka BJ ; et al. (2021)
Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...]
GP00002616
ACC
Q7JV23
Physiology
a single non-synonymous mutation (gCt > gTt) resulting in an alanine to valine substitution in a highly conserved region of the ACC carboxyltransferase (CT) domain
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
acetyl-CoA carboxylase (ACC)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles albimanus
(species) D
Intraspecific
Candidate Gene
Weill M; Malcolm C; Chandre F ; et al. (2004)
The unique mutation in ace-1 giving high insecticide resistance is easily detectable in mosquito vec[...]
GP00000026
Ace
P07140
Physiology
G119S
Anopheles albimanus
(species)
Anopheles albimanus
(species) D
Acetylcholinesterase (Ace-1)
Anopheles albimanus
(species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Candidate Gene
Weill M; Lutfalla G; Mogensen K ; et al. (2003)
Comparative genomics: Insecticide resistance in mosquito vectors.
GP00000027
Ace
P07140
Physiology
G119S
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
Acetylcholinesterase (Ace-1)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Weill M; Lutfalla G; Mogensen K ; et al. (2003)
Comparative genomics: Insecticide resistance in mosquito vectors.
GP00000028
Ace
P07140
Physiology
Gly119Ser (119 is the corresponding position in Torpedo) - GGC to AGC
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
Acetylcholinesterase (Ace-1)
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Weill M; Lutfalla G; Mogensen K ; et al. (2003)
Comparative genomics: Insecticide resistance in mosquito vectors.
GP00000029
Ace
P07140
Physiology
Gly119Ser (119 is the corresponding position in Torpedo) - GGC to AGC
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
Acetylcholinesterase (Ace-1)
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex tritaeniorhynchus
(species) D
Intraspecific
Candidate Gene
Alout H; Berthomieu A; Cui F ; et al. (2007)
Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...]
1 Additional References
GP00000030
Ace
P07140
Physiology
F331W
Culex tritaeniorhynchus
(species)
Culex tritaeniorhynchus
(species) D
Acetylcholinesterase (Ace-1)
Culex tritaeniorhynchus
(species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex vishnui
(species) D
Intraspecific
Candidate Gene
Alout H; Berthomieu A; Cui F ; et al. (2007)
Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 inse[...]
GP00000031
Ace
P07140
Physiology
G119S
Culex vishnui
(species)
Culex vishnui
(species) D
Acetylcholinesterase (Ace-1)
Culex vishnui
(species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
3 Mutations:
Aphis gossypii
cotton aphid - (species)
Intraspecific
Candidate Gene
Shang Q; Pan Y; Fang K ; et al. (2014)
Extensive Ace2 duplication and multiple mutations on Ace1 and Ace2 are related with high level of or[...]
4 Additional References
GP00000036
Ace
P07140
Physiology
3 mutations
Aphis gossypii
cotton aphid - (species)
Aphis gossypii
cotton aphid - (species)
Acetylcholinesterase (Ace-1)
Aphis gossypii
cotton aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Candidate Gene
Assogba BS; Milesi P; Djogbénou LS ; et al. (2016)
The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...]
1 Additional References
GP00001372
Ace
P07140
Physiology
Strict tandem duplication of 203kb encompassing 12 genes ; ace1 heterogeneous gene duplication (susceptible G119 and resistant S119 copies)
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
Acetylcholinesterase (Ace-1)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Anopheles gambiae
African malaria mosquito - (species)
Intraspecific
Candidate Gene
Assogba BS; Milesi P; Djogbénou LS ; et al. (2016)
The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...]
GP00001373
Ace
P07140
Physiology
Strict tandem 3 times duplication of 203kb encompassing 12 genes with partial internal deletion of 97kb in the third copy - ace1 homogeneous gene duplications (all 3 copies S119 resistant)
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species)
Acetylcholinesterase (Ace-1)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Candidate Gene
Assogba BS; Milesi P; Djogbénou LS ; et al. (2016)
The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of [...]
GP00001374
Ace
P07140
Physiology
Strict tandem 5 times duplication of 203kb encompassing 12 genes - ace1 homogeneous gene duplications (all 5 copies S119 resistant)
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
Acetylcholinesterase (Ace-1)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Anazawa Y; Tomita T; Aiki Y ; et al. (2003)
Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...]
2 Additional References
GP00002013
Ace
P07140
Physiology
A201S
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
Acetylcholinesterase (Ace-1)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Nabeshima T; Kozaki T; Tomita T ; et al. (2003)
An amino acid substitution on the second acetylcholinesterase in the pirimicarb-resistant strains of[...]
GP00002015
Ace
P07140
Physiology
Ser431Phe (position 331 in mature Torpedo protein)
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
Acetylcholinesterase (Ace-1)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Chilo suppressalis
striped riceborer - (species) D
Intraspecific
Candidate Gene
Jiang X; Qu M; Denholm I ; et al. (2009)
Mutation in acetylcholinesterase1 associated with triazophos resistance in rice stem borer, Chilo su[...]
GP00002453
Ace
P07140
Physiology
an amino acid mutation A314S in Ch-ace1 (corresponding to A201S in Torpedo californica AChE) was consistently associated with the occurrence of resistance
Chilo suppressalis
striped riceborer - (species)
Chilo suppressalis
striped riceborer - (species) D
Acetylcholinesterase (Ace-1)
Chilo suppressalis
striped riceborer - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Lee DW; Choi JY; Kim WT ; et al. (2007)
Mutations of acetylcholinesterase1 contribute to prothiofos-resistance in Plutella xylostella (L.).
3 Additional References
GP00002454
Ace
P07140
Physiology
2 mutations
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
Acetylcholinesterase (Ace-1)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Bemisia tabaci
(species) D
Intraspecific
Candidate Gene
Mavridis K; Papapostolou KM; Ilias A ; et al. (2022)
Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...]
GP00002512
Ace
P07140
Physiology
F331W
Bemisia tabaci
(species)
Bemisia tabaci
(species) D
Acetylcholinesterase (Ace-1)
Bemisia tabaci
(species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Anazawa Y; Tomita T; Aiki Y ; et al. (2003)
Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...]
1 Additional References
GP00002571
Ace
P07140
Physiology
S119G
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
Acetylcholinesterase (Ace-1)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Anazawa Y; Tomita T; Aiki Y ; et al. (2003)
Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...]
2 Additional References
GP00002572
Ace
P07140
Physiology
G328A
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
Acetylcholinesterase (Ace-1)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Khajehali J; Van Leeuwen T; Grispou M ; et al. (2010)
Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychida[...]
1 Additional References
GP00002573
Ace
P07140
Physiology
F331W
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
Acetylcholinesterase (Ace-1)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Anazawa Y; Tomita T; Aiki Y ; et al. (2003)
Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...]
1 Additional References
GP00002574
Ace
P07140
Physiology
D128E
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
Acetylcholinesterase (Ace-1)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aphis gossypii
cotton aphid - (species)
Intraspecific
Candidate Gene
Li F; Han Z (2004)
Mutations in acetylcholinesterase associated with insecticide resistance in the cotton aphid, Aphis [...]
3 Additional References
GP00002577
Ace
P07140
Physiology
A201S
Aphis gossypii
cotton aphid - (species)
Aphis gossypii
cotton aphid - (species)
Acetylcholinesterase (Ace-1)
Aphis gossypii
cotton aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Cydia pomonella
codling moth - (species) D
Intraspecific
Candidate Gene
Cassanelli S; Reyes M; Rault M ; et al. (2006)
Acetylcholinesterase mutation in an insecticide-resistant population of the codling moth Cydia pomon[...]
1 Additional References
GP00002580
Ace
P07140
Physiology
F399V = F290V
Cydia pomonella
codling moth - (species)
Cydia pomonella
codling moth - (species) D
Acetylcholinesterase (Ace-1)
Cydia pomonella
codling moth - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Alout H; Berthomieu A; Hadjivassilis A ; et al. (2007)
A new amino-acid substitution in acetylcholinesterase 1 confers insecticide resistance to Culex pipi[...]
1 Additional References
GP00002581
Ace
P07140
Physiology
F290V
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
Acetylcholinesterase (Ace-1)
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Rhopalosiphum padi
bird cherry-oat aphid - (species) D
Intraspecific
Candidate Gene
Chen MH; Han ZJ; Qiao XF ; et al. (2007)
Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...]
1 Additional References
GP00002587
Ace
P07140
Physiology
S329(228)P
Rhopalosiphum padi
bird cherry-oat aphid - (species)
Rhopalosiphum padi
bird cherry-oat aphid - (species) D
Acetylcholinesterase (Ace-1)
Rhopalosiphum padi
bird cherry-oat aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Kwon Deok Ho; Cha Deok Jea; Kim Young Ho ; et al. (2012
)
Cloning of the acetylcholinesterase 1 gene and identification of point mutations putatively associat[...]
1 Additional References
GP00002589
Ace
P07140
Physiology
F330S
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
Acetylcholinesterase (Ace-1)
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Kwon Deok Ho; Cha Deok Jea; Kim Young Ho ; et al. (2012
)
Cloning of the acetylcholinesterase 1 gene and identification of point mutations putatively associat[...]
1 Additional References
GP00002590
Ace
P07140
Physiology
F331H
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
Acetylcholinesterase (Ace-1)
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus kanzawai
(species) D
Intraspecific
Candidate Gene
Aiki Yasuhiko; Kozaki Toshinori; Mizuno Hiroshi ; et al. (2005
)
Amino acid substitution in Ace paralogous acetylcholinesterase accompanied by organophosphate resist[...]
1 Additional References
GP00002591
Ace
P07140
Physiology
F331W
Tetranychus kanzawai
(species)
Tetranychus kanzawai
(species) D
Acetylcholinesterase (Ace-1)
Tetranychus kanzawai
(species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Anazawa Y; Tomita T; Aiki Y ; et al. (2003)
Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...]
1 Additional References
GP00002592
Ace
P07140
Physiology
F331C
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
Acetylcholinesterase (Ace-1)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus evansi
red spider mite - (species) D
Intraspecific
Candidate Gene
Carvalho Renato; Yang Yihua; Field Linda M ; et al. (2012
)
Chlorpyrifos resistance is associated with mutation and amplification of the acetylcholinesterase-1 [...]
1 Additional References
GP00002593
Ace
P07140
Physiology
F331W/Y
Tetranychus evansi
red spider mite - (species)
Tetranychus evansi
red spider mite - (species) D
Acetylcholinesterase (Ace-1)
Tetranychus evansi
red spider mite - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Laodelphax striatellus
small brown planthopper - (species) D
Intraspecific
Candidate Gene
Zhang Yueliang; Li Shuo; Xu Lu ; et al. (2013
)
Overexpression of carboxylesterase-1 and mutation (F439H) of acetylcholinesterase-1 are associated w[...]
1 Additional References
GP00002594
Ace
P07140
Physiology
F331H
Laodelphax striatellus
small brown planthopper - (species)
Laodelphax striatellus
small brown planthopper - (species) D
Acetylcholinesterase (Ace-1)
Laodelphax striatellus
small brown planthopper - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Sitobion avenae
English grain aphid - (species) D
Intraspecific
Candidate Gene
Chen Maohua; Han Zhaojun; Qiao Xianfeng ; et al. (2007
)
Resistance mechanisms and associated mutations in acetylcholinesterase genes in Sitobion avenae (Fab[...]
1 Additional References
GP00002595
Ace
P07140
Physiology
L336S
Sitobion avenae
English grain aphid - (species)
Sitobion avenae
English grain aphid - (species) D
Acetylcholinesterase (Ace-1)
Sitobion avenae
English grain aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-1)
Xenobiotic resistance (insecticide)
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Zhang LJ; Jing YP; Li XH ; et al. (2015)
Temperature-sensitive fitness cost of insecticide resistance in Chinese populations of the diamondba[...]
1 Additional References
GP00002598
Ace
P07140
Physiology
A441G
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
Acetylcholinesterase (Ace-1)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Walsh SB; Dolden TA; Moores GD ; et al. (2001)
Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]
GP00000040
Ace
P07140
Physiology
Gly365Ala
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
Acetylcholinesterase (Ace-2)
Musca domestica
house fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Walsh SB; Dolden TA; Moores GD ; et al. (2001)
Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]
GP00000041
Ace
P07140
Physiology
Gly262Val
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
Acetylcholinesterase (Ace-2)
Musca domestica
house fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Walsh SB; Dolden TA; Moores GD ; et al. (2001)
Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]
GP00000043
Ace
P07140
Physiology
Gly262Ala
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
Acetylcholinesterase (Ace-2)
Musca domestica
house fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
4 Mutations:
Coding
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Mutero A; Pralavorio M; Bride JM ; et al. (1994)
Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.
2 Additional References
GP00002011
Ace
P07140
Physiology
4 mutations
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Acetylcholinesterase (Ace-2)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Mutero A; Pralavorio M; Bride JM ; et al. (1994)
Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase.
GP00002012
Ace
P07140
Physiology
Ile199Thr (position 129 in the corresponding mature Torpedo AChE). Tested in vitro in Xenopus oocytes
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Acetylcholinesterase (Ace-2)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Menozzi P; Shi MA; Lougarre A ; et al. (2004)
Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]
GP00002016
Ace
P07140
Physiology
Gly368Ala (position 328 in the corresponding mature Torpedo AChE). Tested in vitro in Xenopus oocytes - GGC>GCC
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Acetylcholinesterase (Ace-2)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Bemisia tabaci
(species) D
Intraspecific
Candidate Gene
Anthony NM; Brown JK; Markham PG ; et al. (1995
)
Molecular analysis of cyclodiene resistance-associated mutations among populations of the sweetpotat[...]
1 Additional References
GP00002565
Ace
P07140
Physiology
Phe392Trp mutation located in the acyl pocket of the active site gorge and recently shown to confer OP insensitivity in Culex tritaeniorhynchus
Bemisia tabaci
(species)
Bemisia tabaci
(species) D
Acetylcholinesterase (Ace-2)
Bemisia tabaci
(species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Menozzi P; Shi MA; Lougarre A ; et al. (2004)
Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]
GP00002568
Ace
P07140
Physiology
E73G
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Acetylcholinesterase (Ace-2)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aphis gossypii
cotton aphid - (species) D
Intraspecific
Candidate Gene
Li Fei; Han Zhaojun (2004
)
Mutations in acetylcholinesterase associated with insecticide resistance in the cotton aphid, Aphis [...]
1 Additional References
GP00002569
Ace
P07140
Physiology
F78L
Aphis gossypii
cotton aphid - (species)
Aphis gossypii
cotton aphid - (species) D
Acetylcholinesterase (Ace-2)
Aphis gossypii
cotton aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Menozzi P; Shi MA; Lougarre A ; et al. (2004)
Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster pop[...]
GP00002570
Ace
P07140
Physiology
E81K
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Acetylcholinesterase (Ace-2)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Kozaki T; Shono T; Tomita T ; et al. (2001)
Fenitroxon insensitive acetylcholinesterases of the housefly, Musca domestica associated with point [...]
1 Additional References
GP00002575
Ace
P07140
Physiology
I129V
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
Acetylcholinesterase (Ace-2)
Musca domestica
house fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Bactrocera oleae
olive fruit fly - (species) D
Intraspecific
Candidate Gene
Vontas JG; Hejazi MJ; Hawkes NJ ; et al. (2002)
Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the ol[...]
1 Additional References
GP00002576
Ace
P07140
Physiology
I129V
Bactrocera oleae
olive fruit fly - (species)
Bactrocera oleae
olive fruit fly - (species) D
Acetylcholinesterase (Ace-2)
Bactrocera oleae
olive fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Haematobia irritans
horn fly - (species) D
Intraspecific
Candidate Gene
Temeyer KB; Li AY; Lohmeyer KH ; et al. (2008)
Acetylcholinesterase mutation in diazinon-resistant Haematobia irritans (L.) (Diptera: Muscidae).
1 Additional References
GP00002578
Ace
P07140
Physiology
G227A
Haematobia irritans
horn fly - (species)
Haematobia irritans
horn fly - (species) D
Acetylcholinesterase (Ace-2)
Haematobia irritans
horn fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
Intraspecific
Candidate Gene
Zhu KY; Lee SH; Clark JM (1996)
A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...]
1 Additional References
GP00002579
Ace
P07140
Physiology
S238G
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
Acetylcholinesterase (Ace-2)
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Walsh SB; Dolden TA; Moores GD ; et al. (2001)
Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]
1 Additional References
GP00002582
Ace
P07140
Physiology
F290Y
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
Acetylcholinesterase (Ace-2)
Musca domestica
house fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Cochliomyia hominivorax
primary screw-worm - (species) D
Intraspecific
Candidate Gene
da Silva NM; de Carvalho RA; de Azeredo-Espin AM (2011)
Acetylcholinesterase cDNA sequencing and identification of mutations associated with organophosphate[...]
GP00002583
Ace
P07140
Physiology
F466Y
Cochliomyia hominivorax
primary screw-worm - (species)
Cochliomyia hominivorax
primary screw-worm - (species) D
Acetylcholinesterase (Ace-2)
Cochliomyia hominivorax
primary screw-worm - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Rhopalosiphum padi
bird cherry-oat aphid - (species) D
Intraspecific
Candidate Gene
Chen MH; Han ZJ; Qiao XF ; et al. (2007)
Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...]
1 Additional References
GP00002585
Ace
P07140
Physiology
F368(290)L
Rhopalosiphum padi
bird cherry-oat aphid - (species)
Rhopalosiphum padi
bird cherry-oat aphid - (species) D
Acetylcholinesterase (Ace-2)
Rhopalosiphum padi
bird cherry-oat aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Rhopalosiphum padi
bird cherry-oat aphid - (species) D
Intraspecific
Candidate Gene
Chen MH; Han ZJ; Qiao XF ; et al. (2007)
Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carba[...]
1 Additional References
GP00002586
Ace
P07140
Physiology
V435(356)A
Rhopalosiphum padi
bird cherry-oat aphid - (species)
Rhopalosiphum padi
bird cherry-oat aphid - (species) D
Acetylcholinesterase (Ace-2)
Rhopalosiphum padi
bird cherry-oat aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Ceratitis capitata
Mediterranean fruit fly - (species) D
Intraspecific
Candidate Gene
Magaña C; Hernández-Crespo P; Brun-Barale A ; et al. (2008)
Mechanisms of resistance to malathion in the medfly Ceratitis capitata.
1 Additional References
GP00002588
Ace
P07140
Physiology
Gly328Ala
Ceratitis capitata
Mediterranean fruit fly - (species)
Ceratitis capitata
Mediterranean fruit fly - (species) D
Acetylcholinesterase (Ace-2)
Ceratitis capitata
Mediterranean fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex tritaeniorhynchus
(species) D
Intraspecific
Candidate Gene
Nabeshima T; Mori A; Kozaki T ; et al. (2004)
An amino acid substitution attributable to insecticide-insensitivity of acetylcholinesterase in a Ja[...]
1 Additional References
GP00002596
Ace
P07140
Physiology
F331W - F455W whose homologous position in Torped AChE (Phe331) is located in the vicinity of the catalytic His in the acyl pocket of the active site gorge
Culex tritaeniorhynchus
(species)
Culex tritaeniorhynchus
(species) D
Acetylcholinesterase (Ace-2)
Culex tritaeniorhynchus
(species)
Published - Accepted by Curator
Acetylcholinesterase (Ace-2)
Xenobiotic resistance (insecticide)
Coding,
SNP
Sitobion avenae
English grain aphid - (species) D
Intraspecific
Candidate Gene
Chen Maohua; Han Zhaojun; Qiao Xianfeng ; et al. (2007
)
Resistance mechanisms and associated mutations in acetylcholinesterase genes in Sitobion avenae (Fab[...]
1 Additional References
GP00002597
Ace
P07140
Physiology
W435R
Sitobion avenae
English grain aphid - (species)
Sitobion avenae
English grain aphid - (species) D
Acetylcholinesterase (Ace-2)
Sitobion avenae
English grain aphid - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Bactrocera oleae
olive fruit fly - (species) D
Intraspecific
Candidate Gene
Vontas JG; Hejazi MJ; Hawkes NJ ; et al. (2002)
Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the ol[...]
GP00000037
Ace
P07140
Physiology
2 mutations
Bactrocera oleae
olive fruit fly - (species)
Bactrocera oleae
olive fruit fly - (species) D
Acetylcholinesterase (Ace)
Bactrocera oleae
olive fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace)
Xenobiotic resistance (insecticide)
Coding,
Deletion
Bactrocera oleae
olive fruit fly - (species) D
Intraspecific
Candidate Gene
Kakani EG; Ioannides IM; Margaritopoulos JT ; et al. (2008)
A small deletion in the olive fly acetylcholinesterase gene associated with high levels of organopho[...]
1 Additional References
GP00000038
Ace
P07140
Physiology
9bp deletion of three glutamine residues at positions 642_644
Bactrocera oleae
olive fruit fly - (species)
Bactrocera oleae
olive fruit fly - (species) D
Acetylcholinesterase (Ace)
Bactrocera oleae
olive fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace)
Xenobiotic resistance (insecticide)
Coding,
SNP
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
Intraspecific
Candidate Gene
Zhu KY; Lee SH; Clark JM (1996)
A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...]
GP00000039
Ace
P07140
Physiology
Ser->Gly at position 238 of the Torpedo AChE
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
Acetylcholinesterase (Ace)
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Walsh SB; Dolden TA; Moores GD ; et al. (2001)
Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]
GP00000042
Ace
P07140
Physiology
Val180Leu
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
Acetylcholinesterase (Ace)
Musca domestica
house fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Walsh SB; Dolden TA; Moores GD ; et al. (2001)
Identification and characterization of mutations in housefly (Musca domestica) acetylcholinesterase [...]
GP00000044
Ace
P07140
Physiology
Phe327Tyr
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
Acetylcholinesterase (Ace)
Musca domestica
house fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Bactrocera dorsalis
oriental fruit fly - (species) D
Intraspecific
Candidate Gene
Hsu JC; Haymer DS; Wu WJ ; et al. (2006)
Mutations in the acetylcholinesterase gene of Bactrocera dorsalis associated with resistance to orga[...]
GP00000045
Ace
P07140
Physiology
2 mutations
Bactrocera dorsalis
oriental fruit fly - (species)
Bactrocera dorsalis
oriental fruit fly - (species) D
Acetylcholinesterase (Ace)
Bactrocera dorsalis
oriental fruit fly - (species)
Published - Accepted by Curator
Acetylcholinesterase (Ace)
Xenobiotic resistance (insecticide)
Coding,
SNP
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
Intraspecific
Candidate Gene
Zhu KY; Lee SH; Clark JM (1996)
A Point Mutation of Acetylcholinesterase Associated with Azinphosmethyl Resistance and Reduced Fitne[...]
GP00002014
Ace
P07140
Physiology
Ser>Gly (238 is the corresponding position in Torpedo)
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
Acetylcholinesterase (Ace)
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Published - Accepted by Curator
achaete-scute complex
Bristle number (abdomen; female-limited)
Cis-regulatory,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Long AD; Lyman RF; Morgan AH ; et al. (2000)
Both naturally occurring insertions of transposable elements and intermediate frequency polymorphism[...]
GP00000046
sc
P10084
Morphology
transposon insertion in non-coding region
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
achaete-scute complex
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
achaete-scute complex
Bristle number (abdomen)
Cis-regulatory,
Indel
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Long AD; Lyman RF; Morgan AH ; et al. (2000)
Both naturally occurring insertions of transposable elements and intermediate frequency polymorphism[...]
GP00000047
sc
P10084
Morphology
indel MC21 in promoter region of scute
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
achaete-scute complex
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
achaete-scute complex
Bristle number (thorax)
Cis-regulatory,
Indel
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Gruber JD; Genissel A; Macdonald SJ ; et al. (2007)
How repeatable are associations between polymorphisms in achaete-scute and bristle number variation [...]
GP00000048
sc
P10084
Morphology
indel MC22 in promoter region of scute
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
achaete-scute complex
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
ACS11
Plant architecture (petiole-to-leaf-length ratio)
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Association Mapping
Kooke R; Kruijer W; Bours R ; et al. (2016)
Genome-Wide Association Mapping and Genomic Prediction Elucidate the Genetic Architecture of Morphol[...]
GP00001235
ACS11
Q9S9U6
Morphology
several candidate amino acid changes
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
ACS11
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
ADAMTS10
Body size (height)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Lettre G (2011)
Recent progress in the study of the genetics of height.
GP00000050
ADAMTS10
Q9H324
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
ADAMTS10
Homo sapiens
human - (species)
Published - Accepted by Curator
adenosine deaminase (AgADA)
Pathogen resistance (parasite)
Coding,
SNP
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Association Mapping
Li J; Wang X; Zhang G ; et al. (2013)
Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles [...]
GP00001463
ADA
P00813
Physiology
c.C427T p.R143C
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
adenosine deaminase (AgADA)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
AGAMOUS-LIKE 50
Leaf number (at flowering time)
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Association Mapping
Seymour DK; Chae E; Grimm DG ; et al. (2016)
Genetic architecture of nonadditive inheritance in Arabidopsis thaliana hybrids.
GP00001450
AGAMOUS-like 50
Q9XIE7
Morphology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
AGAMOUS-LIKE 50
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
AGAMOUS-Like6
Plant architecture
Inflorescence architecture
Coding,
SNP
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Huang X; Effgen S; Meyer RC ; et al. (2012)
Epistatic natural allelic variation reveals a function of AGAMOUS-LIKE6 in axillary bud formation in[...]
GP00000053
AGL6
P29386
Morphology
Morphology
Pro201Leu
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
AGAMOUS-Like6
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Agouti
Coloration (coat; dorso-ventral)
Gene Loss,
Deletion
N
Peromyscus polionotus
oldfield mouse - (species)
Intraspecific
Candidate Gene
Kingsley EP; Manceau M; Wiley CD ; et al. (2009)
Melanism in peromyscus is caused by independent mutations in agouti.
GP00000055
Asip
Q03288
Morphology
125kb deletion including 5' CDS of Agouti N
Peromyscus polionotus
oldfield mouse - (species)
Peromyscus polionotus
oldfield mouse - (species)
Agouti
Peromyscus polionotus
oldfield mouse - (species)
Published - Accepted by Curator
Agouti
Coloration (coat; dorso-ventral)
Coding,
SNP
N
Peromyscus polionotus
oldfield mouse - (species)
Intraspecific
Candidate Gene
Kingsley EP; Manceau M; Wiley CD ; et al. (2009)
Melanism in peromyscus is caused by independent mutations in agouti.
GP00000056
Asip
Q03288
Morphology
Premature stop codon at residue 65 N
Peromyscus polionotus
oldfield mouse - (species)
Peromyscus polionotus
oldfield mouse - (species)
Agouti
Peromyscus polionotus
oldfield mouse - (species)
Published - Accepted by Curator
Agouti
Coloration (coat; dorso-ventral)
Cis-regulatory,
Unknown
Peromyscus polionotus leucocephalus
(subspecies) D
Peromyscus polionotus niveiventris
(subspecies) D
Peromyscus polionotus peninsularis
(subspecies) D
Peromyscus polionotus allophrys
(subspecies) D
Peromyscus polionotus trissyllepsis
(subspecies) D
Peromyscus polionotus ammobates
(subspecies) D
Peromyscus polionotus albifrons
(subspecies) D
Peromyscus polionotus subgriseus
(subspecies) D
Intraspecific
Linkage Mapping
Manceau M; Domingues VS; Mallarino R ; et al. (2011)
The developmental role of Agouti in color pattern evolution.
1 Additional References
GP00000057
Asip
Q03288
Morphology
"A closer investigation of this region revealed three SNPs significantly associated with pigment variation, spanning 1,756 bp, in strong linkage disequilibrium (mean r2 = 0.85). A single SNP on chromosome 4 (chr4) at position chr4: 9,845,301 showed a markedly stronger association with pPC1 than the other two (Fig. 3B). This SNP is located between two untranslated exons (exons 1D and 1E), is 120 bp upstream of a cluster of Short Interspersed Nuclear Elements (SINE) in reverse orientation relative to the transcription of Agouti, and is 5,641 bp upstream of the first coding exon (exon 2). "
"Next, we employ an association-mapping approach to identify an ∼2-kb previously uncharacterized noncoding region of Agouti associated with color variation. We then show that this 2-kb region can drive dermal expression in Mus embryos, demonstrating its regulatory activity in the skin during the establishment of pigmentation."
Peromyscus polionotus subgriseus
(subspecies)
Peromyscus polionotus polionotus
(subspecies)
Peromyscus polionotus albifrons
(subspecies)
Peromyscus polionotus leucocephalus
(subspecies) D
Peromyscus polionotus niveiventris
(subspecies) D
Peromyscus polionotus peninsularis
(subspecies) D
Peromyscus polionotus allophrys
(subspecies) D
Peromyscus polionotus trissyllepsis
(subspecies) D
Peromyscus polionotus ammobates
(subspecies) D
Peromyscus polionotus albifrons
(subspecies) D
Peromyscus polionotus subgriseus
(subspecies) D
Agouti
Peromyscus polionotus leucocephalus
(subspecies)
Peromyscus polionotus niveiventris
(subspecies)
Peromyscus polionotus peninsularis
(subspecies)
Peromyscus polionotus allophrys
(subspecies)
Peromyscus polionotus trissyllepsis
(subspecies)
Peromyscus polionotus ammobates
(subspecies)
Peromyscus polionotus albifrons
(subspecies)
Peromyscus polionotus subgriseus
(subspecies)
Published - Accepted by Curator
Agouti
Coloration (coat)
Coding,
Deletion
N
Equus caballus
horse - (species) D
Intraspecific
Linkage Mapping
Rieder S; Taourit S; Mariat D ; et al. (2001)
Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their associati[...]
1 Additional References
GP00000062
Asip
Q03288
Morphology
11bp deletion in exon 2: g.2174_2184del11 c.191_201del N
Equus caballus
horse - (species)
Equus caballus
horse - (species) D
Agouti
Equus caballus
horse - (species)
Published - Accepted by Curator
Agouti
Coloration (coat)
Coding,
SNP
N
Panthera pardus
leopard - (species) D
Intraspecific
Candidate Gene
Schneider A; David VA; Johnson WE ; et al. (2012)
How the leopard hides its spots: ASIP mutations and melanism in wild cats.
GP00000065
Asip
Q03288
Morphology
nonsense mutation located in exon 4 (C333A) predicted to introduce a stop codon at amino acid position 111 N
Panthera pardus
leopard - (species)
Panthera pardus
leopard - (species) D
Agouti
Panthera pardus
leopard - (species)
Published - Accepted by Curator
Agouti
Coloration (coat)
Coding,
SNP
Catopuma temminckii
Asiatic golden cat - (species)
Intraspecific
Candidate Gene
Schneider A; David VA; Johnson WE ; et al. (2012)
How the leopard hides its spots: ASIP mutations and melanism in wild cats.
GP00000066
Asip
Q03288
Morphology
C128W (384C>G)
Catopuma temminckii
Asiatic golden cat - (species)
Catopuma temminckii
Asiatic golden cat - (species)
Agouti
Catopuma temminckii
Asiatic golden cat - (species)
Published - Accepted by Curator
Agouti
Coloration (coat)
Coding,
SNP
N
Leopardus colocolo
Colocolo - (species) D
Intraspecific
Candidate Gene
Schneider A; Henegar C; Day K ; et al. (2015)
Recurrent evolution of melanism in South American felids.
GP00001731
Asip
Q03288
Morphology
Arg to Cys substitution in the C-terminal region of ASIP (p.R120C) lies in the critical RFF loop (e.g. a triplet motif made of one arginine and two phenylalanine residues) required for binding to the MC1R N
Leopardus colocolo
Colocolo - (species)
Leopardus colocolo
Colocolo - (species) D
Agouti
Leopardus colocolo
Colocolo - (species)
Published - Accepted by Curator
Agouti
Coloration (coat)
Coding,
SNP
N
Leopardus guigna
Kodkod - (species) D
Intraspecific
Candidate Gene
Schneider A; Henegar C; Day K ; et al. (2015)
Recurrent evolution of melanism in South American felids.
GP00001732
Asip
Q03288
Morphology
Cys to Tyr substitution in ASIP (p.C126Y) which affects the key disulfide bond that stabilizes the RFF loop N
Leopardus guigna
Kodkod - (species)
Leopardus guigna
Kodkod - (species) D
Agouti
Leopardus guigna
Kodkod - (species)
Published - Accepted by Curator
Agouti
Coloration (coat)
5 Mutations:
Peromyscus maniculatus
North American deer mouse - (species)
Intraspecific
Association Mapping
Linnen CR; Poh YP; Peterson BK ; et al. (2013)
Adaptive evolution of multiple traits through multiple mutations at a single gene.
1 Additional References
GP00001974
Asip
Q03288
Morphology
5 mutations
Peromyscus maniculatus
North American deer mouse - (species)
Peromyscus maniculatus
North American deer mouse - (species)
Agouti
Peromyscus maniculatus
North American deer mouse - (species)
Published - Accepted by Curator
Agouti
Coloration (coat)
Gene Loss,
Deletion
N
Peromyscus maniculatus
North American deer mouse - (species)
Intraspecific
Candidate Gene
Kingsley EP; Manceau M; Wiley CD ; et al. (2009)
Melanism in peromyscus is caused by independent mutations in agouti.
GP00001975
Asip
Q03288
Morphology
125kb deletion ; recessive mutation N
Peromyscus maniculatus
North American deer mouse - (species)
Peromyscus maniculatus
North American deer mouse - (species)
Agouti
Peromyscus maniculatus
North American deer mouse - (species)
Published - Accepted by Curator
Agouti
Coloration (coat)
Coding,
SNP
N
Peromyscus maniculatus
North American deer mouse - (species)
Intraspecific
Association Mapping
Kingsley EP; Manceau M; Wiley CD ; et al. (2009)
Melanism in peromyscus is caused by independent mutations in agouti.
GP00001976
Asip
Q03288
Morphology
recessive mutation at nucleotide position 193 (in exon 3) resulting in a change from glutamine to a stop codon at amino acid position 65 (Q65term) N
Peromyscus maniculatus
North American deer mouse - (species)
Peromyscus maniculatus
North American deer mouse - (species)
Agouti
Peromyscus maniculatus
North American deer mouse - (species)
Published - Accepted by Curator
Agouti
Coloration (coat)
Coding,
SNP
Sciurus niger
fox squirrel - (species) D
Intraspecific
Candidate Gene
McRobie HR; Moncrief ND; Mundy NI (2019)
Multiple origins of melanism in two species of North American tree squirrel (Sciurus).
GP00002335
Morphology
Gly121Cys
Sciurus niger
fox squirrel - (species)
Sciurus niger
fox squirrel - (species) D
Agouti
Sciurus niger
fox squirrel - (species)
Published - Accepted by Curator
Agouti
Coloration (coat)
Cis-regulatory,
Insertion
Mus musculus molossinus
Japanese wild mouse - (subspecies) D
Intraspecific
Candidate Gene
Tanave A; Imai Y; Koide T (2019)
Nested retrotransposition in the East Asian mouse genome causes the classical nonagouti mutation.
GP00002386
Asip
Q03288
Morphology
Mus musculus molossinus
Japanese wild mouse - (subspecies)
Mus musculus molossinus
Japanese wild mouse - (subspecies) D
Agouti
Mus musculus molossinus
Japanese wild mouse - (subspecies)
Published - Accepted by Curator
Agouti (ASIP)
Coloration (skin; hair)
Cis-regulatory,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Bonilla C; Boxill LA; Donald SA ; et al. (2005)
The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with dar[...]
2 Additional References
GP00000070
Asip
Q03288
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
Agouti (ASIP)
Homo sapiens
human - (species)
Published - Accepted by Curator
Agouti (ASIP)
Coloration (coat)
Coding,
SNP
Monarcha castaneiventris
Makira monarch - (species) D
Intraspecific
Association Mapping
Uy JA; Cooper EA; Cutie S ; et al. (2016)
Mutations in different pigmentation genes are associated with parallel melanism in island flycatcher[...]
GP00001334
Asip
Q03288
Morphology
Ile55Thr
Monarcha castaneiventris
Makira monarch - (species)
Monarcha castaneiventris
Makira monarch - (species) D
Agouti (ASIP)
Monarcha castaneiventris
Makira monarch - (species)
Published - Accepted by Curator
Agouti (ASIP)
Coloration (coat)
Lifespan
2 Mutations:
Coding
N
Ovis aries
sheep - (species) D
Intraspecific
Linkage Mapping
Gratten J; Pilkington JG; Brown EA ; et al. (2010)
The genetic basis of recessive self-colour pattern in a wild sheep population.
1 Additional References
GP00001356
Asip
Q03288
Morphology
Physiology
2 mutations
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
Agouti (ASIP)
Ovis aries
sheep - (species)
Published - Accepted by Curator
Agouti (ASIP)
Coloration (coat)
Coding,
Deletion
N
D
Intraspecific
Candidate Gene
Miller SM; Guthrie AJ; Harper CK (2016)
Single base-pair deletion in ASIP exon 3 associated with recessive black phenotype in impala (Aepyce[...]
GP00001977
Asip
Q03288
Morphology
recessive c.174delA was found in all black phenotype sequences ; premature stop codon (239–241 bp) N
D
Agouti (ASIP)
Published - Accepted by Curator
Agouti (ASIP)
Coloration (coat)
Cis-regulatory,
Unknown
Lepus americanus
snowshoe hare - (species) D
Intraspecific
Association Mapping
Jones MR; Mills LS; Alves PC ; et al. (2018)
Adaptive introgression underlies polymorphic seasonal camouflage in snowshoe hares.
GP00002060
Asip
Q03288
Morphology
exact mutation(s) unknown
Lepus americanus
snowshoe hare - (species)
Lepus americanus
snowshoe hare - (species) D
Agouti (ASIP)
Lepus americanus
snowshoe hare - (species)
Published - Accepted by Curator
Agouti (ASIP)
Coloration (coat)
Cis-regulatory,
Unknown
Lepus timidus
Mountain hare - (species) D
Intraspecific
Association Mapping
Giska I; Farelo L; Pimenta J ; et al. (2019)
Introgression drives repeated evolution of winter coat color polymorphism in hares.
GP00002061
Asip
Q03288
Morphology
exact mutation(s) unknown
Lepus timidus
Mountain hare - (species)
Lepus timidus
Mountain hare - (species) D
Agouti (ASIP)
Lepus timidus
Mountain hare - (species)
Published - Accepted by Curator
agrecan
Body size (height)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Lettre G (2011)
Recent progress in the study of the genetics of height.
GP00000072
ACAN
P16112
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
agrecan
Homo sapiens
human - (species)
Published - Accepted by Curator
AHR
Xenobiotic resistance (TCDD)
Coding,
SNP
N
Rattus norvegicus
Norway rat - (species) D
Intraspecific
Linkage Mapping
Tuomisto JT; Viluksela M; Pohjanvirta R ; et al. (1999)
The AH receptor and a novel gene determine acute toxic responses to TCDD: segregation of the resista[...]
2 Additional References
GP00001813
Ahr
P30561
Physiology
point mutation in the exon/intron 10 boundary in AHR genomic structure that leads to use of 3 alternative cryptic splice sites; potentially creating 3 alternative transcripts and 2 protein products. At the protein level the mutation leads to a total loss of either 43 or 38 amino acids (with altered sequence for the last seven amino acids in the latter case) toward the carboxyl-terminal end in the trans-activation domain of the AhR. H/W rats also harbor a point mutation in exon 10 that will cause a Val-to-Ala substitution in codon 497, but this occurs in a variable region of the AhR N
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species) D
AHR
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
AHR2
Xenobiotic resistance (pollution)
Gene Loss,
Deletion
N
Fundulus heteroclitus
mummichog - (species) D
Intraspecific
Association Mapping
Reid NM; Proestou DA; Clark BW ; et al. (2016)
The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish.
1 Additional References
GP00001806
Ahr
P30561
Physiology
70 kb deletion that removes parts of the two genes AHR1a and AHR2a N
Fundulus heteroclitus
mummichog - (species)
Fundulus heteroclitus
mummichog - (species) D
AHR2
Fundulus heteroclitus
mummichog - (species)
Published - Accepted by Curator
AHR2
Xenobiotic resistance (pollution)
Gene Loss,
Deletion
N
Fundulus heteroclitus
mummichog - (species) D
Intraspecific
Association Mapping
Reid NM; Proestou DA; Clark BW ; et al. (2016)
The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish.
1 Additional References
GP00001807
Ahr
P30561
Physiology
45 kb deletion that removes parts of the two genes AHR1a and AHR2a (from exon 5 of AHR2a to exon 4 of AHR1a) N
Fundulus heteroclitus
mummichog - (species)
Fundulus heteroclitus
mummichog - (species) D
AHR2
Fundulus heteroclitus
mummichog - (species)
Published - Accepted by Curator
AHR2
Xenobiotic resistance (pollution)
Gene Loss,
Deletion
N
Fundulus heteroclitus
mummichog - (species) D
Intraspecific
Association Mapping
Reid NM; Proestou DA; Clark BW ; et al. (2016)
The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish.
1 Additional References
GP00001808
Ahr
P30561
Physiology
83 kb deletion that removes parts of the two genes AHR1a and AHR2a (from exon 11 of AHR2a to exon 6 of AHR1a) N
Fundulus heteroclitus
mummichog - (species)
Fundulus heteroclitus
mummichog - (species) D
AHR2
Fundulus heteroclitus
mummichog - (species)
Published - Accepted by Curator
AHR2
Xenobiotic resistance (pollution; polychlorinated biphenyls; PCBs)
Coding,
Deletion
N
Microgadus tomcod
Atlantic tomcod - (species) D
Intraspecific
Candidate Gene
Wirgin I; Roy NK; Loftus M ; et al. (2011)
Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River.
GP00001809
Ahr
P30561
Physiology
6-bp deletion - (nts 1314 to 1319 in exon 10; TTCCTC) that resulted in a two-amino acid (Phe-Leu) deletion located 43 amino acids downstream of the amino terminal of the AHR2 ligand binding domain N
Microgadus tomcod
Atlantic tomcod - (species)
Microgadus tomcod
Atlantic tomcod - (species) D
AHR2
Microgadus tomcod
Atlantic tomcod - (species)
Published - Accepted by Curator
AHR2
Xenobiotic resistance (pollution)
Gene Loss,
Deletion
N
Fundulus grandis
Gulf killifish - (species) D
Intraspecific
Association Mapping
Oziolor EM; Reid NM; Yair S ; et al. (2019)
Adaptive introgression enables evolutionary rescue from extreme environmental pollution.
GP00002669
Ahr
P30561
Physiology
70 kb deletion that removes parts of the two genes AHR1a and AHR2a N
Fundulus grandis
Gulf killifish - (species)
Fundulus grandis
Gulf killifish - (species) D
AHR2
Fundulus grandis
Gulf killifish - (species)
Published - Accepted by Curator
AIP
Xenobiotic resistance (pollution)
Unknown,
Unknown
N
Fundulus heteroclitus
mummichog - (species) D
Intraspecific
Association Mapping
Reid NM; Proestou DA; Clark BW ; et al. (2016)
The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish.
GP00001812
Aip
O08915
Physiology
exact mutation(s) unknown - very good candidate gene according to association mapping and knowledge about the physiology N
Fundulus heteroclitus
mummichog - (species)
Fundulus heteroclitus
mummichog - (species) D
AIP
Fundulus heteroclitus
mummichog - (species)
Published - Accepted by Curator
AIP
Xenobiotic resistance (pollution)
Unknown,
Unknown
N
Fundulus grandis
Gulf killifish - (species) D
Intraspecific
Association Mapping
Oziolor EM; Reid NM; Yair S ; et al. (2019)
Adaptive introgression enables evolutionary rescue from extreme environmental pollution.
GP00002670
Aip
O08915
Physiology
exact mutation(s) unknown - very good candidate gene according to Fst and knowledge about the physiology N
Fundulus grandis
Gulf killifish - (species)
Fundulus grandis
Gulf killifish - (species) D
AIP
Fundulus grandis
Gulf killifish - (species)
Published - Accepted by Curator
alcohol dehydrogenase (Adh)
Xenobiotic resistance (alcohol)
6 Mutations:
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Choudhary M; Laurie CC (1991)
Use of in vitro mutagenesis to analyze the molecular basis of the difference in Adh expression assoc[...]
4 Additional References
GP00001962
Adh
P00334
Physiology
6 mutations
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
alcohol dehydrogenase (Adh)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
alcohol dehydrogenase (Adh)
Xenobiotic resistance (alcohol)
Coding,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Vigue C; Sofer W (1974)
Adh-n5: a temperature-sensitive mutant at the Adh locus in Drosophila.
GP00001988
Adh
P00334
Physiology
Activity of the purified enzyme is temperature-sensitive; as opposed to the other allele which is not. Exact coding mutation(s) unknown.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
alcohol dehydrogenase (Adh)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
alcohol dehydrogenase (Adh)
Xenobiotic resistance (alcohol)
Cis-regulatory,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Strand DJ; McDonald JF (1989)
Insertion of a copia element 5' to the Drosophila melanogaster alcohol dehydrogenase gene (adh) is a[...]
GP00001989
Adh
P00334
Physiology
insertion of a complete 5.2kb copia retroviral-like transposable element 240 bp upstream from the distal (adult) adh transcriptional start site
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
alcohol dehydrogenase (Adh)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
alcohol dehydrogenase (Adh)
Xenobiotic resistance (alcohol)
Coding,
Insertion
N
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Freeth AL; Gibson JB; Wilks AV (1990)
Aberrant splicing of a naturally occurring alcohol dehydrogenase null activity allele in Drosophila [...]
1 Additional References
GP00001990
Adh
P00334
Physiology
eight extra nucleotides (in two groups of four) in the second intron commencing six bases 3' from the 5' splice site. A stop codon was also found in exon 2. S1 nuclease protection experiments have shown that the insertions in intron 2 disrupt the correct splicing of intron 2. The null allele produces a transcript approximately 100 bases longer than the normal mature adult transcript, and the amount of the null allele transcript is only about 10% of the normal level. N
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
alcohol dehydrogenase (Adh)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
alcohol dehydrogenase (Adh)
Xenobiotic resistance (alcohol)
Coding,
Deletion
N
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Gibson JB; Wilks AV; Agrotis A (1992)
Molecular relationships between alcohol dehydrogenase null-activity alleles from natural populations[...]
GP00001991
Adh
P00334
Physiology
438-bp deletion which removes most of exon 2. Lys to Thr substitution: ACG at the sites 1489--1491 N
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
alcohol dehydrogenase (Adh)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
alcohol dehydrogenase (ADH1B)
Xenobiotic resistance (alcohol)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Li H; Mukherjee N; Soundararajan U ; et al. (2007)
Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and [...]
1 Additional References
GP00000077
ADH1B
P00325
Physiology
Arg47His; the derived allele results in 100-fold enzymatic rate increase and shows signs of positive selection in correlation with history of rice domestication
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
alcohol dehydrogenase (ADH1B)
Homo sapiens
human - (species)
Published - Accepted by Curator
Aldehyde dehydrogenase (Aldh)
Xenobiotic resistance (alcohol)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Fry JD; Donlon K; Saweikis M (2008)
A worldwide polymorphism in aldehyde dehydrogenase in Drosophila melanogaster: evidence for selectio[...]
GP00002007
Aldh
Q9VLC5
Physiology
L479F C9391311T
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Aldehyde dehydrogenase (Aldh)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Allantoin permease DAL4
Nitrogen use (growth rate on allantoin)
Coding,
Indel
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Intraspecific
Linkage Mapping
Ibstedt S; Stenberg S; Bagés S ; et al. (2015)
Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.
GP00001503
DAL4
Q04895
Physiology
c.1201delA a single nucleotide frameshifting insertion (deletion?) N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Allantoin permease DAL4
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Allantoinase DAL1
Nitrogen use (growth rate on allantoin)
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species) D
Intraspecific
Linkage Mapping
Ibstedt S; Stenberg S; Bagés S ; et al. (2015)
Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.
GP00001502
DAL1
P32375
Physiology
c.415C>T p.P139S predicted to be strongly detrimental
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Allantoinase DAL1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
ALS
Xenobiotic resistance (herbicides; ALS inhibitor)
Coding,
SNP
Amaranthus tuberculatus
(species) D
Intraspecific
Linkage Mapping
Patzoldt William L; Tranel Patrick J (2007
)
Multiple ALS mutations confer herbicide resistance in waterhemp (Amaranthus tuberculatus)
GP00001893
ALS
P17597
Physiology
W574L
Amaranthus tuberculatus
(species)
Amaranthus tuberculatus
(species) D
ALS
Amaranthus tuberculatus
(species)
Published - Accepted by Curator
ALS
Xenobiotic resistance (herbicides; ALS inhibitor)
Coding,
SNP
Amaranthus tuberculatus
(species) D
Intraspecific
Linkage Mapping
Patzoldt William L; Tranel Patrick J (2007
)
Multiple ALS mutations confer herbicide resistance in waterhemp (Amaranthus tuberculatus)
GP00001894
ALS
P17597
Physiology
S653N
Amaranthus tuberculatus
(species)
Amaranthus tuberculatus
(species) D
ALS
Amaranthus tuberculatus
(species)
Published - Accepted by Curator
ALS
Xenobiotic resistance (herbicides; ALS inhibitor)
Coding,
SNP
Amaranthus tuberculatus
(species) D
Intraspecific
Linkage Mapping
Patzoldt William L; Tranel Patrick J (2007
)
Multiple ALS mutations confer herbicide resistance in waterhemp (Amaranthus tuberculatus)
GP00001895
ALS
P17597
Physiology
S653T
Amaranthus tuberculatus
(species)
Amaranthus tuberculatus
(species) D
ALS
Amaranthus tuberculatus
(species)
Published - Accepted by Curator
Amhr2
Sex determination (female vs male)
Coding,
SNP
Takifugu rubripes
torafugu - (species)
Takifugu poecilonotus
finepatterned puffer - (species)
Takifugu pardalis
panther puffer - (species)
Intraspecific
Linkage Mapping
Kamiya T; Kai W; Tasumi S ; et al. (2012)
A trans-species missense SNP in Amhr2 is associated with sex determination in the tiger pufferfish, [...]
GP00002147
AMHR2
Q16671
Physiology
His/Asp384 heterozygous males have reduced Amrh2 activity due to decreased activity of the kinase signaling domain
Takifugu rubripes
torafugu - (species)
Takifugu poecilonotus
finepatterned puffer - (species)
Takifugu pardalis
panther puffer - (species)
Takifugu rubripes
torafugu - (species)
Takifugu poecilonotus
finepatterned puffer - (species)
Takifugu pardalis
panther puffer - (species)
Amhr2
Takifugu rubripes
torafugu - (species)
Takifugu poecilonotus
finepatterned puffer - (species)
Takifugu pardalis
panther puffer - (species)
Published - Accepted by Curator
ammonium transporter 2;1
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001431
AMT2
Q9M6N7
Physiology
seven aa substitutions
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
ammonium transporter 2;1
Arabidopsis arenosa
(species)
Published - Accepted by Curator
AMPD1 (=CG32626)
Drug resistance
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Kislukhin G; King EG; Walters KN ; et al. (2013)
The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans.
GP00000083
AMPD1
P23109
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
AMPD1 (=CG32626)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
AMPD1 [clinical; candidate gene study; added for insights on fly-human parallelism]
Drug resistance
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Wessels JA; van der Kooij SM; le Cessie S ; et al. (2007)
A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset[...]
GP00000084
AMPD1
P23109
Physiology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
AMPD1 [clinical; candidate gene study; added for insights on fly-human parallelism]
Homo sapiens
human - (species)
Published - Accepted by Curator
amylase
Starch processing
Gene Amplification,
Insertion
Meles leucurus
Asian badger - (species) D
Intraspecific
Candidate Gene
Abduriyim Shamshidin; Nishita Yoshinori; Abramov AV ; et al. (2019
)
Variation in pancreatic amylase gene copy number among Eurasian badgers (Carnivora, Mustelidae, Mele[...]
GP00001907
Amy1
P00687
Physiology
Copy Number Variation varies between one and four in this species
Meles leucurus
Asian badger - (species)
Meles leucurus
Asian badger - (species) D
amylase
Meles leucurus
Asian badger - (species)
Published - Accepted by Curator
amylase 1 (AMY1)
Starch processing
Gene Amplification,
Insertion
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Perry GH; Dominy NJ; Claw KG ; et al. (2007)
Diet and the evolution of human amylase gene copy number variation.
2 Additional References
GP00000085
AMY1A
P04745
Physiology
Probably gene duplication
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
amylase 1 (AMY1)
Homo sapiens
human - (species)
Published - Accepted by Curator
anthocyanin2 (an2)
Coloration (flowers)
Coding,
Deletion
N
Petunia axillaris
(species) D
Intraspecific
Candidate Gene
Quattrocchio F; Wing J; van der Woude K ; et al. (1999)
Molecular analysis of the anthocyanin2 gene of petunia and its role in the evolution of flower color[...]
GP00000089
AN2
A4GRU8
Morphology
1bp deletion at a.a. 127; premature stop N
Petunia integrifolia
(species)
Petunia axillaris
(species) D
anthocyanin2 (an2)
Petunia axillaris
(species)
Published - Accepted by Curator
anthocyanin2 (an2)
Coloration (flowers)
Coding,
Insertion
N
Petunia axillaris
(species) D
Intraspecific
Candidate Gene
Quattrocchio F; Wing J; van der Woude K ; et al. (1999)
Molecular analysis of the anthocyanin2 gene of petunia and its role in the evolution of flower color[...]
GP00000090
AN2
A4GRU8
Morphology
4bp insertion at a.a. 127; premature stop N
Petunia integrifolia
(species)
Petunia axillaris
(species) D
anthocyanin2 (an2)
Petunia axillaris
(species)
Published - Accepted by Curator
anthocyanin2 (an2)
Coloration (flowers)
Coding,
SNP
N
Petunia axillaris
(species)
Intraspecific
Candidate Gene
Quattrocchio F; Wing J; van der Woude K ; et al. (1999)
Molecular analysis of the anthocyanin2 gene of petunia and its role in the evolution of flower color[...]
GP00000091
AN2
A4GRU8
Morphology
W196* N
Petunia integrifolia
(species)
Petunia axillaris
(species)
anthocyanin2 (an2)
Petunia axillaris
(species)
Published - Accepted by Curator
anthocyanin2 (an2)
Coloration (flowers)
Coding,
Deletion
N
Petunia axillaris
(species) D
Intraspecific
Candidate Gene
Hoballah ME; Gübitz T; Stuurman J ; et al. (2007)
Single gene-mediated shift in pollinator attraction in Petunia.
GP00000092
AN2
A4GRU8
Morphology
1bp deletion; premature stop N
Petunia integrifolia
(species)
Petunia axillaris
(species) D
anthocyanin2 (an2)
Petunia axillaris
(species)
Published - Accepted by Curator
AOP2
Glucosinolate content
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Kliebenstein DJ; Lambrix VM; Reichelt M ; et al. (2001)
Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dio[...]
2 Additional References
GP00000095
AOP2
Q945B5
Physiology
5bp deletion resulting in frameshift N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
AOP2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
AOP3
Glucosinolate content
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Kliebenstein DJ; Lambrix VM; Reichelt M ; et al. (2001)
Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dio[...]
2 Additional References
GP00000096
AOP3
Q9ZTA1
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
AOP3
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
apicoplast ribosomal protein S10
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001531
PF3D7_1460900.1
Q8IKM3
Physiology
p.Val127Met
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
apicoplast ribosomal protein S10
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
APL1 cluster
Pathogen resistance (Plasmodium; malaria parasite)
Unknown,
Unknown
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Linkage Mapping
Riehle MM; Markianos K; Niaré O ; et al. (2006)
Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region.
1 Additional References
GP00000098
APL1A
L7RQU1
Physiology
Not identified
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
APL1 cluster
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
APOE (apolipoprotein E)
Aging
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Joshi PK; Fischer K; Schraut KE ; et al. (2016)
Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.
GP00000099
APOE
P02649
Physiology
Cys112Arg
Homo sapiens
human - (species)
Homo sapiens
human - (species)
APOE (apolipoprotein E)
Homo sapiens
human - (species)
Published - Accepted by Curator
APSR
Sulfate content (shoot)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Loudet O; Saliba-Colombani V; Camilleri C ; et al. (2007)
Natural variation for sulfate content in Arabidopsis thaliana is highly controlled by APR2.
GP00000100
APR2
P92981
Physiology
A399E N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
APSR
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
arcp-1
CO2 avoidance
Aggregation behavior
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Beets I; Zhang G; Fenk LA ; et al. (2019)
Natural Variation in a Dendritic Scaffold Protein Remodels Experience-Dependent Plasticity by Alteri[...]
GP00002067
CELE_F34D10.6
C6KRH4
Behavior
Behavior
8 bp deletion (mfP22) in the open reading frame N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
arcp-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
arginyl-transfer RNA synthetase (RARS)
Heat tolerance
Coding,
SNP
Anolis cristatellus
(species) D
Intraspecific
Association Mapping
Campbell-Staton SC; Winchell KM; Rochette NC ; et al. (2020)
Parallel selection on thermal physiology facilitates repeated adaptation of city lizards to urban he[...]
GP00002620
RARS2
Q5T160
Physiology
C>G threonine>serine at amino acid residue 558 of the RARS gene = adjacent to a predicted protein-binding region22 (AA556–557). There are four non-synonymous polymorphic sites within RARS. Only one shows a significant difference in allele frequency between forest and urban habitats across all populations.
Anolis cristatellus
(species)
Anolis cristatellus
(species) D
arginyl-transfer RNA synthetase (RARS)
Anolis cristatellus
(species)
Published - Accepted by Curator
ARHGAP11B
Neocortex development (basal progenitor amplification)
Coding,
SNP
N
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Florio M; Namba T; Pääbo S ; et al. (2016)
A single splice site mutation in human-specific ARHGAP11B causes basal progenitor amplification.
GP00001442
ARHGAP11B
Q3KRB8
Morphology
c.661C>G new splice site mutation removing 55nt from exon 5 truncating a GAP domain N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
ARHGAP11B
Homo sapiens
human - (species)
Published - Accepted by Curator
ARHGEF3
Hematopoiesis (mean blood platelet volume & blood platelet count)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001605
ARHGEF3
Q9NR81
Physiology
T>C at the associated SNP that disrupts a conserved GATA motif. This variant overlaps with a common-myeloid progenitor (CMP-) and megakaryocyte-erythroid progenitor (MEP-) specific regulatory element that affects the transcription of ARHGEF3
Homo sapiens
human - (species)
Homo sapiens
human - (species)
ARHGEF3
Homo sapiens
human - (species)
Published - Accepted by Curator
aristaless
Coloration (wing, Mullerian mimicry)
Cis-regulatory,
Unknown
Heliconius cydno
(species) D
Intraspecific
Linkage Mapping
Westerman EL; VanKuren NW; Massardo D ; et al. (2018)
Aristaless Controls Butterfly Wing Color Variation Used in Mimicry and Mate Choice.
GP00002059
al
Q06453
Morphology
gain of expression - exact mutation unknown
Heliconius cydno
(species)
Heliconius cydno
(species) D
aristaless
Heliconius cydno
(species)
Published - Accepted by Curator
ARNT-1c
Xenobiotic resistance (pollution)
Unknown,
Unknown
N
Fundulus grandis
Gulf killifish - (species) D
Intraspecific
Association Mapping
Oziolor EM; Reid NM; Yair S ; et al. (2019)
Adaptive introgression enables evolutionary rescue from extreme environmental pollution.
GP00002672
P27540NULL
Physiology
exact mutation(s) unknown - very good candidate gene according to high differentiation region on chromosome 8 and knowledge about the physiology. ARNT1c is a nuclear dimerization partner of aryl hydrocarbon receptor (AHR) required for activation of the xenobiotic response pathway. N
Fundulus grandis
Gulf killifish - (species)
Fundulus grandis
Gulf killifish - (species) D
ARNT-1c
Fundulus grandis
Gulf killifish - (species)
Published - Accepted by Curator
ARNT-L2a
Xenobiotic resistance (pollution)
Unknown,
Unknown
N
Fundulus grandis
Gulf killifish - (species) D
Intraspecific
Association Mapping
Oziolor EM; Reid NM; Yair S ; et al. (2019)
Adaptive introgression enables evolutionary rescue from extreme environmental pollution.
GP00002671
P27540NULL
Physiology
exact mutation(s) unknown - very good candidate gene according to high differentiation region on chromosome 10 and knowledge about the physiology. ARNT-L2a is a nuclear dimerization partner of aryl hydrocarbon receptor (AHR) required for activation of the xenobiotic response pathway. N
Fundulus grandis
Gulf killifish - (species)
Fundulus grandis
Gulf killifish - (species) D
ARNT-L2a
Fundulus grandis
Gulf killifish - (species)
Published - Accepted by Curator
arrow
Coloration (wing)
Cis-regulatory,
Unknown
Danaus chrysippus
African queen - (species)
Intraspecific
Association Mapping
Martin SH; Singh KS; Gordon IJ ; et al. (2020)
Whole-chromosome hitchhiking driven by a male-killing endosymbiont.
GP00002431
cnn
P54623
Morphology
The strongest associations with forewing tip (C locus) occur at the gene arrow and a phylogenetic network for a 100-kb region around this gene similarly clusters individuals by phenotype. In Drosophila Arrow is essential for Wnt signalling in wing development
Danaus chrysippus
African queen - (species)
Danaus chrysippus
African queen - (species)
arrow
Danaus chrysippus
African queen - (species)
Published - Accepted by Curator
AT5G41740/AT5G41750
Hybrid incompatibility (auto-immune necrosis)
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Bomblies K; Lempe J; Epple P ; et al. (2007)
Autoimmune response as a mechanism for a Dobzhansky-Muller-type incompatibility syndrome in plants.
GP00000105
MUF8.2
F4JYI4
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
AT5G41740/AT5G41750
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
AtGA20ox1 (=GA5=Sd1)
Plant size (dwarfism)
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Luo Y; Dong X; Yu T ; et al. (2015)
A Single Nucleotide Deletion in Gibberellin20-oxidase1 Causes Alpine Dwarfism in Arabidopsis.
GP00001243
GA20OX1
Q39110
Morphology
-1bp at position 184 causing premature stop N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
AtGA20ox1 (=GA5=Sd1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
AtHKT1
Salt tolerance
Cis-regulatory,
Deletion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Rus A; Baxter I; Muthukumar B ; et al. (2006)
Natural variants of AtHKT1 enhance Na+ accumulation in two wild populations of Arabidopsis.
1 Additional References
GP00000124
HKT1
Q84TI7
Physiology
725bp deletion of part of upstream repeat region
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
AtHKT1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
AtHKT1
Salt tolerance
Cis-regulatory,
Deletion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Rus A; Baxter I; Muthukumar B ; et al. (2006)
Natural variants of AtHKT1 enhance Na+ accumulation in two wild populations of Arabidopsis.
1 Additional References
GP00000125
HKT1
Q84TI7
Physiology
687bp deletion of part of upstream repeat region
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
AtHKT1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
AtMYC1
Trichome density (leaf)
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Symonds VV; Hatlestad G; Lloyd AM (2011)
Natural allelic variation defines a role for ATMYC1: trichome cell fate determination.
1 Additional References
GP00001268
BHLH12
Q8W2F1
Morphology
P189A
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
AtMYC1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
ATP2B4
Pathogen resistance (Plasmodium; malaria parasite)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Timmann C; Thye T; Vens M ; et al. (2012)
Genome-wide association study indicates two novel resistance loci for severe malaria.
GP00000127
ATP2B4
P23634
Physiology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
ATP2B4
Homo sapiens
human - (species)
Published - Accepted by Curator
ATR13
Pathogenicity
Coding,
SNP
Hyaloperonospora parasitica
(species)
Intraspecific
Linkage Mapping
Allen RL; Bittner-Eddy PD; Grenville-Briggs LJ ; et al. (2004)
Host-parasite coevolutionary conflict between Arabidopsis and downy mildew.
1 Additional References
GP00000128
Atr13
Q5G7K8
Physiology
Multiple coding changes - the avirulence allele ATR13‐Maks9 and the virulence allele ATR13‐Emoy2 only encode differences in the C‐terminal domain (in 11 amino acids) - domain swaps show that one or more of the amino acids in Region A are required for recognition and one or more in Region B are required to elicit a full recognition phenotype. - exact causing mutations unknown
Hyaloperonospora parasitica
(species)
Hyaloperonospora parasitica
(species)
ATR13
Hyaloperonospora parasitica
(species)
Published - Accepted by Curator
ATXN1
Body fat distribution (attenuation)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001552
ATXN1
P54253
Physiology
A>G in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
ATXN1
Homo sapiens
human - (species)
Published - Accepted by Curator
avpr1a
Male sexual fidelity (monogamous regime)
Cis-regulatory,
Unknown
Microtus ochrogaster
prairie vole - (species)
Intraspecific
Candidate Gene
Okhovat M; Berrio A; Wallace G ; et al. (2015)
Sexual fidelity trade-offs promote regulatory variation in the prairie vole brain.
1 Additional References
GP00000129
Avpr1a
Q62463
Behavior
unknown
Microtus ochrogaster
prairie vole - (species)
Microtus ochrogaster
prairie vole - (species)
avpr1a
Microtus ochrogaster
prairie vole - (species)
Published - Accepted by Curator
AZI1
Root growth (root growth responses to low zinc conditions)
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Association Mapping
Bouain N; Satbhai SB; Korte A ; et al. (2018)
Natural allelic variation of the AZI1 gene controls root growth under zinc-limiting condition.
GP00001769
AZI1
Q9SU35
Physiology
exact causing mutation(s) unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
AZI1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
bab
Coloration (abdomen ; sexual trait ; plasticity)
Cis-regulatory,
Deletion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
De Castro S; Peronnet F; Gilles JF ; et al. (2018)
bric à brac (bab), a central player in the gene regulatory network that mediates thermal plasticity [...]
GP00002423
bab1
Q9W0K7
Morphology
a 56-bp deletion that removes two binding sites for Abdominal B (Abd-B), a direct activator of bab, is present in a cis-regulatiry region of bab1 (within the first intron of bab1) in the Dark line.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
bab
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
bab
Insect pheromone attraction
Cis-regulatory,
Unknown
Ostrinia nubilalis
European corn borer - (species)
Intraspecific
Association Mapping
Unbehend M; Kozak GM; Koutroumpa F ; et al. (2021)
bric à brac controls sex pheromone choice by male European corn borer moths.
GP00002424
bab1
Q9W0K7
Behavior; Physiology
A genome-wide association study of pheromone preference under field conditions indicates that preference is controlled by sequence variation within the 293 kb bab intron 1.
Ostrinia nubilalis
European corn borer - (species)
Ostrinia nubilalis
European corn borer - (species)
bab
Ostrinia nubilalis
European corn borer - (species)
Published - Accepted by Curator
bab
Coloration (abdomen; female)
2 Mutations:
Cis-regulatory
SNP
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Rogers WA; Salomone JR; Tacy DJ ; et al. (2013)
Recurrent modification of a conserved cis-regulatory element underlies fruit fly pigmentation divers[...]
GP00002610
bab1
Q9W0K7
Morphology
2 mutations
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
bab
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
bab
Coloration (abdomen; female)
2 Mutations:
Cis-regulatory
SNP
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Rogers WA; Salomone JR; Tacy DJ ; et al. (2013)
Recurrent modification of a conserved cis-regulatory element underlies fruit fly pigmentation divers[...]
GP00002611
bab1
Q9W0K7
Morphology
2 mutations
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
bab
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
bab1
Coloration (abdomen)
3 Mutations:
Cis-regulatory
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Kopp A; Graze RM; Xu S ; et al. (2003)
Quantitative trait loci responsible for variation in sexually dimorphic traits in Drosophila melanog[...]
1 Additional References
GP00000130
bab1
Q9W0K7
Morphology
3 mutations
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
bab1
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
bab2
Fertility (ovariole number)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Green DA; Extavour CG (2012)
Convergent evolution of a reproductive trait through distinct developmental mechanisms in Drosophila[...]
1 Additional References
GP00000132
bab2
Q9W0K4
Physiology
unknown ; loss of function reduces ovariole number
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
bab2
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
BAK1
Hematopoiesis (blood platelet count)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001616
BAK1
Q16611
Physiology
A>G at the associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
BAK1
Homo sapiens
human - (species)
Published - Accepted by Curator
BarH1
Coloration (wing; sex-specific; female-specific)
Cis-regulatory,
Insertion
Colias croceus
clouded yellow - (species) D
Intraspecific
Association Mapping
Woronik A; Tunström K; Perry MW ; et al. (2019)
A transposable element insertion is associated with an alternative life history strategy.
GP00002095
B-H1
Q24255
Morphology
insertion of a Jockey-like transposable element 6 kb downstream of the Colias homolog of BarH-1. BarH-1 expression suppresses orange coloration in the wings.
Colias croceus
clouded yellow - (species)
Colias croceus
clouded yellow - (species) D
BarH1
Colias croceus
clouded yellow - (species)
Published - Accepted by Curator
BCMA
Glucosinolate content
Herbivore resistance
3 Mutations:
Boechera stricta
(species)
Intraspecific
Linkage Mapping
Prasad KV; Song BH; Olson-Manning C ; et al. (2012)
A gain-of-function polymorphism controlling complex traits and fitness in nature.
GP00000136
J9QWI9
Physiology
Physiology
3 mutations
Boechera stricta
(species)
Boechera stricta
(species)
BCMA
Boechera stricta
(species)
Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2
Coloration (ventral scales)
Cis-regulatory,
Unknown
Podarcis muralis
Common wall lizard - (species)
Intraspecific
Association Mapping
Andrade P; Pinho C; Pérez I de Lanuza G ; et al. (2019)
Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall [...]
GP00002120
Bco2
Q99NF1
Morphology
Podarcis muralis
Common wall lizard - (species)
Podarcis muralis
Common wall lizard - (species)
BCO2 = beta-carotene oxygenase 2
Podarcis muralis
Common wall lizard - (species)
Published - Accepted by Curator
BCO2 = beta-carotene oxygenase 2
Coloration (beak)
Cis-regulatory,
Unknown
Geospiza scandens
(species) D
Geospiza fortis
medium ground-finch - (species) D
Geospiza conirostris
(species) D
Geospiza magnirostris
(species) D
Geospiza fuliginosa
(species) D
Camarhynchus parvulus
(species) D
Camarhynchus pauper
(species) D
Camarhynchus pallidus
woodpecker finch - (species) D
Geospiza difficilis
(species) D
Intraspecific
Association Mapping
Enbody ED; Sprehn CG; Abzhanov A ; et al. (2021)
A multispecies BCO2 beak color polymorphism in the Darwin's finch radiation.
GP00002384
BCO2
Q9BYV7
Morphology
"By closely inspecting this region in a combined sample of all 456 finches of the two species we identified a single exonic SNP with a likelihood ratio test (LRT) statistic exceeding 166 (Figure 1C). It is also the only consistently elevated SNP in an analysis of each species alone (Figure S1), is the best fit variant under a recessive model (STAR Methods), and occurs on multiple haplotypes (Figure S1C). This SNP (chr24:6,166,878; p6166878 hereafter) leads to a synonymous change 32 bp into exon 4 of BCO2. "
"The functional importance of the observed synonymous change is uncertain, and the presence of an unidentified linked causal variant cannot be completely ruled out (see Conclusions). However, a functional explanation is possible because codon usage can be under strong selection30 and may have functional consequences on translation,30 RNA stability,31 and transcription.32 Notably, p6166878 changes the highest frequency valine codon (ƒGTG = 27.3%) to the lowest (ƒGTA = 7.6%) in the reference genome. This is in line with the observed phenotypic effect of the yellow mutation because a lower abundance codon is expected to be associated with lower protein expression.33 In this case, less BCO2 activity results in more carotenoid deposition in the yellow morph. In fact, we found that yellow homozygotes showed significantly lower BCO2 expression compared to pink homozygotes in the upper beak of developing embryos (Figure 1F) that were sourced from a variety of different species and islands (Table S1): small sample sizes prohibit species-specific analysis. Among the six heterozygous individuals, the pink allele was expressed more than the yellow allele in five samples tested using a droplet-digital PCR (Figure S2C). Differences in expression between the two alleles, and in the absence of alternative splice variants (STAR Methods), raise the possibility that the synonymous change alters transcription factor binding affinity in exon 4. Further research into tissue-specific expression and the specific transcription factors that regulate BCO2 is warranted."
Geospiza scandens
(species)
Geospiza fortis
medium ground-finch - (species)
Geospiza conirostris
(species)
Geospiza magnirostris
(species)
Geospiza fuliginosa
(species)
Camarhynchus parvulus
(species)
Camarhynchus pauper
(species)
Camarhynchus pallidus
woodpecker finch - (species)
Geospiza difficilis
(species)
Geospiza scandens
(species) D
Geospiza fortis
medium ground-finch - (species) D
Geospiza conirostris
(species) D
Geospiza magnirostris
(species) D
Geospiza fuliginosa
(species) D
Camarhynchus parvulus
(species) D
Camarhynchus pauper
(species) D
Camarhynchus pallidus
woodpecker finch - (species) D
Geospiza difficilis
(species) D
BCO2 = beta-carotene oxygenase 2
Geospiza scandens
(species)
Geospiza fortis
medium ground-finch - (species)
Geospiza conirostris
(species)
Geospiza magnirostris
(species)
Geospiza fuliginosa
(species)
Camarhynchus parvulus
(species)
Camarhynchus pauper
(species)
Camarhynchus pallidus
woodpecker finch - (species)
Geospiza difficilis
(species)
Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)
Resistance to UV irradiation (flavonol glycosylation)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Ishihara H; Tohge T; Viehöver P ; et al. (2016)
Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...]
1 Additional References
GP00001263
BGLU6
Q682B4
Physiology
T-> A of a splice site at position 168 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Beta-glucosidase6 (BGLU6)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)
Resistance to UV irradiation (flavonol glycosylation)
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Ishihara H; Tohge T; Viehöver P ; et al. (2016)
Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...]
1 Additional References
GP00001264
BGLU6
Q682B4
Physiology
1-bp deletion of a splice site at position 395 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Beta-glucosidase6 (BGLU6)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)
Resistance to UV irradiation (flavonol glycosylation)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Ishihara H; Tohge T; Viehöver P ; et al. (2016)
Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...]
1 Additional References
GP00001265
BGLU6
Q682B4
Physiology
GAG to stop codon TAG at position 913 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Beta-glucosidase6 (BGLU6)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)
Resistance to UV irradiation (flavonol glycosylation)
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Ishihara H; Tohge T; Viehöver P ; et al. (2016)
Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...]
1 Additional References
GP00001266
BGLU6
Q682B4
Physiology
A deletion of one nucleotide in the seventh exon (BGLU6 CDS position 678) results in a premature stop codon in the accessions Bor-4, Se-0, Uod-1, and Zdr-1. premature stop codon N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Beta-glucosidase6 (BGLU6)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Beta-glucosidase6 (BGLU6)
Resistance to UV irradiation (flavonol glycosylation)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Ishihara H; Tohge T; Viehöver P ; et al. (2016)
Natural variation in flavonol accumulation in Arabidopsis is determined by the flavonol glucosyltran[...]
1 Additional References
GP00001267
BGLU6
Q682B4
Physiology
GAG to stop codon TAG at position 1138 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Beta-glucosidase6 (BGLU6)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Haemonchus contortus
barber pole worm - (species) D
Intraspecific
Candidate Gene
Kwa MS; Veenstra JG; Roos MH (1994)
Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino ac[...]
1 Additional References
GP00001785
TUB2
P02557
Physiology
Phe200Tyr
Haemonchus contortus
barber pole worm - (species)
Haemonchus contortus
barber pole worm - (species) D
beta-tubulin
Haemonchus contortus
barber pole worm - (species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Trichostrongylus colubriformis
(species) D
Intraspecific
Candidate Gene
Kwa MS; Veenstra JG; Roos MH (1994)
Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino ac[...]
1 Additional References
GP00001786
TUB2
P02557
Physiology
Phe200Tyr
Trichostrongylus colubriformis
(species)
Trichostrongylus colubriformis
(species) D
beta-tubulin
Trichostrongylus colubriformis
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Venturia inaequalis
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001788
TUB2
P02557
Physiology
Phe200Tyr
Venturia inaequalis
(species)
Venturia inaequalis
(species) D
beta-tubulin
Venturia inaequalis
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001789
TUB2
P02557
Physiology
Phe200Tyr
D
beta-tubulin
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium italicum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001790
TUB2
P02557
Physiology
Phe200Tyr
Penicillium italicum
(species)
Penicillium italicum
(species) D
beta-tubulin
Penicillium italicum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium aurantiogriseum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001791
TUB2
P02557
Physiology
Phe200Tyr
Penicillium aurantiogriseum
(species)
Penicillium aurantiogriseum
(species) D
beta-tubulin
Penicillium aurantiogriseum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium aurantiogriseum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001792
TUB2
P02557
Physiology
Glu198Lys
Penicillium aurantiogriseum
(species)
Penicillium aurantiogriseum
(species) D
beta-tubulin
Penicillium aurantiogriseum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium viridicatum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001793
TUB2
P02557
Physiology
Glu198Lys
Penicillium viridicatum
(species)
Penicillium viridicatum
(species) D
beta-tubulin
Penicillium viridicatum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Clarireedia homoeocarpa
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001794
TUB2
P02557
Physiology
Glu1198Lys
Clarireedia homoeocarpa
(species)
Clarireedia homoeocarpa
(species) D
beta-tubulin
Clarireedia homoeocarpa
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Venturia inaequalis
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001795
TUB2
P02557
Physiology
Glu1198Lys
Venturia inaequalis
(species)
Venturia inaequalis
(species) D
beta-tubulin
Venturia inaequalis
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Venturia inaequalis
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001796
TUB2
P02557
Physiology
Glu1198Ala
Venturia inaequalis
(species)
Venturia inaequalis
(species) D
beta-tubulin
Venturia inaequalis
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001797
TUB2
P02557
Physiology
Glu1198Ala
D
beta-tubulin
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Monilinia fructicola
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001798
TUB2
P02557
Physiology
Glu1198Lys
Monilinia fructicola
(species)
Monilinia fructicola
(species) D
beta-tubulin
Monilinia fructicola
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium puberulum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001799
TUB2
P02557
Physiology
Glu1198Lys
Penicillium puberulum
(species)
Penicillium puberulum
(species) D
beta-tubulin
Penicillium puberulum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium puberulum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001800
TUB2
P02557
Physiology
Glu1198Ala
Penicillium puberulum
(species)
Penicillium puberulum
(species) D
beta-tubulin
Penicillium puberulum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium digitatum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001801
TUB2
P02557
Physiology
Glu1198Lys
Penicillium digitatum
(species)
Penicillium digitatum
(species) D
beta-tubulin
Penicillium digitatum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium expansum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001802
TUB2
P02557
Physiology
Glu1198Ala
Penicillium expansum
(species)
Penicillium expansum
(species) D
beta-tubulin
Penicillium expansum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benomyl)
Coding,
SNP
Penicillium italicum
(species) D
Intraspecific
Candidate Gene
Koenraadt Harrie; Somerville Shauna C; Jones AL
Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturi[...]
1 Additional References
GP00001803
TUB2
P02557
Physiology
Glu198Lys
Penicillium italicum
(species)
Penicillium italicum
(species) D
beta-tubulin
Penicillium italicum
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Teladorsagia circumcincta
(species) D
Intraspecific
Candidate Gene
Elard L; Humbert JF (1999)
Importance of the mutation of amino acid 200 of the isotype 1 beta-tubulin gene in the benzimidazole[...]
GP00001815
TUB2
P02557
Physiology
Phe200Tyr
Teladorsagia circumcincta
(species)
Teladorsagia circumcincta
(species) D
beta-tubulin
Teladorsagia circumcincta
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Haemonchus contortus
barber pole worm - (species) D
Intraspecific
Candidate Gene
Prichard R; Oxberry M; Bounhas Y ; et al. (2000
)
Polymerisation and benzimidazole binding assays with recombinant α-and β-tubulins from Haemonchus co[...]
2 Additional References
GP00001816
TUB2
P02557
Physiology
Phe167Tyr - In vitro assays have demonstrated that a Tyr residue in position 167 of b-tubulin impeded BZ binding with recombinant H. contortus b-tubulin (produced in a prokaryote system)
Haemonchus contortus
barber pole worm - (species)
Haemonchus contortus
barber pole worm - (species) D
beta-tubulin
Haemonchus contortus
barber pole worm - (species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Cyathostoma
(genus) D
Intraspecific
Candidate Gene
Silvestre A; Cabaret J (2002)
Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzi[...]
1 Additional References
GP00001817
TUB2
P02557
Physiology
Phe167Tyr - In vitro assays have demonstrated that a Tyr residue in position 167 of b-tubulin impeded BZ binding with recombinant H. contortus and S. cerevisiae b-tubulin (produced in a prokaryote system)
Cyathostoma
(genus)
Cyathostoma
(genus) D
beta-tubulin
Cyathostoma
(genus)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Neurospora crassa
(species) D
Intraspecific
Candidate Gene
Orbach MJ; Porro EB; Yanofsky C (1986)
Cloning and characterization of the gene for beta-tubulin from a benomyl-resistant mutant of Neurosp[...]
GP00001818
TUB2
P02557
Physiology
Phe167Tyr
Neurospora crassa
(species)
Neurospora crassa
(species) D
beta-tubulin
Neurospora crassa
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Teladorsagia circumcincta
(species) D
Intraspecific
Candidate Gene
Silvestre A; Cabaret J (2002)
Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzi[...]
GP00001819
TUB2
P02557
Physiology
Phe167Tyr
Teladorsagia circumcincta
(species)
Teladorsagia circumcincta
(species) D
beta-tubulin
Teladorsagia circumcincta
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Haemonchus contortus
barber pole worm - (species) D
Intraspecific
Candidate Gene
Ghisi M; Kaminsky R; Mäser P (2007)
Phenotyping and genotyping of Haemonchus contortus isolates reveals a new putative candidate mutatio[...]
GP00001820
TUB2
P02557
Physiology
Glu198Ala
Haemonchus contortus
barber pole worm - (species)
Haemonchus contortus
barber pole worm - (species) D
beta-tubulin
Haemonchus contortus
barber pole worm - (species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula yallundae
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
GP00001821
TUB2
P02557
Physiology
Phe200Tyr
Oculimacula yallundae
(species)
Oculimacula yallundae
(species) D
beta-tubulin
Oculimacula yallundae
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula acuformis
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
GP00001822
TUB2
P02557
Physiology
Phe200Tyr
Oculimacula acuformis
(species)
Oculimacula acuformis
(species) D
beta-tubulin
Oculimacula acuformis
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula acuformis
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
1 Additional References
GP00001823
TUB2
P02557
Physiology
E198A
Oculimacula acuformis
(species)
Oculimacula acuformis
(species) D
beta-tubulin
Oculimacula acuformis
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula acuformis
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
1 Additional References
GP00001824
TUB2
P02557
Physiology
E198G
Oculimacula acuformis
(species)
Oculimacula acuformis
(species) D
beta-tubulin
Oculimacula acuformis
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula acuformis
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
1 Additional References
GP00001825
TUB2
P02557
Physiology
E198K
Oculimacula acuformis
(species)
Oculimacula acuformis
(species) D
beta-tubulin
Oculimacula acuformis
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula yallundae
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
1 Additional References
GP00001826
TUB2
P02557
Physiology
E198A
Oculimacula yallundae
(species)
Oculimacula yallundae
(species) D
beta-tubulin
Oculimacula yallundae
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula yallundae
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
1 Additional References
GP00001827
TUB2
P02557
Physiology
E198G
Oculimacula yallundae
(species)
Oculimacula yallundae
(species) D
beta-tubulin
Oculimacula yallundae
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula yallundae
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
1 Additional References
GP00001828
TUB2
P02557
Physiology
E198Q
Oculimacula yallundae
(species)
Oculimacula yallundae
(species) D
beta-tubulin
Oculimacula yallundae
(species)
Published - Accepted by Curator
beta-tubulin
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Oculimacula yallundae
(species) D
Intraspecific
Candidate Gene
Albertini Catherine; Gredt Michel; Leroux Pierre (1999
)
Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in [...]
1 Additional References
GP00001829
TUB2
P02557
Physiology
L240F
Oculimacula yallundae
(species)
Oculimacula yallundae
(species) D
beta-tubulin
Oculimacula yallundae
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001830
TUB2
P02557
Physiology
A185P - missense_variant_c.553G>C_3539974 – A185P N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001832
TUB2
P02557
Physiology
stop_gained_HIGH_c.1267C>T_3538394 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Insertion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001833
TUB2
P02557
Physiology
Trans_3538426_3538832 – insertion of a transposable element = a cut and paste DNA transposon Tc5B - which is part of the TcMar-Tc4 transposon superfamily– 406bp of the reference sequence seem to be disrupted- Steffen Hahnel comment : Since we didn't re-amplify the insertion by PCR; we don't know its exact location; sequence and size. Its identification is only based on the illumina reads of genome sequencing of JU3125. N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001834
TUB2
P02557
Physiology
missense_variant_MODERATE_c.1210G>A_3538451 – D404N N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001835
TUB2
P02557
Physiology
Del_3539006_3539808 – 802bp deletion of coding exon 4 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001836
TUB2
P02557
Physiology
stop_gained_HIGH_c.1135A>T_3539335 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001837
TUB2
P02557
Physiology
stop_gained_HIGH_c.1112C>A_3539358 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001838
TUB2
P02557
Physiology
Del_3539375_3539378 – 3bp deletion in coding exon 4 predicted to cause a frameshift in the ben-1 open reading frame N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001839
TUB2
P02557
Physiology
Del_3539470_3539471 – 1bp deletion in coding exon 4 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001840
TUB2
P02557
Physiology
Del_3539507_3539514 – 7bp deletion N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001841
TUB2
P02557
Physiology
Del_3539559_3539745 – 186 bp deletion in coding exon 4 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Insertion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001842
TUB2
P02557
Physiology
Ins_3539575_3539576 – Steffen Hahnel comment: 1 bp insertion in coding exon 4 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001843
TUB2
P02557
Physiology
missense_variant_MODERATE_c.771G>A_3539699 – M257I N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001844
TUB2
P02557
Physiology
Del_3539746_3539908 – 162 bp deletion in exon3-4 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001845
TUB2
P02557
Physiology
stop_gained_HIGH_c.549C>A_3539978 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001846
TUB2
P02557
Physiology
missense_variant_MODERATE_c.434C>T_3540145 – S145F N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001847
TUB2
P02557
Physiology
missense_variant_MODERATE_c.392A>T_3540187 – comment from Steffen Hahnel: The amino acid change is Q131L. This strain was excluded from the original screen because it was slow growing. We re-phenotyped it later (see Sup Fig. 9) N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001848
TUB2
P02557
Physiology
Del_3540300_3540301 – 1bp deletion in coding exon 2 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Inversion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001849
TUB2
P02557
Physiology
Inv_3540316_3543965 – 3649bp inversion – the text indicates that there is “a 1kb inversion that spans exon 1 and the promoter region” but the nucleotide numbers in the supplemental table indicates that 3.6kb are disrupted. Steffen Hahnel comment: we don't know the exact size of this large structural variation. I estimated conservatively from the BAM files that a region of 3649 bp is messed up in this strain compared to wildtype including one or more inversions. The largest inversion is around 1 kb. If one wants to be sure about size and location you would need to amplify this region by PCR N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Unknown
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001850
TUB2
P02557
Physiology
Del_3540369_3540369 and missense_variant_c.206A>G_3540373 E69G - the amino acid substitution (E69G) co-occurs with a deletion in exon 2 that is predicted to cause a frameshift in the ben-1 open reading frame – not sure which mutation or both are responsible for the phenotype N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001851
TUB2
P02557
Physiology
Del_3540407_3540408 – 1bp deletion in coding exon 2 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001852
TUB2
P02557
Physiology
Del_3540970_3544000 – 3030bp deletion N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001853
TUB2
P02557
Physiology
Del_3541317_3541856 – 539 bp deletion in first coding exon N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001854
TUB2
P02557
Physiology
splice_donor_variant and intron_variant – first coding exon – c.166+1G>A_3541427 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001855
TUB2
P02557
Physiology
stop_gained_HIGH_c.153T>G_3541441 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001856
TUB2
P02557
Physiology
Del_3541499_3541502 – 3bp deletion in first coding exon N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben-1)
Xenobiotic resistance (benzimidazole)
Coding,
Insertion
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Hahnel SR; Zdraljevic S; Rodriguez BC ; et al. (2018)
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resist[...]
GP00001857
TUB2
P02557
Physiology
Ins_3541547_3541548 – 1 bp insertion in first coding exon N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
beta-tubulin (ben-1)
Caenorhabditis elegans
(species)
Published - Accepted by Curator
beta-tubulin (ben4)
Xenobiotic resistance (benzimidazole)
Coding,
SNP
Aspergillus nidulans
(species) D
Intraspecific
Candidate Gene
Jung MK; Wilder IB; Oakley BR (1992)
Amino acid alterations in the benA (beta-tubulin) gene of Aspergillus nidulans that confer benomyl r[...]
1 Additional References
GP00001787
TUB2
P02557
Physiology
Phe200Tyr
Aspergillus nidulans
(species)
Aspergillus nidulans
(species) D
beta-tubulin (ben4)
Aspergillus nidulans
(species)
Published - Accepted by Curator
BHLHE41
Hypoxia response
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Huerta-Sánchez E; Degiorgio M; Pagani L ; et al. (2013)
Genetic signatures reveal high-altitude adaptation in a set of ethiopian populations.
GP00000144
BHLHE41
Q9C0J9
Physiology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
BHLHE41
Homo sapiens
human - (species)
Published - Accepted by Curator
BMP6
Tooth number
Cis-regulatory,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Cleves PA; Ellis NA; Jimenez MT ; et al. (2014)
Evolved tooth gain in sticklebacks is associated with a cis-regulatory allele of Bmp6.
2 Additional References
GP00000154
Bmp6
P20722
Morphology
Candidate enhancer of 190bp recapitulating tooth and fin expression of BMP6
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
BMP6
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
Brassinosteroid-deficient dwarf1 (brd1)
Plant size (height)
Unknown,
Unknown
Zea mays
(species)
Intraspecific
Linkage Mapping
Peiffer JA; Romay MC; Gore MA ; et al. (2014)
The genetic architecture of maize height.
GP00001628
ZEAMMB73_Zm00001d033180
A0A1D6KWT1
Morphology
On chromosome 1 two C>T transitions reduce plant height in 18RIL families
Zea mays
(species)
Zea mays
(species)
Brassinosteroid-deficient dwarf1 (brd1)
Zea mays
(species)
Published - Accepted by Curator
Brevis radix (BRX)
Root size (shorter)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Mouchel CF; Briggs GC; Hardtke CS (2004)
Natural genetic variation in Arabidopsis identifies BREVIS RADIX, a novel regulator of cell prolifer[...]
GP00000157
BRX
Q17TI5
Morphology
premature stop codon in exon 4; TGG>TGA; truncated protein missing approximately two-thirds of the C terminus N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Brevis radix (BRX)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Brevis radix (BRX)
pH tolerance (acidic soil)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Gujas B; Alonso-Blanco C; Hardtke CS (2012)
Natural Arabidopsis brx loss-of-function alleles confer root adaptation to acidic soil.
GP00001236
BRX
Q17TI5
Physiology
K188* (stop codon) N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Brevis radix (BRX)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Brevis radix (BRX)
Root growth
Coding,
Deletion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Beuchat J; Li S; Ragni L ; et al. (2010)
A hyperactive quantitative trait locus allele of Arabidopsis BRX contributes to natural variation in[...]
GP00001262
BRX
Q17TI5
Morphology
21bp deletion at position in spacer 3 (position not given)
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Brevis radix (BRX)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
BvCPSF73-Ia
Bolting time
Coding,
Deletion
N
Beta vulgaris
(species) D
Intraspecific
Linkage Mapping
Tränkner C; Lemnian IM; Emrani N ; et al. (2016)
A Detailed Analysis of the BR Locus Suggests a New Mechanism for Bolting after Winter in Sugar Beet [...]
GP00001411
CPSF73-I
Q9C952
Physiology
2bp deletion causing a frameshift resulting in a two third truncated protein N
Beta vulgaris
(species)
Beta vulgaris
(species) D
BvCPSF73-Ia
Beta vulgaris
(species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide; Bt Cry1Ac)
Coding,
Unknown
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Linkage Mapping
Xu X; Yu L; Wu Y (2005)
Disruption of a cadherin gene associated with resistance to Cry1Ac {delta}-endotoxin of Bacillus thu[...]
GP00000160
BtR
Q19KJ3
Physiology
premature stop codon in exon 4; truncated protein missing approximately two-thirds of the C terminus N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
cadherin
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide)
Coding,
Insertion
N
Heliothis virescens
tobacco budworm - (species) D
Intraspecific
Linkage Mapping
Gahan LJ; Gould F; Heckel DG (2001)
Identification of a gene associated with Bt resistance in Heliothis virescens.
GP00000161
BtR
Q19KJ3
Physiology
Insertion of retrotransposon N
Heliothis virescens
tobacco budworm - (species)
Heliothis virescens
tobacco budworm - (species) D
cadherin
Heliothis virescens
tobacco budworm - (species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide)
Coding,
Deletion
N
Pectinophora gossypiella
pink bollworm - (species) D
Intraspecific
Linkage Mapping
Morin S; Biggs RW; Sisterson MS ; et al. (2003)
Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm.
1 Additional References
GP00000162
BtR
Q19KJ3
Physiology
126bp in-frame deletion N
Pectinophora gossypiella
pink bollworm - (species)
Pectinophora gossypiella
pink bollworm - (species) D
cadherin
Pectinophora gossypiella
pink bollworm - (species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide)
Coding,
Deletion
N
Pectinophora gossypiella
pink bollworm - (species) D
Intraspecific
Linkage Mapping
Morin S; Biggs RW; Sisterson MS ; et al. (2003)
Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm.
1 Additional References
GP00000163
BtR
Q19KJ3
Physiology
202bp deletion N
Pectinophora gossypiella
pink bollworm - (species)
Pectinophora gossypiella
pink bollworm - (species) D
cadherin
Pectinophora gossypiella
pink bollworm - (species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide)
Coding,
Deletion
Pectinophora gossypiella
pink bollworm - (species) D
Intraspecific
Linkage Mapping
Morin S; Biggs RW; Sisterson MS ; et al. (2003)
Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm.
1 Additional References
GP00000164
BtR
Q19KJ3
Physiology
24bp in-frame deletion
Pectinophora gossypiella
pink bollworm - (species)
Pectinophora gossypiella
pink bollworm - (species) D
cadherin
Pectinophora gossypiella
pink bollworm - (species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide)
Coding,
SNP
Pectinophora gossypiella
pink bollworm - (species) D
Intraspecific
Linkage Mapping
Zhang H; Tian W; Zhao J ; et al. (2012)
Diverse genetic basis of field-evolved resistance to Bt cotton in cotton bollworm from China.
GP00000165
BtR
Q19KJ3
Physiology
E1266L R1268E and E1270V - whether each mutation has an effect or only one of them is unknown
Pectinophora gossypiella
pink bollworm - (species)
Pectinophora gossypiella
pink bollworm - (species) D
cadherin
Pectinophora gossypiella
pink bollworm - (species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide; Bt Cry1Ac)
Coding,
SNP
N
Helicoverpa punctigera
(species) D
Intraspecific
Candidate Gene
Walsh T; James B; Chakroun M ; et al. (2018)
Isolating, characterising and identifying a Cry1Ac resistance mutation in field populations of Helic[...]
GP00002055
BtR
Q19KJ3
Physiology
splice site GT mutated in GA so that splicing does not occur correctly and a 58 bp insertion is found in the cDNA sequence of the cadherin gene. This insertion disrupts the coding sequence in cadherin domain 9 causing a downstream frameshift and a premature stop codon for the rest of the protein. This would result in a truncated protein of 1243 amino acids without the putative binding domain; the membrane anchoring domain; presumably retained inside the cell and not exposed to the Cry1Ac; or alternatively; exported into the gut where it would be degraded N
Helicoverpa punctigera
(species)
Helicoverpa punctigera
(species) D
cadherin
Helicoverpa punctigera
(species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
Deletion
Ostrinia furnacalis
Asian corn borer - (species) D
Intraspecific
Candidate Gene
Jin T; Chang X; Gatehouse AM ; et al. (2014)
Downregulation and mutation of a Cadherin gene associated with Cry1Ac resistance in the Asian Corn B[...]
1 Additional References
GP00002464
A0A1B0RHM4
Physiology
MPR-r2 has a 26-amino acid residue deletion in the TBR which results in reduced binding of Cry1Ac compared to the MPR from the susceptible strain.
Ostrinia furnacalis
Asian corn borer - (species)
Ostrinia furnacalis
Asian corn borer - (species) D
cadherin
Ostrinia furnacalis
Asian corn borer - (species)
Published - Accepted by Curator
cadherin
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
SNP
Ostrinia furnacalis
Asian corn borer - (species) D
Intraspecific
Candidate Gene
Jin T; Chang X; Gatehouse AM ; et al. (2014)
Downregulation and mutation of a Cadherin gene associated with Cry1Ac resistance in the Asian Corn B[...]
1 Additional References
GP00002465
A0A1B0RHM4
Physiology
Thr1457Ser
Ostrinia furnacalis
Asian corn borer - (species)
Ostrinia furnacalis
Asian corn borer - (species) D
cadherin
Ostrinia furnacalis
Asian corn borer - (species)
Published - Accepted by Curator
calmodulin binding hydrolase
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001438
Q9FHQ0
Physiology
unknown
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
calmodulin binding hydrolase
Arabidopsis arenosa
(species)
Published - Accepted by Curator
Camta3
Plant size (height)
Unknown,
Unknown
Zea mays
(species)
Intraspecific
Association Mapping
Peiffer JA; Romay MC; Gore MA ; et al. (2014)
The genetic architecture of maize height.
GP00001629
CAMTA3
Q8GSA7
Morphology
C>T transition on chromosome 3
Zea mays
(species)
Zea mays
(species)
Camta3
Zea mays
(species)
Published - Accepted by Curator
Casparian strip membrane domain protein 1
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001432
CASP1
Q9SIH4
Physiology
five aa sustitutions
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
Casparian strip membrane domain protein 1
Arabidopsis arenosa
(species)
Published - Accepted by Curator
catechol-O-methyltransferase (COMT)
Pain sensitivity
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Nackley AG; Shabalina SA; Tchivileva IE ; et al. (2006)
Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary[...]
GP00000171
COMT
P21964
Behavior
G/C - The synonymous mutation(s) affect mRNA stability and loop structures
Homo sapiens
human - (species)
Homo sapiens
human - (species)
catechol-O-methyltransferase (COMT)
Homo sapiens
human - (species)
Published - Accepted by Curator
Catecholamines up
Bristle number
Lifespan
Locomotor activity
Sleep
Coding,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Carbone MA; Jordan KW; Lyman RF ; et al. (2006)
Phenotypic variation and natural selection at catsup, a pleiotropic quantitative trait gene in Droso[...]
1 Additional References
GP00000172
Catsup
Q9V3A4
Morphology
Physiology
Behavior
Behavior
unknown; but most large-effect variants appear to be coding
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Catecholamines up
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
CBF gene cluster
Temperature tolerance (cold)
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Gery C; Zuther E; Schulz E ; et al. (2011)
Natural variation in the freezing tolerance of Arabidopsis thaliana: effects of RNAi-induced CBF dep[...]
GP00000174
B1NSN2
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
CBF gene cluster
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
CCAAT-enhancer-binding protein alpha (CEBPA)
Hematopoiesis (blood basophil count)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001603
CEBPA
P49715
Physiology
C>T at the associated SNP which resides 39kb dowstream from CEBPA near a separate enhancer that influences CEBPA expression along various myeloid lineages. T allele was associated with a 28.6% reduction in enhancer activity.
Homo sapiens
human - (species)
Homo sapiens
human - (species)
CCAAT-enhancer-binding protein alpha (CEBPA)
Homo sapiens
human - (species)
Published - Accepted by Curator
ccdc170
Coloration
Unknown,
Unknown
Anolis sagrei
Brown anole - (species)
Intraspecific
Association Mapping
Feiner N; Brun-Usan M; Andrade P ; et al. (2022)
A single locus regulates a female-limited color pattern polymorphism in a reptile.
GP00002363
Ccdc170
D3YXL0
Morphology
Anolis sagrei
Brown anole - (species)
Anolis sagrei
Brown anole - (species)
ccdc170
Anolis sagrei
Brown anole - (species)
Published - Accepted by Curator
CCL3L1
Pathogen resistance (HIV)
Gene Amplification,
Indel
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Gonzalez E; Kulkarni H; Bolivar H ; et al. (2005)
The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility.
GP00000177
CCL3L1
P16619
Physiology
Copy number Variant
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
CCL3L1
Homo sapiens
human - (species)
Published - Accepted by Curator
CG11699
Xenobiotic resistance
Cis-regulatory,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Association Mapping
Mateo L; Ullastres A; González J (2014)
A transposable element insertion confers xenobiotic resistance in Drosophila.
GP00001399
Dmel\CG11699
Q9VYX5
Physiology
insertion of a 186bp POGON1 element in the 3'UTR
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
CG11699
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Chalcone synthase D (CHS-D)
Coloration (flower)
Unknown,
Insertion
Ipomoea purpurea
common morning-glory - (species) D
Intraspecific
Candidate Gene
Habu Y; Hisatomi Y; Iida S (1998)
Molecular characterization of the mutable flaked allele for flower variegation in the common morning[...]
GP00001459
CHSD
O22045
Morphology
insertion of a 3.9kb long transposable element Tip100 in intron
Ipomoea purpurea
common morning-glory - (species)
Ipomoea purpurea
common morning-glory - (species) D
Chalcone synthase D (CHS-D)
Ipomoea purpurea
common morning-glory - (species)
Published - Accepted by Curator
Chalcone synthase D (CHS-D)
Coloration (flower)
Unknown,
Insertion
Ipomoea purpurea
common morning-glory - (species) D
Intraspecific
Candidate Gene
Habu Y; Hisatomi Y; Iida S (1998)
Molecular characterization of the mutable flaked allele for flower variegation in the common morning[...]
GP00001460
CHSD
O22045
Morphology
2 insertions of Tip100 in opposite orientation at different sites within the same intron
Ipomoea purpurea
common morning-glory - (species)
Ipomoea purpurea
common morning-glory - (species) D
Chalcone synthase D (CHS-D)
Ipomoea purpurea
common morning-glory - (species)
Published - Accepted by Curator
Chalk5
Grain chalkiness
Amylose content
Grain yield
Cis-regulatory,
SNP
Oryza sativa
rice - (species)
Intraspecific
Linkage Mapping
Li Y; Fan C; Xing Y ; et al. (2014)
Chalk5 encodes a vacuolar H(+)-translocating pyrophosphatase influencing grain chalkiness in rice.
GP00001309
Chalk5
A2Y0L3
Morphology
Physiology
Physiology
Two candidate SNPs at positions -721 and - 485 in promoter region
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Chalk5
Oryza sativa
rice - (species)
Published - Accepted by Curator
Chitin synthase 1 (CHS1)
Xenobiotic resistance (insecticide ; benzoylurea)
Coding,
SNP
Plutella xylostella
diamondback moth - (species)
Intraspecific
Candidate Gene
Douris V; Steinbach D; Panteleri R ; et al. (2016)
Resistance mutation conserved between insects and mites unravels the benzoylurea insecticide mode of[...]
GP00001600
CHS1
A3KCN0
Physiology
T>G p.I1042M (I1056 in D. melanogaster) located in the C-terminal transmembrane domain
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species)
Chitin synthase 1 (CHS1)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
Chitin synthase 1 (CHS1)
Xenobiotic resistance (insecticide; benzoylurea)
Coding,
SNP
Plutella xylostella
diamondback moth - (species)
Intraspecific
Candidate Gene
Douris V; Steinbach D; Panteleri R ; et al. (2016)
Resistance mutation conserved between insects and mites unravels the benzoylurea insecticide mode of[...]
GP00001601
CHS1
A3KCN0
Physiology
A>T p.I1042F (I1056 in D. melanogaster) located in the C-terminal transmembrane domain
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species)
Chitin synthase 1 (CHS1)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
Chitin synthase 1 (CHS1)
Xenobiotic resistance (insecticide; etoxazole acaricide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species)
Intraspecific
Linkage Mapping
Demaeght P; Osborne EJ; Odman-Naresh J ; et al. (2014)
High resolution genetic mapping uncovers chitin synthase-1 as the target-site of the structurally di[...]
1 Additional References
GP00001602
chs1
H9U0G2
Physiology
A>T p.I1017F (I1056 in D. melanogaster) located in the C-terminal transmembrane domain
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species)
Chitin synthase 1 (CHS1)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
Chitin synthase 1 (CHS1)
Xenobiotic resistance (insecticide; benzoylurea)
Coding,
SNP
Frankliniella occidentalis
western flower thrips - (species) D
Intraspecific
Candidate Gene
Suzuki Y; Shiotsuki T; Jouraku A ; et al. (2017)
Benzoylurea resistance in western flower thrips Frankliniella occidentalis (Thysanoptera: Thripidae)[...]
GP00002628
CHS1
A3KCN0
Physiology
isoleucine to methionine
Frankliniella occidentalis
western flower thrips - (species)
Frankliniella occidentalis
western flower thrips - (species) D
Chitin synthase 1 (CHS1)
Frankliniella occidentalis
western flower thrips - (species)
Published - Accepted by Curator
CHKov1
Pathogen resistance
Xenobiotic resistance (insecticide)
Coding,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Magwire MM; Bayer F; Webster CL ; et al. (2011)
Successive increases in the resistance of Drosophila to viral infection through a transposon inserti[...]
1 Additional References
GP00000182
CHKov1
Q961V7
Physiology
Physiology
Insertion of a Doc TE element resulting in novel; seemingly functional short protein
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
CHKov1
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
chloroquine resistance transporter
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001533
CRT
Q9N623
Physiology
p.Ile356Thr
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
chloroquine resistance transporter
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
CHRNA3/5 nicotine receptor cluster
Aging
Smoking behavior
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Joshi PK; Fischer K; Schraut KE ; et al. (2016)
Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.
GP00000185
CHRNA3
P32297
Physiology
Physiology
unknown; complex variation with SNP association signal
Homo sapiens
human - (species)
Homo sapiens
human - (species)
CHRNA3/5 nicotine receptor cluster
Homo sapiens
human - (species)
Published - Accepted by Curator
CLH1
Xenobiotic resistance (fungicide: guazatine)
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Association Mapping
Atanasov KE; Barboza-Barquero L; Tiburcio AF ; et al. (2016)
Genome Wide Association Mapping for the Tolerance to the Polyamine Oxidase Inhibitor Guazatine in Ar[...]
GP00001234
CLH1
O22527
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
CLH1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
CMAH
Blood type (feline ABC)
Coding,
SNP
Felis catus
domestic cat - (species) D
Intraspecific
Candidate Gene
Omi T; Nakazawa S; Udagawa C ; et al. (2016)
Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...]
1 Additional References
GP00002163
Cmah
Q61419
Physiology
c.179G>T p.G60V
Felis catus
domestic cat - (species)
Felis catus
domestic cat - (species) D
CMAH
Felis catus
domestic cat - (species)
Published - Accepted by Curator
CMAH
Blood type (feline ABC)
Coding,
SNP
Felis catus
domestic cat - (species) D
Intraspecific
Candidate Gene
Omi T; Nakazawa S; Udagawa C ; et al. (2016)
Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...]
1 Additional References
GP00002164
Cmah
Q61419
Physiology
c.364C>T p.P122S
Felis catus
domestic cat - (species)
Felis catus
domestic cat - (species) D
CMAH
Felis catus
domestic cat - (species)
Published - Accepted by Curator
CMAH
Blood type (feline ABC)
Coding,
Deletion
N
Felis catus
domestic cat - (species) D
Intraspecific
Candidate Gene
Omi T; Nakazawa S; Udagawa C ; et al. (2016)
Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...]
2 Additional References
GP00002165
Cmah
Q61419
Physiology
c.1322delT p.Leu441* N
Felis catus
domestic cat - (species)
Felis catus
domestic cat - (species) D
CMAH
Felis catus
domestic cat - (species)
Published - Accepted by Curator
CMAH
Blood type (feline ABC)
Coding,
SNP
Felis catus
domestic cat - (species) D
Intraspecific
Candidate Gene
Omi T; Nakazawa S; Udagawa C ; et al. (2016)
Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...]
2 Additional References
GP00002166
Cmah
Q61419
Physiology
c.139G>A p.V47M
Felis catus
domestic cat - (species)
Felis catus
domestic cat - (species) D
CMAH
Felis catus
domestic cat - (species)
Published - Accepted by Curator
CMAH
Blood type (feline ABC)
Coding,
SNP
Felis catus
domestic cat - (species) D
Intraspecific
Candidate Gene
Omi T; Nakazawa S; Udagawa C ; et al. (2016)
Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...]
2 Additional References
GP00002167
Cmah
Q61419
Physiology
c.268T>A p.Y89N
Felis catus
domestic cat - (species)
Felis catus
domestic cat - (species) D
CMAH
Felis catus
domestic cat - (species)
Published - Accepted by Curator
CMAH
Blood type (feline ABC)
Coding,
SNP
Felis catus
domestic cat - (species) D
Intraspecific
Candidate Gene
Omi T; Nakazawa S; Udagawa C ; et al. (2016)
Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) [...]
2 Additional References
GP00002168
Cmah
Q61419
Physiology
c.1600G>A p.D534N
Felis catus
domestic cat - (species)
Felis catus
domestic cat - (species) D
CMAH
Felis catus
domestic cat - (species)
Published - Accepted by Curator
CORIN
Coloration (coat)
Coding,
SNP
Panthera tigris
tiger - (species) D
Intraspecific
Linkage Mapping
Xu X; Dong GX; Schmidt-Küntzel A ; et al. (2017)
The genetics of tiger pelage color variations.
GP00002169
Corin
Q9Z319
Morphology
c.1759C >T p.H587Y
Panthera tigris
tiger - (species)
Panthera tigris
tiger - (species) D
CORIN
Panthera tigris
tiger - (species)
Published - Accepted by Curator
cortex
Coloration (wing ; industrial melanism ; camouflage)
Cis-regulatory,
Insertion
Biston betularia
pepper-and-salt moth - (species) D
Intraspecific
Linkage Mapping
Van't Hof AE; Campagne P; Rigden DJ ; et al. (2016)
The industrial melanism mutation in British peppered moths is a transposable element.
GP00001804
cort
Q960N3
Morphology
Putative transposon insertion within the first intron ; consists of of ~9 kb tandemly repeated 2.3 times + three short tandem subrepeat units
Biston betularia
pepper-and-salt moth - (species)
Biston betularia
pepper-and-salt moth - (species) D
cortex
Biston betularia
pepper-and-salt moth - (species)
Published - Accepted by Curator
cortex
Coloration (wing ; leaf mimicry ; camouflage)
Cis-regulatory,
Complex Change
Kallima inachus
orange oakleaf - (species) D
Intraspecific
Association Mapping
Wang S; Teng D; Li X ; et al. (2022)
The evolution and diversification of oakleaf butterflies.
GP00002413
cort
Q960N3
Morphology
Kallima inachus
orange oakleaf - (species)
Kallima inachus
orange oakleaf - (species) D
cortex
Kallima inachus
orange oakleaf - (species)
Published - Accepted by Curator
cortex
Coloration (wing ; leaf mimicry ; camouflage)
Cis-regulatory,
Unknown
Kallima inachus
orange oakleaf - (species) D
Intraspecific
Association Mapping
Wang S; Teng D; Li X ; et al. (2022)
The evolution and diversification of oakleaf butterflies.
GP00002414
cort
Q960N3
Morphology
Kallima inachus
orange oakleaf - (species)
Kallima inachus
orange oakleaf - (species) D
cortex
Kallima inachus
orange oakleaf - (species)
Published - Accepted by Curator
cortex
Coloration (wing ; leaf mimicry ; camouflage)
Cis-regulatory,
Unknown
Kallima inachus
orange oakleaf - (species) D
Intraspecific
Association Mapping
Wang S; Teng D; Li X ; et al. (2022)
The evolution and diversification of oakleaf butterflies.
GP00002415
cort
Q960N3
Morphology
Kallima inachus
orange oakleaf - (species)
Kallima inachus
orange oakleaf - (species) D
cortex
Kallima inachus
orange oakleaf - (species)
Published - Accepted by Curator
cortex
Coloration (wing ; leaf mimicry ; camouflage)
Cis-regulatory,
Unknown
Kallima inachus
orange oakleaf - (species) D
Intraspecific
Association Mapping
Wang S; Teng D; Li X ; et al. (2022)
The evolution and diversification of oakleaf butterflies.
GP00002416
cort
Q960N3
Morphology
Large inversion and many mutations in the large inverted region.
Kallima inachus
orange oakleaf - (species)
Kallima inachus
orange oakleaf - (species) D
cortex
Kallima inachus
orange oakleaf - (species)
Published - Accepted by Curator
cortex
Coloration (wing; mimicry)
Unknown,
Unknown
Papilio clytia
common mime swallowtail - (species)
Intraspecific
Association Mapping
VanKuren NW; Massardo D; Nallu S ; et al. (2019)
Butterfly Mimicry Polymorphisms Highlight Phylogenetic Limits of Gene Reuse in the Evolution of Dive[...]
GP00002419
cort
Q960N3
Morphology
Mapping to a 500-kb region that contains the cortex gene
Papilio clytia
common mime swallowtail - (species)
Papilio clytia
common mime swallowtail - (species)
cortex
Papilio clytia
common mime swallowtail - (species)
Published - Accepted by Curator
cortex
Coloration (wing)
Cis-regulatory,
Insertion
Heliconius melpomene
postman butterfly - (species) D
Intraspecific
Association Mapping
Livraghi L; Hanly JJ; Van Bellghem SM ; et al. (2021)
Cortex cis-regulatory switches establish scale colour identity and pattern diversity in Heliconius.
GP00002660
cort
Q960N3
Morphology
Insertion of two transposable elements (BovB-like and Helitron-like)
Heliconius melpomene
postman butterfly - (species)
Heliconius melpomene
postman butterfly - (species) D
cortex
Heliconius melpomene
postman butterfly - (species)
Published - Accepted by Curator
Couch potato
Diapause
Coding,
SNP
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Schmidt PS; Zhu CT; Das J ; et al. (2008)
An amino acid polymorphism in the couch potato gene forms the basis for climatic adaptation in Droso[...]
GP00000191
cpo
Q01617
Physiology
Ile462Lys
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Couch potato
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Cpm1
Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)
Coding,
SNP
N
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Darboux I; Charles JF; Pauchet Y ; et al. (2007)
Transposon-mediated resistance to Bacillus sphaericus in a field-evolved population of Culex pipiens[...]
GP00002102
Q95WY5
Physiology
Gln396Stop - nonsense mutation which causes the loss of the C-terminal domain required for a proper anchoring of the receptor to the cell surface and thus disrupts a crucial step in the toxic properties of B. sphaericus toxin. N
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
Cpm1
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
Cpm1
Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)
Coding,
Insertion
N
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Darboux I; Charles JF; Pauchet Y ; et al. (2007)
Transposon-mediated resistance to Bacillus sphaericus in a field-evolved population of Culex pipiens[...]
GP00002103
Q95WY5
Physiology
Insertion of a 451-bpTE into the exon 2 of the toxin receptor gene. The insertion induces a new mRNA splicing event that creates a shorter transcript. This new transcript encodes an altered receptor unable to interact with the toxin resulting in resistance to this insecticide. The missing portion includes GPI-anchoring signals N
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
Cpm1
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
Cpm1
Xenobiotic resistance (insecticide; toxin produced by Bacillus sphaericus)
Coding,
Deletion
N
Culex quinquefasciatus
southern house mosquito - (species) D
Intraspecific
Candidate Gene
Guo QY; Cai QX; Yan JP ; et al. (2013)
Single nucleotide deletion of cqm1 gene results in the development of resistance to Bacillus sphaeri[...]
1 Additional References
GP00002552
Q95WY5
Physiology
one-nucleotide deletion which results in a premature stop codon and leads to production of a truncated protein. N
Culex quinquefasciatus
southern house mosquito - (species)
Culex quinquefasciatus
southern house mosquito - (species) D
Cpm1
Culex quinquefasciatus
southern house mosquito - (species)
Published - Accepted by Curator
CPR
Xenobiotic resistance
Gene Amplification,
Insertion
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Linkage Mapping
Fotoukkiaii SM; Wybouw N; Kurlovs AH ; et al. (2021)
High-resolution genetic mapping reveals cis-regulatory and copy number variation in loci associated [...]
GP00002398
Cpr
Q27597
Physiology
Pyflubumide resistant populations are estimated to harbor three CPR copies by two methods, whereas susceptible populations have a single CPR copy.
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
CPR
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
CREBRF
Body size (obesity)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Minster RL; Hawley NL; Su CT ; et al. (2016)
A thrifty variant in CREBRF strongly influences body mass index in Samoans.
GP00001444
CREBRF
Q8IUR6
Morphology
c.1370G>A p.Arg457Gln
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
CREBRF
Homo sapiens
human - (species)
Published - Accepted by Curator
Cryptochrome 2 (CRY2) EDI allele
Flowering time
Fruit shape (fruit length)
Flower morphology (ovule number per fruit)
Fertility (percentage of unfertilized ovules)
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
El-Din El-Assal S; Alonso-Blanco C; Peeters AJ ; et al. (2001)
A QTL for flowering time in Arabidopsis reveals a novel allele of CRY2.
3 Additional References
GP00000192
CRY2
Q96524
Physiology
Morphology
Morphology
Physiology
V367M
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Cryptochrome 2 (CRY2) EDI allele
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
CXCL16
Pathogen resistance (lymphocyte susceptibility to virus)
Coding,
SNP
Equus caballus
horse - (species)
Intraspecific
Association Mapping
Sarkar S; Bailey E; Go YY ; et al. (2016)
Allelic Variation in CXCL16 Determines CD3+ T Lymphocyte Susceptibility to Equine Arteritis Virus In[...]
GP00001591
CXCL16
F7CTX0
Physiology
4 candidate nonsynonymous substitutions within exon 1(in 2 susceptible variants): (1)c.715A>T p.Tyr40Phe (2)c.801G>C w.Asp49His (3)c.804T>A/G p.Phe50Ile (4)c.810G>A p.Glu52Lys
Equus caballus
horse - (species)
Equus caballus
horse - (species)
CXCL16
Equus caballus
horse - (species)
Published - Accepted by Curator
CYC-like HaCYC2c
Flower morphology
Cis-regulatory,
Insertion
Helianthus annuus
common sunflower - (species) D
Intraspecific
Linkage Mapping
Chapman MA; Tang S; Draeger D ; et al. (2012)
Genetic analysis of floral symmetry in Van Gogh's sunflowers reveals independent recruitment of CYCL[...]
GP00000193
CYC
O49250
Morphology
999bp insertion in promoter
Helianthus annuus
common sunflower - (species)
Helianthus annuus
common sunflower - (species) D
CYC-like HaCYC2c
Helianthus annuus
common sunflower - (species)
Published - Accepted by Curator
CYC-like RAY1/RAY2
Flower morphology
Gene Amplification,
Complex Change
Senecio vulgaris
(species)
Intraspecific
Linkage Mapping
Kim M; Cui ML; Cubas P ; et al. (2008)
Regulatory genes control a key morphological and ecological trait transferred between species.
GP00000194
CYC
O49250
Morphology
Gene gain by hybridization
Senecio vulgaris
(species)
Senecio vulgaris
(species)
CYC-like RAY1/RAY2
Senecio vulgaris
(species)
Published - Accepted by Curator
CYCD5;1
Endoreduplication
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Sterken R; Kiekens R; Boruc J ; et al. (2012)
Combined linkage and association mapping reveals CYCD5;1 as a quantitative trait gene for endoredupl[...]
GP00000196
CYCD5-1
Q2V3B2
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
CYCD5;1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Cycloidea (Lcyc)
Flower morphology
Cis-regulatory,
Epigenetic Change
Linaria vulgaris
common toadflax - (species) D
Intraspecific
Linkage Mapping
Cubas P; Vincent C; Coen E (1999)
An epigenetic mutation responsible for natural variation in floral symmetry.
GP00000197
CYC
O49250
Morphology
Stable methylation
Linaria vulgaris
common toadflax - (species)
Linaria vulgaris
common toadflax - (species) D
Cycloidea (Lcyc)
Linaria vulgaris
common toadflax - (species)
Published - Accepted by Curator
CYP(T)
Flower morphology (style length)
Coding,
Insertion
N
Primula vulgaris
(species) D
Intraspecific
Linkage Mapping
Li J; Cocker JM; Wright J ; et al. (2016)
Genetic architecture and evolution of the S locus supergene in Primula vulgaris.
GP00001394
CYP734A1
O48786
Morphology
single base insertion in exon 2 introduces a disruptive premature stop codon N
Primula vulgaris
(species)
Primula vulgaris
(species) D
CYP(T)
Primula vulgaris
(species)
Published - Accepted by Curator
CYP(T)
Flower morphology (style length)
Coding,
SNP
Primula vulgaris
(species) D
Intraspecific
Linkage Mapping
Li J; Cocker JM; Wright J ; et al. (2016)
Genetic architecture and evolution of the S locus supergene in Primula vulgaris.
GP00001395
CYP734A1
O48786
Morphology
G>C p.Asp126His in exon 2
Primula vulgaris
(species)
Primula vulgaris
(species) D
CYP(T)
Primula vulgaris
(species)
Published - Accepted by Curator
Cyp12d1
Xenobiotic resistance (caffeine tolerance)
Gene Amplification,
Insertion
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Najarro MA; Hackett JL; Smith BR ; et al. (2015)
Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila.
GP00000198
Cyp12d1-d
Q7KR10
Physiology
Copy number Variant
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Cyp12d1
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
CYP1A2
Enzymatic activity
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Murayama N; Soyama A; Saito Y ; et al. (2004)
Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring v[...]
GP00000199
CYP1A2
P05177
Physiology
F186L
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
CYP1A2
Homo sapiens
human - (species)
Published - Accepted by Curator
Cyp28d1
Xenobiotic resistance (nicotine ; larval stage)
Gene Amplification,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Chakraborty M; VanKuren NW; Zhao R ; et al. (2018)
Hidden genetic variation shapes the structure of functional elements in Drosophila.
2 Additional References
GP00001407
Cyp28d1
Q9VMT5
Physiology
insertion of a partial 1.5kb Accord transposable element and a Cyp28d1 gene tandem duplication (CNV - 3754 bp) that may play complementary role in resistance levels
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Cyp28d1
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Cyp28d1
Xenobiotic resistance (nicotine ; larval stage)
Coding,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019)
Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.
GP00002113
Cyp28d1
Q9VMT5
Physiology
insertion of a FW element (4720 bp) into the coding region (exon) of the second copy of the Cyp28d1 (there is still another copy of the gene left due to a duplication). Associated with a decrease in Cyp28d2 gene expression and a decrease in nicotin resistance.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Cyp28d1
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Cyp28d1-Cyp28d2
Xenobiotic resistance (nicotine ; larval stage)
Gene Amplification,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019)
Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.
GP00002112
Cyp28d1
Q9VMT5
Physiology
duplication of 6063 bp which includes genes Cyp28d1; Cyp28d2 and CG7742. Associated with increased expression of Cyp28d2 and increased resistance to nicotin
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Cyp28d1-Cyp28d2
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Cyp28d1-Cyp28d2
Xenobiotic resistance (nicotine ; larval stage)
Gene Amplification,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019)
Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.
GP00002114
Cyp28d1
Q9VMT5
Physiology
duplication of a 15297-bp region; which encompasses 5 genes: Msp300 Cyp28d2 Cyp28d1 CG7742 and CG14034. Associated with increased expression of Cyp28d1 gene expression and increased nicotin resistance
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Cyp28d1-Cyp28d2
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
CYP2C9
Xenobiotic resistance (anti-coagulant drug response)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Takeuchi F; McGinnis R; Bourgeois S ; et al. (2009)
A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...]
1 Additional References
GP00000200
CYP2C9
P11712
Physiology
I359L
Homo sapiens
human - (species)
Homo sapiens
human - (species)
CYP2C9
Homo sapiens
human - (species)
Published - Accepted by Curator
CYP321A8
Xenobiotic resistance (organophosphate; chlorpyrifos; pyrethroid; cypermethrin; deltamethrin)
Cis-regulatory,
SNP
Spodoptera exigua
beet armyworm - (species) D
Intraspecific
Candidate Gene
Hu B; Huang H; Hu S ; et al. (2021)
Changes in both trans- and cis-regulatory elements mediate insecticide resistance in a lepidopteron [...]
GP00002394
CYP321A8
A0A286QUG5
Physiology
A > G at position -197bp in a cis-regulatory region, leading to increased expression of the gene
Spodoptera exigua
beet armyworm - (species)
Spodoptera exigua
beet armyworm - (species) D
CYP321A8
Spodoptera exigua
beet armyworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Complex Change
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Association Mapping
Joußen N; Agnolet S; Lorenz S ; et al. (2012)
Resistance of Australian Helicoverpa armigera to fenvalerate is due to the chimeric P450 enzyme CYP3[...]
1 Additional References
GP00002477
CYP337B3
A0A0H3V333
Physiology
The unique P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. The exclusive presence of CYP337B3 in resistant insects of this strain confers a 42-fold resistance to fenvalerate.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
CYP337B3
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Complex Change
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Rasool Akhtar; Joußen Nicole; Lorenz Sybille ; et al. (2014
)
An independent occurrence of the chimeric P450 enzyme CYP337B3 of Helicoverpa armigera confers cyper[...]
1 Additional References
GP00002478
CYP337B3
A0A0H3V333
Physiology
The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. The Pakistani and the Australian CYP337B3 alleles differ by 18 synonymous and three nonsynonymous SNPs and additionally in the length and sequence of the intron.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
CYP337B3
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Complex Change
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Han Yangchun; Yu Wanting; Zhang Weiqing ; et al. (2015
)
Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in[...]
1 Additional References
GP00002479
CYP337B3
A0A0H3V333
Physiology
The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Sequence analysis revealed a distinct CYP337B3 allele (CYP337B3v2) in the Pakistani population and three distinct alleles in the Chinese populations (CYP337B3v2 CYP337B3v3 CYP337B3v4) that differ from the Australian allele (CYP337B3v1) by a number of synonymous and non-synonymous SNPs in addition to variability of the intron sequence and size. This variation may result from different crossing-over positions during recombination of the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-over.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
CYP337B3
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Complex Change
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Han Yangchun; Yu Wanting; Zhang Weiqing ; et al. (2015
)
Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in[...]
1 Additional References
GP00002480
CYP337B3
A0A0H3V333
Physiology
The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Sequence analysis revealed a distinct CYP337B3 allele (CYP337B3v2) in the Pakistani population and three distinct alleles in the Chinese populations (CYP337B3v2 CYP337B3v3 CYP337B3v4) that differ from the Australian allele (CYP337B3v1) by a number of synonymous and non-synonymous SNPs in addition to variability of the intron sequence and size. This variation may result from different crossing-over positions during recombination of the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-over.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
CYP337B3
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Complex Change
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Han Yangchun; Yu Wanting; Zhang Weiqing ; et al. (2015
)
Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in[...]
1 Additional References
GP00002481
CYP337B3
A0A0H3V333
Physiology
The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Sequence analysis revealed a distinct CYP337B3 allele (CYP337B3v2) in the Pakistani population and three distinct alleles in the Chinese populations (CYP337B3v2 CYP337B3v3 CYP337B3v4) that differ from the Australian allele (CYP337B3v1) by a number of synonymous and non-synonymous SNPs in addition to variability of the intron sequence and size. This variation may result from different crossing-over positions during recombination of the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-over.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
CYP337B3
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Complex Change
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Walsh TK; Joussen N; Tian K ; et al. (2018)
Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]
GP00002482
CYP337B3
A0A0H3V333
Physiology
The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Distinct alleles resulting from different crossing-overs within the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-overs.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
CYP337B3
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Complex Change
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Walsh TK; Joussen N; Tian K ; et al. (2018)
Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]
GP00002483
CYP337B3
A0A0H3V333
Physiology
The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Distinct alleles resulting from different crossing-overs within the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-overs.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
CYP337B3
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Complex Change
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Walsh TK; Joussen N; Tian K ; et al. (2018)
Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]
GP00002484
CYP337B3
A0A0H3V333
Physiology
The P450 chimeric gene CYP337B3 arose from unequal crossing-over between two parental P450 genes CYP337B2 and CYP337B1 . CYP337B3 can metabolize pyrethroids in vitro. Neither parental enzyme has the ability to metabolize pyrethroids in vitro. Distinct alleles resulting from different crossing-overs within the CYP337B1 and CYP337B2 parental genes with different alleles of CYP337B1 and CYP337B2 involved in the crossing-overs.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
CYP337B3
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
CYP337B3
Xenobiotic resistance (insecticide; pyrethroid)
Coding,
Insertion
Helicoverpa zea
corn earworm - (species) D
Intraspecific
Candidate Gene
Walsh TK; Joussen N; Tian K ; et al. (2018)
Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]
1 Additional References
GP00002485
CYP337B3
A0A0H3V333
Physiology
Introgression of the CYP337B3v2 resistant allele from Helicoverpa armigera
Helicoverpa zea
corn earworm - (species)
Helicoverpa zea
corn earworm - (species) D
CYP337B3
Helicoverpa zea
corn earworm - (species)
Published - Accepted by Curator
CYP392A16
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Anazawa Y; Tomita T; Aiki Y ; et al. (2003)
Sequence of a cDNA encoding acetylcholinesterase from susceptible and resistant two-spotted spider m[...]
1 Additional References
GP00002471
Ace
P07140
Physiology
several non-synonymous SNP - exact causing amino acid change(s) unknown. Functional analysis of the putative promoter region from the resistant and susceptible parental strains revealed a higher reporter gene expression confirming the presence of cis-acting regulatory mechanisms.
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
CYP392A16
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
CYP392E8
Xenobiotic resistance
Cis-regulatory,
Unknown
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Linkage Mapping
Fotoukkiaii SM; Wybouw N; Kurlovs AH ; et al. (2021)
High-resolution genetic mapping reveals cis-regulatory and copy number variation in loci associated [...]
GP00002397
Physiology
increase in transcription of CYP392E8.
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
CYP392E8
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
CYP4F2
Xenobiotic resistance (anti-coagulant drug response)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Takeuchi F; McGinnis R; Bourgeois S ; et al. (2009)
A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinant[...]
1 Additional References
GP00000203
CYP4F2
P78329
Physiology
V433M
Homo sapiens
human - (species)
Homo sapiens
human - (species)
CYP4F2
Homo sapiens
human - (species)
Published - Accepted by Curator
CYP6AB3
Xenobiotic resistance (imperatorin)
Coding,
SNP
Depressaria pastinacella
(species)
Intraspecific
Candidate Gene
Mao W; Rupasinghe SG; Zangerl AR ; et al. (2007)
Allelic variation in the Depressaria pastinacella CYP6AB3 protein enhances metabolism of plant allel[...]
GP00000204
CYP6AB3
Q7YZS3
Physiology
Ala92Val (and potentiallly 4 other a.a. substitutions)
Depressaria pastinacella
(species)
Depressaria pastinacella
(species)
CYP6AB3
Depressaria pastinacella
(species)
Published - Accepted by Curator
CYP6AY1
Xenobiotic resistance (imidacloprid; buprofezin)
Cis-regulatory,
Unknown
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Pang R; Li Y; Dong Y ; et al. (2014)
Identification of promoter polymorphisms in the cytochrome P450 CYP6AY1 linked with insecticide resi[...]
GP00002399
CYP6AY1
A0A1L1VFS3
Physiology
CYP6AY1 is expressed at a higher level in a field-collected BPH strain that is highly resistant to both imidacloprid and buprofezin. Polymorphism in the promoter region associated with various levels of resistance.
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
CYP6AY1
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
CYP6BG1
Xenobiotic resistance (insecticide)
Cis-regulatory,
Unknown
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Li X; Shan C; Li F ; et al. (2019)
Transcription factor FTZ-F1 and cis-acting elements mediate expression of CYP6BG1 conferring resista[...]
1 Additional References
GP00002064
CYP6BG1
A0A222NX20
Physiology
promoters tested in luciferase assays
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
CYP6BG1
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
CYP6CM1
Xenobiotic resistance (insecticide; imidacloprid)
Cis-regulatory,
SNP
Bemisia tabaci
(species) D
Intraspecific
Candidate Gene
Karunker I; Benting J; Lueke B ; et al. (2008)
Over-expression of cytochrome P450 CYP6CM1 is associated with high resistance to imidacloprid in the[...]
GP00002608
A0A6C0PTH9
Physiology
three single-nucleotide polymorphic (SNP) markers in the intron region of CYP6CM1 that discriminate between the resistant and susceptible CYP6CM1 alleles
Bemisia tabaci
(species)
Bemisia tabaci
(species) D
CYP6CM1
Bemisia tabaci
(species)
Published - Accepted by Curator
CYP6CY3
Xenobiotic resistance (insecticide; neonicotinoid; host plant)
Cis-regulatory,
Insertion
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Bass C; Zimmer CT; Riveron JM ; et al. (2013)
Gene amplification and microsatellite polymorphism underlie a recent insect host shift.
1 Additional References
GP00001474
CYP6CY3
V5SQ25
Physiology
Expansion of a AC dinucleotide microsatellite (from 15 to 48 repeat units) in the promoter 198 bp upstream of the start codon that enhances gene expression
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
CYP6CY3
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
CYP6CY3-CYP6CY4
Xenobiotic resistance (insecticide; neonicotinoid; host plant)
Gene Amplification,
Insertion
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Bass C; Zimmer CT; Riveron JM ; et al. (2013)
Gene amplification and microsatellite polymorphism underlie a recent insect host shift.
3 Additional References
GP00001473
CYP6CY3
V5SQ25
Physiology
gene amplification (from 2 to 14-100 copies) - CYP6CY3 and neighboring gene CYP6CY4 are duplicated in M. p. nicotianae as a large amplicon of ~325 kb creating characteristic breakpoints identifying the region. CYP6CY4 and CYP6CY3 are highly effective at metabolizing nicotine to its nontoxic metabolite cotinine.
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
CYP6CY3-CYP6CY4
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
CYP6D1
Xenobiotic resistance (insecticide)
Cis-regulatory,
Insertion
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Gao J; Scott JG (2006)
Role of the transcriptional repressor mdGfi-1 in CYP6D1v1-mediated insecticide resistance in the hou[...]
GP00002118
CYP6D1
Q27698
Physiology
15 bp insertion which disrupts a putative mdGfi-1 binding site in the CYP6D1v1 promoter. mdGfi-1 is a negative regulator of transcription so this leads to increased expression of CYP6D1
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
CYP6D1
Musca domestica
house fly - (species)
Published - Accepted by Curator
cyp6d2
Xenobiotic resistance (chemotherapeutic agent, camptothecin)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Thomas AM; Hui C; South A ; et al. (2013)
Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with [...]
GP00001983
Cyp6g2
Q9V675
Physiology
G>C in CATAGgtaagga...caagCTCT so that intron 3 is not spliced and the codon GCT (spanning the intron) is transformed into CCT. The splicing is defective and intron 3 is transcribed and results in a stop codon and a protein truncated from its native C terminal part.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
cyp6d2
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
cyp6d2
Xenobiotic resistance (chemotherapeutic agent, camptothecin)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Thomas AM; Hui C; South A ; et al. (2013)
Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with [...]
GP00001984
Cyp6g2
Q9V675
Physiology
N438T (A22652974C) and N439T (A22652978G) - exact causing mutation(s) not identified - semiquantitative RT-PCR revealed that this mutant produces little to no Cyp6d2 transcript. The mutation is thus also cis-regulatory.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
cyp6d2
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
CYP6ER1
Xenobiotic resistance (insecticide; imidacloprid)
Coding,
SNP
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Zimmer CT; Garrood WT; Singh KS ; et al. (2018)
Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]
GP00002472
cyp6er1
A0A2I8B6P1
Physiology
T318S substitution results in a marked (20-fold) and significant increase in resistance compared to the wild-type susceptible variant.
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
CYP6ER1
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
CYP6ER1
Xenobiotic resistance (insecticide; imidacloprid)
Coding,
Deletion
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Zimmer CT; Garrood WT; Singh KS ; et al. (2018)
Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]
GP00002473
cyp6er1
A0A2I8B6P1
Physiology
Deletion of Pro377. This provides a more moderate but significant 4.5-fold increase in resistance.
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
CYP6ER1
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
CYP6ER1
Xenobiotic resistance (insecticide; imidacloprid)
Coding,
Complex Change
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Zimmer CT; Garrood WT; Singh KS ; et al. (2018)
Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]
GP00002474
cyp6er1
A0A2I8B6P1
Physiology
A375del+A376G
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
CYP6ER1
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
CYP6ER1
Xenobiotic resistance (insecticide; imidacloprid)
Cis-regulatory,
Unknown
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Zimmer CT; Garrood WT; Singh KS ; et al. (2018)
Neofunctionalization of Duplicated P450 Genes Drives the Evolution of Insecticide Resistance in the [...]
GP00002475
cyp6er1
A0A2I8B6P1
Physiology
A significant (up to 9.5-fold) increase in expression driven by the promoter of CYP6ER1vA was observed in comparison to all other promoter variants. This suggests that cis-acting elements in the region upstream of CYP6ER1vA are responsible for the high expression of this variant in BPH populations across Southeast Asia.
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
CYP6ER1
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
CYP6FU1
Xenobiotic resistance (insecticide; deltamethrin)
Cis-regulatory,
Unknown
Laodelphax striatellus
small brown planthopper - (species) D
Intraspecific
Candidate Gene
Pu J; Sun H; Wang J ; et al. (2016)
Multiple cis-acting elements involved in up-regulation of a cytochrome P450 gene conferring resistan[...]
GP00002117
CYP6FU1
A0A1S5R631
Physiology
Four cis-acting elements were identified whose influence on up-regulation was much more pronounced in combination than when present singly.
Laodelphax striatellus
small brown planthopper - (species)
Laodelphax striatellus
small brown planthopper - (species) D
CYP6FU1
Laodelphax striatellus
small brown planthopper - (species)
Published - Accepted by Curator
cyp6g1
Xenobiotic resistance (insecticide)
4 Mutations:
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Chung H; Bogwitz MR; McCart C ; et al. (2007)
Cis-regulatory elements in the Accord retrotransposon result in tissue-specific expression of the Dr[...]
GP00000207
Cyp6g1
Q9V674
Physiology
4 mutations
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
cyp6g1
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
cyp6g1
Xenobiotic resistance (insecticide)
Cis-regulatory,
Insertion
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Schlenke TA; Begun DJ (2004)
Strong selective sweep associated with a transposon insertion in Drosophila simulans.
GP00002019
Cyp6g1
Q9V674
Physiology
insertion of a Doc transposable element around 200 bp upstream of the putative transcription start site - mutation associated with increased expression of the gene
Drosophila simulans
(species)
Drosophila simulans
(species) D
cyp6g1
Drosophila simulans
(species)
Published - Accepted by Curator
cyp6g1
Xenobiotic resistance (insecticide)
Cis-regulatory,
Insertion
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Wurmser F; Mary-Huard T; Daudin JJ ; et al. (2013)
Variation of gene expression associated with colonisation of an anthropized environment: comparison [...]
GP00002020
Cyp6g1
Q9V674
Physiology
insertion of a Juan transposable element in the regulatory sequence. The insertion is almost fixed in the Rhône Valley but barely present in Mayotte - mutation associated with increased expression of the gene
Drosophila simulans
(species)
Drosophila simulans
(species) D
cyp6g1
Drosophila simulans
(species)
Published - Accepted by Curator
CYP6P9 cluster (CYP6P9a and CYP6P9b)
Xenobiotic resistance (insecticide)
Cis-regulatory,
Unknown
Anopheles funestus
African malaria mosquito - (species) D
Intraspecific
Candidate Gene
Riveron JM; Irving H; Ndula M ; et al. (2013)
Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in th[...]
1 Additional References
GP00000208
CYP2C9
P11712
Physiology
Cis-regulatory variation in CYP6P9b gene
Anopheles funestus
African malaria mosquito - (species)
Anopheles funestus
African malaria mosquito - (species) D
CYP6P9 cluster (CYP6P9a and CYP6P9b)
Anopheles funestus
African malaria mosquito - (species)
Published - Accepted by Curator
CYP6P9; CYP6P4 cluster
Xenobiotic resistance (insecticide)
5 Mutations:
Anopheles funestus
African malaria mosquito - (species) D
Intraspecific
Linkage Mapping
Wondji CS; Irving H; Morgan J ; et al. (2009)
Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major m[...]
2 Additional References
GP00000209
Q2YH43
Physiology
5 mutations
Anopheles funestus
African malaria mosquito - (species)
Anopheles funestus
African malaria mosquito - (species) D
CYP6P9; CYP6P4 cluster
Anopheles funestus
African malaria mosquito - (species)
Published - Accepted by Curator
CYP79D15
Toxicity levels (cyanogenic glucoside)
Gene Loss,
Deletion
N
Trifolium repens
white clover - (species) D
Intraspecific
Linkage Mapping
Olsen KM; Hsu SC; Small LL (2008)
Evidence on the molecular basis of the Ac/ac adaptive cyanogenesis polymorphism in white clover (Tri[...]
1 Additional References
GP00000211
CYP79D15
B2Y2T9
Physiology
Gene deletion N
Trifolium repens
white clover - (species)
Trifolium repens
white clover - (species) D
CYP79D15
Trifolium repens
white clover - (species)
Published - Accepted by Curator
CYP81F2
Glucosinolate content
Herbivore resistance (aphids)
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Pfalz M; Vogel H; Kroymann J (2009)
The gene controlling the indole glucosinolate modifier1 quantitative trait locus alters indole gluco[...]
GP00000212
CYP81F2
Q9LVD6
Physiology
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
CYP81F2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
CYP9A
Xenobiotic resistance (insecticide; deltamethrin)
Gene Amplification,
Insertion
Spodoptera frugiperda
fall armyworm - (species)
Intraspecific
Association Mapping
Gimenez S; Abdelgaffar H; Goff GL ; et al. (2020)
Adaptation by copy number variation increases insecticide resistance in the fall armyworm.
GP00002476
Physiology
In sensitive alleles the gene cluster is composed of 12 CYP9A genes and two alcohol dehydrogenase genes. All 30 resistant alleles have two copies of this unit while 28 and 6 alleles of the sensitive individuals had one and two copies; respectively.
Spodoptera frugiperda
fall armyworm - (species)
Spodoptera frugiperda
fall armyworm - (species)
CYP9A
Spodoptera frugiperda
fall armyworm - (species)
Published - Accepted by Curator
CYP9A186
Xenobiotic resistance (insecticide; avermectin; emamectin benzoate; abamectin)
Coding,
SNP
Spodoptera exigua
beet armyworm - (species) D
Intraspecific
Linkage Mapping
Zuo Y; Shi Y; Zhang F ; et al. (2021)
Genome mapping coupled with CRISPR gene editing reveals a P450 gene confers avermectin resistance in[...]
GP00002393
CYP9A186
A0A8E4AAI2
Physiology
Heterologous expression and in vitro functional assays further confirm that a natural substitution (F116V) found in the substrate recognition site 1 (SRS1) of the CYP9A186 protein results in enhanced metabolism of EB and abamectin
Spodoptera exigua
beet armyworm - (species)
Spodoptera exigua
beet armyworm - (species) D
CYP9A186
Spodoptera exigua
beet armyworm - (species)
Published - Accepted by Curator
CYP9J26
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Bariami V; Jones CM; Poupardin R ; et al. (2012)
Gene amplification, ABC transporters and cytochrome P450s: unraveling the molecular basis of pyrethr[...]
GP00002606
CYP9J
Q8T4S7
Physiology
CYP9J26 gene amplified about 6–7 times
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
CYP9J26
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
cytochrome b
Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting; famoxadone)
Coding,
SNP
Plasmopara viticola
(species) D
Intraspecific
Candidate Gene
Chen WJ; Delmotte F; Richard-Cervera S ; et al. (2007)
At least two origins of fungicide resistance in grapevine downy mildew populations.
GP00002041
UQCRFS1
P47985
Physiology
Gly143Ala G1256C
Plasmopara viticola
(species)
Plasmopara viticola
(species) D
cytochrome b
Plasmopara viticola
(species)
Published - Accepted by Curator
cytochrome b
Xenobiotic resistance (fungicide; QoI; quinone outside inhibiting; famoxadone)
Coding,
SNP
Plasmopara viticola
(species) D
Intraspecific
Candidate Gene
Chen WJ; Delmotte F; Richard-Cervera S ; et al. (2007)
At least two origins of fungicide resistance in grapevine downy mildew populations.
GP00002042
UQCRFS1
P47985
Physiology
Gly143Ala G1256C
Plasmopara viticola
(species)
Plasmopara viticola
(species) D
cytochrome b
Plasmopara viticola
(species)
Published - Accepted by Curator
cytochrome b
Xenobiotic resistance (fungicide; myxothiazol)
Coding,
SNP
Chlamydomonas reinhardtii
(species) D
Intraspecific
Candidate Gene
Bennoun P; Delosme M; Kück U (1991)
Mitochondrial genetics of Chlamydomonas reinhardtii: resistance mutations marking the cytochrome b g[...]
GP00002043
UQCRFS1
P47985
Physiology
F129L
Chlamydomonas reinhardtii
(species)
Chlamydomonas reinhardtii
(species) D
cytochrome b
Chlamydomonas reinhardtii
(species)
Published - Accepted by Curator
cytochrome c oxidase (COX7A)
Fertility
Lifespan
Locomotor activity
Coding,
Deletion
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Melvin RG; Katewa SD; Ballard JW (2008)
A candidate complex approach to study functional mitochondrial DNA changes: sequence variation and q[...]
1 Additional References
GP00001980
COX7A
Q9VHS2
Physiology
Physiology
Physiology
Deletion of two amino acids (Trp85 and Val86). The deletion occurs in subunit 7A of the mitochondrial electron trans-port chain protein cytochrome c oxidase (cox7A). The nuclear encoded cox7A gene produces a protein that isimported into the mitochondrion and forms a subunit of complexIV (cytochrome c oxidase) of the electron transport chain.
Drosophila simulans
(species)
Drosophila simulans
(species) D
cytochrome c oxidase (COX7A)
Drosophila simulans
(species)
Published - Accepted by Curator
Darkener of apricot (Doa)
Lifespan
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Association Mapping
Hoedjes KM; Kostic H; Keller L ; et al. (2022)
Natural alleles at the Doa locus underpin evolutionary changes in Drosophila lifespan and fecundity.
GP00002662
Doa
P49762
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Darkener of apricot (Doa)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
DC-STAMP domain containing 2 (DCST2)
Body size
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
van der Valk RJ; Kreiner-Møller E; Kooijman MN ; et al. (2015)
A novel common variant in DCST2 is associated with length in early life and height in adulthood.
GP00001509
DCST2
Q5T1A1
Morphology
SNP rs905938 C allele associated with an increase in birth length but probably not the causative mutation
Homo sapiens
human - (species)
Homo sapiens
human - (species)
DC-STAMP domain containing 2 (DCST2)
Homo sapiens
human - (species)
Published - Accepted by Curator
Dca (=smp-30)
Wing size
Cis-regulatory,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Lee SF; Chen Y; Varan AK ; et al. (2011)
Molecular basis of adaptive shift in body size in Drosophila melanogaster: functional and sequence a[...]
1 Additional References
GP00000214
smp-30
Q9VFG5
Morphology
Non-coding
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Dca (=smp-30)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
DDB1
Resistance to UV irradiation (sun exposure to skin)
Cis-regulatory,
Complex Change
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Crawford NG; Kelly DE; Hansen MEB ; et al. (2017)
Loci associated with skin pigmentation identified in African populations.
GP00001363
DDB1
Q16531
Morphology
most strongly associated SNPs are located in a region conserved across vertebrates flanked by TMEM138 and TMEM216 ~36 to 44 kb upstream of DDB1 and in high LD ; includes rs7948623 located 172 bp downstream of TMEM138 which shows enhancer activity in melanoma cells and interacts with the promoters of DDB1
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
DDB1
Homo sapiens
human - (species)
Published - Accepted by Curator
Delta
Bristle number (abdomen)
Cis-regulatory,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Long AD; Lyman RF; Langley CH ; et al. (1998)
Two sites in the Delta gene region contribute to naturally occurring variation in bristle number in [...]
1 Additional References
GP00000216
Dl
P10041
Morphology
unknown; associated site in intron 5
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Delta
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Delta
Bristle number (thorax)
Cis-regulatory,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Long AD; Lyman RF; Langley CH ; et al. (1998)
Two sites in the Delta gene region contribute to naturally occurring variation in bristle number in [...]
1 Additional References
GP00000217
Dl
P10041
Morphology
unknown; associated site in intron 2
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Delta
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Delta-1-pyrroline-5-carboxylate synthase A
Drought response (drought-induced proline accumulation)
2 Mutations:
Coding
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Kesari R; Lasky JR; Villamor JG ; et al. (2012)
Intron-mediated alternative splicing of Arabidopsis P5CS1 and its association with natural variation[...]
GP00001280
P5CSA
P54887
Physiology
2 mutations
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Delta-1-pyrroline-5-carboxylate synthase A
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
desaturase 2 (desat2)
Pheromone production
Cis-regulatory,
Deletion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Takahashi A; Tsaur SC; Coyne JA ; et al. (2001)
The nucleotide changes governing cuticular hydrocarbon variation and their evolution in Drosophila m[...]
1 Additional References
GP00000221
Desat2
Q9VG68
Physiology
16bp deletion about 150bp upstream of transcription start site
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
desaturase 2 (desat2)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
determinant of gall color (dgc)
Coloration (induced gall)
Cis-regulatory,
Unknown
Hormaphis cornu
(species)
Intraspecific
Association Mapping
Korgaonkar A; Han C; Lemire AL ; et al. (2021)
A novel family of secreted insect proteins linked to plant gall development.
GP00002392
Morphology
almost complete silencing of dgc expression in salivary glands of aphids carrying the red gall allele
Hormaphis cornu
(species)
Hormaphis cornu
(species)
determinant of gall color (dgc)
Hormaphis cornu
(species)
Published - Accepted by Curator
Dihydroflavonol 4 reductase (MlDfr)
Coloration (flower)
Coding,
Insertion
N
Erythranthe lewisii
(species) D
Intraspecific
Candidate Gene
Wu CA; Streisfeld MA; Nutter LI ; et al. (2013)
The genetic basis of a rare flower color polymorphism in Mimulus lewisii provides insight into the r[...]
GP00001457
DFRA
P51102
Morphology
A 2 nt (TG) insertion at position 265 causing a frameshift and a greatly truncated protein of 106 aa only about one-fourth of its functional length N
Erythranthe lewisii
(species)
Erythranthe lewisii
(species) D
Dihydroflavonol 4 reductase (MlDfr)
Erythranthe lewisii
(species)
Published - Accepted by Curator
dihydroflavonol reductase (DFR)
Coloration (flowers)
Coding,
Deletion
Iochroma calycinum
(species) D
Intraspecific
Candidate Gene
Coburn RA; Griffin RH; Smith SD (2015)
Genetic basis for a rare floral mutant in an Andean species of Solanaceae.
GP00000224
DFRA
P51102
Morphology
33bp (11 a.a) deletion In coding sequence
Iochroma calycinum
(species)
Iochroma calycinum
(species) D
dihydroflavonol reductase (DFR)
Iochroma calycinum
(species)
Published - Accepted by Curator
dihydroflavonol reductase (DFR)
Coloration (flowers)
Coding,
SNP
Iochroma cyaneum
(species)
Intraspecific
Linkage Mapping
Smith SD; Rausher MD (2011)
Gene loss and parallel evolution contribute to species difference in flower color.
GP00000225
DFRA
P51102
Morphology
12 candidate a.a. substitution in cluding one at a residue known to influence substrate specificity
Iochroma cyaneum
(species)
Iochroma cyaneum
(species)
dihydroflavonol reductase (DFR)
Iochroma cyaneum
(species)
Published - Accepted by Curator
Dihydrofolate reductase (pvdhfr)
Xenobiotic resistance (pyrimethamine)
Unknown,
Unknown
Plasmodium vivax
malaria parasite P. vivax - (species) D
Intraspecific
Association Mapping
Pearson RD; Amato R; Auburn S ; et al. (2016)
Genomic analysis of local variation and recent evolution in Plasmodium vivax.
GP00001484
DHFR
P00374
Physiology
unknown
Plasmodium vivax
malaria parasite P. vivax - (species)
Plasmodium vivax
malaria parasite P. vivax - (species) D
Dihydrofolate reductase (pvdhfr)
Plasmodium vivax
malaria parasite P. vivax - (species)
Published - Accepted by Curator
Dihydropteroate synthase (pvdhps)
Xenobiotic resistance (sulfadoxine)
Unknown,
Unknown
Plasmodium vivax
malaria parasite P. vivax - (species)
Intraspecific
Association Mapping
Pearson RD; Amato R; Auburn S ; et al. (2016)
Genomic analysis of local variation and recent evolution in Plasmodium vivax.
GP00001485
DHPS
Q00LX9
Physiology
unknown
Plasmodium vivax
malaria parasite P. vivax - (species)
Plasmodium vivax
malaria parasite P. vivax - (species)
Dihydropteroate synthase (pvdhps)
Plasmodium vivax
malaria parasite P. vivax - (species)
Published - Accepted by Curator
Diptericin
Pathogen resistance (bacteria)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Association Mapping
Unckless RL; Rottschaefer SM; Lazzaro BP (2015)
The complex contributions of genetics and nutrition to immunity in Drosophila melanogaster.
1 Additional References
GP00000227
DptA
P24492
Physiology
Ser>Arg (AGC>AGA)
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Diptericin
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Diptericin
Pathogen resistance (bacteria)
Coding,
SNP
Drosophila simulans
(species)
Intraspecific
Candidate Gene
Unckless RL; Howick VM; Lazzaro BP (2016)
Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila.
1 Additional References
GP00000228
DptA
P24492
Physiology
Ser>Arg (AGC>AGG)
Drosophila simulans
(species)
Drosophila simulans
(species)
Diptericin
Drosophila simulans
(species)
Published - Accepted by Curator
Distorter on the X (Dox)
Sex determination (sex ratio distortion)
Coding,
Deletion
Drosophila simulans
(species) D
Intraspecific
Linkage Mapping
Tao Y; Araripe L; Kingan SB ; et al. (2007)
A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter.
GP00001969
Physiology
Deletion of 105bp, resulting in the loss of exon III, which deletes one of the 42bp elements that is tandemly repeated in wild-type Dsim\Dox.
Drosophila simulans
(species)
Drosophila simulans
(species) D
Distorter on the X (Dox)
Drosophila simulans
(species)
Published - Accepted by Curator
DOG1 (DELAY OF GERMINATION 1)
Seed dormancy
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Bentsink L; Jowett J; Hanhart CJ ; et al. (2006)
Cloning of DOG1, a quantitative trait locus controlling seed dormancy in Arabidopsis.
3 Additional References
GP00000231
DOG1
A0SVK0
Physiology
Not identified (possibly polyallelic as each cross to the Ler accession showed different DOG1 effects)
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
DOG1 (DELAY OF GERMINATION 1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
DOG1 (DELAY OF GERMINATION 1)
Seed dormancy
Cis-regulatory,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Association Mapping
Kerdaffrec E; Filiault DL; Korte A ; et al. (2016)
Multiple alleles at a single locus control seed dormancy in Swedish Arabidopsis.
GP00001397
DOG1
A0SVK0
Physiology
At least 3 haplotypes defined by 4 SNPs in a putative regulatory region of DOG-1.
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
DOG1 (DELAY OF GERMINATION 1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Dopa oxidase-3 (Dox-3)
Enzymatic activity
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Asada N (1997)
Genetic variants affecting phenoloxidase activity in Drosophila melanogaster.
GP00002000
Physiology
Exact causing mutation(s) unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Dopa oxidase-3 (Dox-3)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Dopa-decarboxylase
Bristle number (abdomen)
Cis-regulatory,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Mackay TF; Lyman RF (2005)
Drosophila bristles and the nature of quantitative genetic variation.
GP00000232
Ddc
P05031
Morphology
Promoter variation
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Dopa-decarboxylase
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Dopa-decarboxylase
Lifespan
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
De Luca M; Roshina NV; Geiger-Thornsberry GL ; et al. (2003)
Dopa decarboxylase (Ddc) affects variation in Drosophila longevity.
GP00000233
Ddc
P05031
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Dopa-decarboxylase
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Doublesex
Coloration (wing ; Batesian mimicry)
Unknown,
Unknown
Papilio polytes
common Mormon - (species)
Intraspecific
Linkage Mapping
Kunte K; Zhang W; Tenger-Trolander A ; et al. (2014)
doublesex is a mimicry supergene.
2 Additional References
GP00001966
dsx
P23023
Morphology
More than 1000 nucleotide substitutions differentiate mimetic and non-mimetic dsx alleles. The non-mimetic Cyrus Dsx protein folds much like other insects (such as Bombyx mori) whereas the mimetic polytes protein structure is highly divergent. Knockdown experiments show that female-specific dsx isoforms expressed from the inverted H allele (dsx(H)) induce mimetic coloration patterns and simultaneously repress non-mimetic patterns.
Papilio polytes
common Mormon - (species)
Papilio polytes
common Mormon - (species)
Doublesex
Papilio polytes
common Mormon - (species)
Published - Accepted by Curator
Doublesex
Coloration (wing ; Batesian mimicry)
Unknown,
Unknown
Papilio memnon
(species)
Intraspecific
Candidate Gene
Iijima T; Kajitani R; Komata S ; et al. (2018)
Parallel evolution of Batesian mimicry supergene in two Papilio butterflies, P. polytes and P. memno[...]
1 Additional References
GP00001967
dsx
P23023
Morphology
A locus containing three genes (dsx; Nach-like and UXT) displays dimorphic sequences strictly associated with the mimetic/nonmimetic phenotypes. Expression of dox; UXT but not Nach-like showed differences correlated with phenotype in female hind wings.
Papilio memnon
(species)
Papilio memnon
(species)
Doublesex
Papilio memnon
(species)
Published - Accepted by Curator
drh-1
Pathogen resistance (viral immunity)
Coding,
Deletion
Caenorhabditis elegans
(species)
Intraspecific
Linkage Mapping
Ashe A; Bélicard T; Le Pen J ; et al. (2013)
A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and an[...]
GP00001308
drh-1
G5EDI8
Physiology
159 base deletion in CDS resulting in truncated but potentially non-null protein
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species)
drh-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
Drip
Fertility
Cis-regulatory,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Bergland AO; Chae HS; Kim YJ ; et al. (2012)
Fine-scale mapping of natural variation in fly fecundity identifies neuronal domain of expression an[...]
GP00000237
Drip
Q9V5Z7
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Drip
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Drosomycin-like 5
Pathogen resistance (fungi)
Gene Amplification,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019)
Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.
GP00002111
Drsl5
Q9VZR2
Physiology
Duplication of the gene and insertion of a 4993-bp region (which comes from part of a neighboring gene). Associated with a >1000-fold expression increase of the gene.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Drosomycin-like 5
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Duffy
Pathogen resistance (Plasmodium; malaria parasite) (malaria)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Tournamille C; Colin Y; Cartron JP ; et al. (1995)
Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-n[...]
GP00000240
ACKR1
Q16570
Physiology
T to C substitution in 5' region at pos -46
Homo sapiens
human - (species)
Homo sapiens
human - (species)
Duffy
Homo sapiens
human - (species)
Published - Accepted by Curator
DYM
Body size (height)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Lettre G (2011)
Recent progress in the study of the genetics of height.
GP00000242
DYM
Q7RTS9
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
DYM
Homo sapiens
human - (species)
Published - Accepted by Curator
EARLY FLOWERING 3(ELF3)
Flowering time
Coding,
Indel
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Jiménez-Gómez JM; Wallace AD; Maloof JN (2010)
Network analysis identifies ELF3 as a QTL for the shade avoidance response in Arabidopsis.
3 Additional References
GP00000244
ELF3
O82804
Physiology
Background-dependent effects of extensive polyQ coding variation
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
EARLY FLOWERING 3(ELF3)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
EARLY FLOWERING 3(ELF3) [possible pseudo-replicate]
Plant growth (hypocotyl elongation ; temperature-dependent)
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Raschke A; Ibañez C; Ullrich KK ; et al. (2015)
Natural variants of ELF3 affect thermomorphogenesis by transcriptionally modulating PIF4-dependent a[...]
GP00001245
ELF3
O82804
Morphology
A362V
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
EARLY FLOWERING 3(ELF3) [possible pseudo-replicate]
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
early responsive to dehydration stress protein 4
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001434
ERD4
Q9C8G5
Physiology
unknown
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
early responsive to dehydration stress protein 4
Arabidopsis arenosa
(species)
Published - Accepted by Curator
EBF1
Body fat distribution (pericardial)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001554
EBF1
Q9UH73
Physiology
A>G & T>G in 2 associated SNPs
Homo sapiens
human - (species)
Homo sapiens
human - (species)
EBF1
Homo sapiens
human - (species)
Published - Accepted by Curator
ebony
Coloration (abdomen)
Cis-regulatory,
Unknown
Drosophila novamexicana
(species) D
Intraspecific
Linkage Mapping
Wittkopp PJ; Stewart EE; Arnold LL ; et al. (2009)
Intraspecific polymorphism to interspecific divergence: genetics of pigmentation in Drosophila.
1 Additional References
GP00000248
e
O76858
Morphology
Not identified
Drosophila americana
(species)
Drosophila novamexicana
(species) D
ebony
Drosophila novamexicana
(species)
Published - Accepted by Curator
ebony
Coloration (thorax)
Cis-regulatory,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Takahashi A; Takahashi K; Ueda R ; et al. (2007)
Natural variation of ebony gene controlling thoracic pigmentation in Drosophila melanogaster.
1 Additional References
GP00000249
e
O76858
Morphology
Not identified
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
ebony
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
ebony
Coloration (posterior abdomen)
Cis-regulatory,
Unknown
Drosophila auraria
(species) D
Intraspecific
Candidate Gene
Johnson WC; Ordway AJ; Watada M ; et al. (2015)
Genetic Changes to a Transcriptional Silencer Element Confers Phenotypic Diversity within and betwee[...]
GP00000250
e
O76858
Morphology
Inactivation of a conserved silencer resulting in gain-of-expression; the increase in ebony expression in the light strain occurred primarily through mutations affecting the ebony male-specific silencer element
Drosophila auraria
(species)
Drosophila auraria
(species) D
ebony
Drosophila auraria
(species)
Published - Accepted by Curator
ebony
Coloration (posterior abdomen)
Cis-regulatory,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Takahashi A; Takano-Shimizu T (2011)
Divergent enhancer haplotype of ebony on inversion In(3R)Payne associated with pigmentation variatio[...]
GP00000252
e
O76858
Morphology
17 nucleotide sites and 2 indels in complete association with the thoracic trident pigmentation intensity in a 13kb region
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
ebony
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
ebony
Coloration (posterior abdomen)
5 Mutations:
Cis-regulatory
SNP
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Rebeiz M; Pool JE; Kassner VA ; et al. (2009)
Stepwise modification of a modular enhancer underlies adaptation in a Drosophila population.
GP00000253
e
O76858
Morphology
5 mutations
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
ebony
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
ebony
Coloration (male-specific)
Cis-regulatory,
SNP
Drosophila malerkotliana
(species)
Intraspecific
Linkage Mapping
Signor SA; Liu Y; Rebeiz M ; et al. (2016)
Genetic Convergence in the Evolution of Male-Specific Color Patterns in Drosophila.
GP00001544
e
O76858
Morphology
5 changes including 4 SNP and 1bp indel in the first intron
Drosophila malerkotliana
(species)
Drosophila malerkotliana
(species)
ebony
Drosophila malerkotliana
(species)
Published - Accepted by Curator
ebony
Coloration (male-specific)
Cis-regulatory,
Unknown
Drosophila pseudoananassae
(species)
Intraspecific
Linkage Mapping
Signor SA; Liu Y; Rebeiz M ; et al. (2016)
Genetic Convergence in the Evolution of Male-Specific Color Patterns in Drosophila.
GP00001545
e
O76858
Morphology
unknown
Drosophila pseudoananassae
(species)
Drosophila pseudoananassae
(species)
ebony
Drosophila pseudoananassae
(species)
Published - Accepted by Curator
Ectodysplasin (EDA)
Scales (loss)
Femoral glands (absent)
Tooth number
Coding,
Insertion
Pogona vitticeps
central bearded dragon - (species) D
Intraspecific
Candidate Gene
Di-Poï N; Milinkovitch MC (2016)
The anatomical placode in reptile scale morphogenesis indicates shared ancestry among skin appendage[...]
GP00002040
Eda
O54693
Morphology
Morphology
Morphology
5′688–bp insertion of a transposon of the LTR-Gypsy family which generates a new splice donor site (gt) 42 bases upstream of the wild-type donor site; thus generating a 14–amino acid deletion in the corresponding transcript
Pogona vitticeps
central bearded dragon - (species)
Pogona vitticeps
central bearded dragon - (species) D
Ectodysplasin (EDA)
Pogona vitticeps
central bearded dragon - (species)
Published - Accepted by Curator
EDAR
Hair thickness
Eccrine gland density
Ear traits = lobe size / lobe attachment / helix rolling / ear protrusion
Tooth morphology (shovel-shaped incisors)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Fujimoto A; Kimura R; Ohashi J ; et al. (2008)
A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickne[...]
4 Additional References
GP00000256
EDAR
Q9UNE0
Morphology
Morphology
Morphology
Morphology
p.Val370Ala; functionally validated in mouse
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
EDAR
Homo sapiens
human - (species)
Published - Accepted by Curator
EGFR
Wing shape (length)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Dworkin I; Palsson A; Gibson G (2005)
Replication of an Egfr-wing shape association in a wild-caught cohort of Drosophila melanogaster.
1 Additional References
GP00000259
Egfr
P04412
Morphology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
EGFR
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
EGFR
Coloration (skin)
Unknown,
Unknown
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Quillen EE; Bauchet M; Bigham AW ; et al. (2012)
OPRM1 and EGFR contribute to skin pigmentation differences between Indigenous Americans and European[...]
GP00001537
EGFR
P00533
Morphology
A>T associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
EGFR
Homo sapiens
human - (species)
Published - Accepted by Curator
egl-4 (Ppa-egl-4)
Insect pheromone attraction
Unknown,
Unknown
Pristionchus pacificus
(species)
Intraspecific
Association Mapping
Hong RL; Witte H; Sommer RJ (2008)
Natural variation in Pristionchus pacificus insect pheromone attraction involves the protein kinase [...]
GP00000260
egl-4
O76360
Behavior
unknown
Pristionchus pacificus
(species)
Pristionchus pacificus
(species)
egl-4 (Ppa-egl-4)
Pristionchus pacificus
(species)
Published - Accepted by Curator
EGLN1
Hypoxia response
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Simonson TS; Yang Y; Huff CD ; et al. (2010)
Genetic evidence for high-altitude adaptation in Tibet.
3 Additional References
GP00000261
EGLN1
Q9GZT9
Physiology
possibly D4E
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
EGLN1
Homo sapiens
human - (species)
Published - Accepted by Curator
EGLN1
Hypoxia response
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Bigham A; Bauchet M; Pinto D ; et al. (2010)
Identifying signatures of natural selection in Tibetan and Andean populations using dense genome sca[...]
GP00000262
EGLN1
Q9GZT9
Physiology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
EGLN1
Homo sapiens
human - (species)
Published - Accepted by Curator
EGLN1
High-altitude adaptation
Hypoxia response
Unknown,
Unknown
Anas flavirostris
Yellow-billed teal - (species) D
Intraspecific
Candidate Gene
Graham AM; McCracken KG (2019)
Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]
GP00002135
EGLN1
Q9GZT9
Physiology
Physiology
probably cis-regulatory because no nonsynonymous mutations in the coding exon with high Fst
Anas flavirostris
Yellow-billed teal - (species)
Anas flavirostris
Yellow-billed teal - (species) D
EGLN1
Anas flavirostris
Yellow-billed teal - (species)
Published - Accepted by Curator
EGLN1
High-altitude adaptation
Hypoxia response
Unknown,
Unknown
Anas georgica
yellow-billed pintail - (species) D
Intraspecific
Candidate Gene
Graham AM; McCracken KG (2019)
Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]
GP00002136
EGLN1
Q9GZT9
Physiology
Physiology
probably cis-regulatory because no nonsynonymous mutations in the coding exon with high Fst
Anas georgica
yellow-billed pintail - (species)
Anas georgica
yellow-billed pintail - (species) D
EGLN1
Anas georgica
yellow-billed pintail - (species)
Published - Accepted by Curator
EGNL1
High-altitude adaptation
Hypoxia response
Cis-regulatory,
Unknown
Anas cyanoptera
cinnamon teal - (species) D
Intraspecific
Candidate Gene
Graham AM; McCracken KG (2019)
Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]
GP00002134
EGLN1
Q9GZT9
Physiology
Physiology
probably cis-regulatory because no nonsynonymous mutations in the coding exon with high Fst
Anas cyanoptera
cinnamon teal - (species)
Anas cyanoptera
cinnamon teal - (species) D
EGNL1
Anas cyanoptera
cinnamon teal - (species)
Published - Accepted by Curator
EIF2AK3
Body size (height)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Lettre G (2011)
Recent progress in the study of the genetics of height.
GP00000264
EIF2AK3
Q9NZJ5
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
EIF2AK3
Homo sapiens
human - (species)
Published - Accepted by Curator
EIF2S2
Coloration (skin)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Liu F; Visser M; Duffy DL ; et al. (2015)
Genetics of skin color variation in Europeans: genome-wide association studies with functional follo[...]
GP00001359
EIF2S2
P20042
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
EIF2S2
Homo sapiens
human - (species)
Published - Accepted by Curator
END3
Temperature tolerance
Virulence
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Intraspecific
Linkage Mapping
Steinmetz LM; Sinha H; Richards DR ; et al. (2002)
Dissecting the architecture of a quantitative trait locus in yeast.
1 Additional References
GP00000267
END3
P39013
Physiology
Physiology
S258N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
END3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
END3
Temperature tolerance
Virulence
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Intraspecific
Linkage Mapping
Steinmetz LM; Sinha H; Richards DR ; et al. (2002)
Dissecting the architecture of a quantitative trait locus in yeast.
1 Additional References
GP00000268
END3
P39013
Physiology
Physiology
D268N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
END3
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
engrailed
Coloration (wing ; Batesian mimicry)
Cis-regulatory,
Unknown
Papilio dardanus
African swallowtail butterfly - (species) D
Intraspecific
Linkage Mapping
Timmermans MJTN; Srivathsan A; Collins S ; et al. (2020)
Mimicry diversification in Papilio dardanus via a genomic inversion in the regulatory region of engr[...]
GP00002428
en
P02836
Morphology
Association with many nucleotide changes in a cis-regulatory region of engrailed. The diverged region exhibits a discrete chromosomal inversion of 40 kb relative to the ancestral orientation that is associated with the cenea morph, but not with the bottom-recessive hippocoonides morph or with non-mimetic allopatric populations.
Papilio dardanus
African swallowtail butterfly - (species)
Papilio dardanus
African swallowtail butterfly - (species) D
engrailed
Papilio dardanus
African swallowtail butterfly - (species)
Published - Accepted by Curator
Enhanced shoot growth under mannitol stress 2 (EGM2)
Plant growth (shoot growth under stress)
2 Mutations:
Coding
SNP
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Trontin C; Kiani S; Corwin JA ; et al. (2014)
A pair of receptor-like kinases is responsible for natural variation in shoot growth response to man[...]
GP00001630
At1g11300
Q9SXB4
Physiology
2 mutations
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Enhanced shoot growth under mannitol stress 2 (EGM2)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
ENSA
Body fat distribution (pericardial)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001558
ENSA
O43768
Physiology
A>G in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
ENSA
Homo sapiens
human - (species)
Published - Accepted by Curator
EPAS1
Hypoxia response
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Simonson TS; Yang Y; Huff CD ; et al. (2010)
Genetic evidence for high-altitude adaptation in Tibet.
1 Additional References
GP00000274
EPAS1
Q99814
Physiology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
EPAS1
Homo sapiens
human - (species)
Published - Accepted by Curator
EPAS1
Hypoxia response
Coding,
SNP
Peromyscus maniculatus
North American deer mouse - (species) D
Intraspecific
Association Mapping
Schweizer RM; Velotta JP; Ivy CM ; et al. (2019)
Physiological and genomic evidence that selection on the transcription factor Epas1 has altered card[...]
GP00002062
EPAS1
Q99814
Physiology
non-synonymous polymorphism located at site 755 in the 14th exon that changes threonine to methionine Thr755Met
Peromyscus maniculatus
North American deer mouse - (species)
Peromyscus maniculatus
North American deer mouse - (species) D
EPAS1
Peromyscus maniculatus
North American deer mouse - (species)
Published - Accepted by Curator
EPAS1
High-altitude adaptation
Hypoxia response
Unknown,
Unknown
Anas cyanoptera
cinnamon teal - (species) D
Intraspecific
Candidate Gene
Graham AM; McCracken KG (2019)
Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]
GP00002131
EPAS1
Q99814
Physiology
Physiology
several candidate coding mutations
Anas cyanoptera
cinnamon teal - (species)
Anas cyanoptera
cinnamon teal - (species) D
EPAS1
Anas cyanoptera
cinnamon teal - (species)
Published - Accepted by Curator
EPAS1
High-altitude adaptation
Hypoxia response
Unknown,
Unknown
Anas flavirostris
Yellow-billed teal - (species) D
Intraspecific
Candidate Gene
Graham AM; McCracken KG (2019)
Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]
GP00002132
EPAS1
Q99814
Physiology
Physiology
several candidate coding mutations
Anas flavirostris
Yellow-billed teal - (species)
Anas flavirostris
Yellow-billed teal - (species) D
EPAS1
Anas flavirostris
Yellow-billed teal - (species)
Published - Accepted by Curator
EPAS1
High-altitude adaptation
Hypoxia response
Unknown,
Unknown
Anas georgica
yellow-billed pintail - (species) D
Intraspecific
Candidate Gene
Graham AM; McCracken KG (2019)
Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-alt[...]
GP00002133
EPAS1
Q99814
Physiology
Physiology
several candidate coding mutations
Anas georgica
yellow-billed pintail - (species)
Anas georgica
yellow-billed pintail - (species) D
EPAS1
Anas georgica
yellow-billed pintail - (species)
Published - Accepted by Curator
Epithiospecifier Modifier1 (ESM1)
Nitrile content
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Zhang Z; Ober JA; Kliebenstein DJ (2006)
The gene controlling the quantitative trait locus EPITHIOSPECIFIER MODIFIER1 alters glucosinolate hy[...]
GP00000277
ESM1
Q9LJG3
Physiology
Not identified
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Epithiospecifier Modifier1 (ESM1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Epithiospecifier protein (ESP)
Plant secondary metabolite (glucosinolate)
Herbivore resistance
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Lambrix V; Reichelt M; Mitchell-Olds T ; et al. (2001)
The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and i[...]
GP00000278
ESP
Q8RY71
Physiology
Physiology
Not identified
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Epithiospecifier protein (ESP)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Epithiospecifier protein (ESP)
Plant secondary metabolite (glucosinolate)
Herbivore resistance
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Lambrix V; Reichelt M; Mitchell-Olds T ; et al. (2001)
The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and i[...]
GP00000279
ESP
Q8RY71
Physiology
Physiology
deletion of 124 bases that eliminates a splice site and 100 nucleotides of the ORF N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Epithiospecifier protein (ESP)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Gene Amplification,
Insertion
Amaranthus palmeri
(species) D
Intraspecific
Candidate Gene
Gaines TA; Zhang W; Wang D ; et al. (2010)
Gene amplification confers glyphosate resistance in Amaranthus palmeri.
GP00001883
At2g45300
P05466
Physiology
Genomes of resistant plants contain from 5-fold to more than 160-fold more copies of the EPSPS gene than did genomes of susceptible plants - the duplicated section of DNA including the 10 kb EPSPS gene is at least 30 kb long
Amaranthus palmeri
(species)
Amaranthus palmeri
(species) D
EPSPS
Amaranthus palmeri
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Gene Amplification,
Insertion
Amaranthus tuberculatus
(species) D
Intraspecific
Candidate Gene
Tranel PJ; Riggins CW; Bell MS ; et al. (2011)
Herbicide resistances in Amaranthus tuberculatus: a call for new options.
GP00001884
At2g45300
P05466
Physiology
4 copies of the EPSPS gene
Amaranthus tuberculatus
(species)
Amaranthus tuberculatus
(species) D
EPSPS
Amaranthus tuberculatus
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Gene Amplification,
Insertion
Lolium multiflorum
Italian ryegrass - (species) D
Intraspecific
Candidate Gene
Salas RA; Dayan FE; Pan Z ; et al. (2012)
EPSPS gene amplification in glyphosate-resistant Italian ryegrass (Lolium perenne ssp. multiflorum) [...]
GP00001885
At2g45300
P05466
Physiology
15-25 copies of the EPSPS gene
Lolium multiflorum
Italian ryegrass - (species)
Lolium multiflorum
Italian ryegrass - (species) D
EPSPS
Lolium multiflorum
Italian ryegrass - (species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Gene Amplification,
Insertion
Bassia scoparia
(species) D
Intraspecific
Candidate Gene
Sammons RD; Gaines TA (2014)
Glyphosate resistance: state of knowledge.
GP00001886
At2g45300
P05466
Physiology
15-25 copies of the EPSPS gene
Bassia scoparia
(species)
Bassia scoparia
(species) D
EPSPS
Bassia scoparia
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Gene Amplification,
Insertion
Amaranthus spinosus
(species) D
Intraspecific
Candidate Gene
Sammons RD; Gaines TA (2014)
Glyphosate resistance: state of knowledge.
GP00001887
At2g45300
P05466
Physiology
26-37 copies of the EPSPS gene
Amaranthus spinosus
(species)
Amaranthus spinosus
(species) D
EPSPS
Amaranthus spinosus
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Eleusine indica
goosegrass - (species) D
Intraspecific
Candidate Gene
Baerson SR; Rodriguez DJ; Tran M ; et al. (2002)
Glyphosate-resistant goosegrass. Identification of a mutation in the target enzyme 5-enolpyruvylshik[...]
GP00001888
At2g45300
P05466
Physiology
Pro106Ser leading to 2-4-fold resistance
Eleusine indica
goosegrass - (species)
Eleusine indica
goosegrass - (species) D
EPSPS
Eleusine indica
goosegrass - (species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Echinochloa colona
(species) D
Intraspecific
Candidate Gene
Morran S; Moretti ML; Brunharo CA ; et al. (2018)
Multiple target site resistance to glyphosate in junglerice (Echinochloa colona) lines from Californ[...]
GP00001889
At2g45300
P05466
Physiology
Pro106Ser leading to resistance
Echinochloa colona
(species)
Echinochloa colona
(species) D
EPSPS
Echinochloa colona
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Echinochloa colona
(species) D
Intraspecific
Candidate Gene
Morran S; Moretti ML; Brunharo CA ; et al. (2018)
Multiple target site resistance to glyphosate in junglerice (Echinochloa colona) lines from Californ[...]
GP00001890
At2g45300
P05466
Physiology
Pro106Leu leading to resistance
Echinochloa colona
(species)
Echinochloa colona
(species) D
EPSPS
Echinochloa colona
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Echinochloa colona
(species) D
Intraspecific
Candidate Gene
Morran S; Moretti ML; Brunharo CA ; et al. (2018)
Multiple target site resistance to glyphosate in junglerice (Echinochloa colona) lines from Californ[...]
GP00001891
At2g45300
P05466
Physiology
Pro106Thr leading to resistance
Echinochloa colona
(species)
Echinochloa colona
(species) D
EPSPS
Echinochloa colona
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Amaranthus tuberculatus
(species) D
Intraspecific
Candidate Gene
Bell Michael S; Hager Aaron G; Tranel Patrick J (2013
)
Multiple resistance to herbicides from four site-of-action groups in waterhemp (Amaranthus tubercula[...]
GP00001892
At2g45300
P05466
Physiology
resistance not due to EPSPS amplification; partly due to P106S mutation
Amaranthus tuberculatus
(species)
Amaranthus tuberculatus
(species) D
EPSPS
Amaranthus tuberculatus
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Lolium multiflorum
Italian ryegrass - (species) D
Intraspecific
Candidate Gene
Jasieniuk Marie; Ahmad Riaz; Sherwood Anna M ; et al. (2008
)
Glyphosate-resistant Italian ryegrass (Lolium multiflorum) in California: distribution, response to [...]
GP00001896
At2g45300
P05466
Physiology
Pro106Ser
Lolium multiflorum
Italian ryegrass - (species)
Lolium multiflorum
Italian ryegrass - (species) D
EPSPS
Lolium multiflorum
Italian ryegrass - (species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Lolium multiflorum
Italian ryegrass - (species) D
Intraspecific
Candidate Gene
Jasieniuk Marie; Ahmad Riaz; Sherwood Anna M ; et al. (2008
)
Glyphosate-resistant Italian ryegrass (Lolium multiflorum) in California: distribution, response to [...]
GP00001897
At2g45300
P05466
Physiology
Pro106Ala conferring 5-15-fold resistance
Lolium multiflorum
Italian ryegrass - (species)
Lolium multiflorum
Italian ryegrass - (species) D
EPSPS
Lolium multiflorum
Italian ryegrass - (species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Eleusine indica
goosegrass - (species) D
Intraspecific
Candidate Gene
Ng CH; Wickneswari R; Salmijah S ; et al. (2003
)
Gene polymorphisms in glyphosate‐resistant and‐susceptible biotypes of Eleusine indica from Malaysia[...]
GP00001898
At2g45300
P05466
Physiology
Pro106Thr leading to 3-fold resistance
Eleusine indica
goosegrass - (species)
Eleusine indica
goosegrass - (species) D
EPSPS
Eleusine indica
goosegrass - (species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Digitaria insularis
(species) D
Intraspecific
Candidate Gene
de Carvalho LB; Alves PL; González-Torralva F ; et al. (2012)
Pool of resistance mechanisms to glyphosate in Digitaria insularis.
GP00001899
At2g45300
P05466
Physiology
Pro106Thr
Digitaria insularis
(species)
Digitaria insularis
(species) D
EPSPS
Digitaria insularis
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Lolium rigidum
(species) D
Intraspecific
Candidate Gene
Kaundun SS; Dale RP; Zelaya IA ; et al. (2011)
A novel P106L mutation in EPSPS and an unknown mechanism(s) act additively to confer resistance to g[...]
GP00001900
At2g45300
P05466
Physiology
Pro106Leu conferring a 1.7-fold resistance increase to glyphosate at the whole plant level
Lolium rigidum
(species)
Lolium rigidum
(species) D
EPSPS
Lolium rigidum
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Lolium rigidum
(species) D
Intraspecific
Candidate Gene
Bostamam Yazid; Malone Jenna M; Dolman Fleur C ; et al. (2012
)
Rigid ryegrass (Lolium rigidum) populations containing a target site mutation in EPSPS and reduced g[...]
GP00001901
At2g45300
P05466
Physiology
Pro106Ser
Lolium rigidum
(species)
Lolium rigidum
(species) D
EPSPS
Lolium rigidum
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Lolium rigidum
(species) D
Intraspecific
Candidate Gene
Bostamam Yazid; Malone Jenna M; Dolman Fleur C ; et al. (2012
)
Rigid ryegrass (Lolium rigidum) populations containing a target site mutation in EPSPS and reduced g[...]
GP00001902
At2g45300
P05466
Physiology
Pro106Thr
Lolium rigidum
(species)
Lolium rigidum
(species) D
EPSPS
Lolium rigidum
(species)
Published - Accepted by Curator
EPSPS
Xenobiotic resistance (herbicides; glyphosate)
Coding,
SNP
Lolium rigidum
(species) D
Intraspecific
Candidate Gene
Yu Q; Cairns A; Powles S (2007)
Glyphosate, paraquat and ACCase multiple herbicide resistance evolved in a Lolium rigidum biotype.
GP00001903
At2g45300
P05466
Physiology
Pro106Ala
Lolium rigidum
(species)
Lolium rigidum
(species) D
EPSPS
Lolium rigidum
(species)
Published - Accepted by Curator
ERECTA
Plant architecture
Leaf architecture
Transpiration
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Masle J; Gilmore SR; Farquhar GD (2005)
The ERECTA gene regulates plant transpiration efficiency in Arabidopsis.
2 Additional References
GP00000280
ERECTA
Q42371
Morphology
Morphology
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
ERECTA
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
ERECTA
Pathogen resistance (Cucumerina fungus)
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Llorente F; Alonso-Blanco C; Sánchez-Rodriguez C ; et al. (2005)
ERECTA receptor-like kinase and heterotrimeric G protein from Arabidopsis are required for resistanc[...]
GP00001244
ERECTA
Q42371
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
ERECTA
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
ERG11 = CYP51A1
Xenobiotic resistance
Coding,
SNP
Candida albicans
(species) D
Intraspecific
Candidate Gene
Sanglard D; Ischer F; Koymans L ; et al. (1998)
Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]
GP00000281
ERG11
P10613
Physiology
Y132H
Candida albicans
(species)
Candida albicans
(species) D
ERG11 = CYP51A1
Candida albicans
(species)
Published - Accepted by Curator
ERG11 = CYP51A1
Xenobiotic resistance
Coding,
SNP
Candida albicans
(species) D
Intraspecific
Candidate Gene
Sanglard D; Ischer F; Koymans L ; et al. (1998)
Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]
GP00000282
ERG11
P10613
Physiology
S405F
Candida albicans
(species)
Candida albicans
(species) D
ERG11 = CYP51A1
Candida albicans
(species)
Published - Accepted by Curator
ERG11 = CYP51A1
Xenobiotic resistance
Coding,
SNP
Candida albicans
(species) D
Intraspecific
Candidate Gene
Sanglard D; Ischer F; Koymans L ; et al. (1998)
Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]
GP00000283
ERG11
P10613
Physiology
G464S
Candida albicans
(species)
Candida albicans
(species) D
ERG11 = CYP51A1
Candida albicans
(species)
Published - Accepted by Curator
ERG11 = CYP51A1
Xenobiotic resistance
Coding,
SNP
Candida albicans
(species) D
Intraspecific
Candidate Gene
Sanglard D; Ischer F; Koymans L ; et al. (1998)
Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole[...]
GP00000284
ERG11
P10613
Physiology
R467K
Candida albicans
(species)
Candida albicans
(species) D
ERG11 = CYP51A1
Candida albicans
(species)
Published - Accepted by Curator
ERG11 = CYP51A1
Xenobiotic resistance
Coding,
Indel
Candida albicans
(species)
Intraspecific
Association Mapping
Coste A; Selmecki A; Forche A ; et al. (2007)
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.
GP00000285
ERG11
P10613
Physiology
Copy number Variant
Candida albicans
(species)
Candida albicans
(species)
ERG11 = CYP51A1
Candida albicans
(species)
Published - Accepted by Curator
ESR1
Aggression behavior
Cis-regulatory,
Unknown
Zonotrichia albicollis
white-throated sparrow - (species) D
Intraspecific
Linkage Mapping
Merritt JR; Grogan KE; Zinzow-Kramer WM ; et al. (2020)
A supergene-linked estrogen receptor drives alternative phenotypes in a polymorphic songbird.
GP00002440
Esr1
P19785
Behavior
Increase in expression of the gene in the white-striped morph. Differential allelic expression in heterozygotes.
Zonotrichia albicollis
white-throated sparrow - (species)
Zonotrichia albicollis
white-throated sparrow - (species) D
ESR1
Zonotrichia albicollis
white-throated sparrow - (species)
Published - Accepted by Curator
esterase A8 and B8
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Qiao CL; Marquine M; Pasteur N ; et al. (1998)
A new esterase gene amplification involved in OP resistance in Culex pipiens mosquitoes from China.
GP00002641
B1
P16854
Physiology
coamplification of both esterase loci (Est-2 and Est-3)
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
esterase A8 and B8
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
esterase B1
Xenobiotic resistance (insecticide; benzoylurea)
Gene Amplification,
Complex Change
Culex tritaeniorhynchus
(species) D
Intraspecific
Candidate Gene
Karunaratne SH; Vaughan A; Paton MG ; et al. (1998)
Amplification of a serine esterase gene is involved in insecticide resistance in Sri Lankan Culex tr[...]
GP00000290
B1
P16854
Physiology
Whole gene amplification
Culex tritaeniorhynchus
(species)
Culex tritaeniorhynchus
(species) D
esterase B1
Culex tritaeniorhynchus
(species)
Published - Accepted by Curator
esterase B1 + esterase A
Xenobiotic resistance (insecticide)
Gene Amplification,
Complex Change
Culex quinquefasciatus
southern house mosquito - (species) D
Intraspecific
Candidate Gene
Rooker S; Guillemaud T; Bergé J ; et al. (1996)
Coamplification of esterase A and B genes as a single unit in Culex pipiens mosquitoes.
GP00000291
B1
P16854
Physiology
Amplification of a region containing both genes
Culex quinquefasciatus
southern house mosquito - (species)
Culex quinquefasciatus
southern house mosquito - (species) D
esterase B1 + esterase A
Culex quinquefasciatus
southern house mosquito - (species)
Published - Accepted by Curator
esterase B1 = esterase beta1
Xenobiotic resistance (insecticide)
Gene Amplification,
Complex Change
Culex quinquefasciatus
southern house mosquito - (species) D
Intraspecific
Candidate Gene
Mouchès C; Pasteur N; Bergé JB ; et al. (1986)
Amplification of an esterase gene is responsible for insecticide resistance in a California Culex mo[...]
3 Additional References
GP00000292
B1
P16854
Physiology
Amplification of esterase B1 only
Culex quinquefasciatus
southern house mosquito - (species)
Culex quinquefasciatus
southern house mosquito - (species) D
esterase B1 = esterase beta1
Culex quinquefasciatus
southern house mosquito - (species)
Published - Accepted by Curator
esterase B4
Xenobiotic resistance (insecticide; chlorpyrifos)
Gene Amplification,
Insertion
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Poirié M; Raymond M; Pasteur N (1992)
Identification of two distinct amplifications of the esterase B locus in Culex pipiens (L.) mosquito[...]
GP00002639
B1
P16854
Physiology
The production of the esterase B is approximately 50- and 500-fold higher in mosquitoes from France and Cyprus (respectively) than in susceptible insects whereas the number of gene copies is about 25 and 250. Differences of about 7- and 95-fold were also found in the degree of chlorpyrifos resistance.
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
esterase B4
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
esterase B5
Xenobiotic resistance (insecticide; chlorpyrifos)
Gene Amplification,
Insertion
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Poirié M; Raymond M; Pasteur N (1992)
Identification of two distinct amplifications of the esterase B locus in Culex pipiens (L.) mosquito[...]
GP00002640
B1
P16854
Physiology
The production of the esterase B is approximately 50- and 500-fold higher in mosquitoes from France and Cyprus (respectively) than in susceptible insects whereas the number of gene copies is about 25 and 250. Differences of about 7- and 95-fold were also found in the degree of chlorpyrifos resistance.
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
esterase B5
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
esterase E4
Xenobiotic resistance (insecticide)
Gene Amplification,
Complex Change
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Field LM; Devonshire AL; Forde BG (1988)
Molecular evidence that insecticide resistance in peach-potato aphids (Myzus persicae Sulz.) results[...]
2 Additional References
GP00000293
P35501
Physiology
Whole gene amplification. Amplification of the E4 gene is closely linked to a chromosomal translocation (the autosomal 1-3 translocation event) and amplified genes are situated at a single heterozygous site on autosome 3 as a tandem array of head-to-tail amplicons.
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
esterase E4
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
esterase FE4
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Blackman RL; Spence JM; Field LM ; et al. (1999
)
Variation in the chromosomal distribution of amplified esterase (FE4) genes in Greek field populatio[...]
2 Additional References
GP00002642
P35502
Physiology
Gene amplification
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
esterase FE4
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
esterase isozyme E3
Xenobiotic resistance (insecticide)
Coding,
SNP
Lucilia cuprina
Australian sheep blowfly - (species)
Intraspecific
Candidate Gene
Newcomb RD; Campbell PM; Ollis DL ; et al. (1997)
A single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and co[...]
GP00000294
LcaE7
Q25252
Physiology
Gly137Asp
Lucilia cuprina
Australian sheep blowfly - (species)
Lucilia cuprina
Australian sheep blowfly - (species)
esterase isozyme E3
Lucilia cuprina
Australian sheep blowfly - (species)
Published - Accepted by Curator
esterase isozyme E3
Xenobiotic resistance (insecticide)
Coding,
SNP
Lucilia cuprina
Australian sheep blowfly - (species)
Intraspecific
Candidate Gene
Jackson CJ; Liu JW; Carr PD ; et al. (2013)
Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resi[...]
GP00000295
LcaE7
Q25252
Physiology
Trp251Leu
Lucilia cuprina
Australian sheep blowfly - (species)
Lucilia cuprina
Australian sheep blowfly - (species)
esterase isozyme E3
Lucilia cuprina
Australian sheep blowfly - (species)
Published - Accepted by Curator
esterase isozyme E3
Xenobiotic resistance (insecticide)
Coding,
SNP
Lucilia sericata
common green bottle fly - (species)
Intraspecific
Candidate Gene
Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006)
Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]
GP00000296
LcaE7
Q25252
Physiology
Trp251Leu
Lucilia sericata
common green bottle fly - (species)
Lucilia sericata
common green bottle fly - (species)
esterase isozyme E3
Lucilia sericata
common green bottle fly - (species)
Published - Accepted by Curator
esterase isozyme E3
Xenobiotic resistance (insecticide)
Coding,
SNP
Lucilia sericata
common green bottle fly - (species) D
Intraspecific
Candidate Gene
Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006)
Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]
GP00000297
LcaE7
Q25252
Physiology
Trp251Ser
Lucilia sericata
common green bottle fly - (species)
Lucilia sericata
common green bottle fly - (species) D
esterase isozyme E3
Lucilia sericata
common green bottle fly - (species)
Published - Accepted by Curator
esterase isozyme E3
Xenobiotic resistance (insecticide)
Coding,
SNP
Lucilia sericata
common green bottle fly - (species) D
Intraspecific
Candidate Gene
Hartley CJ; Newcomb RD; Russell RJ ; et al. (2006)
Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolutio[...]
GP00000298
LcaE7
Q25252
Physiology
Gly137Asp
Lucilia sericata
common green bottle fly - (species)
Lucilia sericata
common green bottle fly - (species) D
esterase isozyme E3
Lucilia sericata
common green bottle fly - (species)
Published - Accepted by Curator
esterase isozyme E3
Xenobiotic resistance (insecticide)
Coding,
SNP
Cochliomyia hominivorax
primary screw-worm - (species) D
Intraspecific
Candidate Gene
da Silva NM; de Carvalho RA; de Azeredo-Espin AM (2011)
Acetylcholinesterase cDNA sequencing and identification of mutations associated with organophosphate[...]
2 Additional References
GP00002584
alphaE7
A0A0G3Z837
Physiology
G137D
Cochliomyia hominivorax
primary screw-worm - (species)
Cochliomyia hominivorax
primary screw-worm - (species) D
esterase isozyme E3
Cochliomyia hominivorax
primary screw-worm - (species)
Published - Accepted by Curator
esterase isozyme E7 = E3
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Claudianos C; Russell RJ; Oakeshott JG (1999)
The same amino acid substitution in orthologous esterases confers organophosphate resistance on the [...]
GP00000299
LcaE7
Q25252
Physiology
Gly137Asp
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
esterase isozyme E7 = E3
Musca domestica
house fly - (species)
Published - Accepted by Curator
esterase NI-EST1
Xenobiotic resistance (organophosphorus insecticides)
Gene Amplification,
Insertion
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Small GJ; Hemingway J (2000)
Molecular characterization of the amplified carboxylesterase gene associated with organophosphorus i[...]
GP00002638
Ces1
Q8VCC2
Physiology
Southern analysis of genomic DNA from the Sri Lankan OP-resistant and susceptible strains suggests that the Nl-EST1 esterase gene is amplified in the resistant strain
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
esterase NI-EST1
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
esterase type I
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Schizaphis graminum
greenbug - (species) D
Intraspecific
Candidate Gene
Ono M; Swanson JJ; Field LM ; et al. (1999)
Amplification and methylation of an esterase gene associated with insecticide-resistance in greenbug[...]
1 Additional References
GP00002637
P35501
Physiology
The type I esterase is amplified 4- to 8-fold in resistant S. graminum and that the amplified sequences contain 5-methylcytosine at MspI/HpaII sites.
Schizaphis graminum
greenbug - (species)
Schizaphis graminum
greenbug - (species) D
esterase type I
Schizaphis graminum
greenbug - (species)
Published - Accepted by Curator
ETC2
Trichome density (leaf)
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Hilscher J; Schlötterer C; Hauser MT (2009)
A single amino acid replacement in ETC2 shapes trichome patterning in natural Arabidopsis population[...]
GP00001237
ETC2
Q84RD1
Morphology
K19E
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
ETC2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
eve
Developmental time
Cis-regulatory,
Deletion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Palsson A; Wesolowska N; Reynisdóttir S ; et al. (2014)
Naturally occurring deletions of hunchback binding sites in the even-skipped stripe 3+7 enhancer.
GP00001986
eve
P06602
Physiology
72bp deletion that removes one of the hb protein-binding sites in the stripe 3+7 enhancer of eve. The deletion also removes half of a putative slp1 protein-binding site.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
eve
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
exp-1
Aggregation behavior
Cis-regulatory,
Unknown
Caenorhabditis elegans
(species)
Intraspecific
Linkage Mapping
Bendesky A; Pitts J; Rockman MV ; et al. (2012)
Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus [...]
GP00000300
exp-1
G5ECJ0
Behavior
unidentified; 6.2kb wide genetic interval 3' of the exp-1 gene
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species)
exp-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
F2RL2
Hematopoiesis (mean blood platelet volume)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001617
F2RL2
O00254
Physiology
A>T at the associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
F2RL2
Homo sapiens
human - (species)
Published - Accepted by Curator
FAAH
Anxiety (fear reduction)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Dincheva I; Drysdale AT; Hartley CA ; et al. (2015)
FAAH genetic variation enhances fronto-amygdala function in mouse and human.
GP00000301
Faah
P97612
Behavior
Pro129Thr (C385A; common variant rs324420)
Homo sapiens
human - (species)
Homo sapiens
human - (species)
FAAH
Homo sapiens
human - (species)
Published - Accepted by Curator
FAR (pheromone gland FAR)
Pheromone production (isomeric/chirality divergence)
Coding,
Unknown
Ostrinia nubilalis
European corn borer - (species)
Intraspecific
Linkage Mapping
Lassance JM; Groot AT; Liénard MA ; et al. (2010)
Allelic variation in a fatty-acyl reductase gene causes divergence in moth sex pheromones.
2 Additional References
GP00000304
pgFAR
D3U9W3
Physiology
Candidate a.a. substitutions with effect validated in vitro
Ostrinia nubilalis
European corn borer - (species)
Ostrinia nubilalis
European corn borer - (species)
FAR (pheromone gland FAR)
Ostrinia nubilalis
European corn borer - (species)
Published - Accepted by Curator
fatty acyl-CoA reductase FAR2-B
Pheromone production (cuticular hydrocarbons)
Unknown,
Unknown
Drosophila serrata
(species)
Intraspecific
Linkage Mapping
Rusuwa BB; Chung H; Allen SL ; et al. (2022)
Natural variation at a single gene generates sexual antagonism across fitness components in Drosophi[...]
GP00002395
Dmel\CG17560
Q9VES6
Physiology
Both alleles of DsFAR2-B appear to be functional. The distinction between the two alleles iss a large number of non-synonymous substitutions.
Drosophila serrata
(species)
Drosophila serrata
(species)
fatty acyl-CoA reductase FAR2-B
Drosophila serrata
(species)
Published - Accepted by Curator
ferredoxin
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001530
PF3D7_1318100
Q8IED5
Physiology
p.Asp193Tyr
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
ferredoxin
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
Ferroportin 2
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001437
IREG2
F4KGN5
Physiology
unknown
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
Ferroportin 2
Arabidopsis arenosa
(species)
Published - Accepted by Curator
FGFR2
Hair thickness
Cis-regulatory,
Unknown
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Fujimoto A; Nishida N; Kimura R ; et al. (2009)
FGFR2 is associated with hair thickness in Asian populations.
GP00000314
FGFR2
P21802
Morphology
Unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
FGFR2
Homo sapiens
human - (species)
Published - Accepted by Curator
fibrinogen-related protein 1 (FREP1)
Pathogen resistance (Plasmodium; malaria parasite)
Coding,
SNP
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Association Mapping
Li J; Wang X; Zhang G ; et al. (2013)
Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles [...]
GP00001465
3290292
Q5TWN1
Physiology
c.T1325A p.Q442L
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
fibrinogen-related protein 1 (FREP1)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
fibrinogen-related protein 30 (FBN30)
Pathogen resistance (parasite)
Coding,
SNP
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Association Mapping
Li J; Wang X; Zhang G ; et al. (2013)
Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles [...]
GP00001464
1270165
Q7QIK0
Physiology
c.T28C p.F10L
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
fibrinogen-related protein 30 (FBN30)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
fiz
Body size
3 Mutations:
Cis-regulatory
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Glaser-Schmitt A; Parsch J (2018)
Functional characterization of adaptive variation within a cis-regulatory element influencing Drosop[...]
GP00002017
fiz
Q9VY04
Morphology
3 mutations
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
fiz
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Flavonoid 3'-5'-hydroxylase (F3'5'H)
Plant secondary metabolite (catechin)
Unknown,
Unknown
Camellia sinensis
(species)
Intraspecific
Linkage Mapping
Jin JQ; Ma JQ; Yao MZ ; et al. (2017)
Functional natural allelic variants of flavonoid 3',5'-hydroxylase gene governing catechin traits in[...]
GP00001620
F3'5'H1
A3KLR7
Physiology
several candidate SNPs
Camellia sinensis
(species)
Camellia sinensis
(species)
Flavonoid 3'-5'-hydroxylase (F3'5'H)
Camellia sinensis
(species)
Published - Accepted by Curator
Flavonoid 3'-hydroxylase (F3'H)
Coloration (flowers; pubescence; seeds)
Coding,
Deletion
N
Glycine soja
(species) D
Intraspecific
Candidate Gene
Guo Y; Qiu LJ (2013)
Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]
GP00000315
CYP75B1
Q9SD85
Morphology
-1bp at +973 resulting in premature stop codon N
Glycine max
soybean - (species)
Glycine soja
(species) D
Flavonoid 3'-hydroxylase (F3'H)
Glycine soja
(species)
Published - Accepted by Curator
Flavonoid 3'-hydroxylase (F3'H)
Coloration (flowers; pubescence; seeds)
Coding,
Deletion
N
Glycine soja
(species) D
Intraspecific
Candidate Gene
Guo Y; Qiu LJ (2013)
Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]
GP00000316
CYP75B1
Q9SD85
Morphology
-1bp at +1164 resulting in premature stop codon N
Glycine max
soybean - (species)
Glycine soja
(species) D
Flavonoid 3'-hydroxylase (F3'H)
Glycine soja
(species)
Published - Accepted by Curator
Flavonoid 3'-hydroxylase (F3'H)
Coloration (flowers; pubescence; seeds)
Coding,
Indel
Glycine soja
(species)
Intraspecific
Candidate Gene
Guo Y; Qiu LJ (2013)
Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]
GP00000317
CYP75B1
Q9SD85
Morphology
a single base insertion of an adenine at position 965 as well as a single base deletion of adenine at position 973 resulting in N322K and Q324T - exact causing mutation(s) unknown
Glycine max
soybean - (species)
Glycine soja
(species)
Flavonoid 3'-hydroxylase (F3'H)
Glycine soja
(species)
Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)
Coloration (flowers; pubescence; seeds)
Coding,
Insertion
N
Glycine soja
(species) D
Intraspecific
Candidate Gene
Guo Y; Qiu LJ (2013)
Allele-specific marker development and selection efficiencies for both flavonoid 3'-hydroxylase and [...]
GP00000322
CYP75A2
P37120
Morphology
53bp insertion at +1352 N
Glycine max
soybean - (species)
Glycine soja
(species) D
flavonoid 3';5'-hydroxylase (F3'5'H)
Glycine soja
(species)
Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)
Coloration (flowers)
Coding,
SNP
Glycine soja
(species)
Intraspecific
Linkage Mapping
Takahashi R; Dubouzet JG; Matsumura H ; et al. (2010)
A new allele of flower color gene W1 encoding flavonoid 3'5'-hydroxylase is responsible for light pu[...]
GP00000323
CYP75A2
P37120
Morphology
V210M (uncertain); no expression level differences detected
Glycine soja
(species)
Glycine soja
(species)
flavonoid 3';5'-hydroxylase (F3'5'H)
Glycine soja
(species)
Published - Accepted by Curator
flavonoid 3';5'-hydroxylase (F3'5'H)
Coloration (flowers)
Cis-regulatory,
Unknown
Phlox drummondii
(species)
Intraspecific
Linkage Mapping
Hopkins R; Rausher MD (2011)
Identification of two genes causing reinforcement in the Texas wildflower Phlox drummondii.
GP00000325
CYP75A2
P37120
Morphology
unknown
Phlox drummondii
(species)
Phlox drummondii
(species)
flavonoid 3';5'-hydroxylase (F3'5'H)
Phlox drummondii
(species)
Published - Accepted by Curator
FLC (=Pep1)
Flowering time
Gene Amplification,
Indel
Arabis alpina
gray rockcress - (species)
Intraspecific
Candidate Gene
Albani MC; Castaings L; Wötzel S ; et al. (2012)
PEP1 of Arabis alpina is encoded by two overlapping genes that contribute to natural genetic variati[...]
GP00000329
FLC
Q9S7Q7
Physiology
complex structural variations
Arabis alpina
gray rockcress - (species)
Arabis alpina
gray rockcress - (species)
FLC (=Pep1)
Arabis alpina
gray rockcress - (species)
Published - Accepted by Curator
FLC (Flowering Locus C)
Flowering time
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Werner JD; Borevitz JO; Uhlenhaut NH ; et al. (2005)
FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions.
1 Additional References
GP00000330
FLC
Q9S7Q7
Physiology
Substitution creating premature Stop (codon 158) N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
FLC (Flowering Locus C)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FLC (Flowering Locus C)
Flowering time
2 Mutations:
Cis-regulatory
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Coustham V; Li P; Strange A ; et al. (2012)
Quantitative modulation of polycomb silencing underlies natural variation in vernalization.
1 Additional References
GP00000331
FLC
Q9S7Q7
Physiology
2 mutations
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
FLC (Flowering Locus C)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FLC (Flowering Locus C)
Flowering time
Cis-regulatory,
Insertion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Michaels SD; He Y; Scortecci KC ; et al. (2003)
Attenuation of FLOWERING LOCUS C activity as a mechanism for the evolution of summer-annual flowerin[...]
3 Additional References
GP00000332
FLC
Q9S7Q7
Physiology
TE insertion in intron 1; a region required for normal FLC regulation. The transposable element renders FLC-Ler subject to repressive chromatin modifications mediated by short interfering RNAs generated from homologous transposable elements in the genome.
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
FLC (Flowering Locus C)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FLC (Flowering Locus C)
Flowering time
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Michaels SD; He Y; Scortecci KC ; et al. (2003)
Attenuation of FLOWERING LOCUS C activity as a mechanism for the evolution of summer-annual flowerin[...]
1 Additional References
GP00000333
FLC
Q9S7Q7
Physiology
Not identified
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
FLC (Flowering Locus C)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FLC (Flowering Locus C)
Flowering time
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Werner JD; Borevitz JO; Uhlenhaut NH ; et al. (2005)
FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions.
1 Additional References
GP00000334
FLC
Q9S7Q7
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
FLC (Flowering Locus C)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FLC (Flowering Locus C)
Flowering time
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Werner JD; Borevitz JO; Uhlenhaut NH ; et al. (2005)
FRIGIDA-independent variation in flowering time of natural Arabidopsis thaliana accessions.
1 Additional References
GP00000335
FLC
Q9S7Q7
Physiology
GA substitution disrupting Splice Site
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
FLC (Flowering Locus C)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FLC (Flowering Locus C)
Flowering time
Cis-regulatory,
Deletion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Sánchez-Bermejo E; Méndez-Vigo B; Picó FX ; et al. (2012)
Novel natural alleles at FLC and LVR loci account for enhanced vernalization responses in Arabidopsi[...]
1 Additional References
GP00000336
FLC
Q9S7Q7
Physiology
50bp deletion in 5'UTR
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
FLC (Flowering Locus C)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FLC (Flowering Locus C)
Flowering time
Coding,
SNP
Capsella rubella
(species)
Intraspecific
Linkage Mapping
Guo YL; Todesco M; Hagmann J ; et al. (2012)
Independent FLC mutations as causes of flowering-time variation in Arabidopsis thaliana and Capsella[...]
GP00000337
FLC
Q9S7Q7
Physiology
Splice site mutation introducing frameshift; removing the last 35 of 198 amino acids
Capsella rubella
(species)
Capsella rubella
(species)
FLC (Flowering Locus C)
Capsella rubella
(species)
Published - Accepted by Curator
FLM (MAF1)
Flowering time
Gene Loss,
Complex Change
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Werner JD; Borevitz JO; Warthmann N ; et al. (2005)
Quantitative trait locus mapping and DNA array hybridization identify an FLM deletion as a cause for[...]
GP00000341
AGL27
Q9AT76
Physiology
Deletion of entire gene N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
FLM (MAF1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FMO2
Xenobiotic resistance (insecticide)
Cis-regulatory,
Insertion
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Mallott M; Hamm S; Troczka BJ ; et al. (2019)
A flavin-dependent monooxgenase confers resistance to chlorantraniliprole in the diamondback moth, P[...]
GP00002065
FMO2
Q99518
Physiology
a putatative transposon (233bp) insertion in the HAW promoter sequence just 140 bp upstream of the start codon of PxFMO2 which was absent in the ROTH promoter, the boundaries of all copies of this element were found to be defined by 34 bp imperfect terminal inverted repeats, increase the expression of the gene PxFMO2 downstream
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
FMO2
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
follistatin
Limb morphology (wing dimorphism)
Flight behavior (wing dimorphism)
Gene Amplification,
Insertion
Acyrthosiphon pisum
pea aphid - (species) D
Intraspecific
Linkage Mapping
Li B; Bickel RD; Parker BJ ; et al. (2020)
A large genomic insertion containing a duplicated follistatin gene is linked to the pea aphid male w[...]
GP00002138
Fs
Q86NV3
Morphology
Behavior
the api allele from winged males is a 120kb insertion that includes a copy of the follistatin gene
Acyrthosiphon pisum
pea aphid - (species)
Acyrthosiphon pisum
pea aphid - (species) D
follistatin
Acyrthosiphon pisum
pea aphid - (species)
Published - Accepted by Curator
February 9, 2021 22:00
foraging
Food-search behavior
Cis-regulatory,
SNP
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Osborne KA; Robichon A; Burgess E ; et al. (1997)
Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila.
2 Additional References
GP00000350
for
Q03043
Behavior
The fors (sitter) and forR (rover) alleles differ in a SNP that lies within a predicted Mad protein-binding site in a region upstream of the pr4 transcription start site. The SNP is a C in fors and an A in forR (the latter is predicted to reduce Mad protein binding).
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
foraging
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
foraging
Food-search behavior
Unknown,
Unknown
Sesamia nonagrioides
Mediterranean corn borer - (species)
Intraspecific
Candidate Gene
Chardonnet F; Capdevielle-Dulac C; Chouquet B ; et al. (2014)
Food searching behaviour of a Lepidoptera pest species is modulated by the foraging gene polymorphis[...]
GP00002619
for
Q03043
Behavior
Association between a coding SNP in foraging gene and foraging activity. But not clear whether the causal mutation is this one.
Sesamia nonagrioides
Mediterranean corn borer - (species)
Sesamia nonagrioides
Mediterranean corn borer - (species)
foraging
Sesamia nonagrioides
Mediterranean corn borer - (species)
Published - Accepted by Curator
foxo
Body size (wing)
Starvation resistance
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Betancourt NJ; Rajpurohit S; Durmaz E ; et al. (2021)
Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster.
1 Additional References
GP00002661
foxo
Q95V55
Morphology
Morphology; Physiology
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
foxo
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
FPN2
Metal tolerance
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Morrissey J; Baxter IR; Lee J ; et al. (2009)
The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis.
GP00000354
IREG2
F4KGN5
Physiology
1bp insertion resulting in frameshift N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
FPN2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FRD3 (FERRIC REDUCTASE DEFECTIVE3)
Metal tolerance
2 Mutations:
Coding
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Pineau C; Loubet S; Lefoulon C ; et al. (2012)
Natural variation at the FRD3 MATE transporter locus reveals cross-talk between Fe homeostasis and Z[...]
GP00000355
DTX43
Q9SFB0
Physiology
2 mutations
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
FRD3 (FERRIC REDUCTASE DEFECTIVE3)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Johanson U; West J; Lister C ; et al. (2000)
Molecular analysis of FRIGIDA, a major determinant of natural variation in Arabidopsis flowering tim[...]
GP00000357
FRI
P0DH90
Physiology
16bp deletion aa313-318 in exon 2 and premature stop codon N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Indel
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Johanson U; West J; Lister C ; et al. (2000)
Molecular analysis of FRIGIDA, a major determinant of natural variation in Arabidopsis flowering tim[...]
1 Additional References
GP00000358
FRI
P0DH90
Physiology
376 bp deletion and 31 bp insertion that delete amino acid 1-15 and at best produce a 45-aa protein N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Indel
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Le Corre V; Roux F; Reboud X (2002)
DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]
GP00000359
FRI
P0DH90
Physiology
Del 2257-2355 in exon 3; deletion of 99 bp combined with an insertion of 61 bp N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Le Corre V; Roux F; Reboud X (2002)
DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]
GP00000360
FRI
P0DH90
Physiology
1bp deletion at 1487 in exon 1 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Le Corre V; Roux F; Reboud X (2002)
DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]
GP00000361
FRI
P0DH90
Physiology
1bp insertion at 766 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Le Corre V; Roux F; Reboud X (2002)
DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]
1 Additional References
GP00000362
FRI
P0DH90
Physiology
Insertion 1 bp at 1454 in exon 1 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Le Corre V; Roux F; Reboud X (2002)
DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]
GP00000363
FRI
P0DH90
Physiology
Trp240* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Le Corre V; Roux F; Reboud X (2002)
DNA polymorphism at the FRIGIDA gene in Arabidopsis thaliana: extensive nonsynonymous variation is c[...]
GP00000364
FRI
P0DH90
Physiology
Glu361* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Gazzani S; Gendall AR; Lister C ; et al. (2003)
Analysis of the molecular basis of flowering time variation in Arabidopsis accessions.
GP00000365
FRI
P0DH90
Physiology
K232* in exon 1 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000366
FRI
P0DH90
Physiology
deletion; E430* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Deletion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000367
FRI
P0DH90
Physiology
deletion of 6 amino acids; LQLDKE422-427*
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Deletion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000368
FRI
P0DH90
Physiology
deletion aa 1-12
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000369
FRI
P0DH90
Physiology
deletion resulting in S121* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000370
FRI
P0DH90
Physiology
deletion; AF375-6* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000371
FRI
P0DH90
Physiology
insertion; I490* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000372
FRI
P0DH90
Physiology
insertion; T258* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000373
FRI
P0DH90
Physiology
Y162* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Shindo C; Aranzana MJ; Lister C ; et al. (2005)
Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis.
GP00000374
FRI
P0DH90
Physiology
K170* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida (FRI)
Flowering time
Water use efficiency
Cis-regulatory,
Deletion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Lovell JT; Juenger TE; Michaels SD ; et al. (2013)
Pleiotropy of FRIGIDA enhances the potential for multivariate adaptation.
GP00000375
FRI
P0DH90
Physiology
Physiology
376 bp deletion within the promoter of the TSU-1 FRI allele
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Frigida (FRI)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida like 1 (FRL1)
Flowering time
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Schläppi MR (2006)
FRIGIDA LIKE 2 is a functional allele in Landsberg erecta and compensates for a nonsense allele of F[...]
GP00000376
FRL1
Q9FFF1
Physiology
E279* in the middle of the conceptual protein sequence N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Frigida like 1 (FRL1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Frigida like 2 (FRL2)
Flowering time
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Schläppi MR (2006)
FRIGIDA LIKE 2 is a functional allele in Landsberg erecta and compensates for a nonsense allele of F[...]
GP00000377
FRL2
Q9C6S2
Physiology
A132P and/or L401Q
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Frigida like 2 (FRL2)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FST/MOCS2
coloration (head feathers)
Cis-regulatory,
Unknown
Erythrura gouldiae
Gouldian finch - (species)
Intraspecific
Association Mapping
Toomey MB; Marques CI; Andrade P ; et al. (2018)
A non-coding region near Follistatin controls head colour polymorphism in the Gouldian finch.
1 Additional References
GP00002125
Morphology
candidate locus is a small (approx. 70 kb) non-coding region mapping to the Z chromosome near the FST and MOCS2
Erythrura gouldiae
Gouldian finch - (species)
Erythrura gouldiae
Gouldian finch - (species)
FST/MOCS2
Erythrura gouldiae
Gouldian finch - (species)
Published - Accepted by Curator
FTO
Body size (weight; variance)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Frayling TM; Timpson NJ; Weedon MN ; et al. (2007)
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and[...]
4 Additional References
GP00000378
FTO
Q9C0B1
Morphology; Physiology
rs1421085 T-to-C single-nucleotide variant disrupts a conserved motif for the ARID5B repressor
Homo sapiens
human - (species)
Homo sapiens
human - (species)
FTO
Homo sapiens
human - (species)
Published - Accepted by Curator
FTO
Body fat distribution (subcutaneous)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001560
FTO
Q9C0B1
Physiology
A>G in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
FTO
Homo sapiens
human - (species)
Published - Accepted by Curator
FUMARASE 2
Plant metabolism (fumarate/malate ratio)
Plant growth (bio-mass production)
Cis-regulatory,
Indel
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Riewe D; Jeon HJ; Lisec J ; et al. (2016)
A naturally occurring promoter polymorphism of the Arabidopsis FUM2 gene causes expression variation[...]
1 Additional References
GP00001286
FUM2
Q9FI53
Physiology
Physiology
2068 bp in promotor region @position -395. AND 3833bp in promotor region @position -1107
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
FUMARASE 2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
FUT2
ABO antigen blood type
Coding,
Deletion
N
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Kelly RJ; Rouquier S; Giorgi D ; et al. (1995)
Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...]
1 Additional References
GP00000379
FUT2
Q10981
Physiology
9.3 kb deletion mediated by recombination between Alu sequences N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
FUT2
Homo sapiens
human - (species)
Published - Accepted by Curator
FUT2
ABO antigen blood type
Coding,
Deletion
N
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Kelly RJ; Rouquier S; Giorgi D ; et al. (1995)
Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...]
2 Additional References
GP00000380
FUT2
Q10981
Physiology
10 kb deletion mediated by recombination between Alu sequences N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
FUT2
Homo sapiens
human - (species)
Published - Accepted by Curator
FUT2
ABO antigen blood type
Coding,
SNP
N
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Kelly RJ; Rouquier S; Giorgi D ; et al. (1995)
Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...]
1 Additional References
GP00000381
FUT2
Q10981
Physiology
premature stop at codon 143: TGG>TGA N
Homo sapiens
human - (species)
Homo sapiens
human - (species)
FUT2
Homo sapiens
human - (species)
Published - Accepted by Curator
FUT2
ABO antigen blood type
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Kelly RJ; Rouquier S; Giorgi D ; et al. (1995)
Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransfera[...]
1 Additional References
GP00000382
FUT2
Q10981
Physiology
Ile129Phe
Homo sapiens
human - (species)
Homo sapiens
human - (species)
FUT2
Homo sapiens
human - (species)
Published - Accepted by Curator
G protein-coupled receptor rhodopsin
Diapause
Unknown,
Unknown
Daphnia magna
(species)
Intraspecific
Linkage Mapping
Roulin AC; Bourgeois Y; Stiefel U ; et al. (2016)
A Photoreceptor Contributes to the Natural Variation of Diapause Induction in Daphnia magna.
GP00001539
RHO
P08100
Physiology
unknown
Daphnia magna
(species)
Daphnia magna
(species)
G protein-coupled receptor rhodopsin
Daphnia magna
(species)
Published - Accepted by Curator
GATA-binding protein 2 (GATA2)
Hematopoiesis (blood basophil count)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001610
GATA2
P23769
Physiology
G>A at the associated SNP. Another variant (rs6782812) in a pleiotropic myeloid enhancer near GATA2 reduced enhancer activity by 69%
Homo sapiens
human - (species)
Homo sapiens
human - (species)
GATA-binding protein 2 (GATA2)
Homo sapiens
human - (species)
Published - Accepted by Curator
GDF5
Body size (height)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Sanna S; Jackson AU; Nagaraja R ; et al. (2008)
Common variants in the GDF5-UQCC region are associated with variation in human height.
1 Additional References
GP00000387
GDF5
P43026
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
GDF5
Homo sapiens
human - (species)
Published - Accepted by Curator
GDF6
Dermal bone size (armor plates)
Cis-regulatory,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Indjeian VB; Kingman GA; Jones FC ; et al. (2016)
Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins.
GP00000388
GDF6
Q6KF10
Morphology
gain of a flank enhancer activity involving a complex repeat region; 1.2kb L2 LINE insertion; 18 small indels and 89 SNPs - the LINE insertion is required but not sufficient, to produce increased flank expression
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
GDF6
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
Ge-1
Pathogen resistance (sigma virus)
Coding,
Deletion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Cao C; Magwire MM; Bayer F ; et al. (2016)
A Polymorphism in the Processing Body Component Ge-1 Controls Resistance to a Naturally Occurring Rh[...]
GP00001993
Ge-1
Q9VKK1
Physiology
78bp deletion ( 2L:11097925 ..11098002 in both Release 5 and Release 6 coordinates) in the fifth exon of Ge-1 which reduces the length of the serine-rich linker region by 26 amino acid residues
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Ge-1
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
GHSR
Body size (height)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Lettre G (2011)
Recent progress in the study of the genetics of height.
GP00000394
GHSR
Q92847
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
GHSR
Homo sapiens
human - (species)
Published - Accepted by Curator
GIBBERELLIC ACID REQUIRING 1 (GA1)
Flower morphology
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Brock MT; Kover PX; Weinig C (2012)
Natural variation in GA1 associates with floral morphology in Arabidopsis thaliana.
GP00000395
GA1
Q38802
Morphology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
GIBBERELLIC ACID REQUIRING 1 (GA1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
GLABROUS1
Trichome (leaves)
Unknown,
Unknown
Arabidopsis
(genus)
Intraspecific
Candidate Gene
Hauser MT; Harr B; Schlötterer C (2001)
Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...]
1 Additional References
GP00000398
GL1
P27900
Morphology
unknown
Arabidopsis
(genus)
Arabidopsis
(genus)
GLABROUS1
Arabidopsis
(genus)
Published - Accepted by Curator
GLABROUS1
Trichome density (leaf)
Gene Loss,
Deletion
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Hauser MT; Harr B; Schlötterer C (2001)
Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...]
1 Additional References
GP00001238
GL1
P27900
Morphology
gene loss: -4.7KB at position -948bp N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
GLABROUS1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
GLABROUS1
Trichome density (leaf)
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Hauser MT; Harr B; Schlötterer C (2001)
Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...]
1 Additional References
GP00001239
GL1
P27900
Morphology
S92F
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
GLABROUS1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
GLABROUS1
Trichome density (leaf)
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Hauser MT; Harr B; Schlötterer C (2001)
Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...]
1 Additional References
GP00001240
GL1
P27900
Morphology
+1bp at position 352 causing premature stop N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
GLABROUS1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
GLABROUS1
Trichome density (leaf)
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Hauser MT; Harr B; Schlötterer C (2001)
Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...]
1 Additional References
GP00001241
GL1
P27900
Morphology
-1bp at position 203 causing premature stop N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
GLABROUS1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
GLABROUS1
Trichome density (leaf)
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Association Mapping
Hauser MT; Harr B; Schlötterer C (2001)
Trichome distribution in Arabidopsis thaliana and its close relative Arabidopsis lyrata: molecular a[...]
1 Additional References
GP00001242
GL1
P27900
Morphology
high frequency pattern of polymorphism identified in the third exon and 3' flank
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
GLABROUS1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
glb-5
CO2 avoidance
Aggregation behavior
Coding,
Indel
N
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
McGrath PT; Rockman MV; Zimmer M ; et al. (2009)
Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory[...]
2 Additional References
GP00000399
glb-5
A3RMS5
Behavior
Behavior
765bp insertion/duplication resulting in a truncation of the last 179 amino acids of the protein and the inclusion of 40 different residues N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
glb-5
Caenorhabditis elegans
(species)
Published - Accepted by Curator
GLC-1
Xenobiotic resistance (antihelmintics)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Ghosh R; Andersen EC; Shapiro JA ; et al. (2012)
Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans.
GP00000400
glc-1
G5EBR3
Physiology
4aa deletion N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
GLC-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
GLO(T)
Flower morphology (anther elevation)
Coding,
Insertion
N
Primula vulgaris
(species) D
Intraspecific
Linkage Mapping
Li J; Cocker JM; Wright J ; et al. (2016)
Genetic architecture and evolution of the S locus supergene in Primula vulgaris.
GP00001393
GLO
Q03378
Morphology
A 2.5 kb retrotransposon in exon 2 severely truncates the protein N
Primula vulgaris
(species)
Primula vulgaris
(species) D
GLO(T)
Primula vulgaris
(species)
Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)
Pathogen resistance (malaria)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Tishkoff SA; Varkonyi R; Cahinhinan N ; et al. (2001)
Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer m[...]
GP00000401
G6PD
P11413
Physiology
Ser188Phe C>T
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Glucose-6-phosphate dehydrogenase (G6PD)
Homo sapiens
human - (species)
Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)
Pathogen resistance (malaria)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Louicharoen C; Patin E; Paul R ; et al. (2009)
Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians.
GP00000402
G6PD
P11413
Physiology
Ser163Gly
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Glucose-6-phosphate dehydrogenase (G6PD)
Homo sapiens
human - (species)
Published - Accepted by Curator
Glucose-6-phosphate dehydrogenase (G6PD)
Pathogen resistance (malaria)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Tishkoff SA; Varkonyi R; Cahinhinan N ; et al. (2001)
Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer m[...]
GP00000403
G6PD
P11413
Physiology
Val68Met G>A at nucleotide position 376 in exon 5 - OMIM code +305900.0002
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Glucose-6-phosphate dehydrogenase (G6PD)
Homo sapiens
human - (species)
Published - Accepted by Curator
Glucose-dependent insulinotropic polypeptide
Glycemia
Adipolysis rate
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Chang CL; Cai JJ; Lo C ; et al. (2011)
Adaptive selection of an incretin gene in Eurasian populations.
GP00000404
GIP
P09681
Physiology
Physiology
Ser103Gly
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Glucose-dependent insulinotropic polypeptide
Homo sapiens
human - (species)
Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)
Xenobiotic resistance (insecticide; abamectin)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Dermauw W; Ilias A; Riga M ; et al. (2012)
The cys-loop ligand-gated ion channel gene family of Tetranychus urticae: implications for acaricide[...]
GP00002601
GluClalpha
Q94900
Physiology
G326E inTu_GluCl3
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
glutamate-gated chloride channel (GluCl)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)
Xenobiotic resistance (insecticide; nodulisporic acid)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Kane NS; Hirschberg B; Qian S ; et al. (2000)
Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasit[...]
GP00002602
GluClalpha
Q94900
Physiology
P299S
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
glutamate-gated chloride channel (GluCl)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)
Xenobiotic resistance (insecticide; ivermectin)
Coding,
SNP
Cooperia oncophora
(species) D
Intraspecific
Candidate Gene
Njue AI; Hayashi J; Kinne L ; et al. (2004)
Mutations in the extracellular domains of glutamate-gated chloride channel alpha3 and beta subunits [...]
GP00002603
GluClalpha
Q94900
Physiology
E114G V235A L256F in the GluCla3 ortholog and V60A R101Hin the GluClb ortholog.
Cooperia oncophora
(species)
Cooperia oncophora
(species) D
glutamate-gated chloride channel (GluCl)
Cooperia oncophora
(species)
Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)
Xenobiotic resistance (insecticide; ivermectin)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Kwon DH; Yoon KS; Clark JM ; et al. (2010)
A point mutation in a glutamate-gated chloride channel confers abamectin resistance in the two-spott[...]
1 Additional References
GP00002604
GluClalpha
Q94900
Physiology
G323D in the highly conserved TM2 region of Tu_GluCl
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
glutamate-gated chloride channel (GluCl)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
glutamate-gated chloride channel (GluCl)
Xenobiotic resistance (insecticide; abamectin)
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Wang X; Wang R; Yang Y ; et al. (2016)
A point mutation in the glutamate-gated chloride channel of Plutella xylostella is associated with r[...]
GP00002634
GluClalpha
Q94900
Physiology
A309V
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
glutamate-gated chloride channel (GluCl)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
glycerol-3-phosphate dehydrogenase (Gpdh)
Enzymatic activity
Cis-regulatory,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Bewley Glenn C (1981
)
Genetic control of the developmental program of L‐glycerol‐3‐phosphate dehydrogenase isozymes in Dro[...]
GP00001992
Gpdh
P13706
Physiology
Exact causal mutation(s) unknown.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
glycerol-3-phosphate dehydrogenase (Gpdh)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
glycerol-3-phosphate dehydrogenase (Gpdh)
Enzymatic activity
Cis-regulatory,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Wilanowski TM; Gibson JB; Symonds JE (1995)
Retrotransposon insertion induces an isozyme of sn-glycerol-3-phosphate dehydrogenase in Drosophila [...]
GP00001998
Gpdh
P13706
Physiology
insertion of a 8kb blood retrotransposon in the 3' region of the Gpdh gene 66bp downstream of the stop codon. This mutation induces a GPDH isozyme-GPDH-4-and alters the pattern of expression of the three normal isozymes-GPDH-1 to GPDH-3.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
glycerol-3-phosphate dehydrogenase (Gpdh)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Glycophorin GYPA-GYPB-GYPE cluster
Pathogen resistance (Plasmodium; malaria parasite)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
; Band G; Rockett KA ; et al. (2015)
A novel locus of resistance to severe malaria in a region of ancient balancing selection.
GP00000406
GYPA
P02724
Physiology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
Glycophorin GYPA-GYPB-GYPE cluster
Homo sapiens
human - (species)
Published - Accepted by Curator
GNBP1
Pathogen resistance
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Sackton TB; Lazzaro BP; Clark AG (2010)
Genotype and gene expression associations with immune function in Drosophila.
GP00000408
GNBP1
Q9NHB0
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
GNBP1
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
GNBP2
Pathogen resistance
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Sackton TB; Lazzaro BP; Clark AG (2010)
Genotype and gene expression associations with immune function in Drosophila.
GP00000409
GNBP2
Q9VVR4
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
GNBP2
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
goldentouch
Coloration
Cis-regulatory,
Insertion
Amphilophus citrinellus
Midas cichlid - (species)
Intraspecific
Association Mapping
Kratochwil CF; Kautt AF; Nater A ; et al. (2022)
An intronic transposon insertion associates with a trans-species color polymorphism in Midas cichlid[...]
GP00002362
Morphology
"Using a new haplotype-resolved long-read assembly we discover an 8.2 kb, transposon-derived inverted repeat in an intron of an undescribed gene, which we term goldentouch in reference to the Greek myth of King Midas. The gene goldentouch is differentially expressed between morphs, presumably due to structural implications of inverted repeats in both DNA and/or RNA (cruciform and hairpin formation). The near-perfect association of the insertion with the phenotype across independent populations suggests that it likely underlies this trans-specific, stable polymorphism."
Amphilophus citrinellus
Midas cichlid - (species)
Amphilophus citrinellus
Midas cichlid - (species)
goldentouch
Amphilophus citrinellus
Midas cichlid - (species)
Published - Accepted by Curator
GPR133
Body size (height; male-limited)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Tönjes A; Koriath M; Schleinitz D ; et al. (2009)
Genetic variation in GPR133 is associated with height: genome wide association study in the self-con[...]
GP00000412
ADGRD1
Q6QNK2
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
GPR133
Homo sapiens
human - (species)
Published - Accepted by Curator
GPRC6A
Cell signaling (membrane receptor activity)
Coding,
Insertion
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Jørgensen S; Have CT; Underwood CR ; et al. (2017)
Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]
GP00001669
GPRC6A
Q5T6X5
Physiology
insertion of KL (6 bp) resulting in sequence KGKKLY in the third intracellular loop (ICL3) with surface expression and function greatly reduced
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
GPRC6A
Homo sapiens
human - (species)
Published - Accepted by Curator
GPRC6A
Cell signaling (membrane receptor activity)
Coding,
Deletion
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Jørgensen S; Have CT; Underwood CR ; et al. (2017)
Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]
GP00001670
GPRC6A
Q5T6X5
Physiology
KGRKLP>KGRK-Y in the third intracellular loop (ICL3) with surface expression and function greatly reduced
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
GPRC6A
Homo sapiens
human - (species)
Published - Accepted by Curator
GPRC6A
Cell signaling (membrane receptor activity)
Coding,
Deletion
N
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Jørgensen S; Have CT; Underwood CR ; et al. (2017)
Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]
GP00001671
GPRC6A
Q5T6X5
Physiology
KGRKLP>KGK--Y in the third intracellular loop (ICL3) responsible for the intracellular retention and lack of function N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
GPRC6A
Homo sapiens
human - (species)
Published - Accepted by Curator
GPRC6A
Cell signaling (membrane receptor activity)
Coding,
SNP
N
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Jørgensen S; Have CT; Underwood CR ; et al. (2017)
Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Contr[...]
GP00001672
GPRC6A
Q5T6X5
Physiology
C>T (aa57) located in the first exon resulting in a premature Stop-codon and non-functional protein N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
GPRC6A
Homo sapiens
human - (species)
Published - Accepted by Curator
Gr5a
Taste sensitivity (sugar; trehalose)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Ueno K; Ohta M; Morita H ; et al. (2001)
Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory rec[...]
2 Additional References
GP00001997
Gr5a
Q9W497
Physiology
Nucleotide change: A5681571G - Amino acid change: T218A
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Gr5a
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
GRAMD3
Body fat distribution (visceral)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001557
GRAMD2B
Q96HH9
Physiology
A>C in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
GRAMD3
Homo sapiens
human - (species)
Published - Accepted by Curator
Growth Hormone Receptor (GHR)
Body size (height)
Coding,
SNP
N
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Zoledziewska M; Sidore C; Chiang CWK ; et al. (2015)
Height-reducing variants and selection for short stature in Sardinia.
GP00000415
GHR
P10912
Morphology
Arg61* N
Homo sapiens
human - (species)
Homo sapiens
human - (species)
Growth Hormone Receptor (GHR)
Homo sapiens
human - (species)
Published - Accepted by Curator
GSDMB
Body fat distribution (subcutaneous)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001556
GSDMB
Q8TAX9
Physiology
T>C in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
GSDMB
Homo sapiens
human - (species)
Published - Accepted by Curator
GSS (glutathione synthetase)
Coloration (skin)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Liu F; Visser M; Duffy DL ; et al. (2015)
Genetics of skin color variation in Europeans: genome-wide association studies with functional follo[...]
GP00001362
GSS
P48637
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
GSS (glutathione synthetase)
Homo sapiens
human - (species)
Published - Accepted by Curator
GSS (glutathione synthetase)
Xenobiotic resistance (arsenic)
Gene Amplification,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Chakraborty M; Emerson JJ; Macdonald SJ ; et al. (2019)
Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits.
1 Additional References
GP00002115
Gss2
Q86B44
Physiology
tandem duplication creating the Gss1/Gss2 gene pair. Associated with increased expression of Gss1.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
GSS (glutathione synthetase)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
GST
Xenobiotic resistance (pyrethroid)
Gene Amplification,
Insertion
Nilaparvata lugens
brown planthopper - (species) D
Intraspecific
Candidate Gene
Vontas JG; Small GJ; Nikou DC ; et al. (2002)
Purification, molecular cloning and heterologous expression of a glutathione S-transferase involved [...]
GP00002643
GstD1
P20432
Physiology
nlgst1-1 is overexpressed in resistant insects. Southern analysis of genomic DNA from the resistant and susceptible strains indicated that GST-based insecticide resistance may be associated with gene amplification in N. lugens.
Nilaparvata lugens
brown planthopper - (species)
Nilaparvata lugens
brown planthopper - (species) D
GST
Nilaparvata lugens
brown planthopper - (species)
Published - Accepted by Curator
GSTe
Xenobiotic resistance (insecticide; DDT)
Coding,
SNP
Anopheles funestus
African malaria mosquito - (species)
Intraspecific
Candidate Gene
Riveron JM; Yunta C; Ibrahim SS ; et al. (2014)
A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in[...]
GP00002455
GstE2
Q7JYZ9
Physiology
L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.
Anopheles funestus
African malaria mosquito - (species)
Anopheles funestus
African malaria mosquito - (species)
GSTe
Anopheles funestus
African malaria mosquito - (species)
Published - Accepted by Curator
GSTe
Xenobiotic resistance (insecticide; DDT)
Coding,
SNP
Spodoptera litura
(species)
Intraspecific
Candidate Gene
Hilliou F; Chertemps T; Maïbèche M ; et al. (2021)
Resistance in the Genus Spodoptera: Key Insect Detoxification Genes.
1 Additional References
GP00002456
GstE2
Q7JYZ9
Physiology
L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.
Spodoptera litura
(species)
Spodoptera litura
(species)
GSTe
Spodoptera litura
(species)
Published - Accepted by Curator
GSTe
Xenobiotic resistance (insecticide; DDT)
Coding,
SNP
Spodoptera frugiperda
fall armyworm - (species)
Intraspecific
Candidate Gene
Hilliou F; Chertemps T; Maïbèche M ; et al. (2021)
Resistance in the Genus Spodoptera: Key Insect Detoxification Genes.
1 Additional References
GP00002457
GstE2
Q7JYZ9
Physiology
L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.
Spodoptera frugiperda
fall armyworm - (species)
Spodoptera frugiperda
fall armyworm - (species)
GSTe
Spodoptera frugiperda
fall armyworm - (species)
Published - Accepted by Curator
GSTe
Xenobiotic resistance (insecticide; DDT)
Coding,
SNP
Spodoptera exigua
beet armyworm - (species)
Intraspecific
Candidate Gene
Hilliou F; Chertemps T; Maïbèche M ; et al. (2021)
Resistance in the Genus Spodoptera: Key Insect Detoxification Genes.
1 Additional References
GP00002458
GstE2
Q7JYZ9
Physiology
L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.
Spodoptera exigua
beet armyworm - (species)
Spodoptera exigua
beet armyworm - (species)
GSTe
Spodoptera exigua
beet armyworm - (species)
Published - Accepted by Curator
GSTe
Xenobiotic resistance (insecticide; DDT)
Coding,
SNP
Spodoptera littoralis
African cotton leafworm - (species)
Intraspecific
Candidate Gene
Hilliou F; Chertemps T; Maïbèche M ; et al. (2021)
Resistance in the Genus Spodoptera: Key Insect Detoxification Genes.
1 Additional References
GP00002459
GstE2
Q7JYZ9
Physiology
L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.
Spodoptera littoralis
African cotton leafworm - (species)
Spodoptera littoralis
African cotton leafworm - (species)
GSTe
Spodoptera littoralis
African cotton leafworm - (species)
Published - Accepted by Curator
GSTe
Xenobiotic resistance (insecticide; DDT)
Coding,
SNP
Anopheles funestus
African malaria mosquito - (species)
Intraspecific
Candidate Gene
Hilliou F; Chertemps T; Maïbèche M ; et al. (2021)
Resistance in the Genus Spodoptera: Key Insect Detoxification Genes.
1 Additional References
GP00002460
GstE2
Q7JYZ9
Physiology
L119F. The resistant allele is more efficient at metabolizing DDT than the susceptible one.
Anopheles funestus
African malaria mosquito - (species)
Anopheles funestus
African malaria mosquito - (species)
GSTe
Anopheles funestus
African malaria mosquito - (species)
Published - Accepted by Curator
GSTE1-E10 cluster
Xenobiotic resistance (drug)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Kislukhin G; King EG; Walters KN ; et al. (2013)
The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans.
GP00000419
GstE1
Q7KK90
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
GSTE1-E10 cluster
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Ha_BtR
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
SNP
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Linkage Mapping
Zhao J; Jin L; Yang Y ; et al. (2010)
Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]
1 Additional References
GP00000426
ABCA2
A0A0S0G7V0
Physiology
Pro53* (161T>A) N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
Ha_BtR
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
Ha_BtR
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
Deletion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Xu X; Yu L; Wu Y (2005)
Disruption of a cadherin gene associated with resistance to Cry1Ac {delta}-endotoxin of Bacillus thu[...]
2 Additional References
GP00000427
ABCA2
A0A0S0G7V0
Physiology
10kb deletion N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
Ha_BtR
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
Ha_BtR
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
Insertion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Yang Y; Chen H; Wu S ; et al. (2006)
Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]
1 Additional References
GP00000428
ABCA2
A0A0S0G7V0
Physiology
Insertion of a LTR retrotransposon N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
Ha_BtR
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
Ha_BtR
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
Insertion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Yang Y; Chen H; Wu S ; et al. (2006)
Identification and molecular detection of a deletion mutation responsible for a truncated cadherin o[...]
1 Additional References
GP00000429
ABCA2
A0A0S0G7V0
Physiology
Insertion of a LTR retrotransposon N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
Ha_BtR
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
Ha_BtR
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
Insertion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Zhao J; Jin L; Yang Y ; et al. (2010)
Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]
1 Additional References
GP00000430
ABCA2
A0A0S0G7V0
Physiology
Insertion of an incomplete RNA transposon (1498bp) N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
Ha_BtR
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
Ha_BtR
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
Insertion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Zhao J; Jin L; Yang Y ; et al. (2010)
Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]
1 Additional References
GP00000431
ABCA2
A0A0S0G7V0
Physiology
Insertion of a DNA transposon N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
Ha_BtR
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
Ha_BtR
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
Insertion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Zhao J; Jin L; Yang Y ; et al. (2010)
Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]
1 Additional References
GP00000432
ABCA2
A0A0S0G7V0
Physiology
Insertion of a LTR retrotransposon N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
Ha_BtR
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
Ha_BtR
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
Insertion
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Zhao J; Jin L; Yang Y ; et al. (2010)
Diverse cadherin mutations conferring resistance to Bacillus thuringiensis toxin Cry1Ac in Helicover[...]
1 Additional References
GP00000433
ABCA2
A0A0S0G7V0
Physiology
Insertion of a LTR retrotransposon N
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
Ha_BtR
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
HAC1 (=ATQ1)
Xenobiotic resistance (soil contamination; arsenate)
Unknown,
Complex Change
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Sánchez-Bermejo E; Castrillo G; del Llano B ; et al. (2014)
Natural variation in arsenate tolerance identifies an arsenate reductase in Arabidopsis thaliana.
1 Additional References
GP00000434
HAC1
Q9C5X9
Physiology
Coding variation and differential gene expression in roots
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
HAC1 (=ATQ1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
HAC1 (=ATQ1)
Xenobiotic resistance (soil contamination; arsenate)
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Chao DY; Chen Y; Chen J ; et al. (2014)
Genome-wide association mapping identifies a new arsenate reductase enzyme critical for limiting ars[...]
GP00000435
HAC1
Q9C5X9
Physiology
1bp deletion resulting in frameshift N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
HAC1 (=ATQ1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
hairy (h)
Bristle number (thorax)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Robin C; Lyman RF; Long AD ; et al. (2002)
hairy: A quantitative trait locus for drosophila sensory bristle number.
GP00000436
h
P14003
Morphology
unknown; complex promoter indel variation shows high-association
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
hairy (h)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
HBS1L-MYB
Hematopoiesis (mean blood corpuscular hemoglobin)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001607
HBS1L
Q9Y450
Physiology
T>C at the associated SNP. Variants in MEP/erythroid-specific elements are putative functional variants
Homo sapiens
human - (species)
Homo sapiens
human - (species)
HBS1L-MYB
Homo sapiens
human - (species)
Published - Accepted by Curator
HBS1L-MYB
Hematopoiesis (mean blood corpuscular hemoglobin)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001608
HBS1L
Q9Y450
Physiology
A>G at the associated SNP. Variants in MEP/erythroid-specific elements are putative functional variants
Homo sapiens
human - (species)
Homo sapiens
human - (species)
HBS1L-MYB
Homo sapiens
human - (species)
Published - Accepted by Curator
HBS1L-MYB
Hematopoiesis (red blood cell count)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001609
HBS1L
Q9Y450
Physiology
C>T at the associated SNP. Variants in MEP/erythroid-specific elements are putative functional variants
Homo sapiens
human - (species)
Homo sapiens
human - (species)
HBS1L-MYB
Homo sapiens
human - (species)
Published - Accepted by Curator
HBS1L-MYB
Hematopoiesis (blood platelet count)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001614
HBS1L
Q9Y450
Physiology
T>C at the associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
HBS1L-MYB
Homo sapiens
human - (species)
Published - Accepted by Curator
heavy metal atpase3 (HMA3)
Metal tolerance
2 Mutations:
Coding
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Chao DY; Silva A; Baxter I ; et al. (2012)
Genome-wide association studies identify heavy metal ATPase3 as the primary determinant of natural v[...]
GP00000443
HMA3
P0CW78
Physiology
2 mutations
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
heavy metal atpase3 (HMA3)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
heavy metal atpase3 (HMA3)
Metal tolerance
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Chao DY; Silva A; Baxter I ; et al. (2012)
Genome-wide association studies identify heavy metal ATPase3 as the primary determinant of natural v[...]
GP00000444
HMA3
P0CW78
Physiology
1-bp deletion resulting in a premature stop codon resulting in hypofunctional transporter. This is a high-frequency allele; suggesting the hyper-functional alleles are only selected in Cd-rich soils N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
heavy metal atpase3 (HMA3)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
heavy metal atpase3 (HMA3)
Metal tolerance
Gene Amplification,
Complex Change
Noccaea caerulescens
(species)
Intraspecific
Candidate Gene
Ueno D; Milner MJ; Yamaji N ; et al. (2011)
Elevated expression of TcHMA3 plays a key role in the extreme Cd tolerance in a Cd-hyperaccumulating[...]
GP00000446
HMA3
P0CW78
Physiology
Copy number Variant
Noccaea caerulescens
(species)
Noccaea caerulescens
(species)
heavy metal atpase3 (HMA3)
Noccaea caerulescens
(species)
Published - Accepted by Curator
heavy metal atpase5 (HMA5)
Metal tolerance
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Kobayashi Y; Kuroda K; Kimura K ; et al. (2008)
Amino acid polymorphisms in strictly conserved domains of a P-type ATPase HMA5 are involved in the m[...]
GP00000450
HMA5
Q9SH30
Physiology
P626L
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
heavy metal atpase5 (HMA5)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
heavy metal atpase5 (HMA5)
Metal tolerance
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Kobayashi Y; Kuroda K; Kimura K ; et al. (2008)
Amino acid polymorphisms in strictly conserved domains of a P-type ATPase HMA5 are involved in the m[...]
GP00000451
HMA5
Q9SH30
Physiology
N923T
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
heavy metal atpase5 (HMA5)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
HECW-1
Pathogen avoidance
Coding,
SNP
Caenorhabditis elegans
(species)
Intraspecific
Linkage Mapping
Chang HC; Paek J; Kim DH (2011)
Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.
GP00000452
hecw-1
G5EEJ0
Behavior
Y322C
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species)
HECW-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
HECW-1
Pathogen avoidance
Coding,
SNP
Caenorhabditis elegans
(species)
Intraspecific
Linkage Mapping
Chang HC; Paek J; Kim DH (2011)
Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.
GP00000453
hecw-1
G5EEJ0
Behavior
Q325P
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species)
HECW-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
hemoglobin; HBA-T1 and T2 paralogues
Hypoxia response
5 Mutations:
Coding
SNP
Peromyscus maniculatus
North American deer mouse - (species) D
Intraspecific
Candidate Gene
Storz JF; Sabatino SJ; Hoffmann FG ; et al. (2007)
The molecular basis of high-altitude adaptation in deer mice.
2 Additional References
GP00000456
HBA1
P69905
Physiology
5 mutations
Peromyscus maniculatus
North American deer mouse - (species)
Peromyscus maniculatus
North American deer mouse - (species) D
hemoglobin; HBA-T1 and T2 paralogues
Peromyscus maniculatus
North American deer mouse - (species)
Published - Accepted by Curator
hemoglobin; HBA2
Hypoxia response
Coding,
SNP
Anas cyanoptera
cinnamon teal - (species) D
Intraspecific
Candidate Gene
McCracken KG; Barger CP; Bulgarella M ; et al. (2009)
Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.
1 Additional References
GP00000457
HBA1
P69905
Physiology
Asn9Ser
Anas cyanoptera
cinnamon teal - (species)
Anas cyanoptera
cinnamon teal - (species) D
hemoglobin; HBA2
Anas cyanoptera
cinnamon teal - (species)
Published - Accepted by Curator
hemoglobin; HBA2
Hypoxia response
Coding,
SNP
Anas flavirostris
Yellow-billed teal - (species) D
Intraspecific
Candidate Gene
McCracken KG; Barger CP; Bulgarella M ; et al. (2009)
Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.
1 Additional References
GP00000458
HBA1
P69905
Physiology
Ala77Thr
Anas flavirostris
Yellow-billed teal - (species)
Anas flavirostris
Yellow-billed teal - (species) D
hemoglobin; HBA2
Anas flavirostris
Yellow-billed teal - (species)
Published - Accepted by Curator
hemoglobin; HBA2
Hypoxia response
Coding,
SNP
Anas flavirostris
Yellow-billed teal - (species) D
Intraspecific
Candidate Gene
Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015)
Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]
GP00000459
HBAD
P02001
Physiology
Ser130Phe
Anas flavirostris
Yellow-billed teal - (species)
Anas flavirostris
Yellow-billed teal - (species) D
hemoglobin; HBA2
Anas flavirostris
Yellow-billed teal - (species)
Published - Accepted by Curator
hemoglobin; HBA2
Hypoxia response
Coding,
SNP
Lophonetta specularioides
crested duck - (species) D
Intraspecific
Candidate Gene
McCracken KG; Barger CP; Bulgarella M ; et al. (2009)
Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.
1 Additional References
GP00000463
HBA1
P69905
Physiology
Ala5Thr
Lophonetta specularioides
crested duck - (species)
Lophonetta specularioides
crested duck - (species) D
hemoglobin; HBA2
Lophonetta specularioides
crested duck - (species)
Published - Accepted by Curator
hemoglobin; HBA2
Hypoxia response
Coding,
SNP
Merganetta armata
(species) D
Intraspecific
Candidate Gene
Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015)
Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]
GP00000464
HBA1
P69905
Physiology
Ala77Thr
Merganetta armata
(species)
Merganetta armata
(species) D
hemoglobin; HBA2
Merganetta armata
(species)
Published - Accepted by Curator
hemoglobin; HBB
Pathogen resistance (Plasmodium; malaria parasite)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Jallow M; Teo YY; Small KS ; et al. (2009)
Genome-wide and fine-resolution association analysis of malaria in West Africa.
GP00000466
HBB
P68871
Physiology
Glu6Val
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
hemoglobin; HBB
Homo sapiens
human - (species)
Published - Accepted by Curator
hemoglobin; HBB
Hypoxia response
2 Mutations:
Coding
SNP
Anas flavirostris
Yellow-billed teal - (species) D
Intraspecific
Candidate Gene
McCracken KG; Barger CP; Bulgarella M ; et al. (2009)
Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.
1 Additional References
GP00000467
HBB
P68871
Physiology
2 mutations
Anas flavirostris
Yellow-billed teal - (species)
Anas flavirostris
Yellow-billed teal - (species) D
hemoglobin; HBB
Anas flavirostris
Yellow-billed teal - (species)
Published - Accepted by Curator
hemoglobin; HBB
Hypoxia response
2 Mutations:
Coding
SNP
Anas georgica
yellow-billed pintail - (species) D
Intraspecific
Candidate Gene
McCracken KG; Barger CP; Bulgarella M ; et al. (2009)
Parallel evolution in the major haemoglobin genes of eight species of Andean waterfowl.
1 Additional References
GP00000468
HBB
P68871
Physiology
2 mutations
Anas georgica
yellow-billed pintail - (species)
Anas georgica
yellow-billed pintail - (species) D
hemoglobin; HBB
Anas georgica
yellow-billed pintail - (species)
Published - Accepted by Curator
hemoglobin; HBB
Hypoxia response
Coding,
SNP
Lophonetta specularioides
crested duck - (species) D
Intraspecific
Candidate Gene
Natarajan C; Projecto-Garcia J; Moriyama H ; et al. (2015)
Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Paral[...]
GP00000472
HBB
P68871
Physiology
Asp94Glu
Lophonetta specularioides
crested duck - (species)
Lophonetta specularioides
crested duck - (species) D
hemoglobin; HBB
Lophonetta specularioides
crested duck - (species)
Published - Accepted by Curator
hemoglobin; HBB-T1 and T2 paralogues
Hypoxia response
4 Mutations:
Coding
SNP
Peromyscus maniculatus
North American deer mouse - (species) D
Intraspecific
Candidate Gene
Storz JF; Runck AM; Sabatino SJ ; et al. (2009)
Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer [...]
1 Additional References
GP00000476
HBB
P68871
Physiology
4 mutations
Peromyscus maniculatus
North American deer mouse - (species)
Peromyscus maniculatus
North American deer mouse - (species) D
hemoglobin; HBB-T1 and T2 paralogues
Peromyscus maniculatus
North American deer mouse - (species)
Published - Accepted by Curator
high expression of osmotically responsive genes 2
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001435
SAL1
Q42546
Physiology
unknown
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
high expression of osmotically responsive genes 2
Arabidopsis arenosa
(species)
Published - Accepted by Curator
HLA-DQA1
Histocompatibility
Cis-regulatory,
Unknown
Papio
baboons - (genus)
Intraspecific
Candidate Gene
Loisel DA; Rockman MV; Wray GA ; et al. (2006)
Ancient polymorphism and functional variation in the primate MHC-DQA1 5' cis-regulatory region.
GP00000478
HLA-DQA1
P01909
Physiology
Promoter variation
Papio
baboons - (genus)
Papio
baboons - (genus)
HLA-DQA1
Papio
baboons - (genus)
Published - Accepted by Curator
HLA-DRB1
Pathogen resistance (typhoid fever)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Dunstan SJ; Hue NT; Han B ; et al. (2014)
Variation at HLA-DRB1 is associated with resistance to enteric fever.
GP00000479
HLA-DRB1
Q30167
Physiology
uncharacterized
Homo sapiens
human - (species)
Homo sapiens
human - (species)
HLA-DRB1
Homo sapiens
human - (species)
Published - Accepted by Curator
HMGA2
Body size (height; bone mineral density)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Weedon MN; Lettre G; Freathy RM ; et al. (2007)
A common variant of HMGA2 is associated with adult and childhood height in the general population.
3 Additional References
GP00000486
HMGA2
P52926
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
HMGA2
Homo sapiens
human - (species)
Published - Accepted by Curator
HP1D2
Sex determination (sex ratio distortion)
Coding,
Deletion
N
Drosophila simulans
(species) D
Intraspecific
Linkage Mapping
Helleu Q; Gérard PR; Dubruille R ; et al. (2016)
Rapid evolution of a Y-chromosome heterochromatin protein underlies sex chromosome meiotic drive.
GP00001467
HP1D2
B4R6K0
Physiology
deletion of 371bp that removes one-half (371bp) of the HP1D2 coding sequence resulting in a frameshift that prevents the translation of the C-terminal chromo shadow domain (CSD) mediating protein N
Drosophila simulans
(species)
Drosophila simulans
(species) D
HP1D2
Drosophila simulans
(species)
Published - Accepted by Curator
Hps4
Coloration (albinism)
Coding,
Deletion
N
Ictalurus punctatus
channel catfish - (species) D
Intraspecific
Association Mapping
Li Y; Geng X; Bao L ; et al. (2017)
A deletion in the Hermansky-Pudlak syndrome 4 (Hps4) gene appears to be responsible for albinism in [...]
GP00002122
Hps4
Q99KG7
Morphology
A 99‐bp deletion was identified spanning intron 2 and exon 3 junction of the Hps4 gene N
Ictalurus punctatus
channel catfish - (species)
Ictalurus punctatus
channel catfish - (species) D
Hps4
Ictalurus punctatus
channel catfish - (species)
Published - Accepted by Curator
hsp70Ba
Temperature tolerance
Cis-regulatory,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Lerman DN; Michalak P; Helin AB ; et al. (2003)
Modification of heat-shock gene expression in Drosophila melanogaster populations via transposable e[...]
GP00002004
Hsp70Ba
Q8INI8
Physiology
A 1447 bp fragment corresponding to the 39 end of a jockey element is inserted 107 bps upstream of the hsp70Ba transcription start site in the T strain. The insertion intervenes between HSEs 2 and 3; displacing HSEs 3 and 4 as well as three GAGA elements.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
hsp70Ba
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
hsp70Ba
Temperature tolerance
Cis-regulatory,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Lerman DN; Michalak P; Helin AB ; et al. (2003)
Modification of heat-shock gene expression in Drosophila melanogaster populations via transposable e[...]
GP00002005
Hsp70Ba
Q8INI8
Physiology
Insertion of a 1222bp non-autonomous P-element at position -184 relative to the Hsp70Ba transcription start site. The P-element intervenes between the second and third heat shock response elements (HSEs).
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
hsp70Ba
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
hsp70Ba
Temperature tolerance
Cis-regulatory,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Lerman DN; Michalak P; Helin AB ; et al. (2003)
Modification of heat-shock gene expression in Drosophila melanogaster populations via transposable e[...]
GP00002006
Hsp70Ba
Q8INI8
Physiology
A non-autonomous 1383bp P-element is inserted 97bp upstream of the Hsp70Ba transcription start site. The P-element intervenes between the second and third heat shock response elements (HSEs).
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
hsp70Ba
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
HSP90
Developmental time
Unknown,
Insertion
Locusta migratoria
migratory locust - (species) D
Intraspecific
Candidate Gene
Chen B; Zhang B; Xu L ; et al. (2017)
Transposable Element-Mediated Balancing Selection at Hsp90 Underlies Embryo Developmental Variation.
GP00002437
daf-21
Q18688
Physiology
an Lm1 SINE insertion in the third exon of the Hsp90 gene produces an alternative splicing form associated with faster development and higher developmental synchrony. Found by scanning Lm1 insertions in natural locust populations.
Locusta migratoria
migratory locust - (species)
Locusta migratoria
migratory locust - (species) D
HSP90
Locusta migratoria
migratory locust - (species)
Published - Accepted by Curator
HUA2
Flowering time
Shoot morphology
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Wang Q; Sajja U; Rosloski S ; et al. (2007)
HUA2 caused natural variation in shoot morphology of A. thaliana.
GP00000491
HUA2
Q9XER9
Physiology
Morphology
K525E N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
HUA2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
HUA2
Flowering time
Coloration (temperature-dependent)
Coding,
Unknown
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Ilk N; Ding J; Ihnatowicz A ; et al. (2015)
Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attrib[...]
1 Additional References
GP00001230
HUA2
Q9XER9
Physiology
Morphology
Premature stop codon resulting in truncation of 290 C-terminal amino-acids (hua-2-5 Ler allele) N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
HUA2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Human Leukocyte Antigen-B (HLA-B)
Pathogen resistance (HIV control)
5 Mutations:
Coding
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
; Pereyra F; Jia X ; et al. (2010)
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
GP00000492
HLA-B
P01889
Physiology
5 mutations
Homo sapiens
human - (species)
Homo sapiens
human - (species)
Human Leukocyte Antigen-B (HLA-B)
Homo sapiens
human - (species)
Published - Accepted by Curator
I Kappa B Kinase Interacting Protein (IKBIP)
Lifespan
Unknown,
Unknown
Nothobranchius furzeri
turquoise killifish - (species)
Intraspecific
Association Mapping
Reichwald K; Petzold A; Koch P ; et al. (2015)
Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish.
GP00001678
IKBIP
Q70UQ0
Physiology
Under positive selection; down regulated in aging skin
Nothobranchius furzeri
turquoise killifish - (species)
Nothobranchius furzeri
turquoise killifish - (species)
I Kappa B Kinase Interacting Protein (IKBIP)
Nothobranchius furzeri
turquoise killifish - (species)
Published - Accepted by Curator
ICARUS1
Plant growth (leaf morphology ; temperature-dependent)
Hypersensitive to DNA damage
2 Mutations:
Coding
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Zhu W; Ausin I; Seleznev A ; et al. (2015)
Natural Variation Identifies ICARUS1, a Universal Gene Required for Cell Proliferation and Growth at[...]
GP00002066
ICA1
A0A0F7PXK5
Physiology
Physiology
2 mutations
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
ICARUS1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
IGK
Pathogen resistance
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001382
IGKV1-5
P01602
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
IGK
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
IIL1
Plant growth (pleiotropic growth abnormalities)
Cis-regulatory,
Insertion
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Sureshkumar S; Todesco M; Schneeberger K ; et al. (2009)
A genetic defect caused by a triplet repeat expansion in Arabidopsis thaliana.
1 Additional References
GP00001229
IIL1
Q94AR8
Morphology
expansion of a GAA/TTC trinucleotide repeat in the third intron
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
IIL1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
IL4
Immune response
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Linkage Mapping
Rockman MV; Hahn MW; Soranzo N ; et al. (2003)
Positive selection on a human-specific transcription factor binding site regulating IL4 expression.
GP00000497
IL4
P05112
Physiology
_524T promoter single base-pair substitution affecting binding of the NFAT transcription factor
Homo sapiens
human - (species)
Homo sapiens
human - (species)
IL4
Homo sapiens
human - (species)
Published - Accepted by Curator
IME1
Sporulation efficiency
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Intraspecific
Linkage Mapping
Gerke J; Lorenz K; Cohen B (2009)
Genetic interactions between transcription factors cause natural variation in yeast.
GP00000498
IME1
P21190
Physiology
L325M and/or 1bp synonymous substitution
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
IME1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
Immune deficiency
Pathogen resistance
Cis-regulatory,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Lazzaro BP; Sceurman BK; Clark AG (2004)
Genetic basis of natural variation in D. melanogaster antibacterial immunity.
GP00000499
imd
Q9NHG0
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Immune deficiency
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Inhibitor of DNA binding 3 (id3)
Lifespan
Unknown,
Unknown
Nothobranchius furzeri
turquoise killifish - (species) D
Intraspecific
Association Mapping
Reichwald K; Petzold A; Koch P ; et al. (2015)
Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish.
GP00001676
ID3
Q02535
Physiology
Signature of selection for id3. upregulated during aging in brain and skin. A radical substitution of a non-polar by a charged aa (A>Q) followed by a 2-aa deletion in the C-terminus
Nothobranchius furzeri
turquoise killifish - (species)
Nothobranchius furzeri
turquoise killifish - (species) D
Inhibitor of DNA binding 3 (id3)
Nothobranchius furzeri
turquoise killifish - (species)
Published - Accepted by Curator
InR
Fertility
Developmental time
Body size
Stress response
Lifespan
Coding,
Indel
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Paaby AB; Bergland AO; Behrman EL ; et al. (2014)
A highly pleiotropic amino acid polymorphism in the Drosophila insulin receptor contributes to life-[...]
1 Additional References
GP00002663
InR
P09208
Morphology
Morphology; Physiology
Physiology
Physiology
Physiology
Deletion of 9 nucleotides in the first exon. The two alleles differ by presence/absence of the three amino acids QHH.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
InR
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Insulin-like growth factor receptor 1 (IGF1R)
Body size (height)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Lettre G (2011)
Recent progress in the study of the genetics of height.
GP00000503
IGF1R
P08069
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
Insulin-like growth factor receptor 1 (IGF1R)
Homo sapiens
human - (species)
Published - Accepted by Curator
IRF4
Coloration (skin)
Cis-regulatory,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Praetorius C; Grill C; Stacey SN ; et al. (2013)
A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway[...]
1 Additional References
GP00001364
IRF4
Q15306
Morphology
a C>T substitution in intron4 located within an enhancer
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
IRF4
Homo sapiens
human - (species)
Published - Accepted by Curator
JAK2
Hematopoiesis (blood platelet count)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001613
JAK2
O60674
Physiology
G>A at the associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
JAK2
Homo sapiens
human - (species)
Published - Accepted by Curator
JAZF1
Body size (height)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Johansson A; Marroni F; Hayward C ; et al. (2009)
Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide assoc[...]
1 Additional References
GP00000507
JAZF1
Q86VZ6
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
JAZF1
Homo sapiens
human - (species)
Published - Accepted by Curator
Jheh1-Jheh2-Jheh3 complex
Oxidative stress resistance
Cis-regulatory,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Association Mapping
González J; Macpherson JM; Petrov DA (2009)
A recent adaptive transposable element insertion near highly conserved developmental loci in Drosoph[...]
1 Additional References
GP00001782
JHEH
Q6U6J0
Physiology
insertion of a transposable element Bari-Jheh associated with downregulation of Juvenile hormone epoxy hydroxylase 2 (Jheh2) and Jheh3 in nonstress conditions and with upregulation of Jheh1 and Jheh2 and downregulation of Jheh3 under oxidative stress conditions
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Jheh1-Jheh2-Jheh3 complex
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
JMJD1C
Hematopoiesis (mean blood platelet volume)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001606
JMJD1C
Q15652
Physiology
T>A at the associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
JMJD1C
Homo sapiens
human - (species)
Published - Accepted by Curator
K+ uptake permease 9
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001430
POT9
O49423
Physiology
unknown
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
K+ uptake permease 9
Arabidopsis arenosa
(species)
Published - Accepted by Curator
KCNH4 - uncertain
Freshwater adaptation
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Association Mapping
Jones FC; Grabherr MG; Chan YF ; et al. (2012)
The genomic basis of adaptive evolution in threespine sticklebacks.
GP00000510
KCNH4
Q9UQ05
Physiology
Large Inversion resulting in alternative transcripts
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
KCNH4 - uncertain
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
KCNQ1
Body size (height)
Unknown,
Epigenetic Change
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Zoledziewska M; Sidore C; Chiang CWK ; et al. (2015)
Height-reducing variants and selection for short stature in Sardinia.
GP00000511
KCNQ1
P51787
Morphology
unknown causative change in an imprinted region - consistent with maternal inheritance detected by the association
Homo sapiens
human - (species)
Homo sapiens
human - (species)
KCNQ1
Homo sapiens
human - (species)
Published - Accepted by Curator
KCS18
Oil composition
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Jasinski S; Lécureuil A; Miquel M ; et al. (2012)
Natural variation in seed very long chain fatty acid content is controlled by a new isoform of KCS18[...]
GP00000512
FAE1
Q38860
Physiology
L407V N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
KCS18
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001510
PF3D7_1343700
Q8IDQ2
Physiology
D353Y affecting the BTB/POZ domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001511
PF3D7_1343700
Q8IDQ2
Physiology
P441L affecting the BTB/POZ domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001512
PF3D7_1343700
Q8IDQ2
Physiology
F446I affecting the encoded propeller and BTB/POZ domains
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001513
PF3D7_1343700
Q8IDQ2
Physiology
G449A affecting the encoded propeller and BTB/POZ domains
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001514
PF3D7_1343700
Q8IDQ2
Physiology
N458Y affecting the encoded propeller and BTB/POZ domains
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001515
PF3D7_1343700
Q8IDQ2
Physiology
A481V affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001516
PF3D7_1343700
Q8IDQ2
Physiology
p.Tyr493His affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001517
PF3D7_1343700
Q8IDQ2
Physiology
N525D affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001518
PF3D7_1343700
Q8IDQ2
Physiology
N537I affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001519
PF3D7_1343700
Q8IDQ2
Physiology
p.Arg539Thr affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001520
PF3D7_1343700
Q8IDQ2
Physiology
p.Ile543Thr affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001521
PF3D7_1343700
Q8IDQ2
Physiology
p.Pro553Leu affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001522
PF3D7_1343700
Q8IDQ2
Physiology
R561H affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001523
PF3D7_1343700
Q8IDQ2
Physiology
V568G affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001524
PF3D7_1343700
Q8IDQ2
Physiology
P574L affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001525
PF3D7_1343700
Q8IDQ2
Physiology
p.Cys580Tyr affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001526
PF3D7_1343700
Q8IDQ2
Physiology
D584V affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001527
PF3D7_1343700
Q8IDQ2
Physiology
F673I affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001528
PF3D7_1343700
Q8IDQ2
Physiology
A675V affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001529
PF3D7_1343700
Q8IDQ2
Physiology
H719N affecting the encoded propeller domain
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kelch 13 (K13)
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Candidate Gene
Straimer J; Gnädig NF; Witkowski B ; et al. (2015)
Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clin[...]
GP00001388
PF13_0238
A0A077LQB4
Physiology
M476I
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
kelch 13 (K13)
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
kin of irre (kire)
Xenobiotic resistance (methylmercury ; development)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Association Mapping
Montgomery SL; Vorojeikina D; Huang W ; et al. (2014)
Genome-wide association analysis of tolerance to methylmercury toxicity in Drosophila implicates myo[...]
GP00001398
kirre
Q9N9Y9
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
kin of irre (kire)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Kit ligand
Coloration (coat)
Cis-regulatory,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Miller CT; Beleza S; Pollen AA ; et al. (2007)
cis-Regulatory changes in Kit ligand expression and parallel evolution of pigmentation in sticklebac[...]
1 Additional References
GP00000522
KITLG
P21583
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
Kit ligand
Homo sapiens
human - (species)
Published - Accepted by Curator
Kit ligand
Coloration (gills; ventrum)
Cis-regulatory,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Linkage Mapping
Miller CT; Beleza S; Pollen AA ; et al. (2007)
cis-Regulatory changes in Kit ligand expression and parallel evolution of pigmentation in sticklebac[...]
GP00000523
KITLG
P21583
Morphology
Not identified
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Kit ligand
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
Kit ligand
Coloration (hair)
Cis-regulatory,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Guenther CA; Tasic B; Luo L ; et al. (2014)
A molecular basis for classic blond hair color in Europeans.
GP00001349
KITLG
P21583
Morphology
A>G SNP(rs12821256) 350kb upstream of transcription start
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Kit ligand
Homo sapiens
human - (species)
Published - Accepted by Curator
KUK
Root development
2 Mutations:
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Association Mapping
Meijón M; Satbhai SB; Tsuchimatsu T ; et al. (2014)
Genome-wide association study using cellular traits identifies a new regulator of root development i[...]
GP00001233
At1g60370
O80758
Morphology
2 mutations
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
KUK
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
L6
Pathogen resistance
Coding,
Insertion
N
Linum usitatissimum
flax - (species)
Intraspecific
Linkage Mapping
Lawrence GJ; Finnegan EJ; Ayliffe MA ; et al. (1995)
The L6 gene for flax rust resistance is related to the Arabidopsis bacterial resistance gene RPS2 an[...]
GP00000528
L6
Q40253
Physiology
Truncated protein due to insertion of a transposable element. Reversion to resistance among descendants of mutant X75 was associated with excision of the newly transposable element Ac. N
Linum usitatissimum
flax - (species)
Linum usitatissimum
flax - (species)
L6
Linum usitatissimum
flax - (species)
Published - Accepted by Curator
LACCASE 8
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001436
LAC8
Q9LFD2
Physiology
unknown
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
LACCASE 8
Arabidopsis arenosa
(species)
Published - Accepted by Curator
lactase (LCT)
Lactose tolerance (adult)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Linkage Mapping
Enattah NS; Sahi T; Savilahti E ; et al. (2002)
Identification of a variant associated with adult-type hypolactasia.
1 Additional References
GP00000529
LCT
P09848
Physiology
C-13910T
Homo sapiens
human - (species)
Homo sapiens
human - (species)
lactase (LCT)
Homo sapiens
human - (species)
Published - Accepted by Curator
lactase (LCT)
Lactose tolerance (adult)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Tishkoff SA; Reed FA; Ranciaro A ; et al. (2007)
Convergent adaptation of human lactase persistence in Africa and Europe.
GP00000530
LCT
P09848
Physiology
C-13907G
Homo sapiens
human - (species)
Homo sapiens
human - (species)
lactase (LCT)
Homo sapiens
human - (species)
Published - Accepted by Curator
lactase (LCT)
Lactose tolerance (adult)
Cis-regulatory,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Tishkoff SA; Reed FA; Ranciaro A ; et al. (2007)
Convergent adaptation of human lactase persistence in Africa and Europe.
GP00000531
LCT
P09848
Physiology
T-13915G
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
lactase (LCT)
Homo sapiens
human - (species)
Published - Accepted by Curator
lactase (LCT)
Lactose tolerance (adult)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Tishkoff SA; Reed FA; Ranciaro A ; et al. (2007)
Convergent adaptation of human lactase persistence in Africa and Europe.
1 Additional References
GP00000532
LCT
P09848
Physiology
G14010C ; In Khoe Pastoralist group lactase persistence (LP)-regulatory region 2 SNPs with greatest frequencies 13910C>T and 14010G>C
Homo sapiens
human - (species)
Homo sapiens
human - (species)
lactase (LCT)
Homo sapiens
human - (species)
Published - Accepted by Curator
lactase (LCT)
Lactose tolerance (adult)
Cis-regulatory,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Jones BL; Raga TO; Liebert A ; et al. (2013)
Diversity of lactase persistence alleles in Ethiopia: signature of a soft selective sweep.
1 Additional References
GP00001714
LCT
P09848
Physiology
T14009G (rs869051967) (ss 820486563)
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
lactase (LCT)
Homo sapiens
human - (species)
Published - Accepted by Curator
lactate dehydrogenase-B (Ldh-B)
Stress response
Cis-regulatory,
Unknown
Fundulus heteroclitus
mummichog - (species)
Intraspecific
Linkage Mapping
Schulte PM; Glemet HC; Fiebig AA ; et al. (2000)
Adaptive variation in lactate dehydrogenase-B gene expression: role of a stress-responsive regulator[...]
GP00000533
ldhb
P20373
Physiology
unknown - candidate 1 bp change in southern populatin generates mammary tumor virus glucocorticoid responsive element
Fundulus heteroclitus
mummichog - (species)
Fundulus heteroclitus
mummichog - (species)
lactate dehydrogenase-B (Ldh-B)
Fundulus heteroclitus
mummichog - (species)
Published - Accepted by Curator
Latexin (Lxn)
Stem cell number (hematopoietic precursors)
Cis-regulatory,
Unknown
Mus musculus
house mouse - (species)
Intraspecific
Linkage Mapping
Liang Y; Jansen M; Aronow B ; et al. (2007)
The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in[...]
GP00000534
Lxn
P70202
Morphology
Not identified
Mus musculus
house mouse - (species)
Mus musculus
house mouse - (species)
Latexin (Lxn)
Mus musculus
house mouse - (species)
Published - Accepted by Curator
LCORL
Body size
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Horikoshi M; Yaghootkar H; Mook-Kanamori DO ; et al. (2013)
New loci associated with birth weight identify genetic links between intrauterine growth[...]
GP00000537
LCORL
Q8N3X6
Morphology
Not identified
Homo sapiens
human - (species)
Homo sapiens
human - (species)
LCORL
Homo sapiens
human - (species)
Published - Accepted by Curator
Ldia2 - Diaphanous-related formin
Shell chirality (coiling)
Coding,
Deletion
N
Lymnaea stagnalis
great pond snail - (species) D
Intraspecific
Association Mapping
Davison A; McDowell GS; Holden JM ; et al. (2016)
Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog.
GP00000538
DIAPH1
O60610
Morphology
1bp deletion resulting in frame-shift (pseudogenization) N
Lymnaea stagnalis
great pond snail - (species)
Lymnaea stagnalis
great pond snail - (species) D
Ldia2 - Diaphanous-related formin
Lymnaea stagnalis
great pond snail - (species)
Published - Accepted by Curator
Lectin-24A
Pathogen resistance (parasitic wasp)
Cis-regulatory,
Deletion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022
)
Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite
GP00002655
lectin-24A
Q9VQU4
Physiology
A cis-regulatory polymorphism in the gene Lectin-24A abolishes expression after infection and strongly reduces survival. 21bp indel (c.-171_-151del)
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Lectin-24A
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Lectin-24A
Pathogen resistance (parasitic wasp)
Coding,
Deletion
N
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022
)
Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite
GP00002656
lectin-24A
Q9VQU4
Physiology
a 165bp deletion in the protein coding sequence that results in a shift in the reading frame and a premature stop codon (p.Phe217_Glu273del*) N
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Lectin-24A
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Lectin-24A
Pathogen resistance (parasitic wasp)
Coding,
SNP
N
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022
)
Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite
GP00002657
Physiology
L81 >STOP - point mutation that introduces a premature stop codon N
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Lectin-24A
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Lectin-24A
Pathogen resistance (parasitic wasp)
Coding,
SNP
N
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022
)
Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite
GP00002658
lectin-24A
Q9VQU4
Physiology
Q254 >STOP - point mutation that introduces a premature stop codon N
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Lectin-24A
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Lectin-24A
Pathogen resistance (parasitic wasp)
Coding,
SNP
N
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Arunkumar Ramesh; Zhou Shuyu Olivia; Day Jonathan P ; et al. (2022
)
Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite
GP00002659
lectin-24A
Q9VQU4
Physiology
F217 >STOP - point mutation that introduces a premature stop codon N
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Lectin-24A
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
LIN28B
Body size (height)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Lettre G (2011)
Recent progress in the study of the genetics of height.
GP00000548
LIN28B
Q6ZN17
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
LIN28B
Homo sapiens
human - (species)
Published - Accepted by Curator
Linamarase
Toxicity levels (cyanogenic glucoside)
Gene Loss,
Deletion
N
Trifolium repens
white clover - (species) D
Intraspecific
Linkage Mapping
Olsen KM; Hsu SC; Small LL (2008)
Evidence on the molecular basis of the Ac/ac adaptive cyanogenesis polymorphism in white clover (Tri[...]
1 Additional References
GP00000549
LI
P26205
Physiology
Gene deletion N
Trifolium repens
white clover - (species)
Trifolium repens
white clover - (species) D
Linamarase
Trifolium repens
white clover - (species)
Published - Accepted by Curator
lncRNA:Hsr omega
Temperature tolerance
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
McKechnie SW; Halford MM; McColl G ; et al. (1998)
Both allelic variation and expression of nuclear and cytoplasmic transcripts of Hsr-omega are closel[...]
1 Additional References
GP00001999
Physiology
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
lncRNA:Hsr omega
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
LPAR1
Hematopoiesis (blood monocyte count)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001612
LPAR1
Q92633
Physiology
A>G at the associated SNP. 2 variants located in an uncharacterized long noncoding RNA
Homo sapiens
human - (species)
Homo sapiens
human - (species)
LPAR1
Homo sapiens
human - (species)
Published - Accepted by Curator
luciferase
Bioluminescence spectrum
Coding,
SNP
Pyrophorus plagiophthalamus
(species)
Intraspecific
Candidate Gene
Stolz U; Velez S; Wood KV ; et al. (2003)
Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle.
2 Additional References
GP00000553
P08659
Physiology
T739G and C740G in exon 4; leading to one amino acid change - colour difference between the yellow- and orange-emitting luciferases is due entirely to S247G
Pyrophorus plagiophthalamus
(species)
Pyrophorus plagiophthalamus
(species)
luciferase
Pyrophorus plagiophthalamus
(species)
Published - Accepted by Curator
luciferase
Bioluminescence spectrum
2 Mutations:
Coding
SNP
Pyrophorus plagiophthalamus
(species)
Intraspecific
Candidate Gene
Stolz U; Velez S; Wood KV ; et al. (2003)
Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle.
2 Additional References
GP00000554
P08659
Physiology
2 mutations
Pyrophorus plagiophthalamus
(species)
Pyrophorus plagiophthalamus
(species)
luciferase
Pyrophorus plagiophthalamus
(species)
Published - Accepted by Curator
luciferase
Bioluminescence spectrum
Coding,
SNP
Pyrophorus plagiophthalamus
(species)
Intraspecific
Candidate Gene
Stolz U; Velez S; Wood KV ; et al. (2003)
Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle.
2 Additional References
GP00001758
P08659
Physiology
exact causing amino acid change(s) unknown
Pyrophorus plagiophthalamus
(species)
Pyrophorus plagiophthalamus
(species)
luciferase
Pyrophorus plagiophthalamus
(species)
Published - Accepted by Curator
LY86
Body fat distribution (visceral/subcutaneous ratio)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001562
LY86
O95711
Physiology
A>T in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
LY86
Homo sapiens
human - (species)
Published - Accepted by Curator
LYPLAL1
Body fat distribution (visceral/subcutaneous ratio)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001561
LYPLAL1
Q5VWZ2
Physiology
T>C in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
LYPLAL1
Homo sapiens
human - (species)
Published - Accepted by Curator
M
Pathogen resistance
Coding,
Deletion
Linum usitatissimum
flax - (species) D
Intraspecific
Linkage Mapping
Anderson PA; Lawrence GJ; Morrish BC ; et al. (1997)
Inactivation of the flax rust resistance gene M associated with loss of a repeated unit within the l[...]
GP00000559
P93244
Physiology
426bp deletion, probably by unequal recombination
Linum usitatissimum
flax - (species)
Linum usitatissimum
flax - (species) D
M
Linum usitatissimum
flax - (species)
Published - Accepted by Curator
mab-23
Male genitalia
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Lints R; Emmons SW (2002)
Regulation of sex-specific differentiation and mating behavior in C. elegans by a new member of the [...]
1 Additional References
GP00001323
mab-23
G5ECK3
Morphology
TGC>TTC - cysteine of the DM motif transformed into phenylalanine; so is likely to disrupt DNA-binding function N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
mab-23
Caenorhabditis elegans
(species)
Published - Accepted by Curator
Mac1
Virulence
Unknown,
Unknown
Cryptococcus neoformans
(species)
Intraspecific
Linkage Mapping
Lin X; Huang JC; Mitchell TG ; et al. (2006)
Virulence attributes and hyphal growth of C. neoformans are quantitative traits and the MATalpha all[...]
GP00000560
CGB_D8050W
E6R4R6
Physiology
unknown
Cryptococcus neoformans
(species)
Cryptococcus neoformans
(species)
Mac1
Cryptococcus neoformans
(species)
Published - Accepted by Curator
MADS AFFECTING FLOWERING 2 (MAF2)
Flowering time
Cis-regulatory,
Insertion
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Rosloski SM; Jali SS; Balasubramanian S ; et al. (2010)
Natural diversity in flowering responses of Arabidopsis thaliana caused by variation in a tandem gen[...]
GP00000561
MAF2
Q84J38
Physiology
Insertion alleles - several
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
MADS AFFECTING FLOWERING 2 (MAF2)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
MAM1
Glucosinolate content
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Kroymann J; Textor S; Tokuhisa JG ; et al. (2001)
A gene controlling variation in Arabidopsis glucosinolate composition is part of the methionine chai[...]
3 Additional References
GP00000562
MAM1
Q9FG67
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
MAM1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
MaMyb2
Coloration (flowers)
Cis-regulatory,
Unknown
Diplacus aurantiacus
(species)
Intraspecific
Linkage Mapping
Streisfeld MA; Young WN; Sobel JM (2013)
Divergent selection drives genetic differentiation in an R2R3-MYB transcription factor that contribu[...]
GP00000563
Myb2
M9QXG2
Morphology
unknown expression-phenotype co-vary
Diplacus aurantiacus
(species)
Diplacus aurantiacus
(species)
MaMyb2
Diplacus aurantiacus
(species)
Published - Accepted by Curator
MAP4K4
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Unknown,
Unknown
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Linkage Mapping
Guo Z; Kang S; Chen D ; et al. (2015)
MAPK signaling pathway alters expression of midgut ALP and ABCC genes and causes resistance to Bacil[...]
GP00001673
MAP4K4
O95819
Physiology
MAP4K4 constitutively up-regulated leading to up-regulated PxABCC1 and down-regulated PxABCC2 and PxABCC3 and reduction of membrane-bound ALP (mALP) expression responsible for reduced Cry1Ac toxin binding to midgut proteins
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
MAP4K4
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
MARVELD3
Pathogen resistance (Plasmodium; malaria parasite)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Timmann C; Thye T; Vens M ; et al. (2012)
Genome-wide association study indicates two novel resistance loci for severe malaria.
GP00000564
MARVELD3
Q96A59
Physiology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
MARVELD3
Homo sapiens
human - (species)
Published - Accepted by Curator
MC1R
Coloration (albinism)
Coding,
Deletion
N
Astyanax mexicanus
Mexican tetra - (species) D
Intraspecific
Linkage Mapping
Gross JB; Borowsky R; Tabin CJ (2009)
A novel role for Mc1r in the parallel evolution of depigmentation in independent populations of the [...]
GP00000567
MC1R
Q01726
Morphology
2bp deletion resulting in frameshift N
Astyanax mexicanus
Mexican tetra - (species)
Astyanax mexicanus
Mexican tetra - (species) D
MC1R
Astyanax mexicanus
Mexican tetra - (species)
Published - Accepted by Curator
MC1R
Coloration (albinism)
Coding,
SNP
Astyanax mexicanus
Mexican tetra - (species) D
Intraspecific
Linkage Mapping
Gross JB; Borowsky R; Tabin CJ (2009)
A novel role for Mc1r in the parallel evolution of depigmentation in independent populations of the [...]
GP00000568
MC1R
Q01726
Morphology
Arg164Cys (position 160 in human; so this mutation resembles the human R160W hypomorphic human mutation)
Astyanax mexicanus
Mexican tetra - (species)
Astyanax mexicanus
Mexican tetra - (species) D
MC1R
Astyanax mexicanus
Mexican tetra - (species)
Published - Accepted by Curator
MC1R
Coloration (coat)
Coding,
SNP
Chaetodipus intermedius
rock pocket mouse - (species) D
Intraspecific
Candidate Gene
Nachman MW; Hoekstra HE; D'Agostino SL (2003)
The genetic basis of adaptive melanism in pocket mice.
GP00000576
MC1R
Q01726
Morphology
R18C
Chaetodipus intermedius
rock pocket mouse - (species)
Chaetodipus intermedius
rock pocket mouse - (species) D
MC1R
Chaetodipus intermedius
rock pocket mouse - (species)
Published - Accepted by Curator
MC1R
Coloration (coat)
Coding,
SNP
Chaetodipus intermedius
rock pocket mouse - (species) D
Intraspecific
Candidate Gene
Nachman MW; Hoekstra HE; D'Agostino SL (2003)
The genetic basis of adaptive melanism in pocket mice.
GP00000577
MC1R
Q01726
Morphology
R109W
Chaetodipus intermedius
rock pocket mouse - (species)
Chaetodipus intermedius
rock pocket mouse - (species) D
MC1R
Chaetodipus intermedius
rock pocket mouse - (species)
Published - Accepted by Curator
MC1R
Coloration (coat)
Coding,
SNP
Chaetodipus intermedius
rock pocket mouse - (species) D
Intraspecific
Candidate Gene
Nachman MW; Hoekstra HE; D'Agostino SL (2003)
The genetic basis of adaptive melanism in pocket mice.
GP00000578
MC1R
Q01726
Morphology
R160W
Chaetodipus intermedius
rock pocket mouse - (species)
Chaetodipus intermedius
rock pocket mouse - (species) D
MC1R
Chaetodipus intermedius
rock pocket mouse - (species)
Published - Accepted by Curator
MC1R
Coloration (coat)
Coding,
SNP
Chaetodipus intermedius
rock pocket mouse - (species) D
Intraspecific
Candidate Gene
Nachman MW; Hoekstra HE; D'Agostino SL (2003)
The genetic basis of adaptive melanism in pocket mice.
GP00000579
MC1R
Q01726
Morphology
Q233H
Chaetodipus intermedius
rock pocket mouse - (species)
Chaetodipus intermedius
rock pocket mouse - (species) D
MC1R
Chaetodipus intermedius
rock pocket mouse - (species)
Published - Accepted by Curator
MC1R
Coloration (coat)
Coding,
SNP
Equus caballus
horse - (species)
Intraspecific
Candidate Gene
Marklund L; Moller MJ; Sandberg K ; et al. (1996)
A missense mutation in the gene for melanocyte-stimulating hormone receptor (MC1R) is associated wit[...]
1 Additional References
GP00000580
MC1R
Q01726
Morphology
S83F
Equus caballus
horse - (species)
Equus caballus
horse - (species)
MC1R
Equus caballus
horse - (species)
Published - Accepted by Curator
MC1R
Coloration (coat)
Coding,
Deletion
Puma yagouaroundi
jaguarundi - (species) D
Intraspecific
Candidate Gene
Eizirik E; Yuhki N; Johnson WE ; et al. (2003)
Molecular genetics and evolution of melanism in the cat family.
GP00000581
MC1R
Q01726
Morphology
Deletion of aa 95-102
Puma yagouaroundi
jaguarundi - (species)
Puma yagouaroundi
jaguarundi - (species) D
MC1R
Puma yagouaroundi
jaguarundi - (species)
Published - Accepted by Curator
MC1R
Coloration (coat)
Coding,
SNP
Mus musculus
house mouse - (species)
Intraspecific
Candidate Gene
Wada A; Kunieda T; Nishimura M ; et al. (2005 Mar-Apr)
A nucleotide substitution responsible for the tawny coat color mutation carried by the MSKR inbred s[...]
GP00000586
MC1R
Q01726
Morphology
W252C
Mus musculus
house mouse - (species)
Mus musculus
house mouse - (species)
MC1R
Mus musculus
house mouse - (species)
Published - Accepted by Curator
MC1R
Coloration (coat)
Coding,
Deletion
Panthera onca
jaguar - (species) D
Intraspecific
Candidate Gene
Eizirik E; Yuhki N; Johnson WE ; et al. (2003)
Molecular genetics and evolution of melanism in the cat family.
GP00000593
MC1R
Q01726
Morphology
Deletion of aa 101-105 and L106T
Panthera onca
jaguar - (species)
Panthera onca
jaguar - (species) D
MC1R
Panthera onca
jaguar - (species)
Published - Accepted by Curator
MC1R
Coloration (coat)
Coding,
SNP
Peromyscus polionotus
oldfield mouse - (species)
Intraspecific
Linkage Mapping
Hoekstra HE; Hirschmann RJ; Bundey RA ; et al. (2006)
A single amino acid mutation contributes to adaptive beach mouse color pattern.
GP00000594
MC1R
Q01726
Morphology
R65C
Peromyscus polionotus
oldfield mouse - (species)
Peromyscus polionotus
oldfield mouse - (species)
MC1R
Peromyscus polionotus
oldfield mouse - (species)
Published - Accepted by Curator
MC1R
Coloration (coat)
Coding,
Deletion
Sciurus carolinensis
gray squirrel - (species) D
Sciurus niger
fox squirrel - (species) D
Intraspecific
Candidate Gene
McRobie H; Thomas A; Kelly J (2009 Nov-Dec)
The genetic basis of melanism in the gray squirrel (Sciurus carolinensis).
1 Additional References
GP00000596
MC1R
Q01726
Morphology
Deletion of 8 a.a.
Sciurus carolinensis
gray squirrel - (species)
Sciurus niger
fox squirrel - (species)
Sciurus carolinensis
gray squirrel - (species) D
Sciurus niger
fox squirrel - (species) D
MC1R
Sciurus carolinensis
gray squirrel - (species)
Sciurus niger
fox squirrel - (species)
Published - Accepted by Curator
MC1R
Coloration (coat)
Coding,
SNP
Ursus americanus
American black bear - (species)
Intraspecific
Candidate Gene
Ritland K; Newton C; Marshall HD (2001)
Inheritance and population structure of the white-phased "Kermode" black bear.
GP00000597
MC1R
Q01726
Morphology
Y298C
Ursus americanus
American black bear - (species)
Ursus americanus
American black bear - (species)
MC1R
Ursus americanus
American black bear - (species)
Published - Accepted by Curator
MC1R
Coloration (feathers)
Coding,
SNP
Anser caerulescens
snow goose - (species)
Intraspecific
Candidate Gene
Mundy NI; Badcock NS; Hart T ; et al. (2004)
Conserved genetic basis of a quantitative plumage trait involved in mate choice.
GP00000599
MC1R
Q01726
Morphology
V85M
Anser caerulescens
snow goose - (species)
Anser caerulescens
snow goose - (species)
MC1R
Anser caerulescens
snow goose - (species)
Published - Accepted by Curator
MC1R
Coloration (feathers)
Coding,
SNP
Coereba flaveola
Bananaquit - (species) D
Intraspecific
Candidate Gene
Theron E; Hawkins K; Bermingham E ; et al. (2001)
The molecular basis of an avian plumage polymorphism in the wild: a melanocortin-1-receptor point mu[...]
GP00000600
MC1R
Q01726
Morphology
E92K
Coereba flaveola
Bananaquit - (species)
Coereba flaveola
Bananaquit - (species) D
MC1R
Coereba flaveola
Bananaquit - (species)
Published - Accepted by Curator
MC1R
Coloration (feathers)
Coding,
Deletion
Falco eleonorae
(species) D
Intraspecific
Candidate Gene
Gangoso L; Grande JM; Ducrest AL ; et al. (2011)
MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the E[...]
GP00000603
MC1R
Q01726
Morphology
Deletion of 3 a.a.
Falco eleonorae
(species)
Falco eleonorae
(species) D
MC1R
Falco eleonorae
(species)
Published - Accepted by Curator
MC1R
Coloration (feathers)
Coding,
SNP
Falco rusticolus
gyrfalcon - (species)
Intraspecific
Candidate Gene
Johnson JA; Ambers AD; Burnham KK (2012 May-Jun)
Genetics of plumage color in the Gyrfalcon (Falco rusticolus): analysis of the melanocortin-1 recept[...]
GP00000604
MC1R
Q01726
Morphology
Val128Ile
Falco rusticolus
gyrfalcon - (species)
Falco rusticolus
gyrfalcon - (species)
MC1R
Falco rusticolus
gyrfalcon - (species)
Published - Accepted by Curator
MC1R
Coloration (feathers)
Coding,
SNP
Malurus leucopterus
white-winged fairy-wren - (species)
Intraspecific
Candidate Gene
Doucet SM; Shawkey MD; Rathburn MK ; et al. (2004)
Concordant evolution of plumage colour, feather microstructure and a melanocortin receptor gene betw[...]
GP00000610
MC1R
Q01726
Morphology
A16T caused by guanine-to-adenine (G_A) transition at site 46; and/or I38N cause by a tyrosine-to-adenine (T_A) transition at site 113; and/or V11N caused by a G_A transition at site 331; and/or Q157R caused by an A_G substitution at site 470; Val166Ileu - exact causing amino acid change(s) unknown
Malurus leucopterus
white-winged fairy-wren - (species)
Malurus leucopterus
white-winged fairy-wren - (species)
MC1R
Malurus leucopterus
white-winged fairy-wren - (species)
Published - Accepted by Curator
MC1R
Coloration (feathers)
Coding,
SNP
Stercorarius parasiticus
(species)
Intraspecific
Candidate Gene
Mundy NI; Badcock NS; Hart T ; et al. (2004)
Conserved genetic basis of a quantitative plumage trait involved in mate choice.
GP00000611
MC1R
Q01726
Morphology
R230H
Stercorarius parasiticus
(species)
Stercorarius parasiticus
(species)
MC1R
Stercorarius parasiticus
(species)
Published - Accepted by Curator
MC1R
Coloration (feathers)
Coding,
SNP
Sula leucogaster
(species)
Intraspecific
Candidate Gene
Baião PC; Parker PG (2012 May-Jun)
Evolution of the melanocortin-1 receptor (MC1R) in Boobies and Gannets (Aves, Suliformes).
GP00000612
MC1R
Q01726
Morphology
R112H
Sula leucogaster
(species)
Sula leucogaster
(species)
MC1R
Sula leucogaster
(species)
Published - Accepted by Curator
MC1R
Coloration (feathers)
Coding,
SNP
Sula sula
red-footed booby - (species)
Intraspecific
Candidate Gene
Baião PC; Schreiber E; Parker PG (2007 Jul-Aug)
The genetic basis of the plumage polymorphism in red-footed boobies (Sula sula): a melanocortin-1 re[...]
GP00000613
MC1R
Q01726
Morphology
V85M and/or H207R; current data cannot determine which one or if both these substitutions are underlying the phenotypic variation
Sula sula
red-footed booby - (species)
Sula sula
red-footed booby - (species)
MC1R
Sula sula
red-footed booby - (species)
Published - Accepted by Curator
MC1R
Coloration (red hair)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Smith R; Healy E; Siddiqui S ; et al. (1998)
Melanocortin 1 receptor variants in an Irish population.
1 Additional References
GP00000615
MC1R
Q01726
Morphology
R151C
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
MC1R
Homo sapiens
human - (species)
Published - Accepted by Curator
MC1R
Coloration (red hair)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Smith R; Healy E; Siddiqui S ; et al. (1998)
Melanocortin 1 receptor variants in an Irish population.
1 Additional References
GP00000616
MC1R
Q01726
Morphology
D294H
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
MC1R
Homo sapiens
human - (species)
Published - Accepted by Curator
MC1R
Coloration (red hair)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Smith R; Healy E; Siddiqui S ; et al. (1998)
Melanocortin 1 receptor variants in an Irish population.
1 Additional References
GP00000617
MC1R
Q01726
Morphology
R160W
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
MC1R
Homo sapiens
human - (species)
Published - Accepted by Curator
MC1R
Coloration (red hair)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Box NF; Wyeth JR; O'Gorman LE ; et al. (1997)
Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair.
3 Additional References
GP00000618
MC1R
Q01726
Morphology
Val60Leu
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
MC1R
Homo sapiens
human - (species)
Published - Accepted by Curator
MC1R
Coloration (red hair)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007)
Genetic determinants of hair, eye and skin pigmentation in Europeans.
1 Additional References
GP00000619
MC1R
Q01726
Morphology
Asp84Glu
Homo sapiens
human - (species)
Homo sapiens
human - (species)
MC1R
Homo sapiens
human - (species)
Published - Accepted by Curator
MC1R
Coloration (red hair)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007)
Genetic determinants of hair, eye and skin pigmentation in Europeans.
1 Additional References
GP00000620
MC1R
Q01726
Morphology
Val92Met
Homo sapiens
human - (species)
Homo sapiens
human - (species)
MC1R
Homo sapiens
human - (species)
Published - Accepted by Curator
MC1R
Coloration (red hair)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007)
Genetic determinants of hair, eye and skin pigmentation in Europeans.
1 Additional References
GP00000621
MC1R
Q01726
Morphology
Arg142His
Homo sapiens
human - (species)
Homo sapiens
human - (species)
MC1R
Homo sapiens
human - (species)
Published - Accepted by Curator
MC1R
Coloration (red hair)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007)
Genetic determinants of hair, eye and skin pigmentation in Europeans.
1 Additional References
GP00000622
MC1R
Q01726
Morphology
Arg151Cys
Homo sapiens
human - (species)
Homo sapiens
human - (species)
MC1R
Homo sapiens
human - (species)
Published - Accepted by Curator
MC1R
Coloration (red hair)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007)
Genetic determinants of hair, eye and skin pigmentation in Europeans.
1 Additional References
GP00000623
MC1R
Q01726
Morphology
Ile155Thr
Homo sapiens
human - (species)
Homo sapiens
human - (species)
MC1R
Homo sapiens
human - (species)
Published - Accepted by Curator
MC1R
Coloration (red hair)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007)
Genetic determinants of hair, eye and skin pigmentation in Europeans.
1 Additional References
GP00000624
MC1R
Q01726
Morphology
Arg160Trp
Homo sapiens
human - (species)
Homo sapiens
human - (species)
MC1R
Homo sapiens
human - (species)
Published - Accepted by Curator
MC1R
Coloration (red hair)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007)
Genetic determinants of hair, eye and skin pigmentation in Europeans.
1 Additional References
GP00000625
MC1R
Q01726
Morphology
Arg163Gln
Homo sapiens
human - (species)
Homo sapiens
human - (species)
MC1R
Homo sapiens
human - (species)
Published - Accepted by Curator
MC1R
Coloration (red hair)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007)
Genetic determinants of hair, eye and skin pigmentation in Europeans.
1 Additional References
GP00000626
MC1R
Q01726
Morphology
Asp294His
Homo sapiens
human - (species)
Homo sapiens
human - (species)
MC1R
Homo sapiens
human - (species)
Published - Accepted by Curator
MC1R
Coloration (scales)
Coding,
SNP
Aspidoscelis inornatus
Little striped whiptail - (species)
Intraspecific
Candidate Gene
Rosenblum EB; Hoekstra HE; Nachman MW (2004)
Adaptive reptile color variation and the evolution of the Mc1r gene.
1 Additional References
GP00000627
MC1R
Q01726
Morphology
I170T
Aspidoscelis inornatus
Little striped whiptail - (species)
Aspidoscelis inornatus
Little striped whiptail - (species)
MC1R
Aspidoscelis inornatus
Little striped whiptail - (species)
Published - Accepted by Curator
MC1R
Coloration (scales)
Coding,
SNP
Holbrookia maculata
lesser earless lizard - (species)
Intraspecific
Candidate Gene
Rosenblum EB; Hoekstra HE; Nachman MW (2004)
Adaptive reptile color variation and the evolution of the Mc1r gene.
1 Additional References
GP00000628
MC1R
Q01726
Morphology
V168I; but failed functional validation in Rosenblum et al. 2010
Holbrookia maculata
lesser earless lizard - (species)
Holbrookia maculata
lesser earless lizard - (species)
MC1R
Holbrookia maculata
lesser earless lizard - (species)
Published - Accepted by Curator
MC1R
Coloration (scales)
Coding,
SNP
Sceloporus undulatus
fence lizard - (species)
Intraspecific
Candidate Gene
Rosenblum EB; Römpler H; Schöneberg T ; et al. (2010)
Molecular and functional basis of phenotypic convergence in white lizards at White Sands.
GP00000629
MC1R
Q01726
Morphology
H208Y
Sceloporus undulatus
fence lizard - (species)
Sceloporus undulatus
fence lizard - (species)
MC1R
Sceloporus undulatus
fence lizard - (species)
Published - Accepted by Curator
MC1R
Coloration (skin)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Lalueza-Fox C; Römpler H; Caramelli D ; et al. (2007)
A melanocortin 1 receptor allele suggests varying pigmentation among Neanderthals.
GP00000630
MC1R
Q01726
Morphology
Arg307Gly
Homo sapiens
human - (species)
Homo sapiens
human - (species)
MC1R
Homo sapiens
human - (species)
Published - Accepted by Curator
MC1R
Coloration (coat)
Coding,
SNP
Monarcha castaneiventris
Makira monarch - (species) D
Intraspecific
Association Mapping
Uy JA; Cooper EA; Cutie S ; et al. (2016)
Mutations in different pigmentation genes are associated with parallel melanism in island flycatcher[...]
GP00001333
MC1R
Q01726
Morphology
Asp119Asn
Monarcha castaneiventris
Makira monarch - (species)
Monarcha castaneiventris
Makira monarch - (species) D
MC1R
Monarcha castaneiventris
Makira monarch - (species)
Published - Accepted by Curator
MC1R
Coloration (coat)
Coding,
SNP
Arctocephalus gazella
antarctic fur seal - (species) D
Intraspecific
Candidate Gene
Norris BJ; Whan VA (2008)
A gene duplication affecting expression of the ovine ASIP gene is responsible for white and black sh[...]
GP00001338
MC1R
Q01726
Morphology
c.C>T p.Ser291Phe
Arctocephalus gazella
antarctic fur seal - (species)
Arctocephalus gazella
antarctic fur seal - (species) D
MC1R
Arctocephalus gazella
antarctic fur seal - (species)
Published - Accepted by Curator
MC1R
Coloration (coat)
Coding,
SNP
Tyto alba
Barn owl - (species) D
Intraspecific
Candidate Gene
San-Jose LM; Ducrest AL; Ducret V ; et al. (2015)
Effect of the MC1R gene on sexual dimorphism in melanin-based colorations.
3 Additional References
GP00001339
MC1R
Q01726
Morphology
p.Val126Ile
Tyto alba
Barn owl - (species)
Tyto alba
Barn owl - (species) D
R
MC1R
Tyto alba
Barn owl - (species)
Reviewed
September 26, 2019 17:00
MC1R
Coloration (feathers)
Coding,
SNP
Stercorarius parasiticus
(species)
Intraspecific
Candidate Gene
Janssen K; Mundy NI (2013)
Molecular population genetics of the melanic plumage polymorphism in Arctic skuas (Stercorarius para[...]
GP00001355
Mc1r
Q01727
Morphology
Melanic and nonmelanic haplotypes in the Arctic skua are defined by three amino acid changes: nonmelanic: His8-Glu12-Arg230; melanic: Arg8-Lys12-His230. The effect of each single amino acid change has not been tested
Stercorarius parasiticus
(species)
Stercorarius parasiticus
(species)
MC1R
Stercorarius parasiticus
(species)
Published - Accepted by Curator
MC1R
Coloration (feathers)
Coding,
SNP
Calidris pugnax
ruff - (species) D
Intraspecific
Association Mapping
Lamichhaney S; Fan G; Widemo F ; et al. (2016)
Structural genomic changes underlie alternative reproductive strategies in the ruff (Philomachus pug[...]
1 Additional References
GP00001466
MC1R
Q01726
Morphology
Several amino acid changes. The His207Arg substitution most likely has functional consequences because the same variant is associated with light color in the red-footed booby.
Calidris pugnax
ruff - (species)
Calidris pugnax
ruff - (species) D
MC1R
Calidris pugnax
ruff - (species)
Published - Accepted by Curator
MC1R
Coloration (coat)
Coding,
SNP
Leopardus geoffroyi
Geoffroy's cat - (species) D
Intraspecific
Candidate Gene
Schneider A; Henegar C; Day K ; et al. (2015)
Recurrent evolution of melanism in South American felids.
GP00001733
MC1R
Q01726
Morphology
All melanistic individuals were heterozygous for four variants that predicted three nonsynonymous substitutions, p.C125R, p.T177I, and p.G194S - In the laboratory mouse a Cys to Arg substitution at the site homologous to felid residue 125 causes constitutive activation of the receptor and the exact same change is thought to be responsible for melanism in the Alaska silver fox - therefore C125R is considered to be the likely causative alteration in the Geoffroy’s cat.
Leopardus geoffroyi
Geoffroy's cat - (species)
Leopardus geoffroyi
Geoffroy's cat - (species) D
MC1R
Leopardus geoffroyi
Geoffroy's cat - (species)
Published - Accepted by Curator
MC4R
Feeding behavior
Coding,
SNP
Astyanax mexicanus
Mexican tetra - (species)
Intraspecific
Linkage Mapping
Aspiras AC; Rohner N; Martineau B ; et al. (2015)
Melanocortin 4 receptor mutations contribute to the adaptation of cavefish to nutrient-poor conditio[...]
GP00000637
mc4r
B0V1P1
Behavior
Gly145Ser (candidate mutation)
Astyanax mexicanus
Mexican tetra - (species)
Astyanax mexicanus
Mexican tetra - (species)
MC4R
Astyanax mexicanus
Mexican tetra - (species)
Published - Accepted by Curator
MC4R
Sexual maturation (onset)
Gene Amplification,
Complex Change
Xiphophorus maculatus
southern platyfish - (species)
Intraspecific
Linkage Mapping
Lampert KP; Schmidt C; Fischer P ; et al. (2010)
Determination of onset of sexual maturation and mating behavior by melanocortin receptor 4 polymorph[...]
GP00000638
mc4r
B0V1P1
Physiology
unknown in the species used in crosses but a strong coreelation of gene copy number is found with the phenotype in two closely related species
Xiphophorus maculatus
southern platyfish - (species)
Xiphophorus maculatus
southern platyfish - (species)
MC4R
Xiphophorus maculatus
southern platyfish - (species)
Published - Accepted by Curator
MCO
Metal tolerance (copper)
Gene Amplification,
Insertion
Erythranthe guttata
spotted monkey flower - (species) D
Intraspecific
Linkage Mapping
Wright KM; Lloyd D; Lowry DB ; et al. (2013)
Indirect evolution of hybrid lethality due to linkage with selected locus in Mimulus guttatus.
1 Additional References
GP00001814
LPR2
Q949X9
Physiology
several recent tandem duplications of this gene are responsible for the 12x increase in expression observed in copper tolerant lines - 6X fold enrichment of aligned reads at MCO
Erythranthe guttata
spotted monkey flower - (species)
Erythranthe guttata
spotted monkey flower - (species) D
MCO
Erythranthe guttata
spotted monkey flower - (species)
Published - Accepted by Curator
MDR1
Xenobiotic resistance
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Kimchi-Sarfaty C; Oh JM; Kim IW ; et al. (2007)
A "silent" polymorphism in the MDR1 gene changes substrate specificity.
GP00001858
ABCB1
P08183
Physiology
C3435T - synonymous mutation Ile - The SNP at position 26/3435 that changes the codon from ATC to ATT (Ile) reduces the codon usage from 47% to 35% (RSCU values change from 20.9 to 15.8). Leads to similar mRNA and protein levels but altered conformation of the protein.
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
MDR1
Homo sapiens
human - (species)
Published - Accepted by Curator
metallothionein (Mtn)
Metal tolerance
Gene Amplification,
Complex Change
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Otto E; Young JE; Maroni G (1986)
Structure and expression of a tandem duplication of the Drosophila metallothionein gene.
1 Additional References
GP00000653
MtnA
P04357
Physiology
Gene duplication
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
metallothionein (Mtn)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
metallothionein (MtnA)
Oxidative stress resistance
Cis-regulatory,
Deletion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Association Mapping
Catalán A; Glaser-Schmitt A; Argyridou E ; et al. (2016)
An Indel Polymorphism in the MtnA 3' Untranslated Region Is Associated with Gene Expression Variatio[...]
GP00002018
MtnA
P04357
Physiology
49bp deletion in the MtnA 3'UTR
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
metallothionein (MtnA)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
MFSD12
Coloration (skin)
Coding,
SNP
N
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Adhikari K; Mendoza-Revilla J; Sohail A ; et al. (2019)
A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasi[...]
1 Additional References
GP00002245
MFSD12
Q6NUT3
Morphology
Y182H N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
MFSD12
Homo sapiens
human - (species)
Published - Accepted by Curator
MFSD12
Coloration (skin)
Cis-regulatory,
Complex Change
N
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Crawford NG; Kelly DE; Hansen MEB ; et al. (2017)
Loci associated with skin pigmentation identified in African populations.
GP00002246
MFSD12
Q6NUT3
Morphology
eight potentially causal SNPs cluster in two regions: one within MFSD12 (intronic SNP and synonymous SNP in exon 9) and the other ~7600 to 9000 base pairs (bp) upstream of MFSD12 ; many SNPs are in predicted regulatory regions active in melanocytes and/or keratinocytes show enhancer activity in luciferase expression assays N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
MFSD12
Homo sapiens
human - (species)
Published - Accepted by Curator
Mi1.2
Pathogen resistance (parasite)
Unknown,
Unknown
Solanum lycopersicum
tomato - (species)
Intraspecific
Linkage Mapping
Rossi M; Goggin FL; Milligan SB ; et al. (1998)
The nematode resistance gene Mi of tomato confers resistance against the potato aphid.
2 Additional References
GP00000655
Mi-1.2
O81137
Physiology
Not identified
Solanum peruvianum
(species)
Solanum lycopersicum
tomato - (species)
Mi1.2
Solanum lycopersicum
tomato - (species)
Published - Accepted by Curator
mir-92a
Trichome pattern (leg)
Cis-regulatory,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Arif S; Murat S; Almudi I ; et al. (2013)
Evolution of mir-92a underlies natural morphological variation in Drosophila melanogaster.
GP00000661
Morphology
Not identified
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
mir-92a
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
mitochondrial tyrosine tRNA
Hybrid incompatibility (F1 hybrid viability; F1 hybrid sterility)
Coding,
SNP
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Meiklejohn CD; Holmbeck MA; Siddiq MA ; et al. (2013)
An Incompatibility between a mitochondrial tRNA and its nuclear-encoded tRNA synthetase compromises [...]
1 Additional References
GP00001971
Physiology
C to T mutation at the base of the anticodon stem, so that G:C becomes G:U in the folded mRNA (see Fig. 1 of Hoekstra et al 2013)
Drosophila simulans
(species)
Drosophila simulans
(species) D
mitochondrial tyrosine tRNA
Drosophila simulans
(species)
Published - Accepted by Curator
MITOGEN-ACTIVATED PROTEIN KINASE 12 (MPK12)
Ozone sensitivity (stomata opening and stomatal CO2-sensitivity)
Coding,
SNP
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Jakobson L; Vaahtera L; Tõldsepp K ; et al. (2016)
Natural Variation in Arabidopsis Cvi-0 Accession Reveals an Important Role of MPK12 in Guard Cell CO[...]
GP00001383
MPK12
Q8GYQ5
Physiology
G53R
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
MITOGEN-ACTIVATED PROTEIN KINASE 12 (MPK12)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Molybdenum transporter1 (MOT1)
Metal tolerance
Cis-regulatory,
Deletion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Baxter I; Muthukumar B; Park HC ; et al. (2008)
Variation in molybdenum content across broadly distributed populations of Arabidopsis thaliana is co[...]
1 Additional References
GP00000676
MOT1
Q9SL95
Physiology
53bp deletion in promoter
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Molybdenum transporter1 (MOT1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Molybdenum transporter1 (MOT1)
Metal tolerance
Gene Amplification,
Insertion
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Association Mapping
Forsberg SK; Andreatta ME; Huang XY ; et al. (2015)
The Multi-allelic Genetic Architecture of a Variance-Heterogeneity Locus for Molybdenum Concentratio[...]
GP00000677
MOT1
Q9SL95
Physiology
330bp duplication followed by minor indels
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Molybdenum transporter1 (MOT1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Molybdenum transporter1 (MOT1)
Metal tolerance
Coding,
SNP
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Poormohammad Kiani S; Trontin C; Andreatta M ; et al. (2012)
Allelic heterogeneity and trade-off shape natural variation for response to soil micronutrient.
GP00001270
MOT1
Q9SL95
Physiology
D104Y
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
Molybdenum transporter1 (MOT1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
MPK12
Water absorption (water use efficiency)
Coding,
SNP
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Des Marais DL; Auchincloss LC; Sukamtoh E ; et al. (2014)
Variation in MPK12 affects water use efficiency in Arabidopsis and reveals a pleiotropic link betwee[...]
GP00001283
MPK12
Q8GYQ5
Physiology
GGT to CGT @position 53
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
MPK12
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
mucilage-modified 2 (mum2)
Mucilage (seeds)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014)
Local evolution of seed flotation in Arabidopsis.
GP00001274
BGAL6
Q9FFN4
Physiology
C->T @position 2223 causing premature stop N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
mucilage-modified 2 (mum2)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
mucilage-modified 2 (mum2)
Mucilage (seeds)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014)
Local evolution of seed flotation in Arabidopsis.
GP00001275
BGAL6
Q9FFN4
Physiology
G->C @position 2240 causing premature stop N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
mucilage-modified 2 (mum2)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
mucilage-modified 2 (mum2)
Mucilage (seeds)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014)
Local evolution of seed flotation in Arabidopsis.
GP00001276
BGAL6
Q9FFN4
Physiology
G->T @position 3425 causing premature stop N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
mucilage-modified 2 (mum2)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
mucilage-modified 2 (mum2)
Mucilage (seeds)
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014)
Local evolution of seed flotation in Arabidopsis.
GP00001277
BGAL6
Q9FFN4
Physiology
TACA insertion @position 4906 causing frame shift + Stop N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
mucilage-modified 2 (mum2)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Mucin gene family
Salt tolerance
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001378
MUC1
P15941
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Mucin gene family
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
Multidrug resistance protein 1 (pvmdr1)
Xenobiotic resistance (mefloquine)
Gene Amplification,
Insertion
Plasmodium vivax
malaria parasite P. vivax - (species) D
Intraspecific
Association Mapping
Pearson RD; Amato R; Auburn S ; et al. (2016)
Genomic analysis of local variation and recent evolution in Plasmodium vivax.
GP00001482
B7STB0
Physiology
37 kb duplication on chromosome 10 that includes pvmdr1
Plasmodium vivax
malaria parasite P. vivax - (species)
Plasmodium vivax
malaria parasite P. vivax - (species) D
Multidrug resistance protein 1 (pvmdr1)
Plasmodium vivax
malaria parasite P. vivax - (species)
Published - Accepted by Curator
multidrug resistance protein 2
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001532
PF3D7_1447900
Q8IKZ6
Physiology
p.Thr484Ile
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
multidrug resistance protein 2
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
MX1
Pathogen resistance (myxovirus)
Coding,
SNP
Gallus gallus
chicken - (species) D
Intraspecific
Ko JH; Jin HK; Asano A ; et al. (2002)
Polymorphisms and the differential antiviral activity of the chicken Mx gene.
GP00002249
MX1
P20591
Physiology
c.1892G>A p.S631N
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species) D
MX1
Gallus gallus
chicken - (species)
Published - Accepted by Curator
MYB1
Coloration (flower)
Coding,
Deletion
N
Ipomoea purpurea
common morning-glory - (species) D
Intraspecific
Candidate Gene
Chang SM; Lu Y; Rausher MD (2005)
Neutral evolution of the nonbinding region of the anthocyanin regulatory gene Ipmyb1 in Ipomoea.
GP00001458
myb1
Q4QS21
Morphology
2 deletions; 6-bp and 19-bp long; the larger produces a frameshift and a premature stop N
Ipomoea purpurea
common morning-glory - (species)
Ipomoea purpurea
common morning-glory - (species) D
MYB1
Ipomoea purpurea
common morning-glory - (species)
Published - Accepted by Curator
Na/K ATPase
Salt tolerance
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001377
ATP1A1
P05023
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
Na/K ATPase
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
Na/K-ATPase alpha-subunit
Xenobiotic resistance (cardiac glycosides)
2 Mutations:
Coding
SNP
Leptodactylus ocellatus
argus frog - (species) D
Intraspecific
Candidate Gene
Moore DJ; Halliday DC; Rowell DM ; et al. (2009)
Positive Darwinian selection results in resistance to cardioactive toxins in true toads (Anura: Bufo[...]
1 Additional References
GP00000701
Atp1a1
Q8VDN2
Physiology
2 mutations
Leptodactylus ocellatus
argus frog - (species)
Leptodactylus ocellatus
argus frog - (species) D
Na/K-ATPase alpha-subunit
Leptodactylus ocellatus
argus frog - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide)
Coding,
SNP
Aphis gossypii
cotton aphid - (species) D
Intraspecific
Candidate Gene
Wang ZJ; Liang CR; Shang ZY ; et al. (2021)
Insecticide resistance and resistance mechanisms in the melon aphid, Aphis gossypii, in Shandong, Ch[...]
GP00002491
nAChRbeta1
P04755
Physiology
R81T
Aphis gossypii
cotton aphid - (species)
Aphis gossypii
cotton aphid - (species) D
nAChR
Aphis gossypii
cotton aphid - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide)
Coding,
SNP
Aphis gossypii
cotton aphid - (species) D
Intraspecific
Candidate Gene
Wang ZJ; Liang CR; Shang ZY ; et al. (2021)
Insecticide resistance and resistance mechanisms in the melon aphid, Aphis gossypii, in Shandong, Ch[...]
GP00002492
nAChRbeta1
P04755
Physiology
K264E
Aphis gossypii
cotton aphid - (species)
Aphis gossypii
cotton aphid - (species) D
nAChR
Aphis gossypii
cotton aphid - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Bass C; Puinean AM; Andrews M ; et al. (2011)
Mutation of a nicotinic acetylcholine receptor β subunit is associated with resistance to neonicotin[...]
2 Additional References
GP00002553
nAChRbeta1
P04755
Physiology
R81T in the loop D region of the nAChR β1 subunit of the resistant clone
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
nAChR
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide; spinosad; spirotetramat)
Coding,
SNP
Frankliniella occidentalis
western flower thrips - (species) D
Intraspecific
Candidate Gene
Puinean AM; Lansdell SJ; Collins T ; et al. (2013)
A nicotinic acetylcholine receptor transmembrane point mutation (G275E) associated with resistance t[...]
3 Additional References
GP00002554
nAChRbeta1
P04755
Physiology
G275E in nAchR alpha 6 due to a single nucleotide change
Frankliniella occidentalis
western flower thrips - (species)
Frankliniella occidentalis
western flower thrips - (species) D
nAChR
Frankliniella occidentalis
western flower thrips - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide)
Coding,
SNP
Thrips palmi
(species) D
Intraspecific
Candidate Gene
Bao WX; Narai Y; Nakano A ; et al. (2014)
Spinosad resistance of melon thrips, Thrips palmi, is conferred by G275E mutation in α6 subunit of n[...]
1 Additional References
GP00002555
nAChRbeta1
P04755
Physiology
G275E in nAchR alpha 6 due to a single nucleotide change
Thrips palmi
(species)
Thrips palmi
(species) D
nAChR
Thrips palmi
(species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Xu X; Ding Q; Wang X ; et al. (2022)
V101I and R81T mutations in the nicotinic acetylcholine receptor β1 subunit are associated with neon[...]
GP00002612
nAChRbeta1
P04755
Physiology
V101I
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
nAChR
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide; spinosad)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Silva WM; Berger M; Bass C ; et al. (2016)
Mutation (G275E) of the nicotinic acetylcholine receptor α6 subunit is associated with high levels o[...]
1 Additional References
GP00002621
nAChRbeta1
P04755
Physiology
G275E in nAchR alpha 6 due to a single nucleotide change
Tuta absoluta
(species)
Tuta absoluta
(species) D
nAChR
Tuta absoluta
(species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide; spinosad)
Coding,
Unknown
N
Bactrocera dorsalis
oriental fruit fly - (species) D
Intraspecific
Candidate Gene
Hsu JC; Feng HT; Wu WJ ; et al. (2012)
Truncated transcripts of nicotinic acetylcholine subunit gene Bdα6 are associated with spinosad resi[...]
GP00002650
CHRNA6
Q15825
Physiology
Mutation in Bdα6 intron 2 (A change to T) just before the truncated/mis-splicing region and in same location with a mutation previously reported in the Pxylα6 gene. Small deletions and insertions leading to premature stop codons in exon 7. N
Bactrocera dorsalis
oriental fruit fly - (species)
Bactrocera dorsalis
oriental fruit fly - (species) D
nAChR
Bactrocera dorsalis
oriental fruit fly - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide; spinosad)
Coding,
SNP
N
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Linkage Mapping
Baxter SW; Chen M; Dawson A ; et al. (2010)
Mis-spliced transcripts of nicotinic acetylcholine receptor alpha6 are associated with field evolved[...]
GP00002651
CHRNA6
Q15825
Physiology
A mutation within the ninth intron splice junction of Pxalpha6 results in mis-splicing of transcripts and produce a predicted protein truncated between the third and fourth transmembrane domains. N
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
nAChR
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide; spinosad)
Coding,
Deletion
N
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Rinkevich FD; Chen M; Shelton AM ; et al. (2010)
Transcripts of the nicotinic acetylcholine receptor subunit gene Pxylα6 with premature stop codons a[...]
GP00002652
CHRNA6
Q15825
Physiology
transcripts with premature stop codons N
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
nAChR
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
nAChR
Xenobiotic resistance (insecticide; spinosad)
Coding,
Deletion
N
Rhyzopertha dominica
lesser grain borer - (species) D
Intraspecific
Candidate Gene
Wang HT; Tsai CL; Chen ME (2018)
Nicotinic acetylcholine receptor subunit α6 associated with spinosad resistance in Rhyzopertha domin[...]
GP00002654
CHRNA6
Q15825
Physiology
Three mutations were found in the resistant strain compared with the susceptible one: (1) a 181-bp fragment truncated at the N-terminus resulting in the appearance of a premature stop codon - (2) one missing bp at the position 997 causing a frame-shift mutation and (3) an 87-bp fragment truncated in the TM2 region. N
Rhyzopertha dominica
lesser grain borer - (species)
Rhyzopertha dominica
lesser grain borer - (species) D
nAChR
Rhyzopertha dominica
lesser grain borer - (species)
Published - Accepted by Curator
nath-10
Fertility (sperm number; egg laying rate)
Coding,
SNP
Caenorhabditis elegans
(species)
Intraspecific
Linkage Mapping
Duveau F; Félix MA (2012)
Role of pleiotropy in the evolution of a cryptic developmental variation in Caenorhabditis elegans.
GP00000718
nath-10
O01757
Morphology
Met746Ile (according to Table S2 C>T but it should be G>A - Needs curation)
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species)
nath-10
Caenorhabditis elegans
(species)
Published - Accepted by Curator
natriuretic peptide precursor type C (NPPC)
Body size (height)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Estrada K; Krawczak M; Schreiber S ; et al. (2009)
A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide si[...]
GP00000719
Nppc
Q61839
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
natriuretic peptide precursor type C (NPPC)
Homo sapiens
human - (species)
Published - Accepted by Curator
natriuretic peptide receptor 3 (NPR3)
Body size (height)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Estrada K; Krawczak M; Schreiber S ; et al. (2009)
A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide si[...]
1 Additional References
GP00000720
NPR3
Q8L746
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
natriuretic peptide receptor 3 (NPR3)
Homo sapiens
human - (species)
Published - Accepted by Curator
Nav1.6 sodium channel
Xenobiotic resistance (TTX)
Coding,
SNP
Thamnophis sirtalis
(species) D
Intraspecific
Candidate Gene
McGlothlin JW; Chuckalovcak JP; Janes DE ; et al. (2014)
Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the gar[...]
GP00000735
SCN8A
Q9UQD0
Physiology
Ile1709Val
Thamnophis sirtalis
(species)
Thamnophis sirtalis
(species) D
Nav1.6 sodium channel
Thamnophis sirtalis
(species)
Published - Accepted by Curator
Nav1.7 sodium channel
Xenobiotic resistance (TTX)
4 Mutations:
Coding
SNP
Thamnophis sirtalis
(species) D
Intraspecific
Candidate Gene
McGlothlin JW; Chuckalovcak JP; Janes DE ; et al. (2014)
Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the gar[...]
GP00000736
SCN9A
Q15858
Physiology
4 mutations
Thamnophis sirtalis
(species)
Thamnophis sirtalis
(species) D
Nav1.7 sodium channel
Thamnophis sirtalis
(species)
Published - Accepted by Curator
ndp (norrin)
Coloration (plumage)
Cis-regulatory,
Insertion
Corvus cornix
hooded crow - (species) D
Intraspecific
Association Mapping
Knief U; Bossu CM; Saino N ; et al. (2019)
Epistatic mutations under divergent selection govern phenotypic variation in the crow hybrid zone.
2 Additional References
GP00002148
Ndp
P48744
Morphology
2.25-kb LTR retrotransposon insertion reducing expression of the NDP gene and candidate gene LRP6 and a large LD haplotype in chr.18 also show a signal
Corvus corone corone
(subspecies)
Corvus cornix
hooded crow - (species) D
ndp (norrin)
Corvus cornix
hooded crow - (species)
Published - Accepted by Curator
ndp (norrin)
Coloration (plumage)
Cis-regulatory,
Insertion
N
Columba livia
rock pigeon - (species) D
Columba guinea
speckled pigeon - (species) D
Intraspecific
Association Mapping
Vickrey AI; Bruders R; Kronenberg Z ; et al. (2018)
Introgression of regulatory alleles and a missense coding mutation drive plumage pattern diversity i[...]
GP00002251
Ndp
P48744
Morphology
CNV driven by tandem repeats with one (bar) two (checker) or four (T-checker) copies per chromosome between approximative positions 1790000 and 1805600 N
Columba livia
rock pigeon - (species)
Columba livia
rock pigeon - (species) D
Columba guinea
speckled pigeon - (species) D
ndp (norrin)
Columba livia
rock pigeon - (species)
Columba guinea
speckled pigeon - (species)
Published - Accepted by Curator
Not much yang (Nmy)
Sex determination (sex ratio distortion)
Coding,
Deletion
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Tao Y; Masly JP; Araripe L ; et al. (2007)
A sex-ratio meiotic drive system in Drosophila simulans. I: an autosomal suppressor.
1 Additional References
GP00001970
Physiology
Loss of one of the inverted repeats that is present in the wild-type Dsim\Nmy locus and loss of most of the sequence located between the inverted repeats (except for a 93bp element in reverse orientation).
Drosophila simulans
(species)
Drosophila simulans
(species) D
Not much yang (Nmy)
Drosophila simulans
(species)
Published - Accepted by Curator
npr-1
Aggregation behavior
Foraging behavior
CO2 avoidance
Pathogen avoidance
Fertility (competitive fitness)
Coding,
SNP
Caenorhabditis elegans
(species)
Intraspecific
Linkage Mapping
de Bono M; Bargmann CI (1998)
Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in[...]
5 Additional References
GP00000739
npr-1
Q18534
Behavior
Behavior
Behavior
Behavior
Behavior; Physiology
Val215Phe (pleiotropic; see other entries)
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species)
npr-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
Oca2
Coloration (albinism)
Catecholamine metabolism
Coding,
Deletion
N
Astyanax mexicanus
Mexican tetra - (species) D
Intraspecific
Linkage Mapping
Protas ME; Hersey C; Kochanek D ; et al. (2006)
Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism.
2 Additional References
GP00000745
Oca2
Q62052
Morphology
Physiology
Deletion of exon 21 N
Astyanax mexicanus
Mexican tetra - (species)
Astyanax mexicanus
Mexican tetra - (species) D
Oca2
Astyanax mexicanus
Mexican tetra - (species)
Published - Accepted by Curator
Oca2
Coloration (albinism)
Catecholamine metabolism
Coding,
Deletion
N
Astyanax mexicanus
Mexican tetra - (species) D
Intraspecific
Linkage Mapping
Protas ME; Hersey C; Kochanek D ; et al. (2006)
Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism.
2 Additional References
GP00000746
Oca2
Q62052
Morphology
Physiology
Almost complete deletion of exon 24; + 2 a.a subsitutions at conserved positions - the two point mutations do not drastically affect the function of OCA2 in cell lines suggesting that the exon 24 deletion is the mutation that causes albinism in the Pachón population N
Astyanax mexicanus
Mexican tetra - (species)
Astyanax mexicanus
Mexican tetra - (species) D
Oca2
Astyanax mexicanus
Mexican tetra - (species)
Published - Accepted by Curator
Oca2
Coloration (eyes; skin, hair)
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Eiberg H; Troelsen J; Nielsen M ; et al. (2008)
Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory el[...]
5 Additional References
GP00000747
Oca2
Q62052
Morphology
Causative SNP in enhancer localized in intron of neighbor gene HERC2 : likely rs12913832 within HERC2 which influences on OCA2 expression in eye hair and skin pigmentation
Homo sapiens
human - (species)
Homo sapiens
human - (species)
Oca2
Homo sapiens
human - (species)
Published - Accepted by Curator
Oca2
Coloration (skin)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Edwards M; Bigham A; Tan J ; et al. (2010)
Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: furth[...]
1 Additional References
GP00000748
Oca2
Q62052
Morphology
His615Arg
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Oca2
Homo sapiens
human - (species)
Published - Accepted by Curator
Oca2
Coloration (albinism)
Coding,
Insertion
N
Pantherophis guttatus
(species) D
Intraspecific
Linkage Mapping
Saenko SV; Lamichhaney S; Martinez Barrio A ; et al. (2015)
Amelanism in the corn snake is associated with the insertion of an LTR-retrotransposon in the OCA2 g[...]
GP00001619
OCA2
Q04671
Morphology
insertion of an LTR-retrotransposon (5832-bp) in the 11th intron resulting after splicing in an additional 397-bp fragment constituted of 3 new exons inserted between exons 11 and 12. Generates truncated protein with two stop codons N
Pantherophis guttatus
(species)
Pantherophis guttatus
(species) D
Oca2
Pantherophis guttatus
(species)
Published - Accepted by Curator
Oca2
Coloration (albinism)
Coding,
Deletion
N
Melanochromis auratus
(species) D
Intraspecific
Candidate Gene
Kratochwil CF; Urban S; Meyer A (2019)
Genome of the Malawi golden cichlid fish (Melanochromis auratus) reveals exon loss of oca2 in an ame[...]
GP00001955
Oca2
Q62052
Morphology
deletion covering a total of 5.4kb including exon 2 and parts of the flanking introns 1 and 2 N
Melanochromis auratus
(species)
Melanochromis auratus
(species) D
Oca2
Melanochromis auratus
(species)
Published - Accepted by Curator
OPRM1
Coloration (skin)
Unknown,
Unknown
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Quillen EE; Bauchet M; Bigham AW ; et al. (2012)
OPRM1 and EGFR contribute to skin pigmentation differences between Indigenous Americans and European[...]
GP00001536
OPRM1
P35372
Morphology
C>T associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
OPRM1
Homo sapiens
human - (species)
Published - Accepted by Curator
opsin - (SWS2)
Color vision (blue- and red-shifts)
2 Mutations:
Coding
SNP
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Candidate Gene
Marques DA; Taylor JS; Jones FC ; et al. (2017)
Convergent evolution of SWS2 opsin facilitates adaptive radiation of threespine stickleback into dif[...]
GP00001679
opn1sw2
Q9W6A8
Physiology
2 mutations
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
opsin - (SWS2)
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
opsin - rhodopsin (LWS)
Color vision (blue shift)
3 Mutations:
Coding
SNP
Pundamilia pundamilia
(species)
Intraspecific
Candidate Gene
Seehausen O; Terai Y; Magalhaes IS ; et al. (2008)
Speciation through sensory drive in cichlid fish.
GP00000777
OPN1LW
P04000
Physiology
3 mutations
Pundamilia pundamilia
(species)
Pundamilia pundamilia
(species)
opsin - rhodopsin (LWS)
Pundamilia pundamilia
(species)
Published - Accepted by Curator
opsin - rhodopsin1 (RH1)
Color vision (green-shift)
Coding,
SNP
Stomoxys calcitrans
stable fly - (species)
Intraspecific
Candidate Gene
Olafson PU; Aksoy S; Attardo GM ; et al. (2021)
The genome of the stable fly, Stomoxys calcitrans, reveals potential mechanisms underlying reproduct[...]
GP00002535
RHO
P08100
Physiology
Met>Leucine residue present at tuning site 17 which is extremely rare across insect LW opsins. In a survey of over 100 insect LW opsins it was detected only in the two corresponding Rh1 orthologs from M. domestica in addition to one in the distantly related species of thrips (Thysanoptera). The site is residue 17 based on the numbering system developed for butterflies which corresponds to residue 57 in Drosophila Rh1.
Stomoxys calcitrans
stable fly - (species)
Stomoxys calcitrans
stable fly - (species)
opsin - rhodopsin1 (RH1)
Stomoxys calcitrans
stable fly - (species)
Published - Accepted by Curator
Optix
Coloration (wing, Mullerian mimicry)
Cis-regulatory,
Unknown
Heliconius pachinus
(species)
Intraspecific
Linkage Mapping
Reed RD; Papa R; Martin A ; et al. (2011)
optix drives the repeated convergent evolution of butterfly wing pattern mimicry.
1 Additional References
GP00000795
Optix
Q95RW8
Morphology
Not identified
Heliconius cydno
(species)
Heliconius pachinus
(species)
Optix
Heliconius pachinus
(species)
Published - Accepted by Curator
Optix
Coloration (wing, Mullerian mimicry)
Cis-regulatory,
Unknown
Heliconius himera
(species)
Intraspecific
Linkage Mapping
Reed RD; Papa R; Martin A ; et al. (2011)
optix drives the repeated convergent evolution of butterfly wing pattern mimicry.
1 Additional References
GP00000796
Optix
Q95RW8
Morphology
Not identified
Heliconius erato
crimson-patched longwing - (species)
Heliconius himera
(species)
Optix
Heliconius himera
(species)
Published - Accepted by Curator
Optix
Coloration (wing, Mullerian mimicry)
Cis-regulatory,
Unknown
Heliconius erato
crimson-patched longwing - (species)
Intraspecific
Linkage Mapping
Reed RD; Papa R; Martin A ; et al. (2011)
optix drives the repeated convergent evolution of butterfly wing pattern mimicry.
1 Additional References
GP00000797
Optix
Q95RW8
Morphology
Not identified
Heliconius erato
crimson-patched longwing - (species)
Heliconius erato
crimson-patched longwing - (species)
Optix
Heliconius erato
crimson-patched longwing - (species)
Published - Accepted by Curator
Optix
Coloration (wing, Mullerian mimicry)
Cis-regulatory,
Unknown
Heliconius melpomene
postman butterfly - (species)
Intraspecific
Linkage Mapping
Reed RD; Papa R; Martin A ; et al. (2011)
optix drives the repeated convergent evolution of butterfly wing pattern mimicry.
1 Additional References
GP00000798
Optix
Q95RW8
Morphology
Not identified
Heliconius melpomene
postman butterfly - (species)
Heliconius melpomene
postman butterfly - (species)
Optix
Heliconius melpomene
postman butterfly - (species)
Published - Accepted by Curator
OR7D4
Olfaction
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Keller A; Zhuang H; Chi Q ; et al. (2007)
Genetic variation in a human odorant receptor alters odour perception.
1 Additional References
GP00000799
OR7D4
Q8NG98
Physiology
P79L
Homo sapiens
human - (species)
Homo sapiens
human - (species)
OR7D4
Homo sapiens
human - (species)
Published - Accepted by Curator
OR7D4
Olfaction
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Keller A; Zhuang H; Chi Q ; et al. (2007)
Genetic variation in a human odorant receptor alters odour perception.
GP00000800
OR7D4
Q8NG98
Physiology
R227G
Homo sapiens
human - (species)
Homo sapiens
human - (species)
OR7D4
Homo sapiens
human - (species)
Published - Accepted by Curator
OR7D4
Olfaction
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Keller A; Zhuang H; Chi Q ; et al. (2007)
Genetic variation in a human odorant receptor alters odour perception.
GP00000801
OR7D4
Q8NG98
Physiology
T133M
Homo sapiens
human - (species)
Homo sapiens
human - (species)
OR7D4
Homo sapiens
human - (species)
Published - Accepted by Curator
OR7D4
Olfaction
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Keller A; Zhuang H; Chi Q ; et al. (2007)
Genetic variation in a human odorant receptor alters odour perception.
GP00000802
OR7D4
Q8NG98
Physiology
S84N
Homo sapiens
human - (species)
Homo sapiens
human - (species)
OR7D4
Homo sapiens
human - (species)
Published - Accepted by Curator
ore
Taste (fruit)
Coding,
SNP
Cucumis sativus
cucumber - (species) D
Intraspecific
Candidate Gene
Qi J; Liu X; Shen D ; et al. (2013)
A genomic variation map provides insights into the genetic basis of cucumber domestication and diver[...]
GP00001390
BCH1
E9JE14
Morphology; Physiology
p.Ala257Asp
Cucumis sativus
cucumber - (species)
Cucumis sativus
cucumber - (species) D
ore
Cucumis sativus
cucumber - (species)
Published - Accepted by Curator
ORGANIC CATION TRANSPORTER 1
Root growth (root length response to exogenous cadaverine)
Cis-regulatory,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Strohm AK; Vaughn LM; Masson PH (2015)
Natural variation in the expression of ORGANIC CATION TRANSPORTER 1 affects root length responses to[...]
GP00001279
OCT1
Q9CAT6
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
ORGANIC CATION TRANSPORTER 1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Overdrive
Hybrid incompatibility (male F1 sterility)
Coding,
SNP
Drosophila pseudoobscura
(species)
Intraspecific
Linkage Mapping
Phadnis N; Orr HA (2009)
A single gene causes both male sterility and segregation distortion in Drosophila hybrids.
GP00000816
Ovd
Q2LZF7
Physiology
6 candidate non-synonymous changes - the effect of single amino acid changes has not been tested
Drosophila pseudoobscura
(species)
Drosophila pseudoobscura
(species)
Overdrive
Drosophila pseudoobscura
(species)
Published - Accepted by Curator
P2RY5
Hair type (woolly)
Coding,
Insertion
N
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Shimomura Y; Wajid M; Ishii Y ; et al. (2008)
Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]
GP00000817
LPAR6
P43657
Morphology
at position 69 insertion of 4bp CATG - causes frameshift at codon 24 (PTC +29) N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
P2RY5
Homo sapiens
human - (species)
Published - Accepted by Curator
P2RY5
Hair type (woolly)
Coding,
Deletion
N
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Shimomura Y; Wajid M; Ishii Y ; et al. (2008)
Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]
GP00001734
LPAR6
P43657
Morphology
2 deletions - one at position 172-175 delAACT and one at position 177 delG - cause frameshift at codon 58 (PTC +31) N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
P2RY5
Homo sapiens
human - (species)
Published - Accepted by Curator
P2RY5
Hair type (woolly)
Coding,
SNP
N
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Shimomura Y; Wajid M; Ishii Y ; et al. (2008)
Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]
GP00001735
LPAR6
P43657
Morphology
188A>T which causes D63V N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
P2RY5
Homo sapiens
human - (species)
Published - Accepted by Curator
P2RY5
Hair type (woolly)
Coding,
SNP
N
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Shimomura Y; Wajid M; Ishii Y ; et al. (2008)
Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]
GP00001736
LPAR6
P43657
Morphology
562A>T which causes I188F N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
P2RY5
Homo sapiens
human - (species)
Published - Accepted by Curator
P2RY5
Hair type (woolly)
Coding,
SNP
N
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Shimomura Y; Wajid M; Ishii Y ; et al. (2008)
Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair[...]
GP00001737
LPAR6
P43657
Morphology
565G>A which causes E189K N
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
P2RY5
Homo sapiens
human - (species)
Published - Accepted by Curator
pannier
Coloration (elytra)
Cis-regulatory,
Unknown
Harmonia axyridis
(species)
Intraspecific
Association Mapping
Ando T; Niimi T (2019)
Development and evolution of color patterns in ladybird beetles: A case study in Harmonia axyridis.
2 Additional References
GP00001705
pnr
P52168
Morphology
exact mutation(s) unknown
Harmonia axyridis
(species)
Harmonia axyridis
(species)
pannier
Harmonia axyridis
(species)
Published - Accepted by Curator
pannier
Coloration (elytra)
Cis-regulatory,
Unknown
Harmonia axyridis
(species)
Intraspecific
Association Mapping
Ando T; Niimi T (2019)
Development and evolution of color patterns in ladybird beetles: A case study in Harmonia axyridis.
2 Additional References
GP00001706
pnr
P52168
Morphology
exact mutation(s) unknown
Harmonia axyridis
(species)
Harmonia axyridis
(species)
pannier
Harmonia axyridis
(species)
Published - Accepted by Curator
pannier
Coloration (elytra)
Cis-regulatory,
Unknown
Harmonia axyridis
(species)
Intraspecific
Association Mapping
Ando T; Niimi T (2019)
Development and evolution of color patterns in ladybird beetles: A case study in Harmonia axyridis.
2 Additional References
GP00001707
pnr
P52168
Morphology
exact mutation(s) unknown
Harmonia axyridis
(species)
Harmonia axyridis
(species)
pannier
Harmonia axyridis
(species)
Published - Accepted by Curator
PAP1
Coloration (anthocyanin accumulation under high-light and low-temperature stress)
Gene Loss,
Deletion
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Ilk N; Ding J; Ihnatowicz A ; et al. (2015)
Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attrib[...]
1 Additional References
GP00001232
MYB75
Q9FE25
Physiology
several deletions in the promoter; first intron; second exon and 3' UTR region (putative loss of function) N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
PAP1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
PAP2
Coloration (anthocyanin accumulation under high-light and low-temperature stress)
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Ilk N; Ding J; Ihnatowicz A ; et al. (2015)
Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attrib[...]
GP00001231
MYB90
Q9ZTC3
Physiology
one SNP in the coding region and several in the putative promoter region
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
PAP2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Linkage Mapping
Ranson H; Jensen B; Vulule JM ; et al. (2000)
Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gamb[...]
GP00000818
para
P35500
Physiology
L1014S
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
para (kdr)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Candidate Gene
Martinez-Torres D; Chandre F; Williamson MS ; et al. (1998)
Molecular characterization of pyrethroid knockdown resistance (kdr) in the major malaria vector Anop[...]
1 Additional References
GP00000819
para
P35500
Physiology
L1014F
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
para (kdr)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Candidate Gene
Jones CM; Liyanapathirana M; Agossa FR ; et al. (2012)
Footprints of positive selection associated with a mutation (N1575Y) in the voltage-gated sodium cha[...]
GP00000820
para
P35500
Physiology
N1575Y
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
para (kdr)
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Anopheles sinensis
(species) D
Intraspecific
Candidate Gene
Tan WL; Wang ZM; Li CX ; et al. (2012)
First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...]
1 Additional References
GP00000821
para
P35500
Physiology
2 mutations
Anopheles sinensis
(species)
Anopheles sinensis
(species) D
para (kdr)
Anopheles sinensis
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Bemisia tabaci
(species) D
Intraspecific
Candidate Gene
Morin S; Williamson MS; Goodson SJ ; et al. (2002)
Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...]
2 Additional References
GP00000822
para
P35500
Physiology
L925I
Bemisia tabaci
(species)
Bemisia tabaci
(species) D
para (kdr)
Bemisia tabaci
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Bemisia tabaci
(species) D
Intraspecific
Candidate Gene
Morin S; Williamson MS; Goodson SJ ; et al. (2002)
Mutations in the Bemisia tabaci para sodium channel gene associated with resistance to a pyrethroid [...]
2 Additional References
GP00000823
para
P35500
Physiology
M918V
Bemisia tabaci
(species)
Bemisia tabaci
(species) D
para (kdr)
Bemisia tabaci
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Blattella germanica
German cockroach - (species) D
Intraspecific
Candidate Gene
Smith TJ; Lee SH; Ingles PJ ; et al. (1997)
The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyre[...]
2 Additional References
GP00000824
para
P35500
Physiology
L993F (=L1014F)
Blattella germanica
German cockroach - (species)
Blattella germanica
German cockroach - (species) D
para (kdr)
Blattella germanica
German cockroach - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Blattella germanica
German cockroach - (species) D
Intraspecific
Candidate Gene
Liu Z; Valles SM; Dong K (2000)
Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...]
2 Additional References
GP00000825
para
P35500
Physiology
C764R (=C785R)
Blattella germanica
German cockroach - (species)
Blattella germanica
German cockroach - (species) D
para (kdr)
Blattella germanica
German cockroach - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Blattella germanica
German cockroach - (species) D
Intraspecific
Candidate Gene
Liu Z; Valles SM; Dong K (2000)
Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown[...]
2 Additional References
GP00000826
para
P35500
Physiology
E434K (=E435K)
Blattella germanica
German cockroach - (species)
Blattella germanica
German cockroach - (species) D
para (kdr)
Blattella germanica
German cockroach - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Rhipicephalus microplus
southern cattle tick - (species) D
Intraspecific
Candidate Gene
He H; Chen AC; Davey RB ; et al. (1999)
Identification of a point mutation in the para-type sodium channel gene from a pyrethroid-resistant [...]
1 Additional References
GP00000827
para
P35500
Physiology
F1538I
Rhipicephalus microplus
southern cattle tick - (species)
Rhipicephalus microplus
southern cattle tick - (species) D
para (kdr)
Rhipicephalus microplus
southern cattle tick - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Chen L; Zhong D; Zhang D ; et al. (2010)
Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes.
1 Additional References
GP00000828
para
P35500
Physiology
L1014F
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
para (kdr)
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Chen L; Zhong D; Zhang D ; et al. (2010)
Molecular ecology of pyrethroid knockdown resistance in Culex pipiens pallens mosquitoes.
GP00000829
para
P35500
Physiology
L1014S
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
para (kdr)
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Cydia pomonella
codling moth - (species) D
Intraspecific
Candidate Gene
Brun-Barale A; Bouvier JC; Pauron D ; et al. (2005)
Involvement of a sodium channel mutation in pyrethroid resistance in Cydia pomonella L, and developm[...]
1 Additional References
GP00000830
para
P35500
Physiology
L1014F
Cydia pomonella
codling moth - (species)
Cydia pomonella
codling moth - (species) D
para (kdr)
Cydia pomonella
codling moth - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Haematobia irritans
horn fly - (species) D
Intraspecific
Candidate Gene
Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep)
Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...]
3 Additional References
GP00000831
para
P35500
Physiology
(=M918T)
Haematobia irritans
horn fly - (species)
Haematobia irritans
horn fly - (species) D
para (kdr)
Haematobia irritans
horn fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Haematobia irritans
horn fly - (species) D
Intraspecific
Candidate Gene
Guerrero FD; Jamroz RC; Kammlah D ; et al. (1997 Aug-Sep)
Toxicological and molecular characterization of pyrethroid-resistant horn flies, Haematobia irritans[...]
1 Additional References
GP00000832
para
P35500
Physiology
L150F (=L1014F)
Haematobia irritans
horn fly - (species)
Haematobia irritans
horn fly - (species) D
para (kdr)
Haematobia irritans
horn fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Heliothis virescens
tobacco budworm - (species) D
Intraspecific
Linkage Mapping
Zhao Y; Park Y; Adams ME (2000)
Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segm[...]
3 Additional References
GP00000834
para
P35500
Physiology
V421M (=V410M)
Heliothis virescens
tobacco budworm - (species)
Heliothis virescens
tobacco budworm - (species) D
para (kdr)
Heliothis virescens
tobacco budworm - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Helicoverpa zea
corn earworm - (species) D
Intraspecific
Linkage Mapping
Hopkins BW; Pietrantonio PV (2010)
The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]
GP00000835
para
P35500
Physiology
V421M (=V410M)
Helicoverpa zea
corn earworm - (species)
Helicoverpa zea
corn earworm - (species) D
para (kdr)
Helicoverpa zea
corn earworm - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Helicoverpa zea
corn earworm - (species) D
Intraspecific
Linkage Mapping
Hopkins BW; Pietrantonio PV (2010)
The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]
GP00000836
para
P35500
Physiology
L1029H (= L1014H)
Helicoverpa zea
corn earworm - (species)
Helicoverpa zea
corn earworm - (species) D
para (kdr)
Helicoverpa zea
corn earworm - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Helicoverpa zea
corn earworm - (species) D
Intraspecific
Linkage Mapping
Hopkins BW; Pietrantonio PV (2010)
The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]
GP00000837
para
P35500
Physiology
V421A (=V410A)
Helicoverpa zea
corn earworm - (species)
Helicoverpa zea
corn earworm - (species) D
para (kdr)
Helicoverpa zea
corn earworm - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Helicoverpa zea
corn earworm - (species) D
Intraspecific
Linkage Mapping
Hopkins BW; Pietrantonio PV (2010)
The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]
GP00000838
para
P35500
Physiology
V421G (=V410G)
Helicoverpa zea
corn earworm - (species)
Helicoverpa zea
corn earworm - (species) D
para (kdr)
Helicoverpa zea
corn earworm - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Hyalella azteca
(species) D
Intraspecific
Candidate Gene
Weston DP; Poynton HC; Wellborn GA ; et al. (2013)
Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...]
1 Additional References
GP00000839
para
P35500
Physiology
L925I in species D
Hyalella azteca
(species)
Hyalella azteca
(species) D
para (kdr)
Hyalella azteca
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Hyalella azteca
(species) D
Intraspecific
Candidate Gene
Weston DP; Poynton HC; Wellborn GA ; et al. (2013)
Multiple origins of pyrethroid insecticide resistance across the species complex of a nontarget aqua[...]
1 Additional References
GP00000840
para
P35500
Physiology
M918L - ATG>CTG
Hyalella azteca
(species)
Hyalella azteca
(species) D
para (kdr)
Hyalella azteca
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
Intraspecific
Candidate Gene
Rinkevich FD; Du Y; Dong K (2013)
Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids.
1 Additional References
GP00000841
para
P35500
Physiology
2 mutations
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
para (kdr)
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Linkage Mapping
Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996)
Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...]
2 Additional References
GP00000842
para
P35500
Physiology
L1014F
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
para (kdr)
Musca domestica
house fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Linkage Mapping
Miyazaki M; Ohyama K; Dunlap DY ; et al. (1996)
Cloning and sequencing of the para-type sodium channel gene from susceptible and kdr-resistant Germa[...]
3 Additional References
GP00000843
para
P35500
Physiology
M918T
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
para (kdr)
Musca domestica
house fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Linkage Mapping
Martinez-Torres D; Foster SP; Field LM ; et al. (1999)
A sodium channel point mutation is associated with resistance to DDT and pyrethroid insecticides in [...]
GP00000844
para
P35500
Physiology
L1014F
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
para (kdr)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Anstead JA; Williamson MS; Eleftherianos I ; et al. (2004)
High-throughput detection of knockdown resistance in Myzus persicae using allelic discriminating qua[...]
GP00000845
para
P35500
Physiology
(=M918T)
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
para (kdr)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
3 Mutations:
Coding
SNP
Pediculus humanus
human louse - (species) D
Intraspecific
Candidate Gene
Hodgdon HE; Yoon KS; Previte DJ ; et al. (2010)
Determination of knockdown resistance allele frequencies in global human head louse populations usin[...]
3 Additional References
GP00000846
para
P35500
Physiology
3 mutations
Pediculus humanus
human louse - (species)
Pediculus humanus
human louse - (species) D
para (kdr)
Pediculus humanus
human louse - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Pediculus humanus
human louse - (species) D
Intraspecific
Linkage Mapping
Lee Si Hyeock; Yoon Kyong-Sup; Williamson Martin S ; et al. (2000
)
Molecular analysis of kdr-like resistance in permethrin-resistant strains of head lice, Pediculus ca[...]
GP00000847
para
P35500
Physiology
L932F
Pediculus humanus
human louse - (species)
Pediculus humanus
human louse - (species) D
para (kdr)
Pediculus humanus
human louse - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Plutella xylostella
diamondback moth - (species)
Intraspecific
Candidate Gene
Sonoda S; Igaki C; Tsumuki H (2008)
Alternatively spliced sodium channel transcripts expressed in field strains of the diamondback moth.
1 Additional References
GP00000848
para
P35500
Physiology
2 mutations
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species)
para (kdr)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Plutella xylostella
diamondback moth - (species)
Intraspecific
Linkage Mapping
Usherwood PN; Davies TG; Mellor IR ; et al. (2007)
Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding [...]
GP00000849
para
P35500
Physiology
T929I
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species)
para (kdr)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Triatoma infestans
(species)
Intraspecific
Candidate Gene
Fabro J; Sterkel M; Capriotti N ; et al. (2012)
Identification of a point mutation associated with pyrethroid resistance in the para-type sodium cha[...]
GP00000850
para
P35500
Physiology
L1014F
Triatoma infestans
(species)
Triatoma infestans
(species)
para (kdr)
Triatoma infestans
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Haddi K; Berger M; Bielza P ; et al. (2012)
Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]
GP00000851
para
P35500
Physiology
M918T
Tuta absoluta
(species)
Tuta absoluta
(species) D
para (kdr)
Tuta absoluta
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Haddi K; Berger M; Bielza P ; et al. (2012)
Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]
GP00000852
para
P35500
Physiology
T929I
Tuta absoluta
(species)
Tuta absoluta
(species) D
para (kdr)
Tuta absoluta
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Haddi K; Berger M; Bielza P ; et al. (2012)
Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channe[...]
GP00000853
para
P35500
Physiology
L1014F
Tuta absoluta
(species)
Tuta absoluta
(species) D
para (kdr)
Tuta absoluta
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles sinensis
(species) D
Intraspecific
Candidate Gene
Tan WL; Wang ZM; Li CX ; et al. (2012)
First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...]
1 Additional References
GP00001689
para
P35500
Physiology
L1014F; Haplotype H02
Anopheles sinensis
(species)
Anopheles sinensis
(species) D
para (kdr)
Anopheles sinensis
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles sinensis
(species)
Intraspecific
Candidate Gene
Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010)
Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...]
1 Additional References
GP00001691
para
P35500
Physiology
L1014S; Haplotype H04
Anopheles sinensis
(species)
Anopheles sinensis
(species)
para (kdr)
Anopheles sinensis
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles vagus
(species) D
Intraspecific
Candidate Gene
Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010)
Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...]
1 Additional References
GP00001692
para
P35500
Physiology
L1014S
Anopheles vagus
(species)
Anopheles vagus
(species) D
para (kdr)
Anopheles vagus
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles sinensis
(species) D
Intraspecific
Candidate Gene
Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010)
Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...]
1 Additional References
GP00001695
para
P35500
Physiology
L1014S
Anopheles sinensis
(species)
Anopheles sinensis
(species) D
para (kdr)
Anopheles sinensis
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles paraliae
(species)
Intraspecific
Candidate Gene
Verhaeghen K; Van Bortel W; Trung HD ; et al. (2010)
Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus population[...]
1 Additional References
GP00001696
para
P35500
Physiology
L1014S
Anopheles paraliae
(species)
Anopheles paraliae
(species)
para (kdr)
Anopheles paraliae
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles sinensis
(species) D
Intraspecific
Candidate Gene
Tan WL; Wang ZM; Li CX ; et al. (2012)
First report on co-occurrence knockdown resistance mutations and susceptibility to beta-cypermethrin[...]
1 Additional References
GP00001699
para
P35500
Physiology
L1014F; Haplotype H04
Anopheles sinensis
(species)
Anopheles sinensis
(species) D
para (kdr)
Anopheles sinensis
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Cimex lectularius
bed bug - (species) D
Intraspecific
Candidate Gene
Yoon KS; Kwon DH; Strycharz JP ; et al. (2008)
Biochemical and molecular analysis of deltamethrin resistance in the common bed bug (Hemiptera: Cimi[...]
4 Additional References
GP00001859
para
P35500
Physiology
2 mutations
Cimex lectularius
bed bug - (species)
Cimex lectularius
bed bug - (species) D
para (kdr)
Cimex lectularius
bed bug - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Varroa destructor
honeybee mite - (species) D
Intraspecific
Candidate Gene
González-Cabrera J; Davies TG; Field LM ; et al. (2013)
An amino acid substitution (L925V) associated with resistance to pyrethroids in Varroa destructor.
1 Additional References
GP00001860
para
P35500
Physiology
L925V
Varroa destructor
honeybee mite - (species)
Varroa destructor
honeybee mite - (species) D
para (kdr)
Varroa destructor
honeybee mite - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Trialeurodes vaporariorum
greenhouse whitefly - (species)
Intraspecific
Candidate Gene
Karatolos N; Gorman K; Williamson MS ; et al. (2012)
Mutations in the sodium channel associated with pyrethroid resistance in the greenhouse whitefly, Tr[...]
1 Additional References
GP00001861
para
P35500
Physiology
M918L - found in samples from China and Europe
Trialeurodes vaporariorum
greenhouse whitefly - (species)
Trialeurodes vaporariorum
greenhouse whitefly - (species)
para (kdr)
Trialeurodes vaporariorum
greenhouse whitefly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Trialeurodes vaporariorum
greenhouse whitefly - (species)
Intraspecific
Candidate Gene
Karatolos N; Gorman K; Williamson MS ; et al. (2012)
Mutations in the sodium channel associated with pyrethroid resistance in the greenhouse whitefly, Tr[...]
1 Additional References
GP00001862
para
P35500
Physiology
2 mutations
Trialeurodes vaporariorum
greenhouse whitefly - (species)
Trialeurodes vaporariorum
greenhouse whitefly - (species)
para (kdr)
Trialeurodes vaporariorum
greenhouse whitefly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Hyalella azteca
(species)
Intraspecific
Candidate Gene
Major KM; Weston DP; Lydy MJ ; et al. (2018)
Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]
GP00001863
para
P35500
Physiology
M918L - ATG>TTG - conferred by a TTG codon rather than CTG - The M918L TTG and the M918L CTG were both identified in the Chualar Creek (HighPU) population and have also been identified in populations of the green peach aphid M. persicae (Panini et al., 2015).
Hyalella azteca
(species)
Hyalella azteca
(species)
para (kdr)
Hyalella azteca
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Hyalella azteca
(species) D
Intraspecific
Candidate Gene
Major KM; Weston DP; Lydy MJ ; et al. (2018)
Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]
GP00001864
para
P35500
Physiology
L925V
Hyalella azteca
(species)
Hyalella azteca
(species) D
para (kdr)
Hyalella azteca
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Panini M; Anaclerio M; Puggioni V ; et al. (2015)
Presence and impact of allelic variations of two alternative s-kdr mutations, M918T and M918L, in th[...]
3 Additional References
GP00001865
para
P35500
Physiology
M918L
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
para (kdr)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Panini M; Anaclerio M; Puggioni V ; et al. (2015)
Presence and impact of allelic variations of two alternative s-kdr mutations, M918T and M918L, in th[...]
1 Additional References
GP00001866
para
P35500
Physiology
M918L
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
para (kdr)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Ishak IH; Jaal Z; Ranson H ; et al. (2015)
Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in the dengue vectors [...]
2 Additional References
GP00002444
para
P35500
Physiology
V1016G
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
para (kdr)
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Ishak IH; Jaal Z; Ranson H ; et al. (2015)
Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in the dengue vectors [...]
1 Additional References
GP00002445
para
P35500
Physiology
F1534C
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
para (kdr)
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
3 Mutations:
Coding
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Plernsub S; Saingamsook J; Yanola J ; et al. (2016)
Additive effect of knockdown resistance mutations, S989P, V1016G and F1534C, in a heterozygous genot[...]
1 Additional References
GP00002446
para
P35500
Physiology
3 mutations
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
para (kdr)
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes albopictus
Asian tiger mosquito - (species) D
Intraspecific
Candidate Gene
Kasai S; Ng LC; Lam-Phua SG ; et al. (2011)
First detection of a putative knockdown resistance gene in major mosquito vector, Aedes albopictus.
1 Additional References
GP00002447
para
P35500
Physiology
F1534C
Aedes albopictus
Asian tiger mosquito - (species)
Aedes albopictus
Asian tiger mosquito - (species) D
para (kdr)
Aedes albopictus
Asian tiger mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Phlebotomus argentipes
(species) D
Intraspecific
Candidate Gene
Balaska S; Fotakis EA; Chaskopoulou A ; et al. (2021)
Chemical control and insecticide resistance status of sand fly vectors worldwide.
GP00002469
para
P35500
Physiology
L1014S
Phlebotomus argentipes
(species)
Phlebotomus argentipes
(species) D
para (kdr)
Phlebotomus argentipes
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Phlebotomus argentipes
(species) D
Intraspecific
Candidate Gene
Balaska S; Fotakis EA; Chaskopoulou A ; et al. (2021)
Chemical control and insecticide resistance status of sand fly vectors worldwide.
GP00002470
para
P35500
Physiology
L1014F
Phlebotomus argentipes
(species)
Phlebotomus argentipes
(species) D
para (kdr)
Phlebotomus argentipes
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Heliothis virescens
tobacco budworm - (species) D
Intraspecific
Candidate Gene
Head DJ; McCaffery AR; Callaghan A (1998)
Novel mutations in the para-homologous sodium channel gene associated with phenotypic expression of [...]
GP00002486
para
P35500
Physiology
2 mutations
Heliothis virescens
tobacco budworm - (species)
Heliothis virescens
tobacco budworm - (species) D
para (kdr)
Heliothis virescens
tobacco budworm - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Head DJ; McCaffery AR; Callaghan A (1998)
Novel mutations in the para-homologous sodium channel gene associated with phenotypic expression of [...]
GP00002487
para
P35500
Physiology
2 mutations
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
para (kdr)
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Haddi K; Tomé HVV; Du Y ; et al. (2017)
Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a [...]
1 Additional References
GP00002488
para
P35500
Physiology
2 mutations
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
para (kdr)
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex quinquefasciatus
southern house mosquito - (species) D
Intraspecific
Candidate Gene
Xu Q; Zhang L; Li T ; et al. (2012)
Evolutionary adaptation of the amino acid and codon usage of the mosquito sodium channel following i[...]
GP00002489
para
P35500
Physiology
3 nonsynonymous A(109)S L(982)F and W(1573)R) and 6 synonymous L(852) G(891) A(1241) D(1245) P(1249) and G(1733)) mutations were identified. The co-existence of all 9 mutations and their homozygousity were found to be important factors for high levels of resistance.
Culex quinquefasciatus
southern house mosquito - (species)
Culex quinquefasciatus
southern house mosquito - (species) D
para (kdr)
Culex quinquefasciatus
southern house mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aphis gossypii
cotton aphid - (species) D
Intraspecific
Candidate Gene
Marshall Kate L; Moran Christopher; Chen Yizhou ; et al. (2012
)
Detection of kdr pyrethroid resistance in the cotton aphid, Aphis gossypii (Hemiptera: Aphididae), u[...]
2 Additional References
GP00002490
para
P35500
Physiology
L1014F
Aphis gossypii
cotton aphid - (species)
Aphis gossypii
cotton aphid - (species) D
para (kdr)
Aphis gossypii
cotton aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus evansi
red spider mite - (species) D
Intraspecific
Linkage Mapping
Nyoni BN; Gorman K; Mzilahowa T ; et al. (2011)
Pyrethroid resistance in the tomato red spider mite, Tetranychus evansi, is associated with mutation[...]
GP00002493
para
P35500
Physiology
M918T - first report of the M918T mutation in the absence of L1014F in any arthropod species.
Tetranychus evansi
red spider mite - (species)
Tetranychus evansi
red spider mite - (species) D
para (kdr)
Tetranychus evansi
red spider mite - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Liriomyza huidobrensis
pea leafminer - (species) D
Intraspecific
Candidate Gene
Davies TG; Field LM; Usherwood PN ; et al. (2007)
DDT, pyrethrins, pyrethroids and insect sodium channels.
GP00002494
para
P35500
Physiology
2 mutations
Liriomyza huidobrensis
pea leafminer - (species)
Liriomyza huidobrensis
pea leafminer - (species) D
para (kdr)
Liriomyza huidobrensis
pea leafminer - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Liriomyza sativae
vegetable leafminer - (species) D
Intraspecific
Candidate Gene
Davies TG; Field LM; Usherwood PN ; et al. (2007)
DDT, pyrethrins, pyrethroids and insect sodium channels.
GP00002495
para
P35500
Physiology
L1014F
Liriomyza sativae
vegetable leafminer - (species)
Liriomyza sativae
vegetable leafminer - (species) D
para (kdr)
Liriomyza sativae
vegetable leafminer - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Thrips tabaci
(species) D
Intraspecific
Candidate Gene
Toda S; Morishita M (2009)
Identification of three point mutations on the sodium channel gene in pyrethroid-resistant Thrips ta[...]
GP00002496
para
P35500
Physiology
2 mutations
Thrips tabaci
(species)
Thrips tabaci
(species) D
para (kdr)
Thrips tabaci
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Thrips tabaci
(species) D
Intraspecific
Candidate Gene
Toda S; Morishita M (2009)
Identification of three point mutations on the sodium channel gene in pyrethroid-resistant Thrips ta[...]
GP00002497
para
P35500
Physiology
T929I
Thrips tabaci
(species)
Thrips tabaci
(species) D
para (kdr)
Thrips tabaci
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aphis gossypii
cotton aphid - (species) D
Intraspecific
Candidate Gene
Carletto J; Martin T; Vanlerberghe-Masutti F ; et al. (2010)
Insecticide resistance traits differ among and within host races in Aphis gossypii.
GP00002498
para
P35500
Physiology
M918L
Aphis gossypii
cotton aphid - (species)
Aphis gossypii
cotton aphid - (species) D
para (kdr)
Aphis gossypii
cotton aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Hyalella azteca
(species) D
Intraspecific
Candidate Gene
Major KM; Weston DP; Lydy MJ ; et al. (2018)
Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]
GP00002499
para
P35500
Physiology
M918L in species B
Hyalella azteca
(species)
Hyalella azteca
(species) D
para (kdr)
Hyalella azteca
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Hyalella azteca
(species) D
Intraspecific
Candidate Gene
Major KM; Weston DP; Lydy MJ ; et al. (2018)
Unintentional exposure to terrestrial pesticides drives widespread and predictable evolution of resi[...]
GP00002500
para
P35500
Physiology
M918L in species C
Hyalella azteca
(species)
Hyalella azteca
(species) D
para (kdr)
Hyalella azteca
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Thrips tabaci
(species) D
Intraspecific
Candidate Gene
Wu M; Gotoh H; Waters T ; et al. (2014)
Identification of an alternative knockdown resistance (kdr)-like mutation, M918L, and a novel mutati[...]
1 Additional References
GP00002501
para
P35500
Physiology
2 mutations
Thrips tabaci
(species)
Thrips tabaci
(species) D
para (kdr)
Thrips tabaci
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Rhipicephalus microplus
southern cattle tick - (species) D
Intraspecific
Candidate Gene
Morgan JA; Corley SW; Jackson LA ; et al. (2009)
Identification of a mutation in the para-sodium channel gene of the cattle tick Rhipicephalus (Boop[...]
1 Additional References
GP00002502
para
P35500
Physiology
L925I - Cytosine to adenine mutation at position 190 in the R. microplus sequence AF134216 results in an amino acid substitution from leucine in the susceptible strain to isoleucine in the resistant strain. A similar mutation has been shown to confer SP resistance in the whitefly Bemisia tabaci.
Rhipicephalus microplus
southern cattle tick - (species)
Rhipicephalus microplus
southern cattle tick - (species) D
para (kdr)
Rhipicephalus microplus
southern cattle tick - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Thrips palmi
(species) D
Intraspecific
Candidate Gene
Bao Wen Xue; Sonoda Shoji (2012
)
Resistance to cypermethrin in melon thrips, Thrips palmi (Thysanoptera: Thripidae), is conferred by [...]
GP00002503
para
P35500
Physiology
T929I
Thrips palmi
(species)
Thrips palmi
(species) D
para (kdr)
Thrips palmi
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
Intraspecific
Candidate Gene
Rinkevich FD; Du Y; Dong K (2013)
Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids.
1 Additional References
GP00002504
para
P35500
Physiology
T929I
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Leptinotarsa decemlineata
Colorado potato beetle - (species) D
para (kdr)
Leptinotarsa decemlineata
Colorado potato beetle - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Sitophilus zeamais
maize weevil - (species) D
Intraspecific
Candidate Gene
Araújo RA; Williamson MS; Bass C ; et al. (2011)
Pyrethroid resistance in Sitophilus zeamais is associated with a mutation (T929I) in the voltage-gat[...]
1 Additional References
GP00002505
para
P35500
Physiology
T929I
Sitophilus zeamais
maize weevil - (species)
Sitophilus zeamais
maize weevil - (species) D
para (kdr)
Sitophilus zeamais
maize weevil - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Frankliniella occidentalis
western flower thrips - (species) D
Intraspecific
Candidate Gene
Forcioli D; Frey B; Frey JE (2002)
High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...]
1 Additional References
GP00002506
para
P35500
Physiology
T929V
Frankliniella occidentalis
western flower thrips - (species)
Frankliniella occidentalis
western flower thrips - (species) D
para (kdr)
Frankliniella occidentalis
western flower thrips - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Frankliniella occidentalis
western flower thrips - (species) D
Intraspecific
Candidate Gene
Forcioli D; Frey B; Frey JE (2002)
High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...]
1 Additional References
GP00002507
para
P35500
Physiology
T929C
Frankliniella occidentalis
western flower thrips - (species)
Frankliniella occidentalis
western flower thrips - (species) D
para (kdr)
Frankliniella occidentalis
western flower thrips - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Frankliniella occidentalis
western flower thrips - (species) D
Intraspecific
Candidate Gene
Forcioli D; Frey B; Frey JE (2002)
High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...]
1 Additional References
GP00002508
para
P35500
Physiology
T929I
Frankliniella occidentalis
western flower thrips - (species)
Frankliniella occidentalis
western flower thrips - (species) D
para (kdr)
Frankliniella occidentalis
western flower thrips - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Frankliniella occidentalis
western flower thrips - (species) D
Intraspecific
Candidate Gene
Forcioli D; Frey B; Frey JE (2002)
High nucleotide diversity in the para-like voltage-sensitive sodium channel gene sequence in the wes[...]
1 Additional References
GP00002509
para
P35500
Physiology
L1014F
Frankliniella occidentalis
western flower thrips - (species)
Frankliniella occidentalis
western flower thrips - (species) D
para (kdr)
Frankliniella occidentalis
western flower thrips - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Plutella xylostella
diamondback moth - (species)
Intraspecific
Linkage Mapping
Endersby NM; Viduka K; Baxter SW ; et al. (2011)
Widespread pyrethroid resistance in Australian diamondback moth, Plutella xylostella (L.), is relate[...]
1 Additional References
GP00002510
para
P35500
Physiology
F1020S
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species)
para (kdr)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Bemisia tabaci
(species) D
Intraspecific
Candidate Gene
Mavridis K; Papapostolou KM; Ilias A ; et al. (2022)
Next-generation molecular diagnostics (TaqMan qPCR and ddPCR) for monitoring insecticide resistance [...]
2 Additional References
GP00002511
para
P35500
Physiology
T929V
Bemisia tabaci
(species)
Bemisia tabaci
(species) D
para (kdr)
Bemisia tabaci
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Ctenocephalides felis
cat flea - (species) D
Intraspecific
Candidate Gene
Bass C; Schroeder I; Turberg A ; et al. (2004)
Identification of mutations associated with pyrethroid resistance in the para-type sodium channel of[...]
1 Additional References
GP00002514
para
P35500
Physiology
T929V
Ctenocephalides felis
cat flea - (species)
Ctenocephalides felis
cat flea - (species) D
para (kdr)
Ctenocephalides felis
cat flea - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Ctenocephalides felis
cat flea - (species) D
Intraspecific
Candidate Gene
Bass C; Schroeder I; Turberg A ; et al. (2004)
Identification of mutations associated with pyrethroid resistance in the para-type sodium channel of[...]
1 Additional References
GP00002515
para
P35500
Physiology
L1014F
Ctenocephalides felis
cat flea - (species)
Ctenocephalides felis
cat flea - (species) D
para (kdr)
Ctenocephalides felis
cat flea - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Rhipicephalus microplus
southern cattle tick - (species) D
Intraspecific
Candidate Gene
Jonsson NN; Cutullè C; Corley SW ; et al. (2010)
Identification of a mutation in the para-sodium channel gene of the cattle tick Rhipicephalus microp[...]
2 Additional References
GP00002516
para
P35500
Physiology
G72V = G933V - G toT non-synonymous mutation at nucleotide position 214 that results in a glycine to valine substitution (G72V)
Rhipicephalus microplus
southern cattle tick - (species)
Rhipicephalus microplus
southern cattle tick - (species) D
para (kdr)
Rhipicephalus microplus
southern cattle tick - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Helicoverpa zea
corn earworm - (species) D
Intraspecific
Linkage Mapping
Hopkins BW; Pietrantonio PV (2010)
The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]
1 Additional References
GP00002517
para
P35500
Physiology
I951V = I936V
Helicoverpa zea
corn earworm - (species)
Helicoverpa zea
corn earworm - (species) D
para (kdr)
Helicoverpa zea
corn earworm - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Lepeophtheirus salmonis
salmon louse - (species) D
Intraspecific
Candidate Gene
Fallang A; Denholm I; Horsberg TE ; et al. (2005)
Novel point mutation in the sodium channel gene of pyrethroid-resistant sea lice Lepeophtheirus salm[...]
1 Additional References
GP00002518
para
P35500
Physiology
Q945R in transmembrane segment IIS5
Lepeophtheirus salmonis
salmon louse - (species)
Lepeophtheirus salmonis
salmon louse - (species) D
para (kdr)
Lepeophtheirus salmonis
salmon louse - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Brengues C; Hawkes NJ; Chandre F ; et al. (2003)
Pyrethroid and DDT cross-resistance in Aedes aegypti is correlated with novel mutations in the volta[...]
1 Additional References
GP00002519
para
P35500
Physiology
I104M = I1011M
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
para (kdr)
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Saavedra-Rodriguez K; Urdaneta-Marquez L; Rajatileka S ; et al. (2007)
A mutation in the voltage-gated sodium channel gene associated with pyrethroid resistance in Latin A[...]
1 Additional References
GP00002520
para
P35500
Physiology
I1011V
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
para (kdr)
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles stephensi
Asian malaria mosquito - (species) D
Intraspecific
Candidate Gene
Enayati AA; Vatandoost H; Ladonni H ; et al. (2003)
Molecular evidence for a kdr-like pyrethroid resistance mechanism in the malaria vector mosquito Ano[...]
2 Additional References
GP00002521
para
P35500
Physiology
L1014F - one point mutation difference involving a single A-T base change encoding a leucine to phenylalanine amino acid substitution in the pyrethroid-resistant strain.
Anopheles stephensi
Asian malaria mosquito - (species)
Anopheles stephensi
Asian malaria mosquito - (species) D
para (kdr)
Anopheles stephensi
Asian malaria mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles stephensi
Asian malaria mosquito - (species) D
Intraspecific
Candidate Gene
Safi NHZ; Ahmadi AA; Nahzat S ; et al. (2019)
Status of insecticide resistance and its biochemical and molecular mechanisms in Anopheles stephensi[...]
GP00002522
para
P35500
Physiology
L1014S
Anopheles stephensi
Asian malaria mosquito - (species)
Anopheles stephensi
Asian malaria mosquito - (species) D
para (kdr)
Anopheles stephensi
Asian malaria mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles subpictus
(species) D
Intraspecific
Candidate Gene
Karunaratne SHPP; Hawkes Nicola J; Perera MDB ; et al. (2007
)
Mutated sodium channel genes and elevated monooxygenases are found in pyrethroid resistant populatio[...]
1 Additional References
GP00002523
para
P35500
Physiology
L1014F - TTA>TTT
Anopheles subpictus
(species)
Anopheles subpictus
(species) D
para (kdr)
Anopheles subpictus
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex quinquefasciatus
southern house mosquito - (species) D
Intraspecific
Candidate Gene
Xu Q; Liu H; Zhang L ; et al. (2005)
Resistance in the mosquito, Culex quinquefasciatus, and possible mechanisms for resistance.
1 Additional References
GP00002524
para
P35500
Physiology
L1014F
Culex quinquefasciatus
southern house mosquito - (species)
Culex quinquefasciatus
southern house mosquito - (species) D
para (kdr)
Culex quinquefasciatus
southern house mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
D
Intraspecific
Candidate Gene
Rothwell JT; Morgan JA; James PJ ; et al. (2011)
Mechanism of resistance to synthetic pyrethroids in buffalo flies in south-east Queensland.
1 Additional References
GP00002525
para
P35500
Physiology
L1014F
D
para (kdr)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Brassicogethes aeneus
(species)
Intraspecific
Candidate Gene
Nauen Ralf; Zimmer Christoph T; Andrews Melanie ; et al. (2012
)
Target-site resistance to pyrethroids in European populations of pollen beetle, Meligethes aeneus F.[...]
1 Additional References
GP00002526
para
P35500
Physiology
L1014F - found in individuals from Denmark and Sweden
Brassicogethes aeneus
(species)
Brassicogethes aeneus
(species)
para (kdr)
Brassicogethes aeneus
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Sitobion avenae
English grain aphid - (species) D
Intraspecific
Candidate Gene
Foster SP; Paul VL; Slater R ; et al. (2014)
A mutation (L1014F) in the voltage-gated sodium channel of the grain aphid, Sitobion avenae, is asso[...]
1 Additional References
GP00002527
para
P35500
Physiology
L1014F
Sitobion avenae
English grain aphid - (species)
Sitobion avenae
English grain aphid - (species) D
para (kdr)
Sitobion avenae
English grain aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Cassanelli S; Cerchiari B; Giannini S ; et al. (2005)
Use of the RFLP-PCR diagnostic test for characterizing MACE and kdr insecticide resistance in the pe[...]
1 Additional References
GP00002528
para
P35500
Physiology
F979S (housefly numbering) located inside the linker segment IIS5-6
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
para (kdr)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles arabiensis
(species)
Intraspecific
Candidate Gene
Stump AD; Atieli FK; Vulule JM ; et al. (2004)
Dynamics of the pyrethroid knockdown resistance allele in western Kenyan populations of Anopheles ga[...]
1 Additional References
GP00002529
para
P35500
Physiology
L1014S
Anopheles arabiensis
(species)
Anopheles arabiensis
(species)
para (kdr)
Anopheles arabiensis
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles culicifacies
(species) D
Intraspecific
Candidate Gene
Singh OP; Dykes CL; Das MK ; et al. (2010)
Presence of two alternative kdr-like mutations, L1014F and L1014S, and a novel mutation, V1010L, in [...]
GP00002530
para
P35500
Physiology
L1014S
Anopheles culicifacies
(species)
Anopheles culicifacies
(species) D
para (kdr)
Anopheles culicifacies
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles culicifacies
(species) D
Intraspecific
Candidate Gene
Singh OP; Bali P; Hemingway J ; et al. (2009)
PCR-based methods for the detection of L1014 kdr mutation in Anopheles culicifacies sensu lato.
GP00002531
para
P35500
Physiology
L1014F
Anopheles culicifacies
(species)
Anopheles culicifacies
(species) D
para (kdr)
Anopheles culicifacies
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles sacharovi
(species)
Intraspecific
Candidate Gene
Lüleyap HU; Alptekin D; Kasap H ; et al. (2002)
Detection of knockdown resistance mutations in Anopheles sacharovi (Diptera: Culicidae) and genetic [...]
2 Additional References
GP00002532
para
P35500
Physiology
L1014S
Anopheles sacharovi
(species)
Anopheles sacharovi
(species)
para (kdr)
Anopheles sacharovi
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles sacharovi
(species)
Intraspecific
Candidate Gene
Yavaşoglu Sİ; Ülger C; Şimşek FM (2021)
The first implementation of allele-specific primers for detecting the knockdown and acetylcholineste[...]
1 Additional References
GP00002533
para
P35500
Physiology
L1014F
Anopheles sacharovi
(species)
Anopheles sacharovi
(species)
para (kdr)
Anopheles sacharovi
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Stomoxys calcitrans
stable fly - (species) D
Intraspecific
Candidate Gene
Olafson PU; Pitzer JB; Kaufman PE (2011)
Identification of a mutation associated with permethrin resistance in the para-type sodium channel o[...]
2 Additional References
GP00002534
para
P35500
Physiology
L1014H
Stomoxys calcitrans
stable fly - (species)
Stomoxys calcitrans
stable fly - (species) D
para (kdr)
Stomoxys calcitrans
stable fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles sinensis
(species) D
Intraspecific
Candidate Gene
Kang S; Jung J; Lee S ; et al. (2012)
The polymorphism and the geographical distribution of the knockdown resistance (kdr) of Anopheles si[...]
1 Additional References
GP00002536
para
P35500
Physiology
L1014C
Anopheles sinensis
(species)
Anopheles sinensis
(species) D
para (kdr)
Anopheles sinensis
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles albimanus
(species) D
Intraspecific
Candidate Gene
Lol JC; Castellanos ME; Liebman KA ; et al. (2013)
Molecular evidence for historical presence of knock-down resistance in Anopheles albimanus, a key ma[...]
1 Additional References
GP00002537
para
P35500
Physiology
L1014C in Nicaragua and Costa Rica individuals
Anopheles albimanus
(species)
Anopheles albimanus
(species) D
para (kdr)
Anopheles albimanus
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles albimanus
(species) D
Intraspecific
Candidate Gene
Lol JC; Castellanos ME; Liebman KA ; et al. (2013)
Molecular evidence for historical presence of knock-down resistance in Anopheles albimanus, a key ma[...]
1 Additional References
GP00002538
para
P35500
Physiology
L1014F in Mexico individuals
Anopheles albimanus
(species)
Anopheles albimanus
(species) D
para (kdr)
Anopheles albimanus
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex pipiens
northern house mosquito - (species) D
Intraspecific
Candidate Gene
Wang ZM; Li CX; Xing D ; et al. (2012)
Detection and widespread distribution of sodium channel alleles characteristic of insecticide resist[...]
1 Additional References
GP00002539
para
P35500
Physiology
L1014C
Culex pipiens
northern house mosquito - (species)
Culex pipiens
northern house mosquito - (species) D
para (kdr)
Culex pipiens
northern house mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles sinensis
(species) D
Intraspecific
Candidate Gene
Tan WL; Li CX; Wang ZM ; et al. (2012)
First detection of multiple knockdown resistance (kdr)-like mutations in voltage-gated sodium channe[...]
1 Additional References
GP00002540
para
P35500
Physiology
L1014W
Anopheles sinensis
(species)
Anopheles sinensis
(species) D
para (kdr)
Anopheles sinensis
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Blattella germanica
German cockroach - (species) D
Intraspecific
Candidate Gene
Pridgeon Julia W; Appel Arthur G; Moar William J ; et al. (2002
)
Variability of resistance mechanisms in pyrethroid resistant German cockroaches (Dictyoptera: Blatte[...]
1 Additional References
GP00002541
para
P35500
Physiology
F999S = F1020S - T to C at nt 2996 resulting in a phenylalanine999 to serine999 amino acid change
Blattella germanica
German cockroach - (species)
Blattella germanica
German cockroach - (species) D
para (kdr)
Blattella germanica
German cockroach - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Kwon Deok Ho; Clark J Marshall; Lee Si Hyeock (2010
)
Cloning of a sodium channel gene and identification of mutations putatively associated with fenpropa[...]
1 Additional References
GP00002542
para
P35500
Physiology
L1024V
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
para (kdr)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997)
Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...]
1 Additional References
GP00002543
para
P35500
Physiology
A1549V = A1410V
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
para (kdr)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997)
Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...]
1 Additional References
GP00002544
para
P35500
Physiology
A1648V = A1494V
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
para (kdr)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Kawada H; Higa Y; Komagata O ; et al. (2009)
Widespread distribution of a newly found point mutation in voltage-gated sodium channel in pyrethroi[...]
1 Additional References
GP00002545
para
P35500
Physiology
F1269C = F1534C
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
para (kdr)
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus cinnabarinus
carmine spider mite - (species) D
Intraspecific
Candidate Gene
Feng YN; Zhao S; Sun W ; et al. (2011)
The sodium channel gene in Tetranychus cinnabarinus (Boisduval): identification and expression analy[...]
1 Additional References
GP00002546
para
P35500
Physiology
F1538I
Tetranychus cinnabarinus
carmine spider mite - (species)
Tetranychus cinnabarinus
carmine spider mite - (species) D
para (kdr)
Tetranychus cinnabarinus
carmine spider mite - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Tsagkarakou A; Van Leeuwen T; Khajehali J ; et al. (2009)
Identification of pyrethroid resistance associated mutations in the para sodium channel of the two-s[...]
1 Additional References
GP00002547
para
P35500
Physiology
F1538I
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
para (kdr)
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Pittendrigh B; Reenan R; ffrench-Constant RH ; et al. (1997)
Point mutations in the Drosophila sodium channel gene para associated with resistance to DDT and pyr[...]
1 Additional References
GP00002548
para
P35500
Physiology
M1524I
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
para (kdr)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Varroa destructor
honeybee mite - (species) D
Intraspecific
Candidate Gene
Hubert J; Nesvorna M; Kamler M ; et al. (2014)
Point mutations in the sodium channel gene conferring tau-fluvalinate resistance in Varroa destructo[...]
GP00002549
para
P35500
Physiology
F975L
Varroa destructor
honeybee mite - (species)
Varroa destructor
honeybee mite - (species) D
para (kdr)
Varroa destructor
honeybee mite - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Varroa destructor
honeybee mite - (species) D
Intraspecific
Candidate Gene
Wang Ruiwu; Liu Zhiqi; Dong Ke ; et al. (2002
)
Association of novel mutations in a sodium channel gene with fluvalinate resistance in the mite, Var[...]
1 Additional References
GP00002550
para
P35500
Physiology
F1528L+M1823I
Varroa destructor
honeybee mite - (species)
Varroa destructor
honeybee mite - (species) D
para (kdr)
Varroa destructor
honeybee mite - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Varroa destructor
honeybee mite - (species) D
Intraspecific
Candidate Gene
Wang Ruiwu; Liu Zhiqi; Dong Ke ; et al. (2002
)
Association of novel mutations in a sodium channel gene with fluvalinate resistance in the mite, Var[...]
GP00002551
para
P35500
Physiology
F758L+L826P+I982V+M1055I = F1528L+L1596P+I1752V+M1823I
Varroa destructor
honeybee mite - (species)
Varroa destructor
honeybee mite - (species) D
para (kdr)
Varroa destructor
honeybee mite - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Stomoxys calcitrans
stable fly - (species) D
Intraspecific
Candidate Gene
Olafson PU; Kaufman PE; Duvallet G ; et al. (2019)
Frequency of kdr and kdr-his Alleles in Stable Fly (Diptera: Muscidae) Populations From the United S[...]
GP00002613
para
P35500
Physiology
L1014F
Stomoxys calcitrans
stable fly - (species)
Stomoxys calcitrans
stable fly - (species) D
para (kdr)
Stomoxys calcitrans
stable fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Singh KS; Cordeiro EMG; Troczka BJ ; et al. (2021)
Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...]
1 Additional References
GP00002614
para
P35500
Physiology
M918I ATG>ATT
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
para (kdr)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Singh KS; Cordeiro EMG; Troczka BJ ; et al. (2021)
Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aph[...]
1 Additional References
GP00002615
para
P35500
Physiology
M918I ATG>ATA
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
para (kdr)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Kushwah RBS; Kaur T; Dykes CL ; et al. (2020)
A new knockdown resistance (kdr) mutation, F1534L, in the voltage-gated sodium channel of Aedes aegy[...]
GP00002625
para
P35500
Physiology
F1534L - Phe (TTC) > Leu (CTC)
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
para (kdr)
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Wang XL; Su W; Zhang JH ; et al. (2016)
Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the[...]
1 Additional References
GP00002629
para
P35500
Physiology
F1845Y
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
para (kdr)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Wang XL; Su W; Zhang JH ; et al. (2016)
Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the[...]
1 Additional References
GP00002630
para
P35500
Physiology
V1848I
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
para (kdr)
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Roditakis E; Mavridis K; Riga M ; et al. (2017)
Identification and detection of indoxacarb resistance mutations in the para sodium channel of the to[...]
1 Additional References
GP00002631
para
P35500
Physiology
V1848I
Tuta absoluta
(species)
Tuta absoluta
(species) D
para (kdr)
Tuta absoluta
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Roditakis E; Mavridis K; Riga M ; et al. (2017)
Identification and detection of indoxacarb resistance mutations in the para sodium channel of the to[...]
1 Additional References
GP00002632
para
P35500
Physiology
F1845Y
Tuta absoluta
(species)
Tuta absoluta
(species) D
para (kdr)
Tuta absoluta
(species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Sun H; Kasai S; Scott JG (2017)
Two novel house fly Vssc mutations, D600N and T929I, give rise to new insecticide resistance alleles[...]
GP00002644
para
P35500
Physiology
super-kdr+D600N - super-kdr+D600N confers higher levels of resistance to seven pyrethroids relative to super-kdr.
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
para (kdr)
Musca domestica
house fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Sun H; Kasai S; Scott JG (2017)
Two novel house fly Vssc mutations, D600N and T929I, give rise to new insecticide resistance alleles[...]
GP00002645
para
P35500
Physiology
kdr+T929I - addition of T929I to the kdr mutation (L1014F) increased resistance to all pyrethroids (except etofenprox) and enhanced resistance by ~1000-fold to acrinathrin and flumethrin.
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
para (kdr)
Musca domestica
house fly - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes albopictus
Asian tiger mosquito - (species) D
Intraspecific
Candidate Gene
Wu Y; Liu Q; Qi Y ; et al. (2021)
Knockdown Resistance (kdr) Mutations I1532T and F1534S Were Identified in Aedes albopictus Field Pop[...]
GP00002646
para
P35500
Physiology
F1534S
Aedes albopictus
Asian tiger mosquito - (species)
Aedes albopictus
Asian tiger mosquito - (species) D
para (kdr)
Aedes albopictus
Asian tiger mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes albopictus
Asian tiger mosquito - (species) D
Intraspecific
Candidate Gene
Wu Y; Liu Q; Qi Y ; et al. (2021)
Knockdown Resistance (kdr) Mutations I1532T and F1534S Were Identified in Aedes albopictus Field Pop[...]
GP00002647
para
P35500
Physiology
I1532T
Aedes albopictus
Asian tiger mosquito - (species)
Aedes albopictus
Asian tiger mosquito - (species) D
para (kdr)
Aedes albopictus
Asian tiger mosquito - (species)
Published - Accepted by Curator
para (kdr)
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Fontaine S; Caddoux L; Brazier C ; et al. (2011)
Uncommon associations in target resistance among French populations of Myzus persicae from oilseed r[...]
1 Additional References
GP00002649
para
P35500
Physiology
L932F
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
para (kdr)
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
pastrel
Pathogen resistance (viruses)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Association Mapping
Magwire MM; Fabian DK; Schweyen H ; et al. (2012)
Genome-wide association studies reveal a simple genetic basis of resistance to naturally coevolving [...]
GP00000854
pst
Q8IQ82
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
pastrel
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Patched1 (Ptc1)
Body size (height)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Lettre G (2011)
Recent progress in the study of the genetics of height.
GP00000855
ptch1
Q98864
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
Patched1 (Ptc1)
Homo sapiens
human - (species)
Published - Accepted by Curator
pax7a
Coloration (scales)
Cis-regulatory,
Unknown
Labeotropheus trewavasae
(species)
Intraspecific
Candidate Gene
Roberts RB; Moore EC; Kocher TD (2017)
An allelic series at pax7a is associated with colour polymorphism diversity in Lake Malawi cichlid f[...]
GP00001422
Pax7
P47239
Morphology
unknown
Labeotropheus trewavasae
(species)
Labeotropheus trewavasae
(species)
pax7a
Labeotropheus trewavasae
(species)
Published - Accepted by Curator
pax7a
Coloration (scales)
Cis-regulatory,
Unknown
Labeotropheus trewavasae
(species)
Intraspecific
Candidate Gene
Roberts RB; Moore EC; Kocher TD (2017)
An allelic series at pax7a is associated with colour polymorphism diversity in Lake Malawi cichlid f[...]
GP00001423
Pax7
P47239
Morphology
unknown
Labeotropheus trewavasae
(species)
Labeotropheus trewavasae
(species)
pax7a
Labeotropheus trewavasae
(species)
Published - Accepted by Curator
pax7a
Coloration (scales)
Cis-regulatory,
Unknown
Labeotropheus trewavasae
(species)
Intraspecific
Candidate Gene
Roberts RB; Moore EC; Kocher TD (2017)
An allelic series at pax7a is associated with colour polymorphism diversity in Lake Malawi cichlid f[...]
GP00001424
Pax7
P47239
Morphology
unknown
Labeotropheus trewavasae
(species)
Labeotropheus trewavasae
(species)
pax7a
Labeotropheus trewavasae
(species)
Published - Accepted by Curator
pdm3
Coloration (female abdomen)
Cis-regulatory,
Complex Change
Drosophila serrata
(species) D
Intraspecific
Linkage Mapping
Yassin A; Delaney EK; Reddiex AJ ; et al. (2016)
The pdm3 Locus Is a Hotspot for Recurrent Evolution of Female-Limited Color Dimorphism in Drosophila[...]
GP00001400
pdm3
A0A0B4LEG2
Morphology
1st intron variant divergent in length and sequence. Dark haplotype contains four tandem sets of three motifs.
Drosophila serrata
(species)
Drosophila serrata
(species) D
pdm3
Drosophila serrata
(species)
Published - Accepted by Curator
pdm3
Coloration (female abdomen)
Cis-regulatory,
Unknown
Drosophila kikkawai
(species)
Intraspecific
Linkage Mapping
Yassin A; Delaney EK; Reddiex AJ ; et al. (2016)
The pdm3 Locus Is a Hotspot for Recurrent Evolution of Female-Limited Color Dimorphism in Drosophila[...]
GP00001401
pdm3
A0A0B4LEG2
Morphology
associated SNPs occur in the intergenic upstream region except one in the second intron
Drosophila kikkawai
(species)
Drosophila kikkawai
(species)
pdm3
Drosophila kikkawai
(species)
Published - Accepted by Curator
pdm3
Coloration (female abdomen)
Unknown,
Unknown
Drosophila burlai
(species)
Intraspecific
Linkage Mapping
Yassin A; Delaney EK; Reddiex AJ ; et al. (2016)
The pdm3 Locus Is a Hotspot for Recurrent Evolution of Female-Limited Color Dimorphism in Drosophila[...]
GP00001402
pdm3
A0A0B4LEG2
Morphology
unknown
Drosophila burlai
(species)
Drosophila burlai
(species)
pdm3
Drosophila burlai
(species)
Published - Accepted by Curator
peel-1
Hybrid incompatibility
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Seidel HS; Ailion M; Li J ; et al. (2011)
A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion i[...]
1 Additional References
GP00001321
peel-1
G5EGC6
Physiology
1bp deletion creating a frameshift starting at amino acid position 43. Total length of wild-type protein is 174 amino acids. N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
peel-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
peel-1
Hybrid incompatibility
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Seidel HS; Ailion M; Li J ; et al. (2011)
A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion i[...]
1 Additional References
GP00001322
peel-1
G5EGC6
Physiology
G>T - glycine to stop codon at position 57. Total length of wild-type protein is 174 amino acids. N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
peel-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
peel-1/zeel-1
Hybrid incompatibility
Gene Loss,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Seidel HS; Rockman MV; Kruglyak L (2008)
Widespread genetic incompatibility in C. elegans maintained by balancing selection.
1 Additional References
GP00001320
peel-1
G5EGC6
Physiology
19kb deletion N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
peel-1/zeel-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
PER36
Mucilage (seeds)
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Macquet A; Ralet MC; Loudet O ; et al. (2007)
A naturally occurring mutation in an Arabidopsis accession affects a beta-D-galactosidase that incre[...]
1 Additional References
GP00001273
PER36
Q9SD46
Physiology
Tyrosine @position 262bp to a stop codon N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
PER36
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Period (per)
Locomotor activity (temperature sensitivity)
Coding,
Indel
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Sawyer LA; Hennessy JM; Peixoto AA ; et al. (1997)
Natural variation in a Drosophila clock gene and temperature compensation.
GP00002002
per
P07663
Behavior
repeat (Thr-Gly) either 17 times or 20 times within the protein coding sequence
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Period (per)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Period (per)
Diapause
Unknown,
Unknown
Pieris napi
(species)
Intraspecific
Association Mapping
Pruisscher P; Nylin S; Wheat CW ; et al. (2021)
A region of the sex chromosome associated with population differences in diapause induction contains[...]
1 Additional References
GP00002427
per
P07663
Physiology
Multiple amino acid differences. Presence of five fixed SNPs between the N and S populations (one intergenic, two intronic and two exonic nonsynonymous substitutions).
Pieris napi
(species)
Pieris napi
(species)
Period (per)
Pieris napi
(species)
Published - Accepted by Curator
PGRP-LC
Pathogen resistance
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Sackton TB; Lazzaro BP; Clark AG (2010)
Genotype and gene expression associations with immune function in Drosophila.
GP00000861
PGRP-LC
Q9GNK5
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
PGRP-LC
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
PHGPx
Xenobiotic resistance (gemcitabine ; female fertility)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Association Mapping
King EG; Kislukhin G; Walters KN ; et al. (2014)
Using Drosophila melanogaster to identify chemotherapy toxicity genes.
GP00001405
PHGPx
Q8IRD4
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
PHGPx
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Phosphate transporter PHO1
Root growth (allometry of lateral roots)
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Association Mapping
Rosas U; Cibrian-Jaramillo A; Ristova D ; et al. (2013)
Integration of responses within and across Arabidopsis natural accessions uncovers loci controlling [...]
GP00001284
PHO1
Q8S403
Morphology
histidine to tyrosine @position 8388425 in chromosome III
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Phosphate transporter PHO1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
phytochrome A (PHYA)
Light sensitivity
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Candidate Gene
Maloof JN; Borevitz JO; Dabi T ; et al. (2001)
Natural variation in light sensitivity of Arabidopsis.
GP00000870
PHYA
P14712
Physiology
M548T
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
phytochrome A (PHYA)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
phytochrome B (PHYB)
Light sensitivity
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Filiault DL; Wessinger CA; Dinneny JR ; et al. (2008)
Amino acid polymorphisms in Arabidopsis phytochrome B cause differential responses to light.
GP00000871
PHYB
P14713
Physiology
I143L
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
phytochrome B (PHYB)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
phytochrome C (PHYC)
Light sensitivity
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Balasubramanian S; Sureshkumar S; Agrawal M ; et al. (2006)
The PHYTOCHROME C photoreceptor gene mediates natural variation in flowering and growth responses of[...]
GP00000873
PHYC
P14714
Physiology
K299*; the predicted Fr-2 PHYC protein therefore lacks half of the GAF domain; and the entire PHY; PAS and histidine kinase domains; all of which are typically required for phytochrome function N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
phytochrome C (PHYC)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
phytochrome D (PHYD)
Leaf morphology (increased petiole length)
Cotyledon morphology (reduced cotyledon area)
Coloration (anthocyanin accumulation in seedling stems)
Plant size (diminished effect of end-of-day pulse of far red light on hypocotyl elongation)
Plant architecture (decrease in number of rosette leaves at onset of flowering)
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Aukerman MJ; Hirschfeld M; Wester L ; et al. (1997)
A deletion in the PHYD gene of the Arabidopsis Wassilewskija ecotype defines a role for phytochrome [...]
GP00000874
PHYD
P42497
Morphology
Morphology
Morphology
Physiology
Morphology
14bp deletion causing premature stop codon N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
phytochrome D (PHYD)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
PigmR
Pathogen resistance (plant fungus pathogen)
Unknown,
Unknown
Oryza sativa
rice - (species)
Intraspecific
Linkage Mapping
Deng Y; Zhai K; Xie Z ; et al. (2017)
Epigenetic regulation of antagonistic receptors confers rice blast resistance with yield balance.
GP00001592
Pigm_GM4.7
A0A1P8CYR1
Physiology
unknown
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
PigmR
Oryza sativa
rice - (species)
Published - Accepted by Curator
PIK3CG
Hematopoiesis (mean blood platelet volume)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001611
PIK3CG
P48736
Physiology
C>G at the associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
PIK3CG
Homo sapiens
human - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000886
Pitx1
P70314
Morphology
488bp promoter region : deletion 1 ; 5 kb deletion
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000887
Pitx1
P70314
Morphology
488bp promoter region : deletion 2 ; 757bp deletion present in the pelvic-reduced BEPA population from Alaska
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000888
Pitx1
P70314
Morphology
488bp promoter region : deletion 3 ; 3.5 kb deletion
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000889
Pitx1
P70314
Morphology
488bp promoter region : deletion 4 ; 757 bp deletion
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000890
Pitx1
P70314
Morphology
488bp promoter region : deletion 5 ; 2 kb deletion
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000891
Pitx1
P70314
Morphology
488bp promoter region : deletion 6 ; 973bp deletion present in the Hump Lake AK pelvic-reduced population (HUMP)
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000892
Pitx1
P70314
Morphology
488bp promoter region : deletion 7 ; 1868bp deletion
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000893
Pitx1
P70314
Morphology
488bp promoter region : deletion 8 ; 8 kb deletion
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
pitx1
Pelvis morphology (loss of ventral spines)
Cis-regulatory,
Deletion
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Linkage Mapping
Shapiro MD; Marks ME; Peichel CL ; et al. (2004)
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks.
1 Additional References
GP00000894
Pitx1
P70314
Morphology
488bp promoter region : deletion 9 ; 8 kb deletion
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
pitx1
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
plep-1
Male-male copulatory behavior
Coding,
SNP
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Noble LM; Chang AS; McNelis D ; et al. (2015)
Natural Variation in plep-1 Causes Male-Male Copulatory Behavior in C. elegans.
GP00000897
plep-1
A0A0K3AR66
Behavior
V278D
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
plep-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
plg-1
Copulatory plug
Coding,
Insertion
N
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Palopoli MF; Rockman MV; TinMaung A ; et al. (2008)
Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans.
GP00000898
Physiology
insertion of transposable element in an exon N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
plg-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
Pm3
Pathogen resistance
Coding,
SNP
Triticum aestivum
bread wheat - (species)
Intraspecific
Linkage Mapping
Yahiaoui N; Kaur N; Keller B (2009)
Independent evolution of functional Pm3 resistance genes in wild tetraploid wheat and domesticated b[...]
1 Additional References
GP00000899
PM3
C1K3M2
Physiology
Various substitution haplotypes - exact causing amino acid change(s) unknown - in hexaploid bread wheat one amino acid change in a solvent‐exposed residue of LRR27 (E1334 to V1334) was sufficient to convert the susceptible Pm3CS into a functional resistance allele (Yahiaoui et al., 2006).
Triticum aestivum
bread wheat - (species)
Triticum aestivum
bread wheat - (species)
Pm3
Triticum aestivum
bread wheat - (species)
Published - Accepted by Curator
PMEI6
Mucilage (seeds)
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Saez-Aguayo S; Rondeau-Mouro C; Macquet A ; et al. (2014)
Local evolution of seed flotation in Arabidopsis.
1 Additional References
GP00001272
AXX17_At2g45450
A0A178VVA1
Physiology
frameshift mutation due to a 1-bp insertion 581 bp after the ATG codon that changed amino acids 194 to 205 followed by the introduction of a stop codon N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
PMEI6
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
poils au dos (pad)
Bristle number (thorax)
Coding,
Deletion
N
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Gibert JM; Marcellini S; David JR ; et al. (2005)
A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription [...]
GP00000915
pad
Q9VEW6
Morphology
29bp deletion N
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
poils au dos (pad)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Pore-forming toxin-like (PFT)
Pathogen resistance (Fusarium)
Gene Loss,
Indel
N
Triticum aestivum
bread wheat - (species)
Intraspecific
Linkage Mapping
Rawat N; Pumphrey MO; Liu S ; et al. (2016)
Wheat Fhb1 encodes a chimeric lectin with agglutinin domains and a pore-forming toxin-like domain co[...]
GP00001563
Q4JEV5
Physiology
PFT gene is present and constitutively expressed in resistant line and absent in susceptible line N
Triticum aestivum
bread wheat - (species)
Triticum aestivum
bread wheat - (species)
Pore-forming toxin-like (PFT)
Triticum aestivum
bread wheat - (species)
Published - Accepted by Curator
pot-2
Telomere length
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Association Mapping
Cook DE; Zdraljevic S; Tanny RE ; et al. (2016)
The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length.
GP00001317
pot-2
O45595
Physiology
Phenylalanine-to-isoleucine (F68I) N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
pot-2
Caenorhabditis elegans
(species)
Published - Accepted by Curator
PPAR-alpha
Hypoxia response
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Simonson TS; Yang Y; Huff CD ; et al. (2010)
Genetic evidence for high-altitude adaptation in Tibet.
1 Additional References
GP00000917
PPARA
Q07869
Physiology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
PPAR-alpha
Homo sapiens
human - (species)
Published - Accepted by Curator
PPAR-delta
Body size (height)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
N'Diaye A; Chen GK; Palmer CD ; et al. (2011)
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of[...]
1 Additional References
GP00000918
PPARD
Q03181
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
PPAR-delta
Homo sapiens
human - (species)
Published - Accepted by Curator
PPAR-gamma
Fertility
Cis-regulatory,
SNP
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Association Mapping
Hoedjes KM; Kostic H; Flatt T ; et al. (2023)
A Single Nucleotide Variant in the PPARγ-homolog Eip75B Affects Fecundity in Drosophila.
GP00002664
Eip75B
P17672
Physiology
This SNP is biallelic with the “T” variant being more common in the late-reproducing long-lived populations (average frequency: 0.84 “T” / 0.16 “G”) as compared to the early-reproducing populations (average frequency: 0.52 “T” / 0.48 “G”).
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
PPAR-gamma
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
ppw-1
Resistance to dsRNA
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Tijsterman M; Okihara KL; Thijssen K ; et al. (2002)
PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of[...]
GP00000921
Physiology
1bp deletion resulting in stop codon N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
ppw-1
Caenorhabditis elegans
(species)
Published - Accepted by Curator
Prdm9
Hybrid incompatibility (F1 male sterility)
Recombination rate (use of recombination hotspots)
Unknown,
Unknown
Mus musculus
house mouse - (species)
Intraspecific
Linkage Mapping
Mihola O; Trachtulec Z; Vlcek C ; et al. (2009)
A mouse speciation gene encodes a meiotic histone H3 methyltransferase.
2 Additional References
GP00000922
Prdm9
Q96EQ9
Physiology
Physiology
possible dosage difference (number of gene copies) interacting with an allele that affects post-transcriptional stability
Mus musculus
house mouse - (species)
Mus musculus
house mouse - (species)
Prdm9
Mus musculus
house mouse - (species)
Published - Accepted by Curator
Prdm9
Recombination rate (use of recombination hotspots)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Berg IL; Neumann R; Sarbajna S ; et al. (2011)
Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots [...]
GP00000923
Prdm9
Q96EQ9
Physiology
Various haplotypes
Homo sapiens
human - (species)
Homo sapiens
human - (species)
Prdm9
Homo sapiens
human - (species)
Published - Accepted by Curator
PRKCD
Pathogen resistance
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001381
PRKCD
Q05655
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
PRKCD
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
Proline specific permease PUT4
Nitrogen use (growth rate on proline)
Cis-regulatory,
Unknown
Saccharomyces cerevisiae
baker's yeast - (species) D
Intraspecific
Linkage Mapping
Ibstedt S; Stenberg S; Bagés S ; et al. (2015)
Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.
GP00001501
PUT4
P15380
Physiology
several synonymous and promoter mutations
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Proline specific permease PUT4
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
prolyl endopeptidase (PREP)
Coloration (scales)
Cis-regulatory,
Unknown
Uta stansburiana
(species) D
Intraspecific
Association Mapping
Corl A; Bi K; Luke C ; et al. (2018)
The Genetic Basis of Adaptation following Plastic Changes in Coloration in a Novel Environment.
GP00002108
PREP
P48147
Morphology
no coding mutation associated with the phenotype - 2 differentiated SNPs in introns and one is a synonymous change.
Uta stansburiana
(species)
Uta stansburiana
(species) D
prolyl endopeptidase (PREP)
Uta stansburiana
(species)
Published - Accepted by Curator
prophenoloxidase 1 (PPO1)
Enzymatic activity
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Asada N (1997)
Genetic variants affecting phenoloxidase activity in Drosophila melanogaster.
GP00002001
Physiology
Exact causing mutation(s) unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
prophenoloxidase 1 (PPO1)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
protein kinase cAMP-dependent type I regulatory subunit alpha (PRKAR1A)
Coloration (scales)
Cis-regulatory,
Unknown
Uta stansburiana
(species) D
Intraspecific
Association Mapping
Corl A; Bi K; Luke C ; et al. (2018)
The Genetic Basis of Adaptation following Plastic Changes in Coloration in a Novel Environment.
GP00002109
Prkar1a
Q9DBC7
Morphology
no coding mutation associated with the phenotype - one differentiated SNP in an intron in the 5' UTR
Uta stansburiana
(species)
Uta stansburiana
(species) D
protein kinase cAMP-dependent type I regulatory subunit alpha (PRKAR1A)
Uta stansburiana
(species)
Published - Accepted by Curator
protein phosphatase
Xenobiotic resistance (artemisinin)
Coding,
SNP
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
Intraspecific
Association Mapping
Miotto O; Amato R; Ashley EA ; et al. (2015)
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
GP00001534
PF3D7_1012700
Q8IJR8
Physiology
p.Val1157Leu
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Plasmodium falciparum
malaria parasite P. falciparum - (species) D
protein phosphatase
Plasmodium falciparum
malaria parasite P. falciparum - (species)
Published - Accepted by Curator
protoporphyrinogen oxidase (PPO2 = PPX2L)
Xenobiotic resistance (herbicides)
Coding,
Deletion
Amaranthus tuberculatus
(species) D
Intraspecific
Linkage Mapping
Patzoldt WL; Hager AG; McCormick JS ; et al. (2006)
A codon deletion confers resistance to herbicides inhibiting protoporphyrinogen oxidase.
GP00000929
PPX2L
Q0NZW6
Physiology
3bp deletion; deletion of G210
Amaranthus tuberculatus
(species)
Amaranthus tuberculatus
(species) D
protoporphyrinogen oxidase (PPO2 = PPX2L)
Amaranthus tuberculatus
(species)
Published - Accepted by Curator
PSMD13
Hematopoiesis (mean blood platelet volume)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001615
PSMD13
Q9UNM6
Physiology
A>G at the associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
PSMD13
Homo sapiens
human - (species)
Published - Accepted by Curator
PSST
Xenobiotic resistance (METI-I acaricide)
Coding,
SNP
Tetranychus urticae
two-spotted spider mite - (species) D
Intraspecific
Candidate Gene
Bajda S; Dermauw W; Panteleri R ; et al. (2017)
A mutation in the PSST homologue of complex I (NADH:ubiquinone oxidoreductase) from Tetranychus urti[...]
GP00002635
ND-20
Q9VXK7
Physiology
H92R
Tetranychus urticae
two-spotted spider mite - (species)
Tetranychus urticae
two-spotted spider mite - (species) D
PSST
Tetranychus urticae
two-spotted spider mite - (species)
Published - Accepted by Curator
PSST
Xenobiotic resistance (METI-I acaricide)
Coding,
SNP
Panonychus citri
citrus red mite - (species) D
Intraspecific
Candidate Gene
Alavijeh ES; Khajehali J; Snoeck S ; et al. (2020)
Molecular and genetic analysis of resistance to METI-I acaricides in Iranian populations of the citr[...]
GP00002636
ND-20
Q9VXK7
Physiology
H92R
Panonychus citri
citrus red mite - (species)
Panonychus citri
citrus red mite - (species) D
PSST
Panonychus citri
citrus red mite - (species)
Published - Accepted by Curator
PTPN1
High-altitude adaptation
Coding,
SNP
Locusta migratoria
migratory locust - (species) D
Intraspecific
Association Mapping
Ding D; Liu G; Hou L ; et al. (2018)
Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan m[...]
GP00002668
P18031NULL
Physiology
one nonsynonymous mutation (c.1046A>T) in PTPN1 in Tibetan locusts which encodes the amino acid substitution p.Asn349Ile at the proline (Pro)-rich domain of PTP1B.
Locusta migratoria
migratory locust - (species)
Locusta migratoria
migratory locust - (species) D
PTPN1
Locusta migratoria
migratory locust - (species)
Published - Accepted by Curator
PVX_084940
Xenobiotic resistance (multiresistance to antimalarial drugs)
Unknown,
Unknown
Plasmodium vivax
malaria parasite P. vivax - (species)
Intraspecific
Association Mapping
Pearson RD; Amato R; Auburn S ; et al. (2016)
Genomic analysis of local variation and recent evolution in Plasmodium vivax.
GP00001487
PVX_084940
A5K0T0
Physiology
unknown
Plasmodium vivax
malaria parasite P. vivax - (species)
Plasmodium vivax
malaria parasite P. vivax - (species)
PVX_084940
Plasmodium vivax
malaria parasite P. vivax - (species)
Published - Accepted by Curator
PVX_101445
Xenobiotic resistance (chloroquine)
Gene Amplification,
Insertion
Plasmodium vivax
malaria parasite P. vivax - (species) D
Intraspecific
Association Mapping
Pearson RD; Amato R; Auburn S ; et al. (2016)
Genomic analysis of local variation and recent evolution in Plasmodium vivax.
GP00001483
PVX_101445
A5K913
Physiology
3 kb duplication on chromosome 14 that includes PVX_101445
Plasmodium vivax
malaria parasite P. vivax - (species)
Plasmodium vivax
malaria parasite P. vivax - (species) D
PVX_101445
Plasmodium vivax
malaria parasite P. vivax - (species)
Published - Accepted by Curator
R2R3-Myb
Coloration (flowers)
Cis-regulatory,
Unknown
Phlox drummondii
(species)
Intraspecific
Linkage Mapping
Hopkins R; Rausher MD (2011)
Identification of two genes causing reinforcement in the Texas wildflower Phlox drummondii.
GP00000948
H8ZS70
Morphology
unknown
Phlox drummondii
(species)
Phlox drummondii
(species)
R2R3-Myb
Phlox drummondii
(species)
Published - Accepted by Curator
RAC1
Pathogen resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Borhan MH; Holub EB; Beynon JL ; et al. (2004)
The arabidopsis TIR-NB-LRR gene RAC1 confers resistance to Albugo candida (white rust) and is depend[...]
GP00000949
ARAC3
Q38912
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RAC1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RALY (hnRNP associated with lethal yellow)
Coloration (coat)
Cis-regulatory,
Insertion
Canis lupus
gray wolf - (species) D
Intraspecific
Association Mapping
Dreger DL; Parker HG; Ostrander EA ; et al. (2013 May-Jun)
Identification of a mutation that is associated with the saddle tan and black-and-tan phenotypes in [...]
GP00001366
RALY
Q9UKM9
Morphology
16 bpduplication g.1875_1890dupCCCCAGGTCAGAGTTT in intron
Canis lupus
gray wolf - (species)
Canis lupus
gray wolf - (species) D
RALY (hnRNP associated with lethal yellow)
Canis lupus
gray wolf - (species)
Published - Accepted by Curator
RAS1
Salt tolerance
Abscisic acid sensitivity
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Ren Z; Zheng Z; Chinnusamy V ; et al. (2010)
RAS1, a quantitative trait locus for salt tolerance and ABA sensitivity in Arabidopsis.
GP00000953
RAS1
O04515
Physiology
Physiology
Premature stop codon; Lys>STOP N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RAS1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RCR3
Pathogen resistance
Coding,
SNP
Solanum peruvianum
(species)
Intraspecific
Candidate Gene
Hörger AC; Ilyas M; Stephan W ; et al. (2012)
Balancing selection at the tomato RCR3 Guardee gene family maintains variation in strength of pathog[...]
GP00000963
Rcr3
Q8S333
Physiology
Candidate amino acid changes are I206K and/or Q222E and/or S330A
Solanum peruvianum
(species)
Solanum peruvianum
(species)
RCR3
Solanum peruvianum
(species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001246
At4g11040
Q9T010
Physiology
G892A
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Gene Loss,
Deletion
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001247
At4g11040
Q9T010
Physiology
gene loss: -5.7KB at position -4.38KB N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001248
At4g11040
Q9T010
Physiology
-23bp at position 1371 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001249
At4g11040
Q9T010
Physiology
-25bp at position 25 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001250
At4g11040
Q9T010
Physiology
-50bp at position 50; -390bp at position 504 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001251
At4g11040
Q9T010
Physiology
-13bp at position 1440 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001252
At4g11040
Q9T010
Physiology
-2bp at position 1456 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001253
At4g11040
Q9T010
Physiology
-4bp at position 1391 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001254
At4g11040
Q9T010
Physiology
-16bp at position 1054 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001255
At4g11040
Q9T010
Physiology
-19bp at position 594 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001256
At4g11040
Q9T010
Physiology
-2bp at position 606 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001257
At4g11040
Q9T010
Physiology
-4bp at position 11 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001258
At4g11040
Q9T010
Physiology
C684A which causes C135* N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001259
At4g11040
Q9T010
Physiology
4 amino acid changes: N45K; G54R; T55K; E208A - the effect of each single amino acid change has not been tested N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001260
At4g11040
Q9T010
Physiology
-1bp at position 498 causing premature STOP N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RDO5 REDUCED DORMANCY5
Seed dormancy
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Xiang Y; Song B; Née G ; et al. (2016)
Sequence Polymorphisms at the REDUCED DORMANCY5 Pseudophosphatase Underlie Natural Variation in Arab[...]
1 Additional References
GP00001261
At4g11040
Q9T010
Physiology
-1bp at position 498 causing premature STOP N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RDO5 REDUCED DORMANCY5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
ref(2)P
Pathogen resistance (sigma virus)
Coding,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Dru P; Bras F; Dezélée S ; et al. (1993)
Unusual variability of the Drosophila melanogaster ref(2)P protein which controls the multiplication[...]
2 Additional References
GP00001994
ref(2)P
P14199
Physiology
Several differences (SNP and indels) are detected between permissive ref(2)Po and restrictive ref(2)Pn strains. Exact causing mutation(s) unknown.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
ref(2)P
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
ref(2)P
Pathogen resistance (sigma virus)
Coding,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
Dru P; Bras F; Dezélée S ; et al. (1993)
Unusual variability of the Drosophila melanogaster ref(2)P protein which controls the multiplication[...]
2 Additional References
GP00001995
ref(2)P
P14199
Physiology
Several differences (SNP and indels) are detected between permissive ref(2)Po and restrictive ref(2)Pp strains. Exact causing mutation(s) unknown.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
ref(2)P
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Regulator of G-protein signaling 2 (RGS2)
Anxiety
Unknown,
Unknown
Mus musculus
house mouse - (species)
Intraspecific
Linkage Mapping
Yalcin B; Willis-Owen SA; Fullerton J ; et al. (2004)
Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mic[...]
GP00000967
Rgs2
O08849
Behavior
unknown
Mus musculus
house mouse - (species)
Mus musculus
house mouse - (species)
Regulator of G-protein signaling 2 (RGS2)
Mus musculus
house mouse - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes aegypti
yellow fever mosquito - (species) D
Intraspecific
Candidate Gene
Thompson M; Shotkoski F; ffrench-Constant R (1993)
Cloning and sequencing of the cyclodiene insecticide resistance gene from the yellow fever mosquito [...]
GP00000968
Rdl
P25123
Physiology
Ala302Ser
Aedes aegypti
yellow fever mosquito - (species)
Aedes aegypti
yellow fever mosquito - (species) D
resistance to dieldrin
Aedes aegypti
yellow fever mosquito - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles arabiensis
(species) D
Intraspecific
Candidate Gene
Du W; Awolola TS; Howell P ; et al. (2005)
Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabi[...]
GP00000969
Rdl
P25123
Physiology
Ala302Ser
Anopheles arabiensis
(species)
Anopheles arabiensis
(species) D
resistance to dieldrin
Anopheles arabiensis
(species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Linkage Mapping
Du W; Awolola TS; Howell P ; et al. (2005)
Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabi[...]
GP00000970
Rdl
P25123
Physiology
Ala302Gly
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
resistance to dieldrin
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Bemisia tabaci
(species) D
Intraspecific
Candidate Gene
Anthony NM; Brown JK; Markham PG ; et al. (1995
)
Molecular analysis of cyclodiene resistance-associated mutations among populations of the sweetpotat[...]
1 Additional References
GP00000971
Rdl
P25123
Physiology
2 mutations
Bemisia tabaci
(species)
Bemisia tabaci
(species) D
resistance to dieldrin
Bemisia tabaci
(species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Blattella germanica
German cockroach - (species) D
Intraspecific
Candidate Gene
Kaku K; Matsumura F (1994)
Identification of the site of mutation within the M2 region of the GABA receptor of the cyclodiene-r[...]
GP00000972
Rdl
P25123
Physiology
Ala302Ser
Blattella germanica
German cockroach - (species)
Blattella germanica
German cockroach - (species) D
resistance to dieldrin
Blattella germanica
German cockroach - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Ctenocephalides felis
cat flea - (species) D
Intraspecific
Candidate Gene
Bass C; Schroeder I; Turberg A ; et al. (2004)
Identification of the Rdl mutation in laboratory and field strains of the cat flea, Ctenocephalides [...]
GP00000973
Rdl
P25123
Physiology
Ala302Ser
Ctenocephalides felis
cat flea - (species)
Ctenocephalides felis
cat flea - (species) D
resistance to dieldrin
Ctenocephalides felis
cat flea - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Ffrench-Constant RH; Rocheleau TA; Steichen JC ; et al. (1993)
A point mutation in a Drosophila GABA receptor confers insecticide resistance.
2 Additional References
GP00000974
Rdl
P25123
Physiology
Ala302Ser - G9155164T
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
resistance to dieldrin
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Lee HJ; Rocheleau T; Zhang HG ; et al. (1993)
Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...]
1 Additional References
GP00000975
Rdl
P25123
Physiology
Ala302Ser
Drosophila simulans
(species)
Drosophila simulans
(species) D
resistance to dieldrin
Drosophila simulans
(species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Lee HJ; Rocheleau T; Zhang HG ; et al. (1993)
Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression [...]
1 Additional References
GP00000976
Rdl
P25123
Physiology
Ala302Gly
Drosophila simulans
(species)
Drosophila simulans
(species) D
resistance to dieldrin
Drosophila simulans
(species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Hypothenemus hampei
coffee berry borer - (species) D
Intraspecific
Candidate Gene
Brun LO; Stuart J; Gaudichon V ; et al. (1995)
Functional haplodiploidy: a mechanism for the spread of insecticide resistance in an important inter[...]
2 Additional References
GP00000977
Rdl
P25123
Physiology
Ala302Ser
Hypothenemus hampei
coffee berry borer - (species)
Hypothenemus hampei
coffee berry borer - (species) D
resistance to dieldrin
Hypothenemus hampei
coffee berry borer - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Thompson M; Steichen JC; ffrench-Constant RH (1993)
Conservation of cyclodiene insecticide resistance-associated mutations in insects.
GP00000978
Rdl
P25123
Physiology
Ala302Ser
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
resistance to dieldrin
Musca domestica
house fly - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Myzus persicae
green peach aphid - (species) D
Intraspecific
Candidate Gene
Anthony N; Unruh T; Ganser D ; et al. (1998)
Duplication of the Rdl GABA receptor subunit gene in an insecticide-resistant aphid, Myzus persicae.
GP00000979
Rdl
P25123
Physiology
Ala302Gly
Myzus persicae
green peach aphid - (species)
Myzus persicae
green peach aphid - (species) D
resistance to dieldrin
Myzus persicae
green peach aphid - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Periplaneta americana
American cockroach - (species) D
Intraspecific
Candidate Gene
Thompson M; Steichen JC; ffrench-Constant RH (1993)
Conservation of cyclodiene insecticide resistance-associated mutations in insects.
GP00000980
Rdl
P25123
Physiology
Ala302Ser
Periplaneta americana
American cockroach - (species)
Periplaneta americana
American cockroach - (species) D
resistance to dieldrin
Periplaneta americana
American cockroach - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Tribolium castaneum
red flour beetle - (species)
Intraspecific
Candidate Gene
Miyazaki M; Matsumura F; Beeman RW (1995)
DNA sequence and site of mutation of the GABA receptor of cyclodiene-resistant red flour beetle, Tri[...]
1 Additional References
GP00000981
Rdl
P25123
Physiology
Ala302Ser
Tribolium castaneum
red flour beetle - (species)
Tribolium castaneum
red flour beetle - (species)
resistance to dieldrin
Tribolium castaneum
red flour beetle - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Drosophila simulans
(species) D
Intraspecific
Candidate Gene
Le Goff G; Hamon A; Bergé JB ; et al. (2005)
Resistance to fipronil in Drosophila simulans: influence of two point mutations in the RDL GABA rece[...]
GP00001981
Rdl
P25123
Physiology
2 mutations
Drosophila simulans
(species)
Drosophila simulans
(species) D
resistance to dieldrin
Drosophila simulans
(species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
ffrench-Constant RH; Steichen JC; Rocheleau TA ; et al. (1993)
A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated[...]
GP00001982
Rdl
P25123
Physiology
Ala301Ser - The lesion in the RdlMD-RR allele has been described as A302S in print but the amino acid replacement is actually A301S.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
resistance to dieldrin
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Gene Amplification,
Insertion
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Remnant EJ; Good RT; Schmidt JM ; et al. (2013)
Gene duplication in the major insecticide target site, Rdl, in Drosophila melanogaster.
GP00002452
Rdl
P25123
Physiology
113-kb duplication containing one WT copy of Rdl and a second copy with two point mutations: an Ala(301) to Ser resistance mutation and Met(360) to Ile replacement. Individuals with this duplication exhibit intermediate dieldrin resistance compared with single copy Ser(301) homozygotes and reduced temperature sensitivity and altered RNA editing associated with the resistant allele. Ectopic recombination between Roo transposable elements is involved in generating this genomic rearrangement. The duplication phenotypes were confirmed by construction of a transgenic artificial duplication integrating the 55.7-kb Rdl locus with a Ser(301) change into an Ala(301) background.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
resistance to dieldrin
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
2 Mutations:
Coding
SNP
Anopheles funestus
African malaria mosquito - (species) D
Intraspecific
Candidate Gene
Wondji CS; Dabire RK; Tukur Z ; et al. (2011)
Identification and distribution of a GABA receptor mutation conferring dieldrin resistance in the ma[...]
GP00002557
Rdl
P25123
Physiology
2 mutations
Anopheles funestus
African malaria mosquito - (species)
Anopheles funestus
African malaria mosquito - (species) D
resistance to dieldrin
Anopheles funestus
African malaria mosquito - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Haematobia irritans
horn fly - (species) D
Intraspecific
Candidate Gene
Domingues LN; Guerrero FD; Becker ME ; et al. (2013)
Discovery of the Rdl mutation in association with a cyclodiene resistant population of horn flies, H[...]
1 Additional References
GP00002558
Rdl
P25123
Physiology
Ala301Ser
Haematobia irritans
horn fly - (species)
Haematobia irritans
horn fly - (species) D
resistance to dieldrin
Haematobia irritans
horn fly - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Culex quinquefasciatus
southern house mosquito - (species) D
Intraspecific
Candidate Gene
Tantely ML; Tortosa P; Alout H ; et al. (2010)
Insecticide resistance in Culex pipiens quinquefasciatus and Aedes albopictus mosquitoes from La Réu[...]
1 Additional References
GP00002559
Rdl
P25123
Physiology
Ala301Ser
Culex quinquefasciatus
southern house mosquito - (species)
Culex quinquefasciatus
southern house mosquito - (species) D
resistance to dieldrin
Culex quinquefasciatus
southern house mosquito - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Aedes albopictus
Asian tiger mosquito - (species) D
Intraspecific
Candidate Gene
Tantely ML; Tortosa P; Alout H ; et al. (2010)
Insecticide resistance in Culex pipiens quinquefasciatus and Aedes albopictus mosquitoes from La Réu[...]
1 Additional References
GP00002560
Rdl
P25123
Physiology
Ala301Ser
Aedes albopictus
Asian tiger mosquito - (species)
Aedes albopictus
Asian tiger mosquito - (species) D
resistance to dieldrin
Aedes albopictus
Asian tiger mosquito - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Laodelphax striatellus
small brown planthopper - (species) D
Intraspecific
Candidate Gene
Nakao T; Kawase A; Kinoshita A ; et al. (2011)
The A2'N mutation of the RDL gamma-aminobutyric acid receptor conferring fipronil resistance in Laod[...]
1 Additional References
GP00002561
Rdl
P25123
Physiology
A301N
Laodelphax striatellus
small brown planthopper - (species)
Laodelphax striatellus
small brown planthopper - (species) D
resistance to dieldrin
Laodelphax striatellus
small brown planthopper - (species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Diabrotica virgifera
(species) D
Intraspecific
Candidate Gene
Wang H; Coates BS; Chen H ; et al. (2013)
Role of a γ-aminobutryic acid (GABA) receptor mutation in the evolution and spread of Diabrotica vir[...]
1 Additional References
GP00002566
Rdl
P25123
Physiology
A301S
Diabrotica virgifera
(species)
Diabrotica virgifera
(species) D
resistance to dieldrin
Diabrotica virgifera
(species)
Published - Accepted by Curator
resistance to dieldrin
Xenobiotic resistance (insecticide)
Coding,
SNP
Rhipicephalus microplus
southern cattle tick - (species) D
Intraspecific
Candidate Gene
Hope M; Menzies M; Kemp D (2010)
Identification of a dieldrin resistance-associated mutation in Rhipicephalus (Boophilus) microplus ([...]
1 Additional References
GP00002567
Rdl
P25123
Physiology
T305L
Rhipicephalus microplus
southern cattle tick - (species)
Rhipicephalus microplus
southern cattle tick - (species) D
resistance to dieldrin
Rhipicephalus microplus
southern cattle tick - (species)
Published - Accepted by Curator
resistant to methyl viologen 1 (RMV1)
Polyamine uptake
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Fujita M; Fujita Y; Iuchi S ; et al. (2012)
Natural variation in a polyamine transporter determines paraquat tolerance in Arabidopsis.
GP00000982
RMV1
Q9FFL1
Physiology
Ile377Phe N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
resistant to methyl viologen 1 (RMV1)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Rhg1
Pathogen resistance (cyst nematode)
Gene Amplification,
Complex Change
Glycine max
soybean - (species)
Intraspecific
Linkage Mapping
Cook DE; Lee TG; Guo X ; et al. (2012)
Copy number variation of multiple genes at Rhg1 mediates nematode resistance in soybean.
GP00000985
rhg1s
Q8L3Y5
Physiology
Copy number Variant : 10-tandem copies of the gene cluster in resistant strains ; the 3 dissimilar genes participate to resistance
Glycine max
soybean - (species)
Glycine max
soybean - (species)
Rhg1
Glycine max
soybean - (species)
Published - Accepted by Curator
Rhg1
Pathogen resistance (cyst nematode)
Cis-regulatory,
Insertion
Glycine max
soybean - (species) D
Intraspecific
Linkage Mapping
Bayless AM; Zapotocny RW; Han S ; et al. (2019)
The rhg1-a (Rhg1 low-copy) nematode resistance source harbors a copia-family retrotransposon within [...]
GP00002049
rhg1s
Q8L3Y5
Physiology
insertion of a copia retrotransposon within the gene Rhg1 Glyma.18G022500 (α-SNAP-encoding). This transposable element is intact and resides within intron 1; anti-sense to the rhg1-a α-SNAP open reading frame.
Glycine max
soybean - (species)
Glycine max
soybean - (species) D
Rhg1
Glycine max
soybean - (species)
Published - Accepted by Curator
RHO2
Temperature tolerance / virulence
Cis-regulatory,
Unknown
Saccharomyces cerevisiae
baker's yeast - (species)
Intraspecific
Linkage Mapping
Steinmetz LM; Sinha H; Richards DR ; et al. (2002)
Dissecting the architecture of a quantitative trait locus in yeast.
1 Additional References
GP00000986
RHO2
P06781
Physiology
3'UTR polymorphism
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
RHO2
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
RLM1
Pathogen resistance
Gene Loss,
Complex Change
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Staal J; Kaliff M; Bohman S ; et al. (2006)
Transgressive segregation reveals two Arabidopsis TIR-NB-LRR resistance genes effective against Lept[...]
GP00000991
RLM1A
F4I594
Physiology
Digenic; deletion of gene1 and premature stop codons in gene2 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RLM1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RLM2 cluster
Pathogen resistance
Gene Loss,
Complex Change
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Staal J; Kaliff M; Bohman S ; et al. (2006)
Transgressive segregation reveals two Arabidopsis TIR-NB-LRR resistance genes effective against Lept[...]
GP00000992
RLM1B
Q9CAK1
Physiology
the locus contains two paralogues; one of which is deleted and the other pseudogenized in Ler-0 N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RLM2 cluster
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RLM3
Pathogen resistance
Gene Loss,
Complex Change
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Staal J; Kaliff M; Dewaele E ; et al. (2008)
RLM3, a TIR domain encoding gene involved in broad-range immunity of Arabidopsis to necrotrophic fun[...]
GP00000993
RLM3
Q9FT77
Physiology
gene deletion N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RLM3
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RME1 [possible pseudo-replicate of laboratory strain entry]
Sporulation efficiency
Cis-regulatory,
Deletion
Saccharomyces cerevisiae
baker's yeast - (species) D
Intraspecific
Linkage Mapping
Gerke J; Lorenz K; Cohen B (2009)
Genetic interactions between transcription factors cause natural variation in yeast.
GP00000995
RME1
P32338
Physiology
single nucleotide deletion in promoter region
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
RME1 [possible pseudo-replicate of laboratory strain entry]
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
RnrS
Xenobiotic resistance (gemcitabine ; female fertility)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Association Mapping
King EG; Kislukhin G; Walters KN ; et al. (2014)
Using Drosophila melanogaster to identify chemotherapy toxicity genes.
GP00001404
RnrS
P48592
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
RnrS
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Root System Architecture 1
Root growth (allometry of lateral roots)
Cis-regulatory,
SNP
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Association Mapping
Rosas U; Cibrian-Jaramillo A; Ristova D ; et al. (2013)
Integration of responses within and across Arabidopsis natural accessions uncovers loci controlling [...]
GP00001285
Root System Architecture 1
F4JL94
Morphology
348bp upstream of the 5'UTR
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
Root System Architecture 1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
ROSEA
Coloration (flowers)
Unknown,
Unknown
Antirrhinum majus
snapdragon - (species)
Intraspecific
Linkage Mapping
Whibley AC; Langlade NB; Andalo C ; et al. (2006)
Evolutionary paths underlying flower color variation in Antirrhinum.
GP00000997
ROS1
Q2VAZ7
Morphology
Not identified
Antirrhinum majus
snapdragon - (species)
Antirrhinum majus
snapdragon - (species)
ROSEA
Antirrhinum majus
snapdragon - (species)
Published - Accepted by Curator
RPM1
Pathogen resistance
Gene Loss,
Indel
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Grant MR; McDowell JM; Sharpe AG ; et al. (1998)
Independent deletions of a pathogen-resistance gene in Brassica and Arabidopsis.
2 Additional References
GP00001000
RPM1
Q39214
Physiology
3.7kb indel with a null-state in the sensitive strains N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPM1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPM1
Pathogen resistance
Gene Loss,
Complex Change
N
Brassica napus
rape - (species)
Intraspecific
Linkage Mapping
Grant MR; McDowell JM; Sharpe AG ; et al. (1998)
Independent deletions of a pathogen-resistance gene in Brassica and Arabidopsis.
GP00001001
RPM1
Q39214
Physiology
deletion N
Brassica napus
rape - (species)
Brassica napus
rape - (species)
RPM1
Brassica napus
rape - (species)
Published - Accepted by Curator
RPP1
Hybrid incompatibility
Unknown,
Complex Change
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Alcázar R; von Reth M; Bautor J ; et al. (2014)
Analysis of a plant complex resistance gene locus underlying immune-related hybrid incompatibility a[...]
1 Additional References
GP00001281
RPP1
F4J339
Physiology
complex
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP1
Hybrid incompatibility
Unknown,
Complex Change
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Alcázar R; von Reth M; Bautor J ; et al. (2014)
Analysis of a plant complex resistance gene locus underlying immune-related hybrid incompatibility a[...]
1 Additional References
GP00001282
RPP1
F4J339
Physiology
complex
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP1-WsA
Pathogen resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Botella MA; Parker JE; Frost LN ; et al. (1998)
Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasiti[...]
GP00001002
RPP1
F4J339
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP1-WsA
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP1-WsB
Pathogen resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Botella MA; Parker JE; Frost LN ; et al. (1998)
Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasiti[...]
GP00001003
RPP1
F4J339
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP1-WsB
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP1-WsC
Pathogen resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Botella MA; Parker JE; Frost LN ; et al. (1998)
Three genes of the Arabidopsis RPP1 complex resistance locus recognize distinct Peronospora parasiti[...]
GP00001004
RPP1
F4J339
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP1-WsC
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP2A-RPP2B
Pathogen resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Sinapidou E; Williams K; Nott L ; et al. (2004)
Two TIR:NB:LRR genes are required to specify resistance to Peronospora parasitica isolate Cala2 in A[...]
GP00001006
RPP2A
P51407
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP2A-RPP2B
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP4
Pathogen resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
van der Biezen EA; Freddie CT; Kahn K ; et al. (2002)
Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mild[...]
GP00001007
RPP4
F4JNA9
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP4
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP5
Pathogen resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
van der Biezen EA; Freddie CT; Kahn K ; et al. (2002)
Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mild[...]
1 Additional References
GP00001008
RPP5
F4JNB7
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP5
Pathogen resistance
Gene Amplification,
Complex Change
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Parker JE; Coleman MJ; Szabò V ; et al. (1997)
The Arabidopsis downy mildew resistance gene RPP5 shares similarity to the toll and interleukin-1 re[...]
1 Additional References
GP00001009
RPP5
F4JNB7
Physiology
Partial duplication sufficient to increase resistance
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPP8
Pathogen resistance
Coding,
Complex Change
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
McDowell JM; Dhandaydham M; Long TA ; et al. (1998)
Intragenic recombination and diversifying selection contribute to the evolution of downy mildew resi[...]
1 Additional References
GP00001010
RPP8
Q8W4J9
Physiology
Chimeric fusion of two paralogues followed by coding divergence
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPP8
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPS2
Pathogen resistance
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Mindrinos M; Katagiri F; Yu GL ; et al. (1994)
The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site [...]
GP00001011
RPS2
Q42484
Physiology
10bp insertion close to the 5' end causing a frameshift N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RPS2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPS2
Pathogen resistance
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Caicedo AL; Schaal BA; Kunkel BN (1999)
Diversity and molecular evolution of the RPS2 resistance gene in Arabidopsis thaliana.
GP00001012
RPS2
Q42484
Physiology
W235* due to G704A N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPS2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPS4
Pathogen resistance
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Narusaka M; Shirasu K; Noutoshi Y ; et al. (2009)
RRS1 and RPS4 provide a dual Resistance-gene system against fungal and bacterial pathogens.
1 Additional References
GP00001013
RPS4
Q9XGM3
Physiology
5bp deletion resulting in frameshift N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
RPS4
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RPS5
Pathogen resistance
Gene Loss,
Complex Change
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Henk AD; Warren RF; Innes RW (1999)
A new Ac-like transposon of Arabidopsis is associated with a deletion of the RPS5 disease resistance[...]
1 Additional References
GP00001014
RPS5
O64973
Physiology
Deletion N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RPS5
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RREB1
Body fat distribution (visceral)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001555
RREB1
Q92766
Physiology
C>G in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
RREB1
Homo sapiens
human - (species)
Published - Accepted by Curator
RRS1
Pathogen resistance
Coding,
SNP
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Narusaka M; Shirasu K; Noutoshi Y ; et al. (2009)
RRS1 and RPS4 provide a dual Resistance-gene system against fungal and bacterial pathogens.
1 Additional References
GP00001015
RRS1
P0DKH5
Physiology
Premature stop codon N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
RRS1
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
RSF1
Sporulation efficiency
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Intraspecific
Linkage Mapping
Gerke J; Lorenz K; Cohen B (2009)
Genetic interactions between transcription factors cause natural variation in yeast.
GP00001016
HFR1
Q9FE22
Physiology
D181G
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
RSF1
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Troczka B; Zimmer CT; Elias J ; et al. (2012)
Resistance to diamide insecticides in diamondback moth, Plutella xylostella (Lepidoptera: Plutellida[...]
2 Additional References
GP00002433
RyR
Q24498
Physiology
G4946E
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
RYR
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Troczka B; Zimmer CT; Elias J ; et al. (2012)
Resistance to diamide insecticides in diamondback moth, Plutella xylostella (Lepidoptera: Plutellida[...]
1 Additional References
GP00002434
RyR
Q24498
Physiology
G4946E due to GGG>GAA
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
RYR
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Roditakis E; Steinbach D; Moritz G ; et al. (2017)
Ryanodine receptor point mutations confer diamide insecticide resistance in tomato leafminer, Tuta a[...]
1 Additional References
GP00002435
RyR
Q24498
Physiology
G4903 corresponds to the G4946E mutation site shown to confer diamide resistance in diamondback moth
Tuta absoluta
(species)
Tuta absoluta
(species) D
RYR
Tuta absoluta
(species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Roditakis E; Steinbach D; Moritz G ; et al. (2017)
Ryanodine receptor point mutations confer diamide insecticide resistance in tomato leafminer, Tuta a[...]
1 Additional References
GP00002436
RyR
Q24498
Physiology
G4903 corresponds to the G4946E mutation site shown to confer diamide resistance in diamondback moth
Tuta absoluta
(species)
Tuta absoluta
(species) D
RYR
Tuta absoluta
(species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Douris V; Papapostolou KM; Ilias A ; et al. (2017)
Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...]
1 Additional References
GP00002438
RyR
Q24498
Physiology
G4903V corresponds to the G4946E mutation site shown to confer diamide resistance in diamondback moth
Tuta absoluta
(species)
Tuta absoluta
(species) D
RYR
Tuta absoluta
(species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide)
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Douris V; Papapostolou KM; Ilias A ; et al. (2017)
Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 [...]
1 Additional References
GP00002439
RyR
Q24498
Physiology
I4790M
Tuta absoluta
(species)
Tuta absoluta
(species) D
RYR
Tuta absoluta
(species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Guo L; Liang P; Zhou X ; et al. (2014)
Novel mutations and mutation combinations of ryanodine receptor in a chlorantraniliprole resistant p[...]
GP00002605
RyR
Q24498
Physiology
E1338D Q4594L I4790M)in highly conserved regions of RyR.
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
RYR
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)
Coding,
Deletion
N
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Gong W; Yan HH; Gao L ; et al. (2014)
Chlorantraniliprole resistance in the diamondback moth (Lepidoptera: Plutellidae).
GP00002609
RyR
Q24498
Physiology
14 amino acid (Q4546-S4559) deletion. RyR transcript levels are lower in resistant strains than in susceptible strains. N
Plutella xylostella
diamondback moth - (species)
Plutella xylostella
diamondback moth - (species) D
RYR
Plutella xylostella
diamondback moth - (species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)
Coding,
SNP
Chilo suppressalis
striped riceborer - (species) D
Intraspecific
Candidate Gene
Yao R; Zhao DD; Zhang S ; et al. (2017)
Monitoring and mechanisms of insecticide resistance in Chilo suppressalis (Lepidoptera: Crambidae), [...]
1 Additional References
GP00002626
RyR
Q24498
Physiology
G4946E
Chilo suppressalis
striped riceborer - (species)
Chilo suppressalis
striped riceborer - (species) D
RYR
Chilo suppressalis
striped riceborer - (species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide ; chlorantraniliprole ; flubendiamide)
Coding,
SNP
Chilo suppressalis
striped riceborer - (species) D
Intraspecific
Candidate Gene
Wei Y; Yan R; Zhou Q ; et al. (2019)
Monitoring and Mechanisms of Chlorantraniliprole Resistance in Chilo suppressalis (Lepidoptera: Cram[...]
GP00002627
RyR
Q24498
Physiology
I4758M
Chilo suppressalis
striped riceborer - (species)
Chilo suppressalis
striped riceborer - (species) D
RYR
Chilo suppressalis
striped riceborer - (species)
Published - Accepted by Curator
RYR
Xenobiotic resistance (insecticide ; diamide)
Coding,
SNP
Spodoptera exigua
beet armyworm - (species) D
Intraspecific
Candidate Gene
Zuo YY; Ma HH; Lu WJ ; et al. (2020)
Identification of the ryanodine receptor mutation I4743M and its contribution to diamide insecticide[...]
2 Additional References
GP00002633
RyR
Q24498
Physiology
I4743M - corresponds to I4790M in PxRyR
Spodoptera exigua
beet armyworm - (species)
Spodoptera exigua
beet armyworm - (species) D
RYR
Spodoptera exigua
beet armyworm - (species)
Published - Accepted by Curator
S locus supergene (GLO/CFB Cluster)
Flower morphology (heterostyly)
Other,
Complex Change
Primula vulgaris
(species)
Intraspecific
Linkage Mapping
Li J; Cocker JM; Wright J ; et al. (2016)
Genetic architecture and evolution of the S locus supergene in Primula vulgaris.
GP00001392
Morphology
Absence/presence of a supergene constituted by a cluster of 6 genes
Primula vulgaris
(species)
Primula vulgaris
(species)
S locus supergene (GLO/CFB Cluster)
Primula vulgaris
(species)
Published - Accepted by Curator
SAP-2
Xenobiotic resistance (insecticide; pyrethroid)
Cis-regulatory,
Unknown
Anopheles gambiae
African malaria mosquito - (species) D
Intraspecific
Association Mapping
Ingham VA; Anthousi A; Douris V ; et al. (2020)
A sensory appendage protein protects malaria vectors from pyrethroids.
GP00002432
SAP-2
Q6H8Z3
Physiology
The gene is highly overexpressed in the appendages of pyrethroid-resistant mosquitoes and its expression is further induced by insecticide exposure. Silencing of SAP2 almost completely restored susceptibility to the pyrethroid deltamethrin and also significantly increased the susceptibility to the other two pyrethroids (permethrin and alpha-cypermethrin).
Anopheles gambiae
African malaria mosquito - (species)
Anopheles gambiae
African malaria mosquito - (species) D
SAP-2
Anopheles gambiae
African malaria mosquito - (species)
Published - Accepted by Curator
SBNO1
Head size
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Taal HR; Pourcain BS; Thiering E ; et al. (2012)
Common variants at 12q15 and 12q24 are associated with infant head circumference.
GP00001023
SBNO1
A3KN83
Morphology
Ser729Asn
Homo sapiens
human - (species)
Homo sapiens
human - (species)
SBNO1
Homo sapiens
human - (species)
Published - Accepted by Curator
scabrous
Bristle number (abdomen)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Lai C; Lyman RF; Long AD ; et al. (1994)
Naturally occurring variation in bristle number and DNA polymorphisms at the scabrous locus of Droso[...]
GP00001024
sca
P21520
Morphology
unknown; but different sites than for thorax association
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
scabrous
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
scabrous
Bristle number (thorax)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Lai C; Lyman RF; Long AD ; et al. (1994)
Naturally occurring variation in bristle number and DNA polymorphisms at the scabrous locus of Droso[...]
GP00001025
sca
P21520
Morphology
unknown; but different sites than for abdomen association
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
scabrous
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
SCARB1
Carotenoid content
Coding,
SNP
N
Serinus canaria
common canary - (species) D
Intraspecific
Linkage Mapping
Toomey MB; Lopes RJ; Araújo PM ; et al. (2017)
High-density lipoprotein receptor SCARB1 is required for carotenoid coloration in birds.
GP00001681
Scarb1
Q61009
Morphology
T>G nucleotide substitution in the splice-donor site immediately downstream of exon 4 of the SCARB1 gene. This mutation results in abnormal splicing; with the most abundant transcript lacking exon 4. Isoform 4 of SCARB1; the most abundant transcript isoform in the white recessive canary; is predicted to lack 68 amino acids; a deficiency which disrupts SCARB1 protein function. N
Serinus canaria
common canary - (species)
Serinus canaria
common canary - (species) D
SCARB1
Serinus canaria
common canary - (species)
Published - Accepted by Curator
scd-2
Diapause
Coding,
SNP
Caenorhabditis elegans
(species)
Intraspecific
Linkage Mapping
Reiner DJ; Ailion M; Thomas JH ; et al. (2008)
C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta[...]
GP00001026
scd-2
O76411
Physiology
Gly985Arg
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species)
scd-2
Caenorhabditis elegans
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (TTX)
Coding,
SNP
Mya arenaria
(species) D
Intraspecific
Candidate Gene
Bricelj VM; Connell L; Konoki K ; et al. (2005)
Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP.
GP00000721
SCN4A
P35499
Physiology
E945D
Mya arenaria
(species)
Mya arenaria
(species) D
SCN4A (Nav1.4)
Mya arenaria
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (TTX)
Coding,
SNP
Thamnophis sirtalis
(species)
Intraspecific
Candidate Gene
Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005)
Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction.
1 Additional References
GP00000730
SCN4A
P35499
Physiology
G1566A in DIV domain
Thamnophis sirtalis
(species)
Thamnophis sirtalis
(species)
SCN4A (Nav1.4)
Thamnophis sirtalis
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (TTX)
Coding,
SNP
Thamnophis sirtalis
(species)
Intraspecific
Candidate Gene
Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005)
Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction.
1 Additional References
GP00000731
SCN4A
P35499
Physiology
I1561V in DIV domain
Thamnophis sirtalis
(species)
Thamnophis sirtalis
(species)
SCN4A (Nav1.4)
Thamnophis sirtalis
(species)
Published - Accepted by Curator
SCN4A (Nav1.4)
Xenobiotic resistance (TTX)
Coding,
SNP
Thamnophis sirtalis
(species)
Intraspecific
Candidate Gene
Geffeney SL; Fujimoto E; Brodie ED ; et al. (2005)
Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction.
1 Additional References
GP00000732
SCN4A
P35499
Physiology
I1556L and/or D1568N and/or G1569V
Thamnophis sirtalis
(species)
Thamnophis sirtalis
(species)
SCN4A (Nav1.4)
Thamnophis sirtalis
(species)
Published - Accepted by Curator
SCR
Self-incompatibility (loss)
Coding,
Inversion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Candidate Gene
Tsuchimatsu T; Suwabe K; Shimizu-Inatsugi R ; et al. (2010)
Evolution of self-compatibility in Arabidopsis by a mutation in the male specificity gene.
1 Additional References
GP00001271
SCRA
P0CG07
Physiology
213 bp inversion causing premature stop N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
SCR
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Serine/threonine protein kinase RIM15
Nitrogen use (growth efficiency)
Coding,
Insertion
N
Saccharomyces cerevisiae
baker's yeast - (species) D
Intraspecific
Linkage Mapping
Ibstedt S; Stenberg S; Bagés S ; et al. (2015)
Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.
GP00001500
RIM15
P43565
Physiology
2 bp insertion 459_460insCA shifting the reading frame to cause an early stop codon (null allele) N
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species) D
Serine/threonine protein kinase RIM15
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
SG3/At4g30720
Growth (shoots)
Coding,
Deletion
N
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Vlad D; Rappaport F; Simon M ; et al. (2010)
Gene transposition causing natural variation for growth in Arabidopsis thaliana.
GP00001036
PDE327
F4JQE2
Physiology
Premature stop codon at the SG3 locus in Bur-0 (a 1bp deletion in exon four of At4g30720 results in a frame shift; predicting a premature stop codon which terminates the ORF after 5 amino acids); but in this accession this gene has a functional copy at a N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
SG3/At4g30720
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
SIR2
Longevity
Coding,
SNP
Saccharomyces cerevisiae
baker's yeast - (species)
Intraspecific
Linkage Mapping
Gresham D; Desai MM; Tucker CM ; et al. (2008)
The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments [...]
GP00001054
SIR2
P06700
Physiology
1 to 5 amino-acid substitutions
Saccharomyces cerevisiae
baker's yeast - (species)
Saccharomyces cerevisiae
baker's yeast - (species)
SIR2
Saccharomyces cerevisiae
baker's yeast - (species)
Published - Accepted by Curator
SLB1/2
Pathogen resistance (Root parasitic plant) (root parasitic plant)
Gene Loss,
Deletion
N
Oryza sativa
rice - (species)
Intraspecific
Linkage Mapping
Cardoso C; Zhang Y; Jamil M ; et al. (2014)
Natural variation of rice strigolactone biosynthesis is associated with the deletion of two MAX1 ort[...]
GP00001631
Os01g0700900
M9R6D3
Physiology
deletion of 2 cytochrome P450 genes (Os010700900 & Os01g0701400) N
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
SLB1/2
Oryza sativa
rice - (species)
Published - Accepted by Curator
SLC24A5 (NCKX5)
Coloration (eyes; skin)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Lamason RL; Mohideen MA; Mest JR ; et al. (2005)
SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans.
5 Additional References
GP00001056
Slc24a5
Q8C261
Morphology
Ala111Thr
Homo sapiens
human - (species)
Homo sapiens
human - (species)
SLC24A5 (NCKX5)
Homo sapiens
human - (species)
Published - Accepted by Curator
SLC45A2=MATP
Coloration (eyes; hair; skin)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Graf J; Hodgson R; van Daal A (2005)
Single nucleotide polymorphisms in the MATP gene are associated with normal human pigmentation varia[...]
3 Additional References
GP00001061
SLC45A2
Q9UMX9
Morphology
Phe374Leu
Homo sapiens
human - (species)
Homo sapiens
human - (species)
SLC45A2=MATP
Homo sapiens
human - (species)
Published - Accepted by Curator
SLC45A2=MATP
Coloration (coat)
Coding,
SNP
Panthera tigris
tiger - (species) D
Intraspecific
Association Mapping
Xu X; Dong GX; Hu XS ; et al. (2013)
The genetic basis of white tigers.
GP00001063
SLC45A2
Q9UMX9
Morphology
A477V
Panthera tigris
tiger - (species)
Panthera tigris
tiger - (species) D
SLC45A2=MATP
Panthera tigris
tiger - (species)
Published - Accepted by Curator
SlMYBATV
Coloration (anthocyanin accumulation in fruits)
Coding,
Insertion
N
Solanum cheesmaniae
(species) D
Intraspecific
Linkage Mapping
Cao X; Qiu Z; Wang X ; et al. (2017)
A putative R3 MYB repressor is the candidate gene underlying atroviolacium, a locus for anthocyanin [...]
GP00001906
CPC
O22059
Morphology; Physiology
SlMYBATV encodes a R3 MYB transcription factor. 4-bp insertion predicted to result in a frame-shift that would alter the protein sequence from amino-acid position 20 onwards by inducing premature termination of translation including the R3/bHLH-binding domain N
Solanum lycopersicum
tomato - (species)
Solanum cheesmaniae
(species) D
SlMYBATV
Solanum cheesmaniae
(species)
Published - Accepted by Curator
slowpoke (slo)
Courtship song (sine song frequency)
Cis-regulatory,
Insertion
Drosophila simulans
(species) D
Intraspecific
Linkage Mapping
Ding Y; Berrocal A; Morita T ; et al. (2016)
Natural courtship song variation caused by an intronic retroelement in an ion channel gene.
GP00001066
slo
Q03720
Behavior
6.7kb "Shelder" retroelement insertion in slowpoke intron; with effect on splicing
Drosophila simulans
(species)
Drosophila simulans
(species) D
slowpoke (slo)
Drosophila simulans
(species)
Published - Accepted by Curator
smooth
Bristle number (abdomen)
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Linkage Mapping
zur Lage P; Shrimpton AD; Flavell AJ ; et al. (1997)
Genetic and molecular analysis of smooth, a quantitative trait locus affecting bristle number in Dro[...]
GP00001996
Morphology
exact causing mutation(s) unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
smooth
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
SOD1
Xenobiotic resistance (paraquat)
Coding,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Vontas JG; Tsakas SC; Loukas M ; et al. (2001)
Low-activity allele of copper-zinc superoxide dismutase (CuZnSOD) in Drosophila increases paraquat g[...]
GP00001985
Sod1
P61851
Physiology
Insertion of a 0.68kb truncated P-element 47bp downstream of the transcription start site.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
SOD1
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
SOD3
Oxidative stress resistance
Blood pressure
Unknown,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Intraspecific
Association Mapping
Jones FC; Chan YF; Schmutz J ; et al. (2012)
A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence i[...]
GP00001380
SOD3
P08294
Physiology
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species)
SOD3
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
Sox5/6
Coloration (wing; mimicry)
Cis-regulatory,
Unknown
Hypolimnas misippus
(species)
Intraspecific
Association Mapping
VanKuren NW; Massardo D; Nallu S ; et al. (2019)
Butterfly Mimicry Polymorphisms Highlight Phylogenetic Limits of Gene Reuse in the Evolution of Dive[...]
GP00002429
Morphology
A 10 kb intergenic region located 48kb upstream of the Sox5/6 gene is strongly associated with the wing phenotype. This cis-regulatory change may also affect another neighboring gene, such as pink.
Hypolimnas misippus
(species)
Hypolimnas misippus
(species)
Sox5/6
Hypolimnas misippus
(species)
Published - Accepted by Curator
spineless (ss)
Color vision (eye; photoreceptor composition)
Cis-regulatory,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Anderson C; Reiss I; Zhou C ; et al. (2017)
Natural variation in stochastic photoreceptor specification and color preference in Drosophila.
GP00001987
ss
E1JIM6
Physiology
Single base insertion in the ss regulatory region upstream of the ss transcription start site. The insertion affects the stochastic on/off expression of the ss protein seen in the R7 photoreceptors: the presence of the insertion results in a significant decrease in the ratio of ss expressing to non-expressing R7 cells.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
spineless (ss)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
SPR
Coloration (ventral scales)
Cis-regulatory,
Unknown
Podarcis muralis
Common wall lizard - (species)
Intraspecific
Association Mapping
Andrade P; Pinho C; Pérez I de Lanuza G ; et al. (2019)
Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall [...]
GP00002119
Spr
Q64105
Morphology
Podarcis muralis
Common wall lizard - (species)
Podarcis muralis
Common wall lizard - (species)
SPR
Podarcis muralis
Common wall lizard - (species)
Published - Accepted by Curator
SR-CII
Pathogen resistance
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Lazzaro BP; Sackton TB; Clark AG (2006)
Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria.
GP00001071
Sr-CII
Q5ELW9
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
SR-CII
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
SRF3
Hybrid Incompatibility
Unknown,
Complex Change
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Alcázar R; García AV; Kronholm I ; et al. (2010)
Natural variation at Strubbelig Receptor Kinase 3 drives immune-triggered incompatibilities between [...]
1 Additional References
GP00001072
SRF3
Q6R2K3
Physiology
Complex haplotype
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
SRF3
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
SRF3
Hybrid Incompatibility
Unknown,
Complex Change
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Alcázar R; García AV; Kronholm I ; et al. (2010)
Natural variation at Strubbelig Receptor Kinase 3 drives immune-triggered incompatibilities between [...]
1 Additional References
GP00001073
SRF3
Q6R2K3
Physiology
Complex haplotype
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
SRF3
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
srx-43
Pheromone response (ascaroside)
Cis-regulatory,
Unknown
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Greene JS; Brown M; Dobosiewicz M ; et al. (2016)
Balancing selection shapes density-dependent foraging behaviour.
1 Additional References
GP00001319
srx-43
O45767
Physiology
unknown
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
srx-43
Caenorhabditis elegans
(species)
Published - Accepted by Curator
srx-44
Pheromone response (ascaroside)
Cis-regulatory,
Unknown
Caenorhabditis elegans
(species) D
Intraspecific
Linkage Mapping
Greene JS; Dobosiewicz M; Butcher RA ; et al. (2016)
Regulatory changes in two chemoreceptor genes contribute to a Caenorhabditis elegans QTL for foragin[...]
1 Additional References
GP00001504
srx-43
O45767
Physiology
Phenotypic change mapped to a small region located between 34bp and 72 bp upstream of the srx-44 start codon. This DNA region contains 9 changes between N2 strain and MY14 strain.
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
srx-44
Caenorhabditis elegans
(species)
Published - Accepted by Curator
str-217
Xenobiotic resistance (insecticide; DEET)
Coding,
Deletion
N
Caenorhabditis elegans
(species) D
Intraspecific
Candidate Gene
Dennis EJ; Dobosiewicz M; Jin X ; et al. (2018)
A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans.
GP00001783
str-217
Q9XX85
Physiology
deletion that leads to a predicted frame shift and early stop codon - the predicted resulting protein has only one transmembrane domain instead of the 7 transmembrane domains - 138-bp deletion in exon 2 and 3 and intervening intron according to https://www.wormbase.org/species/c_elegans/variation/WBVar02076179#02-45-3 and email from Emily Dennis from 9 March 2019 N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
str-217
Caenorhabditis elegans
(species)
Published - Accepted by Curator
str-217
Xenobiotic resistance (insecticide; DEET)
Coding,
SNP
N
Caenorhabditis elegans
(species) D
Intraspecific
Candidate Gene
Dennis EJ; Dobosiewicz M; Jin X ; et al. (2018)
A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans.
GP00001784
str-217
Q9XX85
Physiology
on chromosome V position 17000292 G>A stop_gained 13C>T - Gln5* N
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species) D
str-217
Caenorhabditis elegans
(species)
Published - Accepted by Curator
sulfate transporter 1;1
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001429
SULTR1;1
Q9SAY1
Physiology
unknown
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
sulfate transporter 1;1
Arabidopsis arenosa
(species)
Published - Accepted by Curator
Sulfotransferase-OXA-Resistance (SULT-OR)
Xenobiotic resistance (oxamniquine)
Coding,
Deletion
Schistosoma mansoni
(species) D
Intraspecific
Linkage Mapping
Valentim CL; Cioli D; Chevalier FD ; et al. (2013)
Genetic and molecular basis of drug resistance and species-specific drug action in schistosome paras[...]
GP00001470
SULT-OR
G4VLE5
Physiology
E142del
Schistosoma mansoni
(species)
Schistosoma mansoni
(species) D
Sulfotransferase-OXA-Resistance (SULT-OR)
Schistosoma mansoni
(species)
Published - Accepted by Curator
Sulfotransferase-OXA-Resistance (SULT-OR)
Xenobiotic resistance (oxamniquine)
Coding,
SNP
Schistosoma mansoni
(species) D
Intraspecific
Linkage Mapping
Valentim CL; Cioli D; Chevalier FD ; et al. (2013)
Genetic and molecular basis of drug resistance and species-specific drug action in schistosome paras[...]
GP00001471
SULT-OR
G4VLE5
Physiology
C35R (T>C)
Schistosoma mansoni
(species)
Schistosoma mansoni
(species) D
Sulfotransferase-OXA-Resistance (SULT-OR)
Schistosoma mansoni
(species)
Published - Accepted by Curator
Sulfotransferase-OXA-Resistance (SULT-OR)
Xenobiotic resistance (oxamniquine)
Coding,
SNP
Schistosoma mansoni
(species)
Intraspecific
Candidate Gene
Valentim CL; Cioli D; Chevalier FD ; et al. (2013)
Genetic and molecular basis of drug resistance and species-specific drug action in schistosome paras[...]
GP00001472
SULT-OR
G4VLE5
Physiology
F39 Sm > Y54 Sh (T>A) TTT>TAT
Schistosoma mansoni
(species)
Schistosoma mansoni
(species)
Sulfotransferase-OXA-Resistance (SULT-OR)
Schistosoma mansoni
(species)
Published - Accepted by Curator
SVP (SHORT VEGETATIVE PHASE)
Flowering time
Coding,
SNP
Arabidopsis thaliana
thale cress - (species) D
Intraspecific
Linkage Mapping
Méndez-Vigo B; Martínez-Zapater JM; Alonso-Blanco C (2013)
The flowering repressor SVP underlies a novel Arabidopsis thaliana QTL interacting with the genetic [...]
GP00001087
SVP
Q9FVC1
Physiology
Ala32Val
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species) D
SVP (SHORT VEGETATIVE PHASE)
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
syntaxin1a
Eusociality
Cis-regulatory,
Unknown
Lasioglossum albipes
(species) D
Intraspecific
Association Mapping
Kocher SD; Mallarino R; Rubin BER ; et al. (2018)
The genetic basis of a social polymorphism in halictid bees.
GP00002624
Syx1A
Q24547
Behavior
Increased expression in eusocial individuals compared to solitary individuals
Lasioglossum albipes
(species)
Lasioglossum albipes
(species) D
syntaxin1a
Lasioglossum albipes
(species)
Published - Accepted by Curator
T-box transcription factor (TBX3)
Coloration (coat)
Cis-regulatory,
SNP
Equus caballus
horse - (species) D
Intraspecific
Linkage Mapping
Imsland F; McGowan K; Rubin CJ ; et al. (2016)
Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage colo[...]
GP00001461
TBX3
O15119
Morphology
G>T predicted to affect binding of the CCAT box-binding transcription factors NF-Y and NF-I ; Differs from the wild-type allele by a SNP downstream of the wild-type TBX3 sequence (located 1067bp downstream of the start of the larger nd2 deletion described in the nd2 entry) with allele nd1 = T compared with the wild-type D allele = G); an ancient variant
Equus caballus
horse - (species)
Equus caballus
horse - (species) D
T-box transcription factor (TBX3)
Equus caballus
horse - (species)
Published - Accepted by Curator
TAC1
Xenobiotic resistance (drug)
Coding,
SNP
Candida albicans
(species) D
Intraspecific
Linkage Mapping
Coste A; Turner V; Ischer F ; et al. (2006)
A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of hetero[...]
GP00001090
TAC1
A7IZW4
Physiology
N977D
Candida albicans
(species)
Candida albicans
(species) D
TAC1
Candida albicans
(species)
Published - Accepted by Curator
TAC1
Xenobiotic resistance
Gene Amplification,
Complex Change
Candida albicans
(species) D
Intraspecific
Association Mapping
Coste A; Selmecki A; Forche A ; et al. (2007)
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.
GP00001091
TAC1
A7IZW4
Physiology
Copy number Variant
Candida albicans
(species)
Candida albicans
(species) D
TAC1
Candida albicans
(species)
Published - Accepted by Curator
TAC1
Xenobiotic resistance
Coding,
Deletion
Candida albicans
(species) D
Intraspecific
Association Mapping
Coste A; Selmecki A; Forche A ; et al. (2007)
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.
GP00001092
TAC1
A7IZW4
Physiology
1a.a. deletion
Candida albicans
(species)
Candida albicans
(species) D
TAC1
Candida albicans
(species)
Published - Accepted by Curator
TAC1
Xenobiotic resistance
Coding,
Deletion
Candida albicans
(species) D
Intraspecific
Association Mapping
Coste A; Selmecki A; Forche A ; et al. (2007)
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.
GP00001093
TAC1
A7IZW4
Physiology
7a.a. deletion
Candida albicans
(species)
Candida albicans
(species) D
TAC1
Candida albicans
(species)
Published - Accepted by Curator
TAC1
Xenobiotic resistance (drug)
Coding,
SNP
Candida albicans
(species) D
Intraspecific
Association Mapping
Coste A; Selmecki A; Forche A ; et al. (2007)
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.
GP00001094
TAC1
A7IZW4
Physiology
G980E
Candida albicans
(species)
Candida albicans
(species) D
TAC1
Candida albicans
(species)
Published - Accepted by Curator
TAC1
Xenobiotic resistance (drug)
Coding,
SNP
Candida albicans
(species) D
Intraspecific
Association Mapping
Coste A; Selmecki A; Forche A ; et al. (2007)
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.
GP00001095
TAC1
A7IZW4
Physiology
A736V
Candida albicans
(species)
Candida albicans
(species) D
TAC1
Candida albicans
(species)
Published - Accepted by Curator
TAC1
Xenobiotic resistance (drug)
Coding,
SNP
Candida albicans
(species) D
Intraspecific
Association Mapping
Coste A; Selmecki A; Forche A ; et al. (2007)
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates.
GP00001096
TAC1
A7IZW4
Physiology
T225A
Candida albicans
(species)
Candida albicans
(species) D
TAC1
Candida albicans
(species)
Published - Accepted by Curator
tan
Coloration (abdomen; female)
Cis-regulatory,
Unknown
Drosophila erecta
(species) D
Intraspecific
Linkage Mapping
Yassin A; Bastide H; Chung H ; et al. (2016)
Ancient balancing selection at tan underlies female colour dimorphism in Drosophila erecta.
GP00001097
t
Q9W369
Morphology
exact causing mutation(s) unknown - the t_MSE enhancer from the dark allele drives higher levels of GFP expression in D. melanogaster than from the light allele
Drosophila erecta
(species)
Drosophila erecta
(species) D
tan
Drosophila erecta
(species)
Published - Accepted by Curator
tan
Coloration (abdomen)
Cis-regulatory,
Unknown
Drosophila novamexicana
(species) D
Intraspecific
Linkage Mapping
Wittkopp PJ; Stewart EE; Arnold LL ; et al. (2009)
Intraspecific polymorphism to interspecific divergence: genetics of pigmentation in Drosophila.
GP00001098
t
Q9W369
Morphology
2.7kb non-coding interval; 13 SNPs + 2 indels differing between species
Drosophila americana
(species)
Drosophila novamexicana
(species) D
tan
Drosophila novamexicana
(species)
Published - Accepted by Curator
tan
Coloration (thorax; abdomen; trident)
Cis-regulatory,
Unknown
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Association Mapping
Bastide H; Betancourt A; Nolte V ; et al. (2013)
A genome-wide, fine-scale map of natural pigmentation variation in Drosophila melanogaster.
3 Additional References
GP00002622
t
Q9W369
Morphology
exact causing mutation(s) unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
tan
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Taqpep
Coloration (coat)
Coding,
Insertion
N
Acinonyx jubatus
cheetah - (species) D
Intraspecific
Candidate Gene
Kaelin CB; Xu X; Hong LZ ; et al. (2012)
Specifying and sustaining pigmentation patterns in domestic and wild cats.
GP00001105
Lvrn
Q2KHK3
Morphology
1bp insertion resulting in frameshift p.N977Kfs110 N
Acinonyx jubatus
cheetah - (species)
Acinonyx jubatus
cheetah - (species) D
Taqpep
Acinonyx jubatus
cheetah - (species)
Published - Accepted by Curator
Taqpep
Coloration (coat)
Coding,
SNP
Felis catus
domestic cat - (species) D
Intraspecific
Candidate Gene
Kaelin CB; Xu X; Hong LZ ; et al. (2012)
Specifying and sustaining pigmentation patterns in domestic and wild cats.
GP00001106
Lvrn
Q2KHK3
Morphology
D228N
Felis catus
domestic cat - (species)
Felis catus
domestic cat - (species) D
Taqpep
Felis catus
domestic cat - (species)
Published - Accepted by Curator
Taqpep
Coloration (coat)
Coding,
SNP
N
Felis catus
domestic cat - (species)
Intraspecific
Candidate Gene
Kaelin CB; Xu X; Hong LZ ; et al. (2012)
Specifying and sustaining pigmentation patterns in domestic and wild cats.
GP00001107
Lvrn
Q2KHK3
Morphology
S59stop N
Felis catus
domestic cat - (species)
Felis catus
domestic cat - (species)
Taqpep
Felis catus
domestic cat - (species)
Published - Accepted by Curator
Taqpep
Coloration (coat)
Coding,
SNP
N
Felis catus
domestic cat - (species)
Intraspecific
Linkage Mapping
Kaelin CB; Xu X; Hong LZ ; et al. (2012)
Specifying and sustaining pigmentation patterns in domestic and wild cats.
GP00001108
Lvrn
Q2KHK3
Morphology
W841stop N
Felis catus
domestic cat - (species)
Felis catus
domestic cat - (species)
Taqpep
Felis catus
domestic cat - (species)
Published - Accepted by Curator
TAS1R3
Taste sensitivity (sugar)
Coding,
SNP
Mus musculus
house mouse - (species)
Intraspecific
Linkage Mapping
Max M; Shanker YG; Huang L ; et al. (2001)
Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac.
1 Additional References
GP00001110
TAS1R3
Q7RTX0
Physiology
I60T; is predicted to introduce a novel N-linked glycosylation site which might interfere with receptor dimerization
Mus musculus
house mouse - (species)
Mus musculus
house mouse - (species)
TAS1R3
Mus musculus
house mouse - (species)
Published - Accepted by Curator
TAS2R38
Taste sensitivity (bitter)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Kim UK; Jorgenson E; Coon H ; et al. (2003)
Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthioc[...]
1 Additional References
GP00001111
TAS2R38
P59533
Physiology
P49A and/or A262V and/or V296I
Homo sapiens
human - (species)
Homo sapiens
human - (species)
TAS2R38
Homo sapiens
human - (species)
Published - Accepted by Curator
TAS2R38
Taste sensitivity (bitter)
Coding,
SNP
Pan troglodytes
chimpanzee - (species)
Intraspecific
Candidate Gene
Wooding S; Bufe B; Grassi C ; et al. (2006)
Independent evolution of bitter-taste sensitivity in humans and chimpanzees.
GP00001112
TAS2R38
P59533
Physiology
M1R; eliminates start codon; protein initiates at later Met. Protein apparently null for signalling
Pan troglodytes
chimpanzee - (species)
Pan troglodytes
chimpanzee - (species)
TAS2R38
Pan troglodytes
chimpanzee - (species)
Published - Accepted by Curator
TBX15
Ear shape
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Adhikari K; Reales G; Smith AJ ; et al. (2015)
A genome-wide association study identifies multiple loci for variation in human ear morphology.
GP00001113
TBX15
Q96SF7
Morphology
Tbx15 enhancer variation including rs17023457 T or C alleles that affect CART1 binding on a conserved site
Homo sapiens
human - (species)
Homo sapiens
human - (species)
TBX15
Homo sapiens
human - (species)
Published - Accepted by Curator
Tehao
Pathogen resistance
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Candidate Gene
Lazzaro BP; Sackton TB; Clark AG (2006)
Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria.
GP00001115
Tehao
Q9VJX9
Physiology
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Tehao
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
tetraspanin
Xenobiotic resistance (insecticide; Bt Cry1Ac toxin)
Coding,
SNP
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Association Mapping
Jin L; Wang J; Guan F ; et al. (2018)
Dominant point mutation in a tetraspanin gene associated with field-evolved resistance of cotton bol[...]
GP00002468
Tsp2A
O46101
Physiology
L31S due to a nucleotide substitution T92C. CRISPR knockout of the tetraspanin gene restored susceptibility to a resistant strain whereas inserting the mutation conferred 125-fold resistance in a susceptible strain.
Helicoverpa armigera
cotton bollworm - (species)
Helicoverpa armigera
cotton bollworm - (species) D
tetraspanin
Helicoverpa armigera
cotton bollworm - (species)
Published - Accepted by Curator
TFL1/FvTFL1
Flowering time
Seasonal growth
Cis-regulatory,
Unknown
Fragaria vesca
wild strawberry - (species)
Intraspecific
Linkage Mapping
Koskela EA; Mouhu K; Albani MC ; et al. (2012)
Mutation in TERMINAL FLOWER1 reverses the photoperiodic requirement for flowering in the wild strawb[...]
GP00001120
TFL1
P93003
Physiology
Physiology
unknown
Fragaria vesca
wild strawberry - (species)
Fragaria vesca
wild strawberry - (species)
TFL1/FvTFL1
Fragaria vesca
wild strawberry - (species)
Published - Accepted by Curator
thioester-containing protein 1
Pathogen resistance (Plasmodium; malaria parasite)
Coding,
Unknown
Anopheles coluzzii
(species)
Intraspecific
Linkage Mapping
Blandin SA; Wang-Sattler R; Lamacchia M ; et al. (2009)
Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae.
1 Additional References
GP00001125
TEP-I
Q9GYW4
Physiology
coding change - exact causing mutation(s) unknown
Anopheles gambiae
African malaria mosquito - (species)
Anopheles coluzzii
(species)
thioester-containing protein 1
Anopheles coluzzii
(species)
Published - Accepted by Curator
thyroid-stimulating hormone-beta-2
Metabolic rate
Thyroid Hormone (plasma concentration)
Cis-regulatory,
Unknown
Gasterosteus aculeatus
three-spined stickleback - (species) D
Intraspecific
Candidate Gene
Kitano J; Lema SC; Luckenbach JA ; et al. (2010)
Adaptive divergence in the thyroid hormone signaling pathway in the stickleback radiation.
GP00001288
tshba
B3DJU0
Physiology
Physiology
unknown
Gasterosteus aculeatus
three-spined stickleback - (species)
Gasterosteus aculeatus
three-spined stickleback - (species) D
thyroid-stimulating hormone-beta-2
Gasterosteus aculeatus
three-spined stickleback - (species)
Published - Accepted by Curator
timeless (tim)
Diapause
Locomotor activity
Coding,
Insertion
N
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Tauber E; Zordan M; Sandrelli F ; et al. (2007)
Natural selection favors a newly derived timeless allele in Drosophila melanogaster.
1 Additional References
GP00001129
TIMELESS
Q9UNS1
Physiology
Behavior; Physiology
1bp insertion; allows production of longer protein from upstream start codon N
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
timeless (tim)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
TLR6-TLR1-TLR10 cluster
Immune response
Unknown,
Complex Change
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Laayouni H; Oosting M; Luisi P ; et al. (2014)
Convergent evolution in European and Rroma populations reveals pressure exerted by plague on Toll-li[...]
1 Additional References
GP00001130
TLR1
Q15399
Physiology
Several Complex Haplotypes under positive selection - evidence on Adaptive Introgression from Neanderthal (2 haplotypes) and Denisova (1 haplotype)
Homo sapiens
human - (species)
Homo sapiens
human - (species)
TLR6-TLR1-TLR10 cluster
Homo sapiens
human - (species)
Published - Accepted by Curator
TMEM154
Pathogen resistance (lentivirus)
Coding,
SNP
Ovis aries
sheep - (species) D
Intraspecific
Association Mapping
Heaton MP; Clawson ML; Chitko-Mckown CG ; et al. (2012)
Reduced lentivirus susceptibility in sheep with TMEM154 mutations.
GP00002242
TMEM154
Q6P9G4
Physiology
Mutation at conserved position associated to resistance in homozygous state
Ovis aries
sheep - (species)
Ovis aries
sheep - (species) D
TMEM154
Ovis aries
sheep - (species)
Published - Accepted by Curator
TMPRSS6
Hematopoiesis (mean blood corpuscular hemoglobin)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001618
TMPRSS6
Q8IU80
Physiology
T>C at the associated SNP. Another SNP variant in strong LD p.V736A previously reported to influence iron homeostasis
Homo sapiens
human - (species)
Homo sapiens
human - (species)
TMPRSS6
Homo sapiens
human - (species)
Published - Accepted by Curator
TPCN2
Coloration (coat)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2008)
Two newly identified genetic determinants of pigmentation in Europeans.
GP00001131
TPCN2
Q8NHX9
Morphology
Met484Leu and/or Gly734Gln
Homo sapiens
human - (species)
Homo sapiens
human - (species)
TPCN2
Homo sapiens
human - (species)
Published - Accepted by Curator
tra-3 calpain-like protease
Body size (temperature-size interaction)
Coding,
SNP
Caenorhabditis elegans
(species)
Intraspecific
Linkage Mapping
Kammenga JE; Doroszuk A; Riksen JA ; et al. (2007)
A Caenorhabditis elegans wild type defies the temperature-size rule owing to a single nucleotide pol[...]
GP00001133
tra-3
Q22036
Physiology
F96L
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species)
tra-3 calpain-like protease
Caenorhabditis elegans
(species)
Published - Accepted by Curator
TRIB2
Body fat distribution (pericardial)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001559
TRIB2
Q92519
Physiology
A>G in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
TRIB2
Homo sapiens
human - (species)
Published - Accepted by Curator
Trichohyalin
Hair type (straight)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Medland SE; Nyholt DR; Painter JN ; et al. (2009)
Common variants in the trichohyalin gene are associated with straight hair in Europeans.
GP00001134
TCHH
Q07283
Morphology
Not identified
Homo sapiens
human - (species)
Homo sapiens
human - (species)
Trichohyalin
Homo sapiens
human - (species)
Published - Accepted by Curator
TRIM5alpha
Pathogen resistance (retroviruses)
Coding,
SNP
Cercopithecidae
Old World monkeys - (family)
Intraspecific
Candidate Gene
Newman RM; Hall L; Connole M ; et al. (2006)
Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alpha.
GP00001135
TRIM5
Q9C035
Physiology
several a.a. substitutions with retrovirus-specific activities; under balancing selection in several species
Cercopithecidae
Old World monkeys - (family)
Cercopithecidae
Old World monkeys - (family)
TRIM5alpha
Cercopithecidae
Old World monkeys - (family)
Published - Accepted by Curator
TRIP11 (=GMAP-210)
Body size (height)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Lettre G (2011)
Recent progress in the study of the genetics of height.
GP00001138
TRIP11
Q15643
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
TRIP11 (=GMAP-210)
Homo sapiens
human - (species)
Published - Accepted by Curator
TRPM1
Coloration (coat)
Cis-regulatory,
Insertion
Equus caballus
horse - (species) D
Intraspecific
Linkage Mapping
Bellone RR; Forsyth G; Leeb T ; et al. (2010)
Fine-mapping and mutation analysis of TRPM1: a candidate gene for leopard complex (LP) spotting and [...]
3 Additional References
GP00001140
TRPM1
Q7Z4N2
Morphology
a 1378 bp retroviral LTR insertion in intron 1 of TRPM1
Equus caballus
horse - (species)
Equus caballus
horse - (species) D
TRPM1
Equus caballus
horse - (species)
Published - Accepted by Curator
tryptophan phenylalanine hydroxylase
Enzymatic activity
Coding,
Insertion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Ruiz-Vázquez P; Silva FJ (1999)
Aberrant splicing of the Drosophila melanogaster phenylalanine hydroxylase pre-mRNA caused by the in[...]
GP00002003
Hn
P17276
Physiology
insertion of the transposable element B104/roo in the exon 3 of the Phenylalanine hydroxylase gene. Its presence alters the Phenylalanine hydroxylase splicing pattern; producing at least two aberrant mRNAs which contain part of the B104 sequence interrupting the coding region. This aberrant splicing is provoked by the use of a cryptic donor site encoded by the B104 3' long terminal repeat in combination with either the gene intron 3 acceptor site or a novel acceptor site generated by the target duplication caused by transposition. One of them; referred as mRNA type 1; encodes a truncated protein that could be predictably non-functional. In mRNA type 2; in spite of a 42 nt insertion; the Phenylalanine hydroxylase reading frame is not altered and it would encode for a protein with 14 extra amino acids which would be able to account for the low enzyme activity detected in this mutant.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
tryptophan phenylalanine hydroxylase
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Tva
Pathogen resistance (virus)
Coding,
SNP
Gallus gallus
chicken - (species) D
Intraspecific
Candidate Gene
Elleder D; Melder DC; Trejbalova K ; et al. (2004)
Two different molecular defects in the Tva receptor gene explain the resistance of two tvar lines of[...]
GP00002256
tva
Q6JBY7
Physiology
c.120C>G p.C40W
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species) D
Tva
Gallus gallus
chicken - (species)
Published - Accepted by Curator
Tva
Pathogen resistance (virus)
Coding,
Insertion
N
Gallus gallus
chicken - (species) D
Intraspecific
Candidate Gene
Elleder D; Melder DC; Trejbalova K ; et al. (2004)
Two different molecular defects in the Tva receptor gene explain the resistance of two tvar lines of[...]
GP00002257
tva
Q6JBY7
Physiology
c.48insCTCG N
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species) D
Tva
Gallus gallus
chicken - (species)
Published - Accepted by Curator
Tva
Pathogen resistance (virus)
Coding,
Deletion
N
Gallus gallus
chicken - (species) D
Intraspecific
Candidate Gene
Chen W; Liu Y; Li H ; et al. (2015)
Intronic deletions of tva receptor gene decrease the susceptibility to infection by avian sarcoma an[...]
GP00002258
tva
Q6JBY7
Physiology
c.502_511delCGCTCACCCC N
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species) D
Tva
Gallus gallus
chicken - (species)
Published - Accepted by Curator
Tva
Pathogen resistance (virus)
Coding,
Deletion
N
Gallus gallus
chicken - (species) D
Intraspecific
Candidate Gene
Chen W; Liu Y; Li H ; et al. (2015)
Intronic deletions of tva receptor gene decrease the susceptibility to infection by avian sarcoma an[...]
GP00002259
tva
Q6JBY7
Physiology
c.502_516delCGCTCACCCCGCCCC N
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species) D
Tva
Gallus gallus
chicken - (species)
Published - Accepted by Curator
Tva
Pathogen resistance (virus)
Coding,
Deletion
N
Gallus gallus
chicken - (species) D
Intraspecific
Candidate Gene
Reinišová M; Plachý J; Trejbalová K ; et al. (2012)
Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptib[...]
GP00002260
tva
Q6JBY7
Physiology
c.506-515del10 ; splicing N
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species) D
Tva
Gallus gallus
chicken - (species)
Published - Accepted by Curator
Tva
Pathogen resistance (virus)
Coding,
Deletion
N
Gallus gallus
chicken - (species) D
Intraspecific
Candidate Gene
Reinišová M; Plachý J; Trejbalová K ; et al. (2012)
Intronic deletions that disrupt mRNA splicing of the tva receptor gene result in decreased susceptib[...]
GP00002261
tva
Q6JBY7
Physiology
c.507-511del5 ; splicing N
Gallus gallus
chicken - (species)
Gallus gallus
chicken - (species) D
Tva
Gallus gallus
chicken - (species)
Published - Accepted by Curator
two pore channel
Xenobiotic resistance (soil contamination; serpentine)
Unknown,
Unknown
Arabidopsis arenosa
(species) D
Intraspecific
Association Mapping
Arnold BJ; Lahner B; DaCosta JM ; et al. (2016)
Borrowed alleles and convergence in serpentine adaptation.
GP00001433
TPC1
Q94KI8
Physiology
unknown
Arabidopsis arenosa
(species)
Arabidopsis arenosa
(species) D
two pore channel
Arabidopsis arenosa
(species)
Published - Accepted by Curator
Tyramine receptor 3
Exploration decision
Unknown,
Unknown
Caenorhabditis elegans
(species)
Intraspecific
Linkage Mapping
Bendesky A; Tsunozaki M; Rockman MV ; et al. (2011)
Catecholamine receptor polymorphisms affect decision-making in C. elegans.
GP00001141
tyra-3
Q7JNP9
Behavior
Non-coding
Caenorhabditis elegans
(species)
Caenorhabditis elegans
(species)
Tyramine receptor 3
Caenorhabditis elegans
(species)
Published - Accepted by Curator
tyrosinase (TYR)
Coloration (eyes; hair; skin)
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Sulem P; Gudbjartsson DF; Stacey SN ; et al. (2007)
Genetic determinants of hair, eye and skin pigmentation in Europeans.
2 Additional References
GP00001144
Tyr
P11344
Morphology
R402Q
Homo sapiens
human - (species)
Homo sapiens
human - (species)
tyrosinase (TYR)
Homo sapiens
human - (species)
Published - Accepted by Curator
tyrosinase (TYR)
Coloration (coat)
Coding,
SNP
Panthera leo
lion - (species) D
Intraspecific
Association Mapping
Cho YS; Hu L; Hou H ; et al. (2013)
The tiger genome and comparative analysis with lion and snow leopard genomes.
GP00001346
Tyr
P11344
Morphology
c.260G>A p.Arg87Gln
Panthera leo
lion - (species)
Panthera leo
lion - (species) D
tyrosinase (TYR)
Panthera leo
lion - (species)
Published - Accepted by Curator
tyrosinase (TYR)
Coloration (skin; coat)
Coding,
SNP
Equus asinus
ass - (species) D
Intraspecific
Candidate Gene
Utzeri VJ; Bertolini F; Ribani A ; et al. (2016)
The albinism of the feral Asinara white donkeys (Equus asinus) is determined by a missense mutation [...]
GP00001347
Tyr
P11344
Morphology
c.604C>G p.His202Asp
Equus asinus
ass - (species)
Equus asinus
ass - (species) D
tyrosinase (TYR)
Equus asinus
ass - (species)
Published - Accepted by Curator
tyrosinase (TYR)
Coloration (skin; eye; freckles)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Wilde S; Timpson A; Kirsanow K ; et al. (2014)
Direct evidence for positive selection of skin, hair, and eye pigmentation in Europeans during the l[...]
GP00001348
Tyr
P11344
Morphology
c. C>A p.Ser192Tyr
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
tyrosinase (TYR)
Homo sapiens
human - (species)
Published - Accepted by Curator
tyrosinase (TYR)
Coloration (skin)
Coding,
Deletion
Megaptera novaeangliae
humpback whale - (species) D
Intraspecific
Candidate Gene
Polanowski AM; Robinson-Laverick SM; Paton D ; et al. (2012 Jan-Feb)
Variation in the tyrosinase gene associated with a white humpback whale (Megaptera novaeangliae).
GP00002314
Tyr
P11344
Morphology
(264 del C) at codon 88
Megaptera novaeangliae
humpback whale - (species)
Megaptera novaeangliae
humpback whale - (species) D
tyrosinase (TYR)
Megaptera novaeangliae
humpback whale - (species)
Published - Accepted by Curator
tyrosinase (TYR)
Coloration (skin)
Coding,
SNP
Fejervarya kawamurai
(species) D
Intraspecific
Candidate Gene
Miura I; Tagami M; Fujitani T ; et al. (2018)
Spontaneous tyrosinase mutations identified in albinos of three wild frog species.
GP00002321
Tyr
P11344
Morphology
c.169G>A p.Gly57Arg
Fejervarya kawamurai
(species)
Fejervarya kawamurai
(species) D
tyrosinase (TYR)
Fejervarya kawamurai
(species)
Published - Accepted by Curator
tyrosinase (TYR)
Coloration (coat; albinism)
Coding,
Deletion
N
Nyctereutes procyonoides viverrinus
(subspecies) D
Intraspecific
Candidate Gene
Mae Y; Nagara K; Miyazaki M ; et al. (2020)
Complex intragene deletion leads to oculocutaneous albinism in tanuki (Japanese raccoon dog).
GP00002374
Tyr
P11344
Morphology
"We examined the structure and nucleotide sequence of TYR in an albino tanuki and found that the third exon was removed due to a deletion of approximately 11 kb. In addition, two nonsynonymous nucleotide substitutions were found in the fifth exon. These mutations are possible causes of the albino phenotype; however, the order of occurrence is unclear. Even if the 11-kb deletion was not the first of these mutations, it is considered to cause a total loss of the tyrosinase function because the third exon carries codons for one of the two copper-binding sites of tyrosinase and these sites are essential for the enzyme function. Intriguingly, the deletion was not a simple removal of an 11-kb segment: an internal portion was retained as a segment in the reverse orientation. We propose possible formation processes for this mutation that involve multiple DNA scission events, or an inversion followed by a deletion." N
Nyctereutes procyonoides viverrinus
(subspecies)
Nyctereutes procyonoides viverrinus
(subspecies) D
tyrosinase (TYR)
Nyctereutes procyonoides viverrinus
(subspecies)
Published - Accepted by Curator
tyrosinase (TYR)
Coloration (coat)
Coding,
SNP
Cervus elaphus
red deer - (species) D
Intraspecific
Candidate Gene
Reiner G; Tramberend K; Nietfeld F ; et al. (2020)
A genome-wide scan study identifies a single nucleotide substitution in the tyrosinase gene associat[...]
GP00002375
Tyr
P11344
Morphology
"a non-synonymous mutation with exchange of a glycine residue at position 291 of the tyrosinase protein by arginine was identified as the cause of dilution of the coat colour"
The mutation is on nucleotide 871 (G > A) but the exact codons are not specified in the paper.
Cervus elaphus
red deer - (species)
Cervus elaphus
red deer - (species) D
tyrosinase (TYR)
Cervus elaphus
red deer - (species)
Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)
Coloration (coat)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Kenny EE; Timpson NJ; Sikora M ; et al. (2012)
Melanesian blond hair is caused by an amino acid change in TYRP1.
GP00001155
Tyrp1
P07147
Morphology
R93C
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
tyrosinase-related protein 1 (TYRP1)
Homo sapiens
human - (species)
Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)
Coloration (eyes; hair; skin)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Frudakis T; Thomas M; Gaskin Z ; et al. (2003)
Sequences associated with human iris pigmentation.
1 Additional References
GP00001157
Tyrp1
P07147
Morphology
unknown
Homo sapiens
human - (species)
Homo sapiens
human - (species)
tyrosinase-related protein 1 (TYRP1)
Homo sapiens
human - (species)
Published - Accepted by Curator
tyrosinase-related protein 1 (TYRP1)
Coloration (feathers)
Coding,
Insertion
N
Falco cherrug
Saker falcon - (species) D
Intraspecific
Candidate Gene
Cortimiglia C; Castiglioni B; Pizzi F ; et al. (2017)
Involvement of tyrosinase-related protein 1 gene in the light brown plumage phenotype of Falco cherr[...]
GP00002285
Tyrp1
P07147
Morphology
c.79_80insT in exon 1 resulting in a frameshift change and a premature stop codon at position 81 of the deduced protein sequence ; which in the wild-type form contains 536 amino acids N
Falco cherrug
Saker falcon - (species)
Falco cherrug
Saker falcon - (species) D
tyrosinase-related protein 1 (TYRP1)
Falco cherrug
Saker falcon - (species)
Published - Accepted by Curator
tyrosyl-tRNA synthetase (mt-TyrRS)
Hybrid incompatibility (F1 hybrid viability; F1 hybrid sterility)
Coding,
SNP
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Meiklejohn CD; Holmbeck MA; Siddiq MA ; et al. (2013)
An Incompatibility between a mitochondrial tRNA and its nuclear-encoded tRNA synthetase compromises [...]
1 Additional References
GP00001972
TyrRS-m
Q9W107
Physiology
C to T mutation at the base of the anticodon stem, so that G:C becomes G:U in the folded mRNA (see Fig. 1 of Hoekstra et al 2013)
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
tyrosyl-tRNA synthetase (mt-TyrRS)
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
TZP
Plant growth (hypocotyl growth - light and temperature dependant)
Coding,
Insertion
N
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Loudet O; Michael TP; Burger BT ; et al. (2008)
A zinc knuckle protein that negatively controls morning-specific growth in Arabidopsis thaliana.
GP00001269
TZP
Q9FIX7
Morphology
8bp insertion causing premature stop N
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
TZP
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
UBE2E2
Body fat distribution (visceral/subcutaneous ratio)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Chu AY; Deng X; Fisher VA ; et al. (2017)
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyt[...]
GP00001553
UBE2E2
Q96LR5
Physiology
T>C in associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
UBE2E2
Homo sapiens
human - (species)
Published - Accepted by Curator
Ubiquitin-specific peptidase 46 (Usp46)
Escape behavior (immobility in inescapable situations)
Coding,
Deletion
Mus musculus
house mouse - (species) D
Intraspecific
Linkage Mapping
Tomida S; Mamiya T; Sakamaki H ; et al. (2009)
Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and for[...]
GP00001159
Usp46
P62069
Behavior
1a.a. deletion
Mus musculus
house mouse - (species)
Mus musculus
house mouse - (species) D
Ubiquitin-specific peptidase 46 (Usp46)
Mus musculus
house mouse - (species)
Published - Accepted by Curator
UDP-glycosyltransferase 89A2
Plant secondary metabolites (xylosides vs. glucosides ratio)
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Li X; Svedin E; Mo H ; et al. (2014)
Exploiting natural variation of secondary metabolism identifies a gene controlling the glycosylation[...]
GP00001278
UGT89A2
Q9LZD8
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
UDP-glycosyltransferase 89A2
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Ugt86Dd
Xenobiotic resistance (nicotine ; larval stage)
Coding,
Deletion
N
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Association Mapping
Marriage TN; King EG; Long AD ; et al. (2014)
Fine-mapping nicotine resistance loci in Drosophila using a multiparent advanced generation inter-cr[...]
1 Additional References
GP00001406
Ugt86Dd
Q9VGT8
Physiology
22-bp frameshift deletion in Ugt86Dd - CRISPR-induced deletions in Ugt86Dd lead to a large reduction in resistance N
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
Ugt86Dd
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
Vanaso / disc losts
Olfactory behavior
Unknown,
Unknown
Drosophila melanogaster
fruit fly - (species)
Intraspecific
Linkage Mapping
Fanara JJ; Robinson KO; Rollmann SM ; et al. (2002)
Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior.
GP00001164
dlt
Q8T626
Behavior
unknown
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species)
Vanaso / disc losts
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
VGLL3 (vestigial-like family member 3 gene )
Age of sexual maturity
Unknown,
Unknown
Salmo salar
Atlantic salmon - (species)
Intraspecific
Association Mapping
Barson NJ; Aykanat T; Hindar K ; et al. (2015)
Sex-dependent dominance at a single locus maintains variation in age at maturity in salmon.
1 Additional References
GP00001167
VGLL3
A8MV65
Physiology
candidate amino-acid substitutions
Salmo salar
Atlantic salmon - (species)
Salmo salar
Atlantic salmon - (species)
VGLL3 (vestigial-like family member 3 gene )
Salmo salar
Atlantic salmon - (species)
Published - Accepted by Curator
VIN3
Flowering time
Unknown,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Ågren J; Oakley CG; Lundemo S ; et al. (2017)
Adaptive divergence in flowering time among natural populations of Arabidopsis thaliana: Estimates o[...]
GP00001538
VIN3
Q9FIE3
Physiology
4 nonsynonymous substitutions and a 3 bp deletion
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
VIN3
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (anti-coagulant drug response; warfarin)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Linkage Mapping
Rost S; Fregin A; Ivaskevicius V ; et al. (2004)
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
2 Additional References
GP00001168
VKORC1
Q9BQB6
Physiology
R98W
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Vkorc1
Homo sapiens
human - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (anti-coagulant drug response; warfarin)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Rost S; Fregin A; Ivaskevicius V ; et al. (2004)
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
2 Additional References
GP00001169
VKORC1
Q9BQB6
Physiology
V29L
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Vkorc1
Homo sapiens
human - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (anti-coagulant drug response; warfarin)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Rost S; Fregin A; Ivaskevicius V ; et al. (2004)
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
2 Additional References
GP00001170
VKORC1
Q9BQB6
Physiology
V45A
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Vkorc1
Homo sapiens
human - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (anti-coagulant drug response; warfarin)
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Rost S; Fregin A; Ivaskevicius V ; et al. (2004)
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
2 Additional References
GP00001171
VKORC1
Q9BQB6
Physiology
R58G
Homo sapiens
human - (species)
Homo sapiens
human - (species) D
Vkorc1
Homo sapiens
human - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Mus musculus
house mouse - (species)
Intraspecific
Candidate Gene
Pelz HJ; Rost S; Hünerberg M ; et al. (2005)
The genetic basis of resistance to anticoagulants in rodents.
GP00001172
VKORC1
Q9BQB6
Physiology
L128S
Mus musculus
house mouse - (species)
Mus musculus
house mouse - (species)
Vkorc1
Mus musculus
house mouse - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Mus musculus
house mouse - (species)
Intraspecific
Candidate Gene
Pelz HJ; Rost S; Hünerberg M ; et al. (2005)
The genetic basis of resistance to anticoagulants in rodents.
GP00001173
VKORC1
Q9BQB6
Physiology
Y139C
Mus musculus
house mouse - (species)
Mus musculus
house mouse - (species)
Vkorc1
Mus musculus
house mouse - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Mus spretus
western wild mouse - (species)
Intraspecific
Candidate Gene
Song Y; Endepols S; Klemann N ; et al. (2011)
Adaptive introgression of anticoagulant rodent poison resistance by hybridization between old world [...]
GP00001174
VKORC1
Q9BQB6
Physiology
Several candidate coding changes
Mus musculus
house mouse - (species)
Mus spretus
western wild mouse - (species)
Vkorc1
Mus spretus
western wild mouse - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Rattus norvegicus
Norway rat - (species)
Intraspecific
Linkage Mapping
Rost S; Fregin A; Ivaskevicius V ; et al. (2004)
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
GP00001175
VKORC1
Q9BQB6
Physiology
Y139C
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species)
Vkorc1
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Rattus norvegicus
Norway rat - (species)
Intraspecific
Candidate Gene
Pelz HJ; Rost S; Hünerberg M ; et al. (2005)
The genetic basis of resistance to anticoagulants in rodents.
GP00001176
VKORC1
Q9BQB6
Physiology
S56P
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species)
Vkorc1
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Rattus norvegicus
Norway rat - (species)
Intraspecific
Candidate Gene
Pelz HJ; Rost S; Hünerberg M ; et al. (2005)
The genetic basis of resistance to anticoagulants in rodents.
GP00001177
VKORC1
Q9BQB6
Physiology
L128S
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species)
Vkorc1
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Rattus norvegicus
Norway rat - (species)
Intraspecific
Candidate Gene
Pelz HJ; Rost S; Hünerberg M ; et al. (2005)
The genetic basis of resistance to anticoagulants in rodents.
GP00001178
VKORC1
Q9BQB6
Physiology
L128Q
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species)
Vkorc1
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Rattus norvegicus
Norway rat - (species)
Intraspecific
Candidate Gene
Pelz HJ; Rost S; Hünerberg M ; et al. (2005)
The genetic basis of resistance to anticoagulants in rodents.
GP00001179
VKORC1
Q9BQB6
Physiology
L120Q
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species)
Vkorc1
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Rattus norvegicus
Norway rat - (species)
Intraspecific
Candidate Gene
Pelz HJ; Rost S; Hünerberg M ; et al. (2005)
The genetic basis of resistance to anticoagulants in rodents.
GP00001180
VKORC1
Q9BQB6
Physiology
Y139S
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species)
Vkorc1
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Rattus norvegicus
Norway rat - (species)
Intraspecific
Candidate Gene
Lasseur R; Longin-Sauvageon C; Videmann B ; et al. (2005)
Warfarin resistance in a French strain of rats.
1 Additional References
GP00001181
VKORC1
Q9BQB6
Physiology
Y139F
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species)
Vkorc1
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
Vkorc1
Xenobiotic resistance (rodenticide; warfarin)
Coding,
SNP
Rattus norvegicus
Norway rat - (species)
Intraspecific
Candidate Gene
Tanaka KD; Kawai YK; Ikenaka Y ; et al. (2013)
A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats.
GP00001182
VKORC1
Q9BQB6
Physiology
R33P
Rattus norvegicus
Norway rat - (species)
Rattus norvegicus
Norway rat - (species)
Vkorc1
Rattus norvegicus
Norway rat - (species)
Published - Accepted by Curator
VRN1
Flowering time
Cis-regulatory,
Indel
Lolium perenne
(species)
Intraspecific
Candidate Gene
Asp T; Byrne S; Gundlach H ; et al. (2011)
Comparative sequence analysis of VRN1 alleles of Lolium perenne with the co-linear regions in barley[...]
GP00001183
VRN1
Q8L3W1
Physiology
8.6kb indel in first intron
Lolium perenne
(species)
Lolium perenne
(species)
VRN1
Lolium perenne
(species)
Published - Accepted by Curator
WDR66
Hematopoiesis (mean blood platelet volume)
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Guo MH; Nandakumar SK; Ulirsch JC ; et al. (2017)
Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mech[...]
GP00001604
WDR66
Q8TBY9
Physiology
A>G at the associated SNP
Homo sapiens
human - (species)
Homo sapiens
human - (species)
WDR66
Homo sapiens
human - (species)
Published - Accepted by Curator
WntA
Coloration (wing, Mullerian mimicry)
Cis-regulatory,
Unknown
Heliconius erato
crimson-patched longwing - (species)
Intraspecific
Association Mapping
Martin A; Papa R; Nadeau NJ ; et al. (2012)
Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand.
GP00001205
WntA
A0A077DF90
Morphology
unknown
Heliconius erato
crimson-patched longwing - (species)
Heliconius erato
crimson-patched longwing - (species)
WntA
Heliconius erato
crimson-patched longwing - (species)
Published - Accepted by Curator
WntA
Coloration (wing, Mullerian mimicry)
Cis-regulatory,
Unknown
Heliconius hecale
(species)
Intraspecific
Linkage Mapping
Martin A; Papa R; Nadeau NJ ; et al. (2012)
Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand.
GP00001206
WntA
A0A077DF90
Morphology
unknown
Heliconius hecale
(species)
Heliconius hecale
(species)
WntA
Heliconius hecale
(species)
Published - Accepted by Curator
WntA
Coloration (wing, Mullerian mimicry)
Cis-regulatory,
Unknown
Heliconius ismenius
(species)
Intraspecific
Linkage Mapping
Martin A; Papa R; Nadeau NJ ; et al. (2012)
Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand.
GP00001207
WntA
A0A077DF90
Morphology
unknown
Heliconius ismenius
(species)
Heliconius ismenius
(species)
WntA
Heliconius ismenius
(species)
Published - Accepted by Curator
WntA
Coloration (wing; Batesian mimicry)
Cis-regulatory,
Unknown
Limenitis arthemis
white admiral - (species)
Intraspecific
Linkage Mapping
Gallant JR; Imhoff VE; Martin A ; et al. (2014)
Ancient homology underlies adaptive mimetic diversity across butterflies.
GP00001208
WntA
A0A077DF90
Morphology
Complex Haplotype in first intron perfectly associated with phenotype: 173 fixed single-nucleotide polymorphisms (SNPs) in complete linkage disequilibrium (LD) located 23
Limenitis arthemis
white admiral - (species)
Limenitis arthemis
white admiral - (species)
WntA
Limenitis arthemis
white admiral - (species)
Published - Accepted by Curator
WntA
Coloration (wing, Mullerian mimicry)
Cis-regulatory,
Indel
Heliconius cydno
(species)
Intraspecific
Linkage Mapping
Gallant JR; Imhoff VE; Martin A ; et al. (2014)
Ancient homology underlies adaptive mimetic diversity across butterflies.
1 Additional References
GP00001209
WntA
A0A077DF90
Morphology
1.8-kb indel that was perfectly associated with variation in forewing melanin patterning
Heliconius cydno
(species)
Heliconius cydno
(species)
WntA
Heliconius cydno
(species)
Published - Accepted by Curator
WntA
Coloration (wing, Mullerian mimicry)
Cis-regulatory,
Unknown
Heliconius pachinus
(species)
Intraspecific
Linkage Mapping
Martin A; Papa R; Nadeau NJ ; et al. (2012)
Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand.
1 Additional References
GP00001210
WntA
A0A077DF90
Morphology
Complex cis-regulatory haplotype : 170 fixed differences were detected among comparisons of allopatric H. c. galanthus and H. pachinus
Heliconius cydno
(species)
Heliconius pachinus
(species)
WntA
Heliconius pachinus
(species)
Published - Accepted by Curator
WntA
Coloration (wing, Mullerian mimicry)
Cis-regulatory,
Unknown
Heliconius erato
crimson-patched longwing - (species)
Intraspecific
Linkage Mapping
Martin A; Papa R; Nadeau NJ ; et al. (2012)
Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand.
GP00001211
WntA
A0A077DF90
Morphology
Not identified
Heliconius himera
(species)
Heliconius erato
crimson-patched longwing - (species)
WntA
Heliconius erato
crimson-patched longwing - (species)
Published - Accepted by Curator
WntA
Coloration (wing, Mullerian mimicry)
Cis-regulatory,
Unknown
Heliconius erato
crimson-patched longwing - (species)
Intraspecific
Linkage Mapping
Martin A; Papa R; Nadeau NJ ; et al. (2012)
Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand.
GP00001212
WntA
A0A077DF90
Morphology
Not identified
Heliconius himera
(species)
Heliconius erato
crimson-patched longwing - (species)
WntA
Heliconius erato
crimson-patched longwing - (species)
Published - Accepted by Curator
WntA
Coloration (wing, Mullerian mimicry)
Cis-regulatory,
Unknown
Heliconius erato
crimson-patched longwing - (species)
Intraspecific
Linkage Mapping
Martin A; Papa R; Nadeau NJ ; et al. (2012)
Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand.
GP00001213
WntA
A0A077DF90
Morphology
Not identified
Heliconius himera
(species)
Heliconius erato
crimson-patched longwing - (species)
WntA
Heliconius erato
crimson-patched longwing - (species)
Published - Accepted by Curator
WntA
Coloration (wing, Mullerian mimicry)
Cis-regulatory,
Unknown
Heliconius melpomene
postman butterfly - (species)
Intraspecific
Linkage Mapping
Martin A; Papa R; Nadeau NJ ; et al. (2012)
Diversification of complex butterfly wing patterns by repeated regulatory evolution of a Wnt ligand.
GP00001214
WntA
A0A077DF90
Morphology
unknown ; non-coding with effect on spatial gene expression
Heliconius melpomene
postman butterfly - (species)
Heliconius melpomene
postman butterfly - (species)
WntA
Heliconius melpomene
postman butterfly - (species)
Published - Accepted by Curator
WRR4
Pathogen resistance
Coding,
Unknown
Arabidopsis thaliana
thale cress - (species)
Intraspecific
Linkage Mapping
Borhan MH; Gunn N; Cooper A ; et al. (2008)
WRR4 encodes a TIR-NB-LRR protein that confers broad-spectrum white rust resistance in Arabidopsis t[...]
GP00001215
ADR2
Q9C7X0
Physiology
unknown
Arabidopsis thaliana
thale cress - (species)
Arabidopsis thaliana
thale cress - (species)
WRR4
Arabidopsis thaliana
thale cress - (species)
Published - Accepted by Curator
Xa1
Pathogen resistance
Unknown,
Unknown
Oryza sativa
rice - (species)
Intraspecific
Linkage Mapping
Yoshimura S; Yamanouchi U; Katayose Y ; et al. (1998)
Expression of Xa1, a bacterial blight-resistance gene in rice, is induced by bacterial inoculation.
GP00001216
XA1
A0A0H5AGW3
Physiology
unknown
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Xa1
Oryza sativa
rice - (species)
Published - Accepted by Curator
Xa21
Pathogen resistance
Coding,
Unknown
Oryza sativa
rice - (species)
Intraspecific
Linkage Mapping
Song WY; Wang GL; Chen LL ; et al. (1995)
A receptor kinase-like protein encoded by the rice disease resistance gene, Xa21.
GP00001217
Xa21
A0PIA3
Physiology
unknown
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Xa21
Oryza sativa
rice - (species)
Published - Accepted by Curator
Xa26
Pathogen resistance
Coding,
Unknown
Oryza sativa
rice - (species)
Intraspecific
Linkage Mapping
Sun X; Cao Y; Yang Z ; et al. (2004)
Xa26, a gene conferring resistance to Xanthomonas oryzae pv. oryzae in rice, encodes an LRR receptor[...]
GP00001218
Xa26
Q00KZ8
Physiology
unknown
Oryza sativa
rice - (species)
Oryza sativa
rice - (species)
Xa26
Oryza sativa
rice - (species)
Published - Accepted by Curator
yellow
Coloration (body; wing)
Cis-regulatory,
Inversion
Drosophila melanogaster
fruit fly - (species) D
Intraspecific
Candidate Gene
Zakharenko LP; p6acheva EM; Romanova OA ; et al. (2000)
hobo-induced rearrangements are responsible for mutation bursts at the yellow locus in a natural pop[...]
GP00001961
y
P09957
Morphology
y[2-717] - Inversion that occurred between two hobo elements: one located 129 bp from the start site of yellow transcription and the other in the distal telomere region. The yellow phenotype is caused by the separation of the body and wing enhancers from the transcription unit.
Drosophila melanogaster
fruit fly - (species)
Drosophila melanogaster
fruit fly - (species) D
yellow
Drosophila melanogaster
fruit fly - (species)
Published - Accepted by Curator
yellow
Coloration (wing)
Cis-regulatory,
Unknown
Danaus chrysippus
African queen - (species)
Intraspecific
Association Mapping
Martin SH; Singh KS; Gordon IJ ; et al. (2020)
Whole-chromosome hitchhiking driven by a male-killing endosymbiont.
GP00002430
y
P09957
Morphology
A cluster of SNPs most strongly associated with background colour (B locus) is found just upstream of the gene yellow and a phylogenetic network for a 30-kb region around yellow groups individuals nearly perfectly by phenotype; although some individuals classed as heterozygous were intermingled with homozygotes.
Danaus chrysippus
African queen - (species)
Danaus chrysippus
African queen - (species)
yellow
Danaus chrysippus
African queen - (species)
Published - Accepted by Curator
yellow
Coloration (body; wing)
Coding,
Insertion
N
Musca domestica
house fly - (species) D
Intraspecific
Candidate Gene
Heinze SD; Kohlbrenner T; Ippolito D ; et al. (2017)
CRISPR-Cas9 targeted disruption of the yellow ortholog in the housefly identifies the brown body loc[...]
GP00002623
y
P09957
Morphology
a 4 bp insertion at amino acid position 67 that causes a frameshift and a premature stop codon N
Musca domestica
house fly - (species)
Musca domestica
house fly - (species) D
yellow
Musca domestica
house fly - (species)
Published - Accepted by Curator
zic1/zic4
Fin morphology (skeleton; dorsal fin; caudal fin)
Pigmentation (ventralized trunk)
Cis-regulatory,
Insertion
Oryzias latipes
Japanese medaka - (species) D
Intraspecific
Linkage Mapping
Moriyama Y; Kawanishi T; Nakamura R ; et al. (2012)
The medaka zic1/zic4 mutant provides molecular insights into teleost caudal fin evolution.
1 Additional References
GP00002038
Zic1
P46684
Morphology
Morphology
The mutant phenotype is caused by a dramatic decrease of zic1/zic4 expression in the dorsal somites. The insertion of a transposon (“Albatross”) into an enhancer region (downstream of zic4) of the transcription factors zic1 and zic4 causes this phenotype. Both genes are expressed by a bi-directional promoter. The transposon insertion is proposed to interfere with the transcriptional regulation of zic1/zic4; resulting in the disturbance of the expression of the transcription factors in the dorsal somites (the expression of zic1/zic4 in other parts of the body is not affected in this mutant) and ultimately causing a ventralized trunk phenotype. In Inoue et al. (2017) it was shown that the transposon “Albatross” is actually larger than originally predicted; and is now called “Teratorn”. Teratorn is around 180kb long and appears to originate from the fusion of a DNA transposon and a herpesvirus.
Oryzias latipes
Japanese medaka - (species)
Oryzias latipes
Japanese medaka - (species) D
zic1/zic4
Oryzias latipes
Japanese medaka - (species)
Published - Accepted by Curator
Zmr1
Xenobiotic resistance (fungicide)
Melanin content
2 Mutations:
Cis-regulatory
Zymoseptoria tritici
(species)
Intraspecific
Linkage Mapping
Krishnan P; Meile L; Plissonneau C ; et al. (2018)
Transposable element insertions shape gene regulation and melanin production in a fungal pathogen of[...]
GP00001715
CMR1
Q06F33
Physiology
Physiology
2 mutations
Zymoseptoria tritici
(species)
Zymoseptoria tritici
(species)
Zmr1
Zymoseptoria tritici
(species)
Published - Accepted by Curator
ZmVPP1
Drought tolerance
Cis-regulatory,
Insertion
Zea mays
(species)
Intraspecific
Association Mapping
Wang X; Wang H; Liu S ; et al. (2016)
Genetic variation in ZmVPP1 contributes to drought tolerance in maize seedlings.
GP00001567
GRMZM2G170927
A0A172DSU8
Physiology
A 366-bp insertion in the promoter containing 3 MYB cis elements confers drought-inducible expression of ZmVPP1 in drought-tolerant genotypes
Zea mays
(species)
Zea mays
(species)
ZmVPP1
Zea mays
(species)
Published - Accepted by Curator
β-adrenergic octopamine receptor gene (AOR)
Xenobiotic resistance (amitraz)
Coding,
SNP
Rhipicephalus microplus
southern cattle tick - (species) D
Intraspecific
Association Mapping
Corley SW; Jonsson NN; Piper EK ; et al. (2013)
Mutation in the RmβAOR gene is associated with amitraz resistance in the cattle tick Rhipicephalus m[...]
1 Additional References
GP00002396
Oct-TyrR
P22270
Physiology
L64I
Rhipicephalus microplus
southern cattle tick - (species)
Rhipicephalus microplus
southern cattle tick - (species) D
β-adrenergic octopamine receptor gene (AOR)
Rhipicephalus microplus
southern cattle tick - (species)
Published - Accepted by Curator